Clinical trials: therapeutic conventional surgery
Locally Advanced Soft Tissue Sarcoma
Neoadjuvant Lurbinectedin and Preoperative Radiation for Treating Soft Tissue Sarcomas
This is a multi-center, multi-arm open-label phase Ib/II clinical study assessing the efficacy of concurrent lurbinectedin in combination with radiotherapy in patients with locally advanced, resectable, high-grade sarcomas.
- Trial name
- NCT06217536
- Testing
- Lurbinectedin, Radiotherapy, Non-investigational surgery
- Sponsor
- University of California, San Francisco
Ischemic Stroke
Registry Study of Stenting for Symptomatic Intracranial Artery Stenosis in China
The SAMMPRIS suggested that aggressive treatment was superior to intravascular stenting in patients with severe symptomatic intracranial atherosclerotic stenosis (ICAS) due to high complication rate in patients in stenting group.
- Trial name
- NCT01968122
- Testing
- intravascular stent therapy
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Zhongrong Miao
Healing of Colorectal Anastomoses
Characterising the Natural History of Mucosal Metabolism During Colorectal Anastomotic Healing
This pilot study aims to investigate anastomotic healing and its underlying mechanisms at a mucosal level. It is a first-in-human study which will demonstrate the safety of post-operative endoscopic assessment of a colorectal…
- Trial name
- NCT04740957
- Testing
- Distal limb reintroduction of ileostomy effluent
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Imperial College London
Lacrimal Duct Obstruction
A Comparative Study of Two Endoscopic Operations for Lacrimal Duct Obstruction
To compare the clinical effects between the silicone nasolacrimal intubation under nasoendoscopy and dacryocystorhinostomy on patients with lacrimal duct obstruction.
- Trial name
- ACSOTEOFLDO (NCT02636257)
- Testing
- Recessive Spherical Headed Silicone Intubation, Dacryocystorhinostomy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Chronic Low-back Pain
Evaluation of Multi-Tined Expandable Electrode (MEE) Efficacy and Safety in Treatment of Lumbar Facet Arthropathy by Radiofrequency Neurotomies Compared to Conservative Medical Management.
The purpose of this study is to better understand how people feel after a radiofrequency ablation standard of care surgery using a different type of needle (multi-tined expandable electrode/MEE) in comparison to receiving…
- Trial name
- MEE (NCT04730700)
- Testing
- Radiofrequency Ablation with MEE, Conventional Medical Management
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Kansas Medical Center
Distal Radius Fractures
Volar Locking Plate vs Fragment Specific Fixation in Wrist Fractures
The treatment of unstable, non-reducible distal radial fractures is still controversial. The aim of the present study is to compare the subjective, clinical and radiographic outcome of the TriMed fragment-specific system with a…
- Trial name
- NCT01311531
- Testing
- Open reduction and fixation with TriMed fragment-specific system, Open reduction and fixation with TriMed volar locking plate
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Region Skane
Anxiety Disorder, Breast Cancer
Hypnosis in Reducing Pain and Other Side Effects in Women Undergoing Surgery for Breast Cancer
RATIONALE: Hypnosis may be effective in reducing pain and other side effects in women undergoing surgery for breast cancer. PURPOSE: This clinical trial is studying how well hypnosis works in reducing pain and other side effects…
- Conditions
- Anxiety Disorder, Breast Cancer, Nausea and Vomiting, Pain
- Trial name
- NCT00748267
- Testing
- questionnaire administration, hypnotherapy, therapeutic conventional surgery
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- City of Hope Medical Center
Breast Cancer
Ritonavir and Its Effects on Biomarkers in Women Undergoing Surgery for Newly Diagnosed Breast Cancer
RATIONALE: Ritonavir may stop the growth of tumor cells by blocking some of the enzymes needed for cancer cell growth. Studying samples of blood and tissue from patients with breast cancer in the laboratory may help doctors learn…
- Trial name
- NCT01009437
- Testing
- ritonavir, therapeutic conventional surgery
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Bladder Cancer, Bladder Neoplasm
En Bloc TURBT With Collins Loop vs Conventional TURBT
This is a prospective, randomized, randomized and single-blind study in patients diagnosed with primary bladder CV. Patients diagnosed by cystoscopy of a bladder tumor and with indication for endoscopic surgical treatment, who…
- Conditions
- Bladder Cancer, Bladder Neoplasm, Bladder Urothelial Carcinoma, Bladder Cancer Stage
- Trial name
- TURBT (NCT05027412)
- Testing
- En bloc TURBT Collins Loop, Conventional TURBT
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Hospital Universitario de Fuenlabrada
Breast Cancer
Tamoxifen With or Without Combination Chemotherapy in Treating Postmenopausal Women With Operable Invasive Breast Cancer
RATIONALE: Estrogen can stimulate the growth of breast cancer cells. Hormone therapy using tamoxifen may fight breast cancer by blocking the uptake of estrogen.
- Trial name
- NCT00002581
- Testing
- cyclophosphamide, fluorouracil, methotrexate
- Where
- 9 sites in United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Scottish Cancer Therapy Network
Bladder Cancer, Transitional Cell Cancer of the Renal Pelvis and Ureter
Neoadjuvant Ifosfamide, Doxorubicin, Gemcitabine, and Cisplatin in Treating Patients Who Are Undergoing Radical Cystectomy for Locally Advanced Carcinoma (Cancer) of the Urothelium
RATIONALE: Drugs used in chemotherapy, such as ifosfamide, doxorubicin, gemcitabine, and cisplatin, work in different ways to stop tumor cells from dividing so they stop growing or die.
- Conditions
- Bladder Cancer, Transitional Cell Cancer of the Renal Pelvis and Ureter, Urethral Cancer
- Trial name
- NCT00080795
- Testing
- filgrastim, cisplatin, doxorubicin hydrochloride
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Neoplasms
Trial of Tomotherapy in Breast Cancer
Tomotherapy is a new radiation therapy system that uses an integrated CT scanner during delivery of radiation treatment to improve the accuracy of the treatment.
- Trial name
- TomoBreast (NCT00459628)
- Testing
- Conventional radiotherapy, Tomotherapy
- Where
- Belgium
- Volunteers
- 118 people
- Sponsor
- Vrije Universiteit Brussel
Sarcoma
MRI Sarcoma Non Invasive Thermometry
RATIONALE: Hyperthermia therapy kills tumor cells by heating them to several degrees above body temperature. Using MRI to measure heat may help to determine the effectiveness of hyperthermia therapy.
- Trial name
- NCT00093509
- Testing
- doxorubicin hydrochloride, ifosfamide and mesna, hyperthermia treatment with an MRI Compatible Radiofrequency Extremity Hyperthermia Applicator
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Mark Dewhirst
ACL Injury, ACL Sprain
Isoinertial Rehabilitation in Recovering Hamstring Strength Following Surgical Anterior Cruciate Ligament Reconstruction
The present experimental study aims to evaluate the effectiveness and tolerability of isoinertial strength training of the hamstrings using machines in patients with ACL-R during the intermediate post-intervention phases.
- Conditions
- ACL Injury, ACL Sprain, ACL Tear, Anterior Cruciate Ligament Rupture
- Trial name
- NCT06063915
- Testing
- Isoinertial training, Strength Training
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Università degli studi di Roma Foro Italico
Post Operative Pain, Craniofacial Pain
Sphenopalatine Ganglion Block and Pain Management in Neurosurgery
Post craniotomy pain is defined as headache developed up to 7 days from a craniotomy, not otherwise explained. A moderate to severe pain affects from 60 to 84% of patients.
- Trial name
- SpheNoPain (NCT05136625)
- Testing
- Sphenopalatine ganglion block, Standard Preparation
- Where
- Italy
- Volunteers
- 84 people
- Sponsor
- University Hospital of Ferrara
Esophagus Cancer
Goal-directed Enteral Nutritional Perioperative Management
This clinical trial aims to determine whether perioperative goal-directed nutritional therapy can prevent postoperative pulmonary and other major complications in malnourished esophageal squamous cell cancer patients.
- Trial name
- GENTLEMAN (NCT06510543)
- Testing
- Goal-directed EN therapy, Conventional EN therapy
- Where
- 17 sites in China
- Volunteers
- 400 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Breast Cancer
Implantable Microdevice for In Vivo Drug Sensitivity Testing in Patients With Early Stage, HER2-Positive or Triple Negative Breast Cancer
The purpose of this study is to test the safety and feasibility of placing and removing a small device that contains anti-cancer drugs in a breast tumor of patients who plan on having breast surgery without treatment prior or…
- Trial name
- NCT02521363
- Testing
- KIBUR MICRODEVICE, anthracycline and taxane based chemotherapy
- Where
- 6 sites in United States
- Volunteers
- 11 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Prostate Adenocarcinoma, Stage I Prostate Adenocarcinoma AJCC v7
Hypofractionated Radiation Therapy or Conventional Radiation Therapy After Surgery in Treating Patients With Prostate Cancer
This randomized phase III trial studies how well hypofractionated radiation therapy works compared to conventional radiation therapy after surgery in treating patients with prostate cancer.
- Conditions
- Prostate Adenocarcinoma, Stage I Prostate Adenocarcinoma AJCC v7, Stage II Prostate Adenocarcinoma AJCC v7, Stage III Prostate Adenocarcinoma AJCC v7
- Trial name
- NCT03274687
- Testing
- Hypofractionated Radiation Therapy, Laboratory Biomarker Analysis, Quality-of-Life Assessment
- Where
- 241 sites in United States, Canada and 1 more
- Volunteers
- 296 people
- Sponsor
- NRG Oncology
Hepatocellular Carcinoma (HCC), Artificial Intelligent
Construction and Clinical Validation of a Predictive Model for Postoperative Adjuvant Therapy in Hepatocellular Carcinoma Based on Whole-Slide Digital Pathological Images and Deep Learning
Hepatocellular carcinoma (HCC) is a high-mortality global malignancy with a heavy disease burden in China. Although curative surgical resection improves survival for early-stage HCC patients, the 5-year postoperative recurrence…
- Conditions
- Hepatocellular Carcinoma (HCC), Artificial Intelligent, Adjuvant Chemoradiotherapy, TACE
- Trial name
- NCT07417800
- Testing
- AI adjuvant therapy
- Where
- China
- Volunteers
- 11,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Partial Edentulism, Tooth Loss
The Influence of the Crown-implant Ratio on the Crestal Bone Level and Implant Secondary Stability
The aim of the study was to determine whether implant length and the crown-to-implant (C/I) ratio influence implant stability and the loss of the surrounding marginal bone, and whether short implants can be used instead of sinus…
- Trial name
- NCT03471000
- Testing
- Short implants Treatment, Regular implants Treatment
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Jakub Hadzik
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