Clinical trials: surgery and procedures, open to volunteers
Lung Carcinoma
Home-Based Respiratory Muscle Training and Aerobic Exercise Programs to Improve Lung Health in Current and Former Cigarette Smokers
This clinical trial studies whether home-based respiratory muscle training (RMT) and aerobic exercise (AE) programs can be used to improve lung health in current and former cigarette smokers.
- Trial name
- NCT07553819
- Testing
- Accelerometry, Aerobic Exercise, Biospecimen Collection
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Non-Small Cell Lung Cancer, Minimal Residual Disease
Patient-Specific MRD Liquid Biopsy in Resected NSCLC: Plasma and Bronchial Washing ctDNA
This is a multicenter, prospective, observational pilot cohort study in patients with surgically resected non-small cell lung cancer (NSCLC, pathologic stage IA3-IIIA).
- Trial name
- LUNG-MRDetect (NCT07921888)
- Testing
- Patient-specific tumor-informed MRD assay (plasma and bronchial washing ctDNA), Bronchoscopy with bronchial washing for reserach
- Where
- 3 sites in South Korea
- Volunteers
- 40 people
- Sponsor
- Eun Hye Lee
Metastatic Dedifferentiated Liposarcoma, Metastatic Undifferentiated Pleomorphic Sarcoma
Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas
This phase III trial compares the effect of immunotherapy (pembrolizumab) plus chemotherapy (doxorubicin) to chemotherapy (doxorubicin) alone in treating patients with dedifferentiated liposarcoma (DDLPS), undifferentiated…
- Conditions
- Metastatic Dedifferentiated Liposarcoma, Metastatic Undifferentiated Pleomorphic Sarcoma, Stage III Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8, Stage IV Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8
- Trial name
- NCT06422806
- Testing
- Biospecimen Collection, Diagnostic Imaging Testing, Doxorubicin
- Where
- 269 sites in United States, Canada and 1 more
- Volunteers
- 365 people
- Sponsor
- National Cancer Institute (NCI)
Malignant Solid Neoplasm
Immune Checkpoint Inhibitor Toxicity Risk Prediction in Solid Tumors
This study examines how certain risk factors (such as age, gender, other medical conditions, and the type of immunotherapy used to treat the cancer) affect whether a patient with a malignant solid tumor will develop mild or…
- Trial name
- NCT04871542
- Testing
- Biospecimen Collection, Questionnaire Administration
- Where
- 849 sites in United States, Chile and 3 more
- Volunteers
- 2,062 people
- Sponsor
- SWOG Cancer Research Network
Low Grade Astrocytoma, Low Grade Glioma
A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma
This phase III trial compares the effect of selumetinib versus the standard of care treatment with carboplatin and vincristine (CV) in treating patients with newly diagnosed or previously untreated low-grade glioma (LGG) that…
- Conditions
- Low Grade Astrocytoma, Low Grade Glioma, Metastatic Low Grade Astrocytoma, Metastatic Low Grade Glioma
- Trial name
- NCT04166409
- Testing
- Biospecimen Collection, Carboplatin, Echocardiography Test
- Where
- 132 sites in United States, Canada and 1 more
- Volunteers
- 170 people
- Sponsor
- National Cancer Institute (NCI)
Acute Ischemic Stroke, Basilar Artery Occlusion
Selective Intra-Arterial Hypothermia After Endovascular Treatment for Acute Basilar Artery Occlusion
This study will examine whether cooling part of the brain through a catheter after endovascular treatment improves recovery in adults with acute basilar artery occlusion, a type of severe stroke.
- Trial name
- NCT07896655
- Testing
- Mechanical thrombectomy, Normothermic saline infusion, 4°C saline infusion
- Where
- 2 sites in China
- Volunteers
- 818 people
- Sponsor
- Guangdong Second Provincial General Hospital
COPD (Chronic Obstructive Pulmonary Disease), Sarcopenia in Elderly
The Aim of the Study is to Decipher the Alterations in Signalling Pathways of Skeletal Muscle Stem Cells (Satellite Cells (SCs)) in Individuals With COPD, as Well as to Examine the Effect of Exercise Training on SCs.
The aim of the study is to decipher the alterations in signalling pathways of skeletal muscle stem cells (satellite cells (SCs)) in individuals with COPD, as well as to examine the effect of exercise training on SCs.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Sarcopenia in Elderly, Skeletal Muscle Atrophy, Cachexia-Anorexia Syndrome
- Trial name
- SCOOP (NCT07923656)
- Testing
- Exercise training
- Where
- 3 sites in France
- Volunteers
- 26 people
- Sponsor
- University Hospital, Bordeaux
Abscess
Efficacy of Methylene Blue Photodynamic Therapy for Treatment of Deep Tissue Abscesses
The objective of this Phase 2 study is to evaluate the efficacy of methylene blue photodynamic therapy (MB-PDT) performed at the time of percutaneous abscess drainage for disinfection of deep tissue abscesses.
- Trial name
- NCT06052956
- Testing
- Methylene Blue, Lipid Emulsion, Insertion of optical fiber
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Rochester
Symptomatic Irreversible Pulpitis, Symptomatic Apical Periodontitis
Effect of Cryotherapeutic and Nanotherapeutic Sodium Hypochlorite on Post-Operative Endodontic Pain.
This randomized clinical trial aims to compare the effects of conventional, cryotherapeutic, and nanotherapeutic sodium hypochlorite solutions used as final root canal irrigants on postoperative pain and substance P levels.
- Trial name
- NCT07923669
- Testing
- Cryotherapeutic Sodium Hypochlorite Irrigation., Nanotherapeutic Sodium Hypochlorite Irrigation
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- October 6 University
Glioblastoma
Beginning Radiation Immediately With GammaTile at GBM Excision Versus Standard of Care
This is a Phase 3 prospective, randomized, superiority, open-label, multi-site study. The overview of this study is as follows: A Screening/Baseline Period of 21 days.
- Trial name
- BRIDGES (NCT07195591)
- Testing
- GammaTile®, External Beam Radiation Therapy, Temozolomide
- Where
- 20 sites in United States
- Volunteers
- 766 people
- Sponsor
- GT Medical Technologies, Inc.
Ovarian Carcinoma
A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer
This clinical trial evaluates how well two surgical procedures (bilateral salpingectomy and bilateral salpingo-oophorectomy) work in reducing the risk of ovarian cancer for individuals with BRCA1 mutations.
- Trial name
- NCT04251052
- Testing
- Bilateral Salpingectomy, Bilateral Salpingectomy with Oophorectomy, Biospecimen Collection
- Where
- 630 sites in United States, Canada and 1 more
- Volunteers
- 1,956 people
- Sponsor
- NRG Oncology
Orbital Atherectomy
Trial to Assess Non-inferiority of an Orbital Atherectomy Only Versus a Calcium-tailored Debulking Approach
Some patients with coronary artery disease have severely calcified vessels. In these cases, placing a stent - a small tube that helps keep the artery open - can be very difficult.
- Trial name
- OrFitA (NCT07105930)
- Testing
- Debulging approach using the orbital atherectomy system, Debulging using rotational atherectomy, scoring or cutting balloons, or shockwave therapy
- Where
- Germany
- Volunteers
- 310 people
- Sponsor
- IHF GmbH - Institut für Herzinfarktforschung
Recurrent Glioblastoma, IDH-Wildtype, Recurrent MGMT-Methylated Glioblastoma
Testing the Addition of an Anti-cancer Drug, Selinexor, to the Usual Chemotherapy Treatment (Temozolomide) for Brain Tumors That Have Returned After Previous Treatment
This phase I/II trial tests the safety, side effects and best dose of selinexor given in combination with the usual chemotherapy (temozolomide) and compares the effect of this combination therapy versus the usual chemotherapy…
- Trial name
- NCT05432804
- Testing
- Biospecimen Collection, Magnetic Resonance Imaging, Selinexor
- Where
- 39 sites in United States
- Volunteers
- 97 people
- Sponsor
- National Cancer Institute (NCI)
Preterm Birth, Enterocolitis, Necrotizing
Study of the Influence of Intraperitoneal Insufflation of CO2 by Laparoscopy on the Short-term Evolution of Premature Infants With Ulcerative Necrotizing Enterocolitis
Ulcerative-necrotizing enterocolitis (ECUN) is an infectious and inflammatory disease of the digestive tract, which can lead to intestinal necrosis or perforation.
- Trial name
- NECO2 (NCT05882448)
- Testing
- laparotomy, Laparoscopy
- Where
- 2 sites in France
- Volunteers
- 54 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Solid Tumor, Adult, Solid Tumor, Childhood
An Exploratory Study to Evaluate Immune Determinants of the Response to Adoptive Cell Therapy (ACT) in Solid and Hematologic Tumors
This is a study to explore the phenotypic and transcriptional changes of different cellular components in the tumor following the injection of somatic cell therapy drugs.
- Conditions
- Solid Tumor, Adult, Solid Tumor, Childhood, Hematologic Cancer
- Trial name
- PIONEER (NCT05481502)
- Testing
- Tumor biopsy, Blood sample, Bone marrow sample
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Digestive System Surgical Procedures, Anastomosis, Surgical
Prospective, Multicenter, Randomized Controlled Phase III Trial of Biological Mesh for Alimentary Tract Reconstruction in Digestive Surgery
The goal of the Phase III clinical trial is to evaluate whether using a biological mesh helps improve the efficacy and safety of alimentary tract reconstruction surgery.
- Conditions
- Digestive System Surgical Procedures, Anastomosis, Surgical, Postoperative Hemorrhage, Anastomotic Leaks
- Trial name
- NCT07921732
- Testing
- Biological Mesh for Digestive Surgery, Conventional Stapling
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Recurrent Ganglioneuroblastoma, Recurrent Neuroblastoma
Testing the Addition of Iberdomide to Therapy in People With Neuroblastoma That Has Come Back, Not Responded to Treatment, or Gotten Worse
This phase I/II trial studies the side effects and best dose of iberdomide when given together with chemoimmunotherapy drugs and to see how well it works in treating patients with neuroblastoma that has come back after a period…
- Conditions
- Recurrent Ganglioneuroblastoma, Recurrent Neuroblastoma, Refractory Ganglioneuroblastoma, Refractory Neuroblastoma
- Trial name
- NCT07437963
- Testing
- Bone Marrow Aspiration, Bone Marrow Biopsy, Computed Tomography
- Where
- 4 sites in United States
- Volunteers
- 76 people
- Sponsor
- National Cancer Institute (NCI)
Spontaneous Bacterial Peritonitis, Paracentesis
Optimal Treatment Strategy for Spontaneous Bacterial Peritonitis
Spontaneous bacterial peritonitis (SBP) is a serious infection that occurs in patients with liver cirrhosis and ascites and is associated with substantial morbidity and mortality.
- Conditions
- Spontaneous Bacterial Peritonitis, Paracentesis, Treatment Efficacy, Adverse Events
- Trial name
- NCT07923318
- Testing
- Routine Follow-up Paracentesis at 48 Hours, Other
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Chonnam National University Hospital
Acute Biphenotypic Leukemia, Acute Myeloid Leukemia
Venetoclax and CLAG-M for the Treatment of Acute Myeloid Leukemia and High-Grade Myeloid Neoplasms
This phase I/II trial finds the best dose, side effects and how well giving venetoclax in combination with cladribine, cytarabine, granulocyte colony-stimulating factor, and mitoxantrone (CLAG-M) in treating patients with acute…
- Conditions
- Acute Biphenotypic Leukemia, Acute Myeloid Leukemia, Mixed Phenotype Acute Leukemia, Myeloid Neoplasm
- Trial name
- NCT04797767
- Testing
- Cladribine, Cytarabine, Mitoxantrone
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Washington
Acute Leukemia, High Risk, Acute Leukemia Refractory
Thiotepa + TBI + Fludarabine + Etoposide for Allo-HSCT in Patients With R/R or High-risk Acute Leukemia
This study is a multi-center, prospective, single-arm clinical trial, with 50 participants expected to take part in it. The primary objective of this study is to assess the efficacy and safety of a conditioning regimen comprising…
- Conditions
- Acute Leukemia, High Risk, Acute Leukemia Refractory, Acute Leukemia, Relapsed
- Trial name
- NCT07920796
- Testing
- Thiotepa, Fludarabine, Etoposide
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Guangdong Second Provincial General Hospital
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