Clinical trials: pills and oral medicines
Pulmonary Arterial Hypertension
EXPEDITE: A Study of Remodulin Induction Followed by Orenitram Optimization to Treat Pulmonary Arterial Hypertension
This was a multicenter, open-label study to evaluate the dose of Orenitram® (treprostinil) Extended Release Tablets achieved at 16 weeks after a short-term course of Remodulin® (treprostinil) Injection in subjects with pulmonary…
- Trial name
- NCT03497689
- Testing
- Intravenous/Subcutaneous Treprostinil; Oral Treprostinil
- Where
- 11 sites in United States
- Volunteers
- 36 people
- Sponsor
- United Therapeutics
HIV Infections
Safety and Drug Detection Study of Dapivirine Vaginal Ring and Oral TRUVADA® in Breastfeeding Mother-Infant Pairs
The purpose of this study is to evaluate the safety and drug detection of the dapivirine vaginal ring and oral Truvada in breastfeeding mother-infant pairs.
- Trial name
- NCT04140266
- Testing
- Dapivirine (DPV) Vaginal Ring (VR)-004, Truvada Tablet
- Where
- 4 sites in Malawi, South Africa and 2 more
- Volunteers
- 394 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy
A Study of ALXN1840 (Coated and Non-coated) Administered With And Without Omeprazole In Healthy Adults
This was single-center, open-label, randomized, 3-period, 3-treatment, 6-sequence crossover study evaluating the PK of single doses of WTX101 in healthy participants based on the measurement of plasma total Mo concentration.
- Trial name
- NCT05319912
- Testing
- ALXN1840 Enteric-coated Tablet, ALXN1840 Non-coated Capsule, Omeprazole
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Alexion Pharmaceuticals, Inc.
Driving Behavior, Driving Under the Influence
Validation of the Drug Impaired Driving Scenario (DIDS) on the CRCDS-miniSim
Subjects will participate in a 4-visit study protocol at the National Advanced Driving Simulator, part of the University of Iowa, in which they will be asked to complete assorted questionnaires, computerized cognitive tasks, and…
- Trial name
- PDID (NCT04970342)
- Testing
- 0.75 mg Alprazolam Capsule, Cannabis (6.18% THC / <0.025% CBD), Cannabis (0%/ THC / 0% CBD)
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Timothy L. Brown
Chronic Lymphocytic Leukemia
Study to Assess the Efficacy and Safety of Ublituximab and Umbralisib in Participants With Chronic Lymphocytic Leukemia (CLL) Currently Treated With Ibrutinib, Acalabrutinib or Venetoclax
Phase 2, two cohort trial evaluating the addition of ublituximab and umbralisib on the rate of minimal residual disease (MRD) negativity in participants with Chronic Lymphocytic Leukemia (CLL), who are currently on treatment with…
- Trial name
- NCT04016805
- Testing
- Ublituximab, Umbralisib, Ibrutinib
- Where
- 3 sites in United States
- Volunteers
- 41 people
- Sponsor
- TG Therapeutics, Inc.
Childhood Absence Epilepsy
Cannabidiol Oral Solution in Pediatric Participants With Treatment-Resistant Childhood Absence Seizures
The primary purpose of this study is to assess the efficacy of Cannabidiol Oral Solution in the treatment of pediatric participants with treatment-resistant childhood absence seizures.
- Trial name
- NCT03336242
- Testing
- Cannabidiol Oral Solution
- Where
- 11 sites in United States
- Volunteers
- 20 people
- Sponsor
- Radius Pharmaceuticals, Inc.
Penicillin Allergy, Penicillin Sensitivity
Inpatient Penicillin Allergy Delabeling Study
The study will identify pediatric patients 3-18 years old who have penicillin allergy label in the electronic medical record. Those who are identified will be stratified into no-risk, low-risk and high-risk category using a…
- Conditions
- Penicillin Allergy, Penicillin Sensitivity, Penicillin Reaction, Penicillin Intolerance
- Trial name
- NCT05020327
- Testing
- Graded Oral Amoxicillin Challenge, De-labelling in electronic medical record, Referral to Allergy Immunology/Retention of Allergy Label
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Postoperative Pain
Comparing Opioid Prescription Patterns in Total Joint Arthroplasty Patients
The United States constitutes <5% of the world's population but over 80% of the opioid supply and 99% of the hydrocodone supply.
- Trial name
- NCT03236155
- Testing
- opioid pain pills
- Where
- United States
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Caries,Dental
Clinical Trial Proximal Caries Infiltration and Detection
The purpose of this study is to investigate the clinical efficacy of resin infiltration (Icon, DMG, Germany) compared to fluoride varnish (Duraphat Fluoride Varnish, Colgate, USA) in the management of proximal early caries…
- Trial name
- NCT01796106
- Testing
- Resin infiltration, Fluoride varnish & Oral hygiene instruction
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- DMG Dental Material Gesellschaft mbH
Tuberculosis, Pulmonary
Early Bactericidal Activity of Rifampin + Meropenem + Amoxicillin/Clavulanate in Adults With Pulmonary TB
The overall goal of this exploratory proof-of-concept study is to determine whether, in participants with pulmonary tuberculosis caused by M.
- Trial name
- NCT03174184
- Testing
- Rifampin, MEROPENEM 2 grams TID, MEROPENEM 1 gram TID
- Where
- South Africa
- Volunteers
- 112 people
- Sponsor
- Johns Hopkins University
Gastro Intestinal Bleeding, Hematemesis
Study of Early Endocapsule (EC) in Clinical Decision Unit Versus Standard of Care Work-up for GI Bleeding
This study will evaluate the use of the Olympus EndoCapsule EC-10 video capsule compared with the standard of care workup for patients in the Clinical Decision Unit who have symptoms of gastrointestinal (GI) bleeding.
- Conditions
- Gastro Intestinal Bleeding, Hematemesis, Melena
- Trial name
- NCT03955055
- Testing
- Video Capsule Endoscopy
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Christopher Marshall
Allergic Rhinitis, Allergic Rhinoconjunctivitis
Adolescent Mite Allergy Safety Evaluation
This is a 28-day clinical trial studying the safety of the house dust mite tablet in adolescents with allergic rhinitis/rhinoconjunctivitis.
- Trial name
- AMASE (NCT04541004)
- Testing
- HDM SLIT-tablet
- Where
- 27 sites in Czechia, Germany and 1 more
- Volunteers
- 253 people
- Sponsor
- ALK-Abelló A/S
Atopic Dermatitis
Phase 2B Study to Evaluate ASN002 in Subjects With Moderate to Severe Atopic Dermatitis (RADIANT)
This is a randomized double-blind/placebo study evaluate the efficacy of ASN002 in subjects with moderate to severe atopic dermatitis (AD).
- Trial name
- NCT03531957
- Testing
- ASN002
- Where
- 47 sites in United States, Canada and 1 more
- Volunteers
- 244 people
- Sponsor
- Asana BioSciences
Diabetes Mellitus, Type 1
Evaluation of TTP399 in Patients With Type 1 Diabetes
The purpose of this study is to evaluate the safety and efficacy of TTP399 in Type 1 diabetics. This study will be in 2 phases: phase 1 will evaluate the safety of different TTP399 dosage regimens over 1 week of daily dosing.
- Trial name
- SimpliciT1 (NCT03335371)
- Testing
- TTP399
- Where
- 15 sites in United States
- Volunteers
- 115 people
- Sponsor
- vTv Therapeutics
Cholera (Disorder)
VAXCHORA Pediatric Study to Assess Safety and Immunogenicity
VAXCHORA (Cholera Vaccine, Live, Oral) is a vaccine indicated for active immunization against disease caused by Vibrio cholerae serogroup O1.
- Trial name
- NCT03220737
- Testing
- VAXCHORA (Cholera Vaccine, Live, Oral)
- Where
- 10 sites in United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Bavarian Nordic
Missed Abortion, Anembryonic Pregnancy
Ulipristal Acetate for Use in Early Pregnancy Loss
The investigators will study the feasibility of using 90mg ulipristal acetate, a selective progesterone receptor agonist, as an adjunct to 800mcg vaginal misoprostol for the medical management of early pregnancy loss.
- Conditions
- Missed Abortion, Anembryonic Pregnancy, Non-Viable Pregnancy
- Trial name
- NCT05216952
- Testing
- Ulipristal Acetate Tablets, Misoprostol Pill
- Where
- 4 sites in United States
- Volunteers
- 3 people
- Sponsor
- University of North Carolina, Chapel Hill
Covid19
Estradiol and Progesterone in Hospitalized COVID-19 Patients
The purpose of this study is to determine to what extent a short systemic steroid therapy with estradiol and progesterone, administered early to hospitalized and confirmed COVID-19 positive patients of both sexes in addition to…
- Trial name
- NCT04865029
- Testing
- Estradiol Cypionate 5 mg/ml, Progesterone 200 mg Oral Capsule
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Tulane University
HIV Infections
The Pharmacokinetics, Safety, and Tolerability of Abacavir/Dolutegravir/Lamivudine Dispersible and Immediate Release Tablets in HIV-1-Infected Children Less Than 12 Years of Age
The purpose of this study was to examine the pharmacokinetics, safety, and tolerability of abacavir/dolutegravir/lamivudine dispersible and immediate release tablets in children living with HIV less than 12 years of age.
- Trial name
- NCT03760458
- Testing
- Abacavir (ABC)/Dolutegravir (DTG)/Lamivudine (3TC) Dispersible Tablets, Abacavir (ABC)/Dolutegravir (DTG)/Lamivudine (3TC) Immediate Release Tablets (Immediate release)
- Where
- 14 sites in United States, Botswana and 2 more
- Volunteers
- 57 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Obesity, Glucose Homeostasis
Bazedoxifene/Conjugated Estrogens (BZA/CE) Improvement of Metabolism (BIM)
The goal of this pilot clinical study is to perform a randomized placebo-controlled study to assess the beneficial effect of a 3 month-treatment with Bazedoxifene/Conjugated Estrogens (BZA/CE) vs.
- Conditions
- Obesity, Glucose Homeostasis, Postmenopausal Symptoms
- Trial name
- BIM (NCT02237079)
- Testing
- Bazedoxifene/Conjugated Estrogens (BZA/CE)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Tulane University Health Sciences Center
Hereditary Angioedema, HAE
Efficacy and Safety Study of BCX7353 as an Oral Treatment for the Prevention of Attacks in HAE
This is a phase 3, multicenter, randomized, double-blind, placebo-controlled trial to evaluate the efficacy and safety of oral BCX7353 in preventing acute angioedema attacks in patients with Type I and Type II HAE.
- Trial name
- APeX-2 (NCT03485911)
- Testing
- BCX7353 capsules
- Where
- 47 sites in United States, Austria and 9 more
- Volunteers
- 121 people
- Sponsor
- BioCryst Pharmaceuticals
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