Clinical trials: pharmacological study, completed
Mild Cognitive Impairment, Memory Impairment
Diminishing Accelerated Long-term Forgetting in Mild Cognitive Impairment
This study is designed as a prospective, double-blind, placebo-controlled, randomized parallel-group study that will be completed at the clinical research facility at St. James' Hospital and at Trinity College Dublin, Ireland.
- Conditions
- Mild Cognitive Impairment, Memory Impairment, Memory Disorders in Old Age
- Trial name
- NCT05289804
- Testing
- NITESGON, Lidocaine / Prilocaine Topical Cream, C5/C6 stimulation
- Where
- Ireland
- Volunteers
- 80 people
- Sponsor
- University of Dublin, Trinity College
In Vitro Fertilization
Corifollitropin Alfa in Participants Undergoing Repeated Controlled Ovarian Stimulation (COS) Cycles Using a Multiple Dose Gonadatropin Releasing Hormone (GnRH) Antagonist Protocol (Study 38825)(P05714)
The objective of the trial is to assess the non-immunogenicity and safety of corifollitropin alfa (also known as Org 36286, SCH 900962 and MK-8962) in participants undergoing repeated COS cycles using a multiple dose GnRH…
- Trial name
- Trust (NCT00696878)
- Testing
- Corifollitropin alfa, FSH, GnRH antagonist
- Volunteers
- 682 people
- Sponsor
- Organon and Co
Hypertrophic Cardiomyopathy
Sacubitril/Valsartan vs Lifestyle in Hypertrophic Cardiomyopathy
The overall aim of this project is to establish potential benefits of a novel lifestyle (physical activity and dietary nitrate) and pharmacological (angiotensin receptor neprilysin inhibitor) interventions in patients with…
- Trial name
- SILICOFCM (NCT03832660)
- Testing
- Lifestyle, Sacubitril/Valsartan
- Where
- 5 sites in Germany, Italy and 2 more
- Volunteers
- 168 people
- Sponsor
- Newcastle University
Prostate Cancer, Prostate Cancer Locally Advanced
Hypofractionated Radiotherapy With Magnetic Resonance Imaging-Guided Focal Boost and Pelvic Irradiation in High-Risk Prostate Cancer
This study evaluated long-term disease control and side effects of a moderately hypofractionated radiotherapy protocol for men with high-risk prostate cancer.
- Conditions
- Prostate Cancer, Prostate Cancer Locally Advanced, Prostatic Neoplams
- Trial name
- NCT07900555
- Testing
- Hypofractionated IMRT with focal simultaneous integrated boost and elective pelvic irradiation, Androgen Deprivation Therapy (ADT)
- Where
- Norway
- Volunteers
- 191 people
- Sponsor
- Haukeland University Hospital
Healthy Adult Subjects
Dietary Supplement With and Without a Probiotic
Complex oligosaccharides can alter the gut microbiome by aiding in the growth of certain organisms, and possibly, inhibiting others. The synergy with a probiotic may enhance gastrointestinal colonization.
- Trial name
- NCT04433208
- Testing
- Complex oligosaccharide, Probiotic, PPI
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Prolacta Bioscience
Adenocarcinoma of the Pancreas, Recurrent Pancreatic Cancer
Saracatinib in Treating Patients With Previously Treated Metastatic Pancreatic Cancer
This phase II trial is studying how well saracatinib works in treating patients with previously treated metastatic pancreatic cancer.
- Conditions
- Adenocarcinoma of the Pancreas, Recurrent Pancreatic Cancer, Stage IV Pancreatic Cancer
- Trial name
- NCT00735917
- Testing
- saracatinib, pharmacogenomic studies, pharmacological study
- Where
- 9 sites in United States, Australia and 1 more
- Volunteers
- 19 people
- Sponsor
- National Cancer Institute (NCI)
Prostate Cancer
Preoperative Brimonidine on IOP of Patients Undergoing RALP
Patients with prostate cancer undergoing robot assisted radical laparoscopic prostatectomy (RALP) in steep Trendelenburg position (sTBURG) are noted to have elevated intraocular pressures (IOP) intraoperatively.
- Trial name
- IOPsTBURG (NCT02818816)
- Testing
- brimonidine tartrate 0.2%, Carboxymethylcellulose Eye Drops
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- University Health Network, Toronto
Healthy, Renal Insufficiency
Safety, Tolerability and Pharmacokinetics of KBP-5074 in Healthy Subjects and Subjects With Renal Impairment
This multiple ascending dose (MAD) study in healthy subjects and subjects with mild to moderate renal impairment will evaluate the safety, tolerability and pharmacokinetics of KBP-5074.
- Trial name
- NCT02653014
- Testing
- KBP-5074
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- KBP Biosciences
Carcinoma, Non-Small-Cell Lung, Metastatic Lung Non-Small Cell Carcinoma
Palliative RadIotherapy of Multiple Metastatic Sites Before First Line of Systemic Therapy With Immune Checkpoint Inhibitors and Chemotherapy in Metastatic Non-Small-Cell Lung Cancer
The study is designed as a non-randomized Phase 2 clinical intervention study. The study will include patients with disseminated Non-Small Cell Lung Carcinoma (NSCLC) which are eligible for first line of systemic treatment with…
- Conditions
- Carcinoma, Non-Small-Cell Lung, Metastatic Lung Non-Small Cell Carcinoma, Non Small Cell Lung Cancer
- Trial name
- PRIMM (NCT05440916)
- Testing
- Palliative Radiotherapy: 5 x 4Gy, chemotherapy + immune checkpoint inhibitors
- Where
- 3 sites in Slovenia
- Volunteers
- 50 people
- Sponsor
- University Medical Centre Maribor
Open-Angle Glaucoma, Ocular Hypertension
Fixed Combination Brinzolamide 1%/Timolol 0.5% Versus Brinzolamide 1% + Timolol 0.5% in Open-Angle Glaucoma or Ocular Hypertension
The purpose of this study was to compare the intraocular pressure (IOP)-lowering efficacy and safety of AZARGA™ (Brinzolamide 1%/Timolol 0.5% Ophthalmic Suspension), dosed twice daily versus AZOPT® (Brinzolamide 1% Ophthalmic…
- Trial name
- NCT01357616
- Testing
- Brinzolamide 1% / Timolol 0.5% fixed combination ophthalmic suspension, Brinzolamide 1% ophthalmic suspension, Timolol 0.5% ophthalmic solution
- Volunteers
- 328 people
- Sponsor
- Alcon Research
Staphylococcus Aureus Infection
Probability of Target Attainment With Standard Intermittent Bolus Administration of Cefazolin in Patients With Complicated Infections Caused by Staphylococcus Aureus
Given the paucity of pharmacological data on cefazolin treatment of Methicillin-susceptible S. aureus (MSSA) complicated S. aureus infection (CSAI), the primary purpose of this study is to investigate the probability of…
- Trial name
- TARGET II (NCT04503252)
- Testing
- Blood samples for the measurement of the concentration of cefazolin, S. aureus culture isolate, structured telephone interview
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University Hospital, Basel, Switzerland
Rheumatoid Arthritis, Healthy Volunteers
A Study in Normal Healthy People, Testing Different Versions of a Pill That Will be Used to Treat Rheumatoid Arthritis.
The study will try, in 2 separate parts, each using 12 research subjects, to see how a new form of the pill CE 224,535 gets released into the bloodstream and whether that is affected by food.
- Trial name
- NCT00838058
- Testing
- CE-224,535, CE 224,535
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Pfizer
Chemotherapy-induced Nausea and Vomiting
Safety of a Three-Day Fosaprepitant Regimen for the Prevention of Chemotherapy-Induced Nausea and Vomiting in Pediatric Participants (MK-0517-045)
The purpose of this study is to evaluate the safety and tolerability of a 3-day intravenous (IV) fosaprepitant dimeglumine (MK-0517) regimen for the prevention of CINV in pediatric participants scheduled to receive emetogenic…
- Trial name
- NCT04054193
- Testing
- Fosaprepitant Dimeglumine, 5-HT3 antagonist, Dexamethasone
- Where
- 26 sites in United States, Greece and 7 more
- Volunteers
- 103 people
- Sponsor
- Merck Sharp & Dohme LLC
Cardiogenic Shock
Study of Multistep Pharmacological and Invasive Management for Cardiogenic Shock
The purpose of this study is to evaluate efficacy and safety of i.v. adrenaline infusion as an early and fast haemodynamic stabilizer, associated with a tight tissue perfusion monitoring, in the context of a stepwise progression…
- Trial name
- NCT02591771
- Testing
- adrenaline
- Where
- 2 sites in Italy
- Volunteers
- 24 people
- Sponsor
- Niguarda Hospital
Surgical Procedure, Unspecified
Non-pharmacological Pain Management After Surgery
The purpose of this study is to test the impact of a bundled NOHARM Conversation Guide with clinical decision support intervention embedded within an Electronic Health Record (EHR) on pain and function 3 months following surgery.
- Trial name
- NOHARM (NCT04570371)
- Testing
- Conversation Guide + Clinical Support
- Where
- 2 sites in United States
- Volunteers
- 81,938 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Lung Cancer
Gold Sodium Thiomalate in Treating Patients With Advanced Non-Small Cell Lung Cancer
RATIONALE: Gold sodium thiomalate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase I trial is studying the side effects and best dose of gold sodium thiomalate in…
- Trial name
- NCT00575393
- Testing
- gold sodium thiomalate, gene expression analysis, fluorine F 18 fluorothymidine
- Where
- 3 sites in United States
- Volunteers
- 17 people
- Sponsor
- Mayo Clinic
Healthy
Single Dose Phase I Study of FYU-981
The purpose of this study is to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of single doses of FYU-981 administered orally to healthy male adults in fasted and fed conditions.
- Trial name
- NCT02348307
- Testing
- FYU-981, (Oral single dosing)
- Where
- Japan
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Fuji Yakuhin Co., Ltd.
Breast Cancer
Evaluating the Effect of Candesartan vs Placebo in Prevention of Trastuzumab-associated Cardiotoxicity
Evaluating the effect of the angiotensin II-receptor (AT1) blocker candesartan vs placebo in prevention of trastuzumab-associated cardiotoxicity in patients with primary breast cancer treated with trastuzumab.
- Trial name
- NCT00459771
- Testing
- AT1 blocker candesartan
- Where
- 19 sites in Netherlands
- Volunteers
- 210 people
- Sponsor
- The Netherlands Cancer Institute
COVID19, Thromboembolism
Impact of an Intensified Thromboprofylaxis Protocol in COVID-19
The aim of this study is to investigate and compare the mortality, the incidence of DVT and the incidence of kidney and liver failure in patients admitted to the ICU before and after the implementation of an intensified…
- Trial name
- NCT04394000
- Testing
- thromboprofylaxis protocol, standard protocol
- Where
- Belgium
- Volunteers
- 72 people
- Sponsor
- Jessa Hospital
Healthy Subjects
Study Evaluating the Pharmacokinetics of the Potential Drug Interaction Between CYP2C9 Inhibitor and Substrate
This is an open-label, randomized, 2-period crossover, inpatient study to be performed in healthy subjects. The study will consist of 2 treatment periods: There will be 2 parallel cohorts of 12 subjects each who will be enrolled…
- Trial name
- NCT00369304
- Testing
- pharmacokinetic (how the body absorbs and eliminates) interaction
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
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