Clinical trials: therapeutic conventional surgery
Back Pain, Spinal Cord Stimulation
Efficacy of Spinal Cord Stimulation in Patients With a Failed Back Surgery Syndrome.
When patients suffer from chronic pain after multiple back surgeries, this is denominated as the 'failed back surgery syndrome'. A possible treatment for these patients is spinal cord stimulation.
- Trial name
- HDS (NCT03462147)
- Testing
- Spinal cord stimulation
- Where
- Belgium
- Volunteers
- 6 people
- Sponsor
- Ziekenhuis Oost-Limburg
Pancreatic Cancer
Surgery Followed by Radiation Therapy and Chemotherapy in Treating Patients With Cancer of the Pancreas
RATIONALE: Surgery to remove the pancreas, some of the small intestine, and lymph nodes may be more effective treatment for cancer of the pancreas than surgery to remove the pancreas and some of the small intestine alone.
- Trial name
- NCT00003049
- Testing
- fluorouracil, leucovorin calcium, conventional surgery
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Lateral Patellar Compression Syndrome
Rehabilitation Efficacy of Low-Load Blood Flow Restriction Training for Lateral Patellar Compression Syndrome
The purpose of this study is to understand the effect of low-load blood flow restriction training on the rehabilitation effect of patients after lateral patellar compression syndrome surgery, and to observe the differences…
- Trial name
- LL-BFRT (NCT06988917)
- Testing
- the regular rehabilitation program, The blood flow limiting pressure band
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University Third Hospital
Breast Cancer
Cryosurgery in Treating Women With Breast Lesions
RATIONALE: Cryosurgery kills cancer cells by freezing them. Cryosurgery followed by lumpectomy or mastectomy may be an effective treatment for breast lesions.
- Trial name
- NCT00020852
- Testing
- conventional surgery, cryosurgery
- Where
- United States
- Sponsor
- Jonsson Comprehensive Cancer Center
Colorectal Cancer Metastatic
Improving SUrgery of Liver Metastases: a Trial of the Arterial Chemotherapy Network
National trial, multicenter, randomized, phase II comparing treatment intensification with hepatic arterial infusion chemotherapy plus systemic chemotherapy (CT) to systemic chemotherapy alone in patients with liver-only…
- Trial name
- SULTAN (NCT03164655)
- Testing
- Oxaliplatin, Cetuximab, Bevacizumab, Panitumumab, Irinotecan, Leucovorin, 5-Fluorouracil
- Where
- 4 sites in France
- Volunteers
- 20 people
- Sponsor
- UNICANCER
Uterine Cervical Neoplasms, Uterine Neoplasms
Sentinel Node Mapping in Women With Cervical and Endometrial Cancer
This study aims to evaluate the effect of SLN mapping on the incidence and severity of lymphedema in women with early stage cervical and endometrial cancer.
- Trial name
- SENTIREC I (NCT02825355)
- Where
- 3 sites in Denmark
- Volunteers
- 512 people
- Sponsor
- University of Southern Denmark
Hyperglycemia, Postoperative Complications
Intensive Insulin Therapy as Therapeutic Strategy for Non-diabetic Hyperglycemia After Surgery in ICU
The current study hypothesizes that the use of Intravenous intensive insulin therapy (IV-IIT) may be beneficial than IV conventional insulin therapy (IV-CIT) for improving the outcome of non-diabetic surgical patients had…
- Conditions
- Hyperglycemia, Postoperative Complications, Insulin Resistance
- Trial name
- NCT04554615
- Testing
- Insulin
- Where
- Saudi Arabia
- Volunteers
- 86 people
- Sponsor
- Tanta University
Coronary Artery Disease
ROtational Atherectomy, Lithotripsy or LasER for the Treatment of CAlcified STEnosis
Some data exist about the efficacy and safety of rotational atherectomy, intravascular lithotripsy and excimer laser to modify calcified plaques.
- Trial name
- ROLLERCOASTR (NCT04181268)
- Testing
- Percutaneous coronary Intervention
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Hospital Universitario La Paz
Rectal Cancer
Magnetic Resonance Tumour Regression Grade (mrTRG) as a Novel Biomarker - Phase III Non CTIMP Trial
Open to patients undergoing any pre-operative treatment for locally advanced rectal cancer, TRIGGER is the only phase III clinical trial in the UK offering watch and wait.
- Trial name
- TRIGGER (NCT02704520)
- Testing
- High resolution MRI scan, mrTRG assessment
- Where
- 10 sites in United Kingdom
- Volunteers
- 441 people
- Sponsor
- Imperial College London
Stage II Grade B Periodontitis
Clinical & Biochemical Evaluation of Antioxidant Vs. Chlorhexidine as an Adjunctive to Non-Surgical Treatment of Stage II-grade B Periodontitis
This randomized clinical trial aims to evaluate and compare the clinical and biochemical effects of an antioxidant agent and chlorhexidine when used as adjuncts to non-surgical periodontal therapy in patients with Stage II Grade…
- Trial name
- NCT07801417
- Testing
- Perioscience Gel, High Cure Chlorhexidine Gel, High Cure Chlorhexidine Gel + Perioscience Gel
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Al-Azhar University
Negative-Pressure Wound Therapy, Diabetic Foot
Comparison Between Negative Pressure Wound Therapy and Conventional Wound Dressings Before and After Split-Thickness Skin Grafting in Diabetic Foot Wounds
The aim of this thesis is to compare the efficacy of Vacuum assisted closure device versus conventional dressing before and after split thickness skin grafting in diabetic foot wounds.
- Trial name
- NCT05716503
- Testing
- Negative Pressure Wound Therapy (NPWT), Ordinary dressings with antibiotic ointment and gauze
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Sohag University
Internet-Based Cognitive Behavioral Therapy
Efficacy of Internet-Based Cognitive Behavioral Therapy for Back Muscle Strength Loss, Chronic Pain, and Poor Patient Recovery Perceptions After Lumbar Fusion
This study aims to develop an Internet-based Cognitive Behavioral Therapy protocol for core muscle training, based on an understanding of factors impeding postoperative core muscle training in lumbar surgery patients.
- Trial name
- NCT07030582
- Testing
- Internet-delivered cognitive behavioral therapy, Basic Postoperative Care, Conventional Postoperative Care
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Jiawei Jiang
Trochanteric Fracture of Femur
CM Asia Nail With AS2 Without AS2 （AS2 Study）
The purpose of this study is to compare reduction positon maintenance rate at 3 weeks post-operatively between patients operated with Anterior Support Screw (AS2) and without AS2 technique in RCT setting.
- Trial name
- NCT03196193
- Testing
- Open Reduction and Internal Fixation, ZNN CM Asia, Anterior Support Screw
- Where
- 12 sites in Japan
- Volunteers
- 240 people
- Sponsor
- Zimmer Biomet
Polycythemia Vera (PV)
A Study to Evaluate P1101 in Japanese PV Patients
This is a Phase 3 single arm study to investigate efficacy and safety of P1101's rapid titration for adult Japanese patients with PV.
- Trial name
- NCT06002490
- Testing
- P1101, Low-dose aspirin, Phlebotomy
- Where
- 6 sites in Japan
- Volunteers
- 21 people
- Sponsor
- PharmaEssentia Japan K.K.
Breast Cancer
Chemotherapy Plus Surgery in Treating Women With Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining surgery with chemotherapy may kill more tumor cells.
- Trial name
- NCT00003013
- Testing
- CMF regimen, cyclophosphamide, doxorubicin hydrochloride
- Where
- 28 sites in Austria, Czechia and 9 more
- Volunteers
- 450 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Hypothermia, Blood Loss,
Comparison of Active and Passive Perioperative Warming Techniques in Reducing Intraoperative Blood Loss
This is a randomized, open label, parallel two arm, clinical study, which compare the Bair Hugger forced-air warming blanket and the conventional warming care practice in China on patients undergoing major surgery to determine…
- Conditions
- Hypothermia, Blood Loss,, Blood Coagulation Disorders
- Trial name
- NCT02214524
- Testing
- Bair Hugger forced air warming system
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Cervical Cancer
Chemotherapy Followed By Surgery Vs Radiotherapy Plus Chemotherapy in Patients With Stage IB or II Cervical Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving chemotherapy drugs before surgery may shrink the tumor so that it can be removed during surgery.
- Trial name
- NCT00039338
- Testing
- conventional surgery, neoadjuvant chemotherapy, brachytherapy
- Where
- 24 sites in Austria, Belgium and 6 more
- Volunteers
- 686 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Lung Cancer
Combination Chemotherapy Followed by Radiation Therapy Before Surgery in Treating Patients With Stage IIIB NSCLC
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high energy x-rays to damage tumor cells.
- Trial name
- NCT00030810
- Testing
- Hyperfractionated, Taxotere/Cisplatin, conventional surgery
- Where
- Switzerland
- Volunteers
- 46 people
- Sponsor
- Swiss Cancer Institute
Primary Hyperparathyroidism, Thyroid Disease
Optimization and Individualization of Diagnostic Scintigraphy Protocol and Minimally Invasive Radio-guided Parathyroid Surgery
The radio-guided technique offers both help with in-vivo identification and ex-vivo confirmation of parathyroid adenoma. In-vivo accuracy is most important but its results are not satisfactory.
- Conditions
- Primary Hyperparathyroidism, Thyroid Disease, Parathyroid Diseases, Parathyroid Adenoma
- Trial name
- NCT04344886
- Testing
- Conventional (dual-phase) SPECT/CT, Multi-phase SPECT/CT, Conventional minimally-invasive radio-guided parathyroidectomy
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- University Hospital Ostrava
Colon Cancer Liver Metastases, Liver Neoplasms
Associating Liver Partition With Portal Vein Ligation for Staged Hepatectomy (ALPPS) vs. Two-Stage Hepatectomy (TSH) for Marginally Resectable Colorectal Liver Metastases (CRLM)
Surgical resection has offered the best option for prolonged survival in patients with colorectal liver metastases. Limiting factor for major liver resections is the size of the future liver remnant (FLR).
- Conditions
- Colon Cancer Liver Metastases, Liver Neoplasms, Liver Diseases, Secondary Malignant Neoplasm of Liver
- Trial name
- ALPPSforCRLM (NCT02758977)
- Testing
- ALPPS, TWO STAGE HEPATECTOMY
- Where
- Switzerland
- Volunteers
- 214 people
- Sponsor
- University of Zurich
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