Clinical trials: pills and oral medicines
Relapsing Multiple Sclerosis
Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.
The purpose of this Phase 3b study is to assess the efficacy, safety and tolerability of remibrutinib after switching from ocrelizumab and compared to continuous ocrelizumab treatment, in patients living with relapsing multiple…
- Trial name
- NCT06846281
- Testing
- Remibrutinib oral treatment, Ocrelizumab
- Where
- 131 sites in United States, Argentina and 17 more
- Volunteers
- 400 people
- Sponsor
- Novartis Pharmaceuticals
Peanut Allergic Subjects, Peanut Allergies
Oral Immunotherapy for Children With Peanut Allergy
This clinical trial aims to investigate if oral immunotherapy can help children with peanut allergy tolerate peanut. Children aged 6 months to 4 years can take part in the trial.
- Conditions
- Peanut Allergic Subjects, Peanut Allergies, Peanut Hypersensitivity, Food Allergy Peanut
- Trial name
- NCT07895095
- Testing
- Oral immunotherapy with peanut
- Where
- 5 sites in Denmark
- Volunteers
- 56 people
- Sponsor
- Laura Ozer Kettner
Obstructive Sleep Apnea, Cognitive Decline
The Effects of Successful OSA Treatment on Memory and AD Biomarkers in Older Adults Study
The Effects of Successful OSA TreatmENT on Memory and AD BIomarkers in Older AduLts (ESSENTIAL) study is a 5-year, multicenter randomized open-label trial that will screen 400 cognitively normal older adults recruited from…
- Trial name
- ESSENTIAL (NCT05988385)
- Testing
- Positive airway pressure, Oral appliance therapy, Positional therapy
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- California Pacific Medical Center Research Institute
Alcohol Drinking
Nicotinic Receptor Genetic Variation and Alcohol Reward
Background: People with the brain disease AUD (alcohol use disorder) have a serious problem with drinking. Researchers want to study how different people react to alcohol, and how genes affect this.
- Trial name
- NCT03294460
- Testing
- Alcohol (Oral), Alcohol (IV), Alcohol (Ethanol)
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Lumbar Degenerative Disease, Lumbar Spondylolisthesis
Perioperative Nutrition Management in Patients Undergoing Open Posterior Lumbar Surgery
Patients undergoing open posterior lumbar fusion surgery often experience postoperative gastrointestinal problems, such as bloating, constipation, and delayed passage of gas and stool, and may be at nutritional risk.
- Conditions
- Lumbar Degenerative Disease, Lumbar Spondylolisthesis, Lumbar Disc Herniation
- Trial name
- NCT07893938
- Testing
- Oral nutritional supplements (ONS), Carbohydrate loading (OCL), 'Probiotics (Bifidobacterium and Lactobacillus triple live capsules)'
- Where
- China
- Volunteers
- 90 people
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Essential Arterial Hypertension
Fixed-dose Combination of an Angiotensin Receptor Blocker and Thiazide Diuretic for Essential Hypertension
This is a phase III, non-inferiority, randomized, double-blind, double-dummy, active-controlled, multicenter study to compare the efficacy and safety of N0877 versus double combination with already established efficacy on…
- Trial name
- ATHESA (NCT06608472)
- Testing
- N0877, Benicar HCT ® Tablets 40 mg/25 mg
- Sponsor
- Eurofarma Laboratorios S.A.
Thirst
Effectiveness of Enzyme Spray Intervention on Thirst Relief in Patients With Endotracheal Intubation.
Thirst is a common and distressing symptom among intensive care unit (ICU) patients with endotracheal intubation. Endotracheal intubation, nil per os (NPO) status, oxygen therapy, and medication effects may contribute to oral…
- Trial name
- NCT07533552
- Testing
- Enzyme-based oral spray (Oral7®), Distilled water oral spray
- Where
- Taiwan
- Volunteers
- 76 people
- Sponsor
- Yeh,Shiao Feng
Renal Impairment
Renal Impairment Pharmacokinetics (PK) Trial of Afabicin
The primary purpose of this study is to assess the effect of renal impairment on the PK of afabicin desphosphono after a single oral 80 milligrams (mg) or intravenous (IV) 55 mg dose of afabicin.
- Trial name
- NCT07758608
- Testing
- Afabicin Oral, Afabicin IV
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Debiopharm International SA
Recurrent Bacterial Vaginosis
Probiotics as an Adjunct to Antibiotics for Recurrent Bacterial Vaginosis
This randomized clinical trial aims to compare the recurrence of bacterial vaginosis (BV) in women receiving probiotics alongside antibiotic treatment versus women receiving antibiotic treatment alone.
- Trial name
- NCT07893782
- Testing
- Probiotic Combination Cap/Tab
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- Nishtar Medical University
Eczema, Dermatitis
Effects of Treatments on Atopic Dermatitis
Background: Atopic dermatitis, or eczema, is a chronic skin disorder. Patients sometimes have infections with S. aureus bacteria.
- Conditions
- Eczema, Dermatitis, Skin Diseases, Genetic, Dermatitis, Atopic
- Trial name
- NCT01631617
- Testing
- Trimethoprim/sulfamethoxazole (TMP/SMZ), Cephalexin, Doxycycline
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Aortic Stenosis Disease, Aortic Stenosis Symptomatic
Exercise and Diet Supplements for Older Patients Undergoing TAVI: the IRON-TAVI Trial
he IRON-TAVI trial is a prospective, randomized, multicenter study evaluating whether a multidomain rehabilitation program can improve outcomes in older patients undergoing transcatheter aortic valve implantation for severe…
- Conditions
- Aortic Stenosis Disease, Aortic Stenosis Symptomatic, Aortic Stenosis
- Trial name
- IRON-TAVI (NCT07895719)
- Testing
- Personalized Multidomain Exercise Program, Oral Protein and Iron Nutritional Supplementation, Usual Care
- Where
- Italy
- Volunteers
- 450 people
- Sponsor
- University Hospital of Ferrara
Tonsillectomy and Adenotonsillectomy in Children
Boyle-Davis Mouth Gag Timing in Pediatric Tonsil Surgery
The aim of this randomized controlled trial is to compare the effects of placing the Boyle-Davis mouth gag 3 minutes versus 10 minutes after endotracheal intubation on the hemodynamic response in pediatric patients aged 3-12…
- Trial name
- NCT07889206
- Testing
- Early Boyle-Davis Mouth Gag Placement, Delayed Boyle-Davis Mouth Gag Placement
- Volunteers
- 40 people
- Sponsor
- Yahyali State Hospital
Migraine
Efficacy and Safety of Rizatriptan-Naproxen (10/550 mg) in the Acute Treatment of Migraine
A phase III study, multicenter, double-blind, double-dummy, randomized, single-dose, placebo-controlled study to evaluate the efficacy and safety of Rizatriptan-Naproxen (10/550 mg) in the acute treatment of migraine.
- Trial name
- RELIEF (NCT04384367)
- Testing
- Rizatriptan 10 mg + Naproxen 550mg, Maxalt 10Mg Tablet, Flanax 550mg
- Where
- 2 sites in Brazil
- Volunteers
- 2,068 people
- Sponsor
- Eurofarma Laboratorios S.A.
Gastric Lesion, Gastritis
Capsule Gastric Endoscopy for Gastric Disease Screening in Simulated Home Scenarios
The goal of this clinical trial is to evaluate the diagnostic accuracy of the AI-integrated Capsule Gastroscopy (ACG) system in simulated home-use conditions for detecting upper gastrointestinal (UGI) abnormalities.
- Conditions
- Gastric Lesion, Gastritis, Upper Gastrointestinal Bleeding (UGIB), Gastric Dysplasia
- Trial name
- NCT06848400
- Testing
- AI-integrated Capsule Gastroscopy (ACG) examination, Electronic gastroduodenoscopy (EGD) examination
- Where
- 12 sites in China, Hong Kong and 1 more
- Volunteers
- 482 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Nephrotic Syndrome, Proteinuria
Rituximab Plus Cyclosporine in Idiopathic Membranous Nephropathy
Background: Membranous nephropathy is associated with damage to the walls of the glomeruli, the small blood vessels in the kidneys that filter waste products from the blood.
- Conditions
- Nephrotic Syndrome, Proteinuria, Autoimmune Disease, Glomerular Disease
- Trial name
- NCT00977977
- Testing
- Rituximab Infusion, Oral Cyclosporine
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Paroxysmal Atrial Fibrillation
Conscious Sedation Versus General Anesthesia for Pulsed Field Ablation in Paroxysmal Atrial Fibrillation
This prospective, multicenter, randomized, controlled, noninferiority trial will compare local anesthesia with conscious sedation and general anesthesia in patients undergoing pulsed field ablation for paroxysmal atrial…
- Trial name
- PULSE-SED (NCT07877519)
- Testing
- Local Anesthesia With Conscious Sedation, General Anesthesia, VARIPULSE Pulsed Field Ablation System
- Where
- China
- Volunteers
- 390 people
- Sponsor
- China National Center for Cardiovascular Diseases
Prostate Cancer
Detecting Metastases by PyL PET/CT in Subjects Starting Enzalutamide for Untreated Castration Resistant Prostate Cancer.
This study aimed to evaluate the diagnostic performance of 18F-DCFPyL (PyL) PET/CT in subjects presenting not previously treated for castration resistant prostate cancer and showing negative or equivocal findings per…
- Trial name
- PROSTEP-002 (NCT04655365)
- Testing
- Enzalutamide capsule
- Where
- 4 sites in Canada
- Volunteers
- 30 people
- Sponsor
- CHU de Quebec-Universite Laval
Cognitive Change, Cytokine Levels
The Effect of Oral Use of Lyophilised Royal Jelly on Cognitive Functions and Immune System in Elderly Individuals
Dementia is a significant public health problem, affecting 47 million people worldwide in 2015, according to World Health Organization data. It is expected to increase to 75 million in 2030 and reach 132 million in 2050.
- Conditions
- Cognitive Change, Cytokine Levels, Neuroinflammation
- Trial name
- NCT06404203
- Testing
- Balparmak Apitera Royal Jelly Herbal Capsule Food Supplement 500 mg/day, Balparmak Apitera Royal Jelly Herbal Capsule Food Supplement 1000 mg/day, Balparmak Apitera Royal Jelly Herbal Capsule Food Supplement 1500 mg/day
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medipol University
Hypertensive Disorder of Pregnancy, Preeclampsia
Blood Pressure Goal in Preterm Preeclampsia
The purpose of this study is to compare latency (prolongation of pregnancy from diagnosis till delivery) in patients with hypertensive disorders of pregnancy (HDP) with severe features < 34 weeks gestational age (GA), undergoing…
- Trial name
- NCT07894705
- Testing
- Treating BP acutely with intravenous or rapid acting oral medications
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Ohio State University
Primary Osteoporosis
Quanduzhong Capsules for Primary Osteoporosis
The goal of this clinical trial is to learn if Quan Duzhong Capsules work to treat primary osteoporosis in adults. It will also learn about the safety of Quan Duzhong Capsules.
- Trial name
- QZDC-PO (NCT07895082)
- Testing
- Quan Duzhong Capsules
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
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