Clinical trials: pills and oral medicines
Severe Sudden Sensorineural Hearing Loss
Efficacy of SENS 401 in Subjects With Severe or Profound Sudden Sensorineural Hearing Loss
Primary objective of the study is to assess the efficacy of SENS-401 on hearing loss in comparison to placebo at the end of the 4-week treatment period
- Trial name
- AUDIBLE-S (NCT03603314)
- Testing
- SENS-401
- Where
- 26 sites in Bulgaria, Canada and 8 more
- Volunteers
- 115 people
- Sponsor
- Sensorion
Long-Term Memory Decline, Mild Cognitive Impairment
Wayfinding Intervention in High-Fidelity Long-Term Memory
Therapeutic treatment is yet available for declining memory, which is an impairment affecting the quality of life for many older adults and patients with cognitive impairment.
- Trial name
- LABYR (NCT04253587)
- Testing
- LabyrinthVR, Coherence, Tablet
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Alzheimer Disease
GAIN Trial: Phase 2/3 Study of COR388 in Subjects With Alzheimer's Disease
This is a randomized, double-blind, placebo-controlled study that assessed the efficacy, safety, and tolerability of 2 dose levels of COR388 in subjects with a clinical diagnosis of mild to moderate Alzheimer's disease (AD)…
- Trial name
- NCT03823404
- Testing
- COR388 capsule
- Where
- 93 sites in United States, France and 4 more
- Volunteers
- 643 people
- Sponsor
- Cortexyme Inc.
Bipolar II Disorder
Differential Responses to Drugs and Sweet Tastes
Young adults who exhibit "bipolar phenotype" (BPP), defined as occasional episodes of mood elevation and heightened activity, are at risk for several psychiatric disorders, including problem use of drugs and alcohol.
- Trial name
- HAP (NCT03810703)
- Testing
- d-amphetamine 10 mg oral capsule, d-amphetamine 20 mg oral capsule
- Where
- 2 sites in United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Attention Deficit Hyperactivity Disorder, ADHD
Efficacy and Safety of Methylphenidate HCl ER Capsules in Children and Adolescents With ADHD
This multi-center parallel study is designed to study the efficacy and safety of fixed doses of methylphenidate extended release (ER) capsules of four dose levels compared with a placebo group in pediatric patients with Attention…
- Trial name
- NCT01239030
- Testing
- Methylphenidate Hydrochloride Extended Release Capsules
- Where
- 16 sites in United States
- Volunteers
- 230 people
- Sponsor
- Rhodes Pharmaceuticals, L.P.
Antibiotic-associated Diarrhea
Mechanisms of Preventing Antibiotic-Associated Diarrhea and the Role for Probiotics
The focus of the study is to better understand the mechanisms causing antibiotic-associated diarrhea (AAD) and how probiotics may prevent some of the iatrogenic effects of antibiotic medications.
- Trial name
- YOBIOTIC (NCT03755765)
- Testing
- Amoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet, BB-12, Control
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Constipation
Naloxegol to Prevent Lower Gastrointestinal Paralysis in Critically Ill Adults Administered Opioids
This study evaluates the addition of naloxegol (Movantik) to a laxative protocol in critically ill adults requiring scheduled opioid (e.g. fentanyl) therapy.
- Trial name
- NCT02977286
- Testing
- Naloxegol Oral Tablet, Docusate Sodium 100 Mg oral capsule [Colace], Senna 217 Mg Oral Tablet
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Tufts Medical Center
Herpes Simplex Type II
Effect of Tenofovir on Genital Herpes Simplex Virus (HSV) Shedding
The investigators propose a randomized, double blind, placebo-controlled, cross-over trial to evaluate the effect of oral and topical (vaginal gel) tenofovir on genital herpes simplex virus (HSV) shedding among herpes simplex…
- Trial name
- NCT01448616
- Testing
- TDF, Vaginal TFV Gel
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- University of Washington
Coronavirus Infection, Coronavirus
University of Utah COVID-19 Hydrochloroquine Trial
A novel coronavirus, SARS-CoV-2, is responsible for a rapidly spreading pandemic that has reached 160 countries, infecting over 500,000 individuals and killing more than 24,000 people.
- Conditions
- Coronavirus Infection, Coronavirus, Infectious Disease
- Trial name
- NCT04342169
- Testing
- Hydroxychloroquine
- Where
- United States
- Volunteers
- 368 people
- Sponsor
- University of Utah
Epidermolysis Bullosa
A Neurokinin-1 Receptor Antagonist for the Treatment of Pruritus in Patients With Epidermolysis Bullosa
To determine if Serlopitant (when taken by mouth) is safe and works on itch in patients aged 13 and above with EB.
- Trial name
- NCT03836001
- Testing
- Serlopitant Tablet
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Stanford University
Neoplasms, Breast
Study In Women And Men With Metastatic Breast Cancer That Have Overexpression Of ErbB2
This was a randomized, double-blind, placebo-controlled, multicenter, Phase III study to evaluate and compare the efficacy and safety of Lapatinib + Paclitaxel versus Placebo + Paclitaxel in men and women with ErbB2 amplified…
- Trial name
- NCT00281658
- Testing
- Lapatinib (GW572016) oral tablets, Paclitaxel infusion
- Where
- 54 sites in Brazil, China and 6 more
- Volunteers
- 444 people
- Sponsor
- Novartis Pharmaceuticals
Emergencies
Optimized Health-Related Social Needs Screening and Community Linkages
The objective of this study is to to understand the most effective method for health-related social need (HRSN) screening in the challenging environment of an emergency department by randomizing patients to oral or written HRSN…
- Trial name
- NCT03834441
- Testing
- Oral HRSN screening, Written HRSN screening
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Massachusetts General Hospital
Drug Use
Pharmacokinetic Properties of 200 and 400 mg Acyclovir Tablet in Indonesia Healthy Subject
The objective of this present study was to asses the pharmacokinetic properties of acyclovir tablet from new product formulation (PT.
- Trial name
- NCT04988646
- Testing
- Acyclovir 200 MG, Acyclovir 400 MG, Zovirax 200 MG Tablet
- Where
- Indonesia
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- PT. Kimia Farma (Persero) Tbk
Cocaine Use Disorder
Suvorexant and Cocaine
The research proposed here will translate findings from preclinical research and provide the initial clinical evidence that orexin antagonism reduces motivation for cocaine, as well as other cocaine-associated maladaptive…
- Trial name
- NCT03937986
- Testing
- Suvorexant, Cocaine
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- William Stoops
Esophageal Food Bolus Obstruction
Esophageal Food Impaction
This study is designed to obtain data on the safety and efficacy of oral nitroglycerin solution for the treatment of esophageal food impaction in patients presenting to the Emergency Department with presumed esophageal food…
- Trial name
- ONEFIT (NCT03305848)
- Testing
- Nitrostat 0.4Mg Sublingual Tablet
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- HealthPartners Institute
Alzheimer's Disease, Disruptive Behavior
Prazosin for Agitation in Alzheimer's Disease
The study evaluates the effects of Prazosin on agitation in adults with Alzheimer's disease. Two thirds of the participants will participate in the medication portion, while one third will participate in the placebo portion
- Trial name
- NCT03710642
- Testing
- Prazosin
- Where
- 14 sites in United States
- Volunteers
- 35 people
- Sponsor
- Alzheimer's Disease Cooperative Study (ADCS)
Malaria
Bioequivalence Trial of Pyronaridine Artesunate To-be-marketed Tablet to the Clinical Trial Reference Tablet
The primary objective of this study is to determine the bioequivalence of the combination of pyronaridine and artesunate (180:60mg) to-be-marketed tablet to the clinical trial reference tablet administered as a single total dose…
- Trial name
- NCT00682630
- Testing
- pyronaridine artesunate clinical trial reference tablets, pyronaridine artesunate to-be-marketed tablets
- Where
- Switzerland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Alcohol Use Disorder
Medication Development for Protracted Abstinence in Alcoholism: CORT118335 Versus Placebo
The hypotheses under test are that subjects with alcohol use disorder (AUD) of moderate or greater severity treated with CORT118335 will report decreased craving for alcohol following alcohol exposure in the laboratory and report…
- Trial name
- NCT04466215
- Testing
- Miricorilant
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The Scripps Research Institute
Healthy Volunteers
Study to Investigate the Absorption, Metabolism, and Excretion of [14C]-GDC-9545 Following a Single Oral Dose (Part 1) and to Evaluate the Absolute and Relative Bioavailability of Oral Capsule Formulations of GDC-9545 (Part 2) in Healthy Female Subjects of Non-Childbearing Potential
This is an open-label, single-center, two part study in healthy female subjects of non-childbearing potential to investigate the absorption, metabolism, and excretion of [14C]-GDC-9545 (Part 1), the absolute bioavailability of…
- Trial name
- NCT04680273
- Testing
- [14C]-GDC-9545, GDC-9545 Solution for Infusion, GDC-9545/F12 Capsule
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Healthy Volunteers
Analysis of Crushed and Whole Tablet Genvoya
Step-wise, two sequential, single-dose, bioequivalence study in 12 healthy volunteers to determine whether crushed Genvoya tablet is bioequivalent to whole Genvoya tablet.
- Trial name
- NCT03717129
- Testing
- Genvoya Oral dose, Genvoya Crushed Dose
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
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