Clinical trials: polymerase chain reaction
Leukemia
Studying Biomarker Expression in Samples From Patients With Down Syndrome and Acute Myeloid Leukemia or Other Transient Myeloproliferative Disorder
RATIONALE: Studying samples of blood, tissue, and bone marrow from patients with cancer in the laboratory may help doctors learn about changes that occur in RNA and identify biomarkers related to cancer.
- Trial name
- NCT01511575
- Testing
- RNA analysis, reverse transcriptase-polymerase chain reaction, laboratory biomarker analysis
- Volunteers
- 60 people
- Sponsor
- Children's Oncology Group
Colorectal Cancer
Ursodiol, Combination Chemotherapy, and Bevacizumab in Treating Patients With Stage IV Colorectal Cancer
RATIONALE: Drugs used in chemotherapy, such as ursodiol, oxaliplatin, leucovorin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00873275
- Testing
- bevacizumab, FOLFOX regimen, fluorouracil
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- City of Hope Medical Center
Prostate Cancer
Genetic Testing in Predicting Biomarkers of Recurrence in Patients With Prostate Cancer Undergoing Surgery
This trial studies the side effects and best way to perform genetic testing in predicting biomarkers of recurrence in patients with prostate cancer undergoing surgery.
- Trial name
- NCT00977457
- Testing
- DNA analysis, DNA methylation analysis, RNA analysis
- Where
- United States
- Volunteers
- 1,045 people
- Sponsor
- City of Hope Medical Center
Transplantation, Liver
Liver Immunosuppression Free Trial
LIFT is prospective randomised marker-based trial to assess the clinical utility and safety of biomarker-guided immunosuppression withdrawal in liver transplantation.
- Trial name
- LIFT (NCT02498977)
- Testing
- Biomarker, Tacrolimus, cyclosporine and/or mycophenolic acid, mycophenolate mofetil or azathioprine
- Where
- 2 sites in United Kingdom
- Volunteers
- 116 people
- Sponsor
- King's College London
Brain and Central Nervous System Tumors, Thrombocytopenia
Pharmacokinetics in Patients With Newly Diagnosed High-Grade Glioma Receiving Temozolomide and Radiation Therapy
RATIONALE: Studying samples of blood in the laboratory from patients receiving temozolomide may help doctors learn how temozolomide works in the body.
- Trial name
- NCT00471653
- Testing
- temozolomide, comparative genomic hybridization, polymorphism analysis
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Chemotherapeutic Agent Toxicity, Sarcoma
CYP3A5 Gene as a Risk Factor for Kidney Damage in Young Patients With Cancer Treated With Ifosfamide
RATIONALE: Studying the genes expressed in samples of blood from young patients with cancer treated with ifosfamide may help doctors identify risk factors for kidney damage.
- Conditions
- Chemotherapeutic Agent Toxicity, Sarcoma, Unspecified Childhood Solid Tumor, Protocol Specific
- Trial name
- NCT00514345
- Testing
- gene expression analysis, polymorphism analysis, management of therapy complications
- Where
- 21 sites in Ireland, United Kingdom
- Volunteers
- 300 people
- Sponsor
- Children's Cancer and Leukaemia Group
Melanoma (Skin)
Detection of Melanoma Markers in Lymph Nodes or Peripheral Blood of Patients With Melanoma
RATIONALE: Diagnostic procedures may improve the ability to detect the presence or recurrence of disease. PURPOSE: Diagnostic trial to detect melanoma markers in the lymph nodes or peripheral blood of patients who have melanoma.
- Trial name
- NCT00004153
- Testing
- reverse transcriptase-polymerase chain reaction, sentinel lymph node biopsy
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- University of Chicago
Cervical Cancer Susceptible Population Classification
Cervical Cancer Susceptible Population Classification
Cervical cancer is the third most common lethal tumor globally, causing around a quarter million deaths annually, despite the availability of HPV vaccines.
- Trial name
- NCT06405945
- Testing
- PCR and sequence
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Anhui Provincial Hospital
Extrahepatic Bile Duct Cancer, Gallbladder Cancer
Capecitabine, Epirubicin, and Carboplatin in Treating Patients With Progressive, Unresectable, or Metastatic Cancer
RATIONALE: Drugs used in chemotherapy, such as capecitabine, epirubicin, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Extrahepatic Bile Duct Cancer, Gallbladder Cancer, Gastric Cancer, Liver Cancer
- Trial name
- NCT00486356
- Testing
- capecitabine, carboplatin, epirubicin hydrochloride
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Nebraska
Outbreaks
Respiratory Outbreak Mitigation in Long-Term Care Using Point-of-Care Testing
Outbreaks of seasonal respiratory viruses can spread rapidly in long-term care homes. Timely results for diagnostic tests remains a challenge for respiratory viruses due to the logistics of using a reference laboratory with…
- Trial name
- PROMPT-LTC (NCT06660433)
- Testing
- Point-of-care respiratory test platform, Existing respiratory virus testing platform
- Where
- 2 sites in Canada
- Volunteers
- 24 people
- Sponsor
- Michael Garron Hospital
Dengue Fever
Prospective Study on the Risks of Dengue Fever for the Fetus.
Dengue is the most common arbovirus worldwide (390 million people infected each year) and belongs to the Flavivirus genus of the Flaviviridae family like Zika.
- Trial name
- ERiDenF (NCT04822441)
- Testing
- data collection
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Hematopoietic/Lymphoid Cancer, Accelerated Phase Chronic Myelogenous Leukemia
Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell Transplant
RATIONALE: Infection prophylaxis and management may help prevent cytomegalovirus (CMV) infection caused by a stem cell transplant.
- Conditions
- Hematopoietic/Lymphoid Cancer, Accelerated Phase Chronic Myelogenous Leukemia, Acute Undifferentiated Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
- Trial name
- NCT01199562
- Testing
- infection prophylaxis and management, laboratory biomarker analysis, flow cytometry
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- City of Hope Medical Center
Reversible Pulpitis
Effect of Liners on Pulpal Outcome and Restoration Survival After Partial Caries Excavation
Aim of the study was to determine the effectiveness of cavity liners regarding survival of restoration beneath composite restoration after partial caries removal in permanent teeth with deep caries and to evaluate and compare the…
- Trial name
- NCT03286959
- Testing
- PCR with calcium hydroxide, PCR with RMGIC, PCR with direct composite
- Volunteers
- 198 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Contraception
Acceptability of Depo-subQ in Uniject
This is an observational study to assess the experience of current depot medroxyprogesterone acetate (DMPA) intramuscular (IM) clients and providers when they try Depo-subQ in Uniject and offer recommendations for the…
- Trial name
- NCT01667276
- Where
- 2 sites in Senegal, Uganda
- Volunteers
- 476 people, healthy volunteers welcome
- Sponsor
- FHI 360
Contraception
Assessing Preference for 3 Female Condoms: A Comparative Evaluation of the PATH Woman's Condom, FC2 and the Reddy 6
Evaluation of preference for three female condoms (FC).
- Trial name
- NCT01452503
- Testing
- Path Women's Condom, FC2 female condom, Reddy 6 female condom (V-Amour)
- Where
- South Africa
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- FHI 360
Lupus Erythematosus, Systemic, Adverse Effects
Exploration of Genotype Based Personalized Prescription of Cyclophosphamide in Systemic Lupus Erythematosus Treatment
The purpose of this study is to investigate the relationship between the side effects of cyclophosphamide in the treatment of systemic lupus erythematosus (SLE) in Han Chinese and the genetic polymorphisms of drug metabolizing…
- Trial name
- NCT01060410
- Testing
- Polymorphism Analysis, Cyclophosphamide, Pharmacokinetic analysis
- Where
- China
- Volunteers
- 222 people
- Sponsor
- Sun Yat-sen University
Invasive Candidiasis; Treatment With Echinocandin
Evaluate the Performance of Genetic Amplification by Polymerase Chain Reaction (PCR) and the "Mannan Antigenemia and Antimannan Antibodies Couple as a Means of Diagnosis and a Marker of Follow-up in Invasive Candidiasis.
The study consists in taking 4 tubes of blood at different times over a period of 10 days, via a catheter (central venous or arterial catheter) already in place in the usual therapeutic management.
- Trial name
- EMPIRICAND (NCT02333448)
- Testing
- Blood sample taken on the day the treatment is initiated, Blood sample taken on day 3 after initiation of treatment, Blood sample taken on day 5 after initiation of
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Potentially Malignant Lesions, Oral Lichen Planus
Diagnostic Accuracy of lncRNA DQ786243 and miRNA146a in Saliva of Oral Potentially Malignant Lesions
The aim of this study is to evaluate salivary expression of lncRNA DQ786243 as a potential marker for diagnosis of oral potentially malignant lesions compared to normal controls and its effect on salivary expression of miRNA146a.
- Conditions
- Potentially Malignant Lesions, Oral Lichen Planus, Leukoplakia, Oral
- Trial name
- NCT05730855
- Testing
- Real-time Polymerase Chain Reaction technique
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Leukemia, Myelodysplastic Syndromes
Detection of Residual Disease in Children Receiving Therapy for Acute Myeloid Leukemia or Myelodysplastic Syndrome
RATIONALE: Diagnostic procedures may improve the ability to detect residual disease. PURPOSE: Clinical trial to detect the presence of residual disease in children who are receiving therapy for acute myeloid leukemia or…
- Trial name
- NCT00003790
- Testing
- polymerase chain reaction, flow cytometry
- Where
- 43 sites in United States, Australia and 1 more
- Volunteers
- 496 people
- Sponsor
- Children's Oncology Group
Idiopathic Thrombocytopenic Purpura
Triple Therapy in Patients With Idiopathic Thrombocytopenic Purpura : What is Behind?
Idiopathic thrombocytopenic purpura (ITP) is a benign hematological disorder characterized by isolated thrombocytopenia. Development of antiplatelet autoantibodies is the main pathogenetic mechanism in patients with ITP.
- Trial name
- NCT04128358
- Testing
- Serological assay for blood born viral hepatitis, Quantitative microbiological test for HCV
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Assiut University