Clinical trials: therapeutic conventional surgery
Esophageal Cancer
Oxaliplatin and Fluorouracil Plus Radiation Therapy in Treating Patients With Primary Esophageal or Stomach Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00004257
- Testing
- fluorouracil, oxaliplatin, conventional surgery
- Where
- United States
- Sponsor
- Albany Medical College
Diabetic Foot Ulcer Healing Trajectories
Efficacy of Negative Pressure Wound Therapy Versus Conventional Moist Dressings on Diabetic Foot Ulcer Healing Trajectories
Background: Diabetic foot ulcers (DFUs) are severe, chronic complications of diabetes carrying a high risk of amputation. While Negative Pressure Wound Therapy (NPWT) is an active biophysical treatment, clinical evidence using…
- Trial name
- DF-WOUND-RCT (NCT07745075)
- Testing
- Vacuum-Assisted Closure (VAC / NPWT)
- Where
- Jordan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jerash Private University
Anxiety
Cranial Electro Therapy Stimulation in Reducing Perioperative Anxiety
Cranial electro stimulation (CES) provides safe, adequate, side-effect free sedation without excessive drowsiness in preoperative settings.
- Trial name
- NCT00928772
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- University of Oklahoma
Head and Neck Cancer
PEG-interferon Alfa-2b in Treating Patients With Stage II, Stage III, or Stage IV Head and Neck Cancer That Can Be Removed By Surgery
RATIONALE: SCH 54031 (PEG-interferon alfa-2b) may interfere with the growth of tumor cells and slow the growth of head and neck cancer. It may also stop the growth of head and neck cancer by blocking blood flow to the tumor.
- Trial name
- NCT00276523
- Testing
- PEG-interferon alfa-2b, Conventional surgery, Neoadjuvant therapy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
Pancreatic Cancer
Neoadjuvant Treatment in Resectable Pancreatic Cancer
Sequential Neoadjuvant Chemoradiotherapy (CRT) Followed by Curative Surgery vs. Primary Surgery Alone for Resectable, Non-metastasized Pancreatic Adenocarcinoma
- Trial name
- NEOPA (NCT01900327)
- Testing
- External Beam Radiation, Gemcitabine neoadjuvant, Surgery
- Where
- 16 sites in Germany
- Volunteers
- 32 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Noise Cancelling Headphones, Postoperative Pain
Research on the Effect of Noise Cancelling Headphones in Reducing Postoperative Pain
this randomized controlled trial selects patients undergoing gynecological laparoscopy under general anesthesia. By using noise reduction earphones during surgery, the patient's postoperative pain score and demand for opioids are…
- Trial name
- NCT06918470
- Testing
- Standard monitoring techniques, noise cancelling headphones
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Maternal and Child Health Hospital of Hubei Province
Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor
High-Dose Thiotepa Plus Peripheral Stem Cell Transplantation in Treating Patients With Refractory Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Conditions
- Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Ovarian Cancer
- Trial name
- NCT00003173
- Testing
- filgrastim, thiotepa, autologous bone marrow transplantation
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Distal Radius Fractures
Volar Locking Plate vs Fragment Specific Fixation in Wrist Fractures
The treatment of unstable, non-reducible distal radial fractures is still controversial. The aim of the present study is to compare the subjective, clinical and radiographic outcome of the TriMed fragment-specific system with a…
- Trial name
- NCT01311531
- Testing
- Open reduction and fixation with TriMed fragment-specific system, Open reduction and fixation with TriMed volar locking plate
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Region Skane
Colorectal Cancer
Celecoxib, Leucovorin, Fluorouracil, and Oxaliplatin in Treating Patients With Metastatic Colorectal Cancer
RATIONALE: Drugs used in chemotherapy, such as leucovorin, fluorouracil, and oxaliplatin, use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00072553
- Testing
- celecoxib, fluorouracil, leucovorin calcium
- Where
- France
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
Papillary Thyroid Microcarcinoma
A Multicenter Trial of Radiofrequency Ablation vs. Surgery as Treatment of Papillary Thyroid Microcarcinoma.
The treatment of Papillary Thyroid Microcarcinoma (PTMC) nowadays varies among physicians, surgeons and radiologist. The recently published articles show that the prognosis of PTMC by different means of treatment strategies tends…
- Trial name
- NCT03808779
- Testing
- Radiofrequency Ablation, Conventional Surgery
- Where
- 3 sites in China, Ukraine
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Corneal Neovascularization, Corneal Graft Failure
Subconjunctival IVIg (Gamunex-C) Injection for Corneal Neovascularization and Inflammatory Conditions
The purpose of the study is to test the investigational drug Gamunex-C on the growth of blood vessels over the cornea. This study is being conducted by Dr. Balamurali Ambati at the Moran Eye Center at the University of Utah.
- Conditions
- Corneal Neovascularization, Corneal Graft Failure, Anterior Segment Inflammation
- Trial name
- NCT02042027
- Testing
- Gamunex-C
- Where
- United States
- Sponsor
- University of Utah
Post-stroke Dysphagia, Acupuncture
Acupuncture for Post-Stroke Dysphagia: A Clinical Study
Employing a nested design, a partially randomized preference study (Study II) is embedded within a prospective, multicenter cohort study (Study I).
- Trial name
- NCT07493902
- Testing
- acupuncture
- Where
- China
- Volunteers
- 3,232 people
- Sponsor
- First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Breast Cancer
Optimal Surgical Approach for Early-Stage Breast Cancer in Chinese Patients Aged ≤ 40 Years: a Cohort Study
The optimal surgical treatment option (BCS+RT versus MAST) for young patients with early-stage breast cancer remains debated. The present study aims to explore trends in surgical management and compare survival outcomes between…
- Trial name
- NCT06603805
- Testing
- MAST group, breast-conserving surgery plus adjuvant radiotherapy
- Volunteers
- 974 people
- Sponsor
- West China Hospital
Prostate Cancer
Neoadjuvant Exisulind in Treating Patients Who Are Undergoing Radical Prostatectomy for Stage II or Stage III Prostate Cancer
RATIONALE: Drugs used in chemotherapy, such as exisulind, work in different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00078910
- Testing
- exisulind, conventional surgery, neoadjuvant therapy
- Where
- 3 sites in United States
- Volunteers
- 130 people
- Sponsor
- National Cancer Institute (NCI)
Coronary Artery Bypass Graft
Prehabilitation and Coronary Artery Bypass Grafting
To evaluate the effects of Prehabilitation Resistance training on frailty and functional capacity in mild to moderate clinically frail patients awaiting Coronary Artery Bypass Grafting) CABG.
- Trial name
- NCT04993976
- Testing
- Resistant training (Prehabilitation), Active Comparator: Control group
- Where
- Pakistan
- Volunteers
- 74 people
- Sponsor
- Riphah International University
Colon Cancer
Early Commencement of Adjuvant Chemotherapy for Colon Cancer
This study sets up the final study end point and three detailed goals as the following. The main objective of study: This trial is done to assess the safety and benefit of early adjuvant chemotherapy from 10 to 14 days after…
- Trial name
- ECTX (NCT01460589)
- Testing
- timing to initiate the adjuvant FOLFOX chemotherapy
- Where
- 2 sites in South Korea
- Volunteers
- 303 people
- Sponsor
- Kyungpook National University Hospital
Retinopathy of Prematurity
Bevacizumab Eliminates the Angiogenic Threat for Retinopathy of Prematurity
The purpose of this study was to determine the efficacy and additional advantages of intravitreal bevacizumab in the treatment of ROP for both Zone I and Zone II Posterior.
- Trial name
- BEAT-ROP (NCT00622726)
- Testing
- Bevacizumab, Conventional Laser for ROP
- Where
- 15 sites in United States
- Volunteers
- 150 people
- Sponsor
- The University of Texas Health Science Center, Houston
Glaucoma, Cataract
The in Vivo Effect of Medical and Surgical Glaucoma Treatments on the Schlemm's Canal Micro-structure
The purpose of our current series of studies is to evaluate different glaucoma treatments in vivo effect on the conventional outflow pathway, and specifically on the Schlemm's canal (SC) anatomy using Enhanced Depth Imaging…
- Trial name
- NCT02807935
- Testing
- Optical coherence tomography imaging
- Where
- Israel
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Coronary Artery Disease
Magnetic Navigation for Contrast and Radiation Reduction
Rationale: Magnetic navigation in complex lesions/vessels may result in reduced contrast and irradiation for patients undergoing percutaneous coronary intervention. The investigators aim to compare the use of the 2 techniques.
- Trial name
- MAGNA (NCT01276808)
- Testing
- Magnetic navigation PCI, Conventional PCI
- Where
- Netherlands
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Onze Lieve Vrouwe Gasthuis
Sarcoma
Intensity-Modulated Radiation Therapy in Treating Patients Undergoing Surgery for Stage IB, Stage II, or Stage III Soft Tissue Sarcoma
RATIONALE: Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue.
- Trial name
- NCT00740597
- Testing
- gene expression analysis, polymerase chain reaction, western blotting
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- City of Hope Medical Center
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