Clinical trials: therapeutic conventional surgery
Glioblastoma, Glioblastoma Multiforme
Neoadjuvant Radio-chemotherapy Safety Pilot Study in Patients With Glioblastoma
The goal of this clinical trial is to evaluate the safety and efficacy of neoadjuvant radiochemotherapy in the surgical resection of glioblastoma (GBM).
- Conditions
- Glioblastoma, Glioblastoma Multiforme, Glioblastoma, IDH-wildtype, Radiotherapy; Complications
- Trial name
- GLINERA (NCT06418113)
- Testing
- hypofractionated stereotactic radiotherapy, Stereotactic biopsy, resection
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Hospital San Carlos, Madrid
Postoperative Complications, Pulmonary Complication
Low-Dose Norepinephrine With Conservative Fluid Therapy in Hepatobiliary Surgery
This prospective randomized controlled study aims to compare the effect of low-dose norepinephrine combined with conservative goal-directed fluid therapy versus conventional fluid therapy on postoperative pulmonary complications…
- Trial name
- NCT07892586
- Testing
- Conventional Fluid Therapy, Low-Dose Norepinephrine, Conservative Goal-Directed Fluid Therapy
- Volunteers
- 100 people
- Sponsor
- Assiut University
Prostate Cancer
Diindolylmethane in Treating Patients With Stage I or Stage II Prostate Cancer Undergoing Radical Prostatectomy
RATIONALE: The use of diindolylmethane, a substance found in cruciferous vegetables, may slow the growth of tumor cells. PURPOSE: This phase II trial is studying how well diindolylmethane works in treating patients with stage I…
- Trial name
- NCT00888654
- Testing
- B-Dim, Radical Prosatectomy
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Simple Renal Cyst
Measurement of Renal Functional Reserve Change In Patients With SRC Before and After Laparoscopic Deroofing
Renal functional reserve may be improved in patients with simple renal cysts after laparoscopic deroofing.
- Trial name
- NCT03259594
- Testing
- Laparoscopic deroofing, 100 g of amino acids supplementation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- ou tongwen
Neurofibromatosis Type 1, Sarcoma
Combination Chemotherapy in Treating Patients With Stage III or Stage IV Malignant Peripheral Nerve Sheath Tumors
RATIONALE: Drugs used in chemotherapy, such as doxorubicin, ifosfamide, and etoposide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00304083
- Testing
- filgrastim, doxorubicin hydrochloride, etoposide
- Where
- 17 sites in United States
- Volunteers
- 48 people
- Sponsor
- Sarcoma Alliance for Research through Collaboration
Atrial Fibrillation, Severe Heart Failure
Ablation of Atrial Fibrillation in Heart Failure Patients
The aim of the study is to evaluate the impact of cryoablation of atrial fibrillation in patients with severe chronic heart failure (CHF) on long term outcome of CHF and efficacy (endurance) of the procedure itself.
- Trial name
- CONTRA-HF (NCT03062241)
- Testing
- Cryoablation
- Where
- Poland
- Volunteers
- 330 people
- Sponsor
- Medical University of Silesia
Head and Neck Cancer
Surgery and Radiation Therapy With or Without Interleukin-2 in Treating Patients With Cancer of the Mouth or Oropharynx
RATIONALE: Interleukin-2 may stimulate a person's white blood cells to kill cancer cells of the mouth or oropharynx. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00002702
- Testing
- aldesleukin, adjuvant therapy, conventional surgery
- Where
- 7 sites in Italy
- Volunteers
- 260 people
- Sponsor
- European Institute of Oncology
Liver Cancer
Combination Chemotherapy and Thalidomide in Treating Younger Patients Undergoing Surgery For Newly Diagnosed Liver Cancer
RATIONALE: Drugs used in chemotherapy, such as cisplatin and doxorubicin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00276705
- Testing
- cisplatin, cyclophosphamide, doxorubicin hydrochloride
- Where
- 21 sites in Ireland, United Kingdom
- Volunteers
- 47 people
- Sponsor
- Children's Cancer and Leukaemia Group
Lung Collapse
Brochoscopic Intervention Versus Conventional Management in Acute Lung Collapse in the Pediatric Intensive Care Unit
This prospective RCT at Cairo University Children Hospitals enrolls critically ill pediatric patients (intubated, NIV, or post-extubation) with lung atelectasis unresponsive to 48 hours of conventional recruitment.
- Trial name
- picu (NCT07383129)
- Testing
- bronchoscope, chest physiotherapy and suction
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Cairo University
Lumbar Spinal Stenosis
Comparision of Endoscopic Discectomy and Microdiscectomy for the Treatment of Lumbar Spinal Stenosis
The purpose of this study is to conduct a multicenter comparison of the clinical efficacy of Endo-Surgi Plus endoscopic technique, UBE endoscopic technique, and microdiscectomy technique in the treatment of lumbar spinal…
- Trial name
- NCT06719037
- Testing
- Endo-Surgi Plus endoscopic surgery, Unilateral biportal endoscopic surgery, Microdiscectomy
- Where
- China
- Volunteers
- 324 people
- Sponsor
- Qilu Hospital of Shandong University
Periodontitis
IL-32 Isoforms Levels in GCF and Plasma of the Patients With Periodontitis
Interleukin (IL)-32, which has been recently reported to be associated with periodontitis, has been suggested to have pleiotropic effect due to its 9 different isoforms.
- Trial name
- NCT04350489
- Testing
- Non-surgical periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Malignant Solid Neoplasm, Metastatic Malignant Neoplasm in the Brain
Pre-Operative or Post-Operative Stereotactic Radiosurgery in Treating Patients With Operative Metastatic Brain Tumors
This phase III trial studies the side effects and how well stereotactic radiosurgery (SRS) works before or after surgery in patients with tumors that has spread to the brain or that can be removed by surgery.
- Trial name
- NCT03750227
- Testing
- Conventional Surgery, Questionnaire Administration, Stereotactic Radiosurgery
- Where
- 4 sites in United States
- Volunteers
- 140 people
- Sponsor
- Mayo Clinic
Deprivation Amblyopia, Congenital Cataract
Augmented Reality Training for Amblyopia After Congenital Cataract Surgery
This study will evaluate whether augmented reality training is effective and safe for treating unilateral amblyopia after congenital cataract surgery in children.
- Trial name
- NCT07693790
- Testing
- Augmented Reality Amblyopia Training, Conventional Patching
- Volunteers
- 88 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Cardiovascular Diseases, Heart Diseases
Occluded Artery Trial (OAT)
The purpose of this study is to determine whether opening an occluded infarcted artery 3-28 days after an acute myocardial infarction in high-risk asymptomatic patients reduces the composite endpoint of mortality, recurrent…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Myocardial Infarction, Heart Failure, Congestive
- Trial name
- OAT (NCT00004562)
- Testing
- Beta adrenergic blockers, Platelet inhibitors, PTCA and stents
- Where
- United States
- Volunteers
- 2,201 people
- Sponsor
- NYU Langone Health
Rectal Cancer
Watchful Waiting for Complete Responders to Therapy in Rectal Cancer
The purpose of this project is to determine if in a selected group of patients, at higher risk of wound dehiscence and other complications, treatment by local excision and management by a "watchful waiting" or an initial…
- Trial name
- NCT05526079
- Testing
- Watchfuf waiting
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Henry Ford Health System
Rotated Teeth
Er,Cr:YSGG Laser-aided Fiberotomy in the Prevention of the Lower Incisors Rotational Relapse
To establish the effect of erbium, chromium,yttrium,scandium,gallium and garnet (Er,Cr: YSGG) laser-aided circumferential supracrestal fiberotomy compared to a conventional circumferential supracrestal fiberotomy group, after…
- Trial name
- laser (NCT04384237)
- Testing
- Er,Cr:YSGG laser-aided CSF, Conventional CSF
- Where
- Colombia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fundación Universitaria CIEO
Lower Extremity Ischemia
CRAIL - Controlled Reperfusion of the Acutely Ischemic Limb
The purpose of this study is to prove the findings of a preliminary study which strongly suggest the hypothesis that the result of conventional embolectomy for acute, severe lower-limb ischemia can be improved by controlled…
- Trial name
- CRAIL (NCT00567801)
- Testing
- conventional embolectomy/thrombectomy, embolectomy/thrombectomy with controlled reperfusion
- Where
- 23 sites in Austria, Germany
- Volunteers
- 250 people
- Sponsor
- University Hospital Freiburg
Stress, Psychological, Periodontal Diseases
Effect of Stress on Periodontal Therapy (NPT)
Aim of this study: is to evaluate the influence of stress level on the response of non surgical periodontal therapy in patients affected by severe periodontitis divided into "Medium/High stress level" or "Low stress level" based…
- Conditions
- Stress, Psychological, Periodontal Diseases, Periodontitis, Non Surgical Periodontal Therapy
- Trial name
- NCT04739475
- Testing
- Non Surgical Periodontal Therapy
- Where
- Italy
- Volunteers
- 89 people
- Sponsor
- University of Turin, Italy
Estrogen Receptor Positive, HER2/Neu Negative
Radiation Therapy Before Surgery in Treating Patients With Hormone Receptor Positive, HER2 Negative Breast Cancer
This phase II trial studies how well radiation therapy before surgery works in treating patients with hormone receptor positive, HER2 negative breast cancer.
- Conditions
- Estrogen Receptor Positive, HER2/Neu Negative, Invasive Breast Carcinoma, Progesterone Receptor Positive
- Trial name
- NCT03359954
- Testing
- Radiation Therapy, Therapeutic Conventional Surgery
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- M.D. Anderson Cancer Center
Primary Spontaneous Pneumothorax, Pleural Disease
Study Designed to Optimize the Treatment of Primary Pneumothorax
Knowledge about incidence, risk factors and genetic predispositions of primary spontaneous pneumothorax in young adults is very limited, and treatment has also been controversial.The Aim of this study is to optimize the…
- Trial name
- TOPP (NCT02866305)
- Testing
- VATS bullectomy and mechanical pleuradesis., Chest tube insertion, Epidural
- Where
- 3 sites in Denmark
- Volunteers
- 300 people
- Sponsor
- Odense University Hospital
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