Clinical trials: surgery and procedures
Stage IB Lung Non-Small Cell Carcinoma AJCC v7, Stage II Lung Non-Small Cell Cancer AJCC v7
Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial)
This ALCHEMIST trial studies genetic testing in screening patients with stage IB-IIIA non-small cell lung cancer that has been or will be removed by surgery.
- Conditions
- Stage IB Lung Non-Small Cell Carcinoma AJCC v7, Stage II Lung Non-Small Cell Cancer AJCC v7, Stage IIA Lung Cancer AJCC v8, Stage IIB Lung Cancer AJCC v8
- Trial name
- NCT02194738
- Testing
- Biospecimen Collection, Carboplatin, Cisplatin
- Where
- 1,660 sites in United States, Guam and 1 more
- Volunteers
- 7,458 people
- Sponsor
- National Cancer Institute (NCI)
Lateral Epicondylitis
Effect of Ultrasound-Guided Posterior Cutaneous Nerve of the Forearm Epicondylar Branch Block on Pain and Function in Lateral Epicondylitis (PCNF-BrEpi)
This study evaluates the effect of an ultrasound-guided posterior cutaneous nerve of the forearm epicondylar branch block on pain and functional status in patients with lateral epicondylitis.
- Trial name
- PCNF-BrEpi (NCT07894718)
- Testing
- Ultrasound-guided triamcinolone injection, Ultrasound-guided PCNF-BrEpi block, Conventional therapy (home exercise program and epicondylitis band)
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8
Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed by Hormone Therapy With Ribociclib for the Treatment of High Anatomic Stage Breast Cancer With Low Recurrence Risk, The RxFINE-Low Trial
This phase III trial compares standard of care hormone therapy plus ribociclib to chemotherapy followed by hormone therapy plus ribociclib for the treatment of patients with high anatomic stage breast cancer with low risk of the…
- Conditions
- Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Anatomic Stage IIIC Breast Cancer AJCC v8, Estrogen Receptor-Positive Breast Carcinoma
- Trial name
- NCT07391774
- Testing
- Anastrozole, Biospecimen Collection, Bone Scan
- Where
- 226 sites in United States, Puerto Rico
- Volunteers
- 1,978 people
- Sponsor
- National Cancer Institute (NCI)
Evaluation of Isolated Stoppa Approach in BC Fracture Acetabulum
Stoppa Approach Vs Anterior & Posterior Fixation in Management of BC Fracture Acetabulum
Double-column acetabular fractures are complex injuries that require stable anatomical reduction and fixation to restore hip function.
- Trial name
- RCT (NCT07896044)
- Testing
- Sequential anterior and posterior approaches for double column acetabular fractures, Isolated Modified Stoppa approach for management of double column acetabular fractures
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Tympanic Membrane Perforation, Chronic Otitis Media
Platelet-Rich Fibrin in Revision Cartilage Tympanoplasty
The aim of this study is to evaluate the success rate of revision surgery using a conchal cartilage graft supported with autologous platelet-rich fibrin (PRF), performed under local anesthesia, in patients who previously…
- Trial name
- NCT07893418
- Testing
- PRF-supported conchal cartilage tympanoplasty under local anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Nonunion Fracture
Allograft vs. Autograft Nonunion
The purpose of this research study is to find out if patients treated for nonunion fracture with autograft or allograft return to activity faster.
- Trial name
- NCT07310082
- Testing
- Autograft, Allograft
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Wake Forest University Health Sciences
Alveolar Bone Deficiency
Long-Term Stability of Soft and Hard Tissues After Guided Bone Regeneration in the Maxillary Anterior Region
This study examines the long-term condition of bone and gum tissues around dental implants in the upper front jaw after guided bone regeneration (GBR), a procedure used to rebuild bone at implant sites.
- Trial name
- NCT07893873
- Testing
- Guided Bone Regeneration
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Fuming He
Advanced Lung Non-Small Cell Carcinoma, Stage IIIB Lung Cancer AJCC v8
Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial
This phase III trial compares the effect of adding chemotherapy to immunotherapy (pembrolizumab) versus immunotherapy alone in treating patients with stage IIIB-IV lung cancer.
- Conditions
- Advanced Lung Non-Small Cell Carcinoma, Stage IIIB Lung Cancer AJCC v8, Stage IIIC Lung Cancer AJCC v8, Stage IV Lung Cancer AJCC v8
- Trial name
- NCT06096844
- Testing
- Carboplatin, Computed Tomography, Magnetic Resonance Imaging
- Where
- 328 sites in United States
- Volunteers
- 304 people
- Sponsor
- National Cancer Institute (NCI)
Lumbar Disc Herniation, Lumbar Radiculopathy
Selective Nerve Root Block Versus Sham to Reduce Surgery for Lumbar Disc Herniation
The SELDISC trial will investigate whether a selective nerve root block can reduce the need for surgery in adults with a herniated disc in the lower back.
- Conditions
- Lumbar Disc Herniation, Lumbar Radiculopathy, Lumbar Disc Herniation With Radiculopathy
- Trial name
- SELDISC (NCT07895589)
- Testing
- Selective Nerve Root Block
- Where
- 2 sites in Sweden
- Volunteers
- 262 people
- Sponsor
- Karolinska Institutet
Cesarean Delivery
Anesthesia and Neonatal Outcomes After Cesarean Delivery
This retrospective observational study examines the association between the type of anesthesia used during cesarean delivery and early neonatal outcomes.
- Trial name
- NCT07893808
- Testing
- General Anesthesia (GA), Neuraxial Anesthesia (NA)
- Where
- Turkey (Türkiye)
- Volunteers
- 21,926 people
- Sponsor
- Serra Topal
Osteomyelitis Chronic
Evaluation of the Efficiency of the Bone Substitute Cerament-G Locally Delivering Gentamicin in the Treatment of Chronic Osteomyelitis of Long Bones
Chronic osteomyelitis is a serious osteoarticular infection that most often occurs in the long bones (tibia, femur, humerus), responsible for significant morbidity with risk of fracture and amputation.
- Trial name
- CONVICTION (NCT04805164)
- Testing
- Corticotomy and use of the bone substitute : Cerament-G device., Corticotomy
- Where
- 15 sites in France
- Volunteers
- 220 people
- Sponsor
- Hospices Civils de Lyon
Acute Myeloid Leukemia
Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial)
This phase II MyeloMATCH treatment trial compares cytarabine with daunorubicin versus cytarabine with daunorubicin and venetoclax versus venetoclax with azacitidine for the treatment of younger patients with intermediate risk…
- Trial name
- NCT05554393
- Testing
- Azacitidine, Biospecimen Collection, Bone Marrow Aspiration
- Where
- 187 sites in United States, Canada and 1 more
- Volunteers
- 153 people
- Sponsor
- National Cancer Institute (NCI)
Paraesophageal Hernia
Gastropexy in the Repair of Patients With Paraesophageal Hernias
Patients scheduled for surgery for primary paraesophageal herniation are randomized to either conventional surgical hernia repair or with the addition of gastropexy.
- Trial name
- PEH3 (NCT06107634)
- Testing
- Gastropexy, Paraesophageal hernia repair
- Where
- 6 sites in Sweden
- Volunteers
- 150 people
- Sponsor
- Ersta Diakoni
Hemodynamic Instability
Advanced vs Standard Hemodynamic Monitoring During Propofol Sedation for ERCP: A Prospective Study
The aim of this study is to evaluate whether there is a difference in hemodynamic events requiring intervention between patients monitored with advanced hemodynamic monitoring using the MostCare system and those monitored with…
- Trial name
- NCT07538115
- Testing
- Hemodynamic Monitoring, Standard Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Hitit University
Metastatic Dedifferentiated Liposarcoma, Metastatic Undifferentiated Pleomorphic Sarcoma
Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas
This phase III trial compares the effect of immunotherapy (pembrolizumab) plus chemotherapy (doxorubicin) to chemotherapy (doxorubicin) alone in treating patients with dedifferentiated liposarcoma (DDLPS), undifferentiated…
- Conditions
- Metastatic Dedifferentiated Liposarcoma, Metastatic Undifferentiated Pleomorphic Sarcoma, Stage III Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8, Stage IV Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8
- Trial name
- NCT06422806
- Testing
- Biospecimen Collection, Diagnostic Imaging Testing, Doxorubicin
- Where
- 269 sites in United States, Canada and 1 more
- Volunteers
- 365 people
- Sponsor
- National Cancer Institute (NCI)
Hepatocellular Carcinoma Non-Resectable
Overcoming Immunotherapy Resistance in Hepatocellular Carcinoma
Each year, approximately 1,000 patients in the Netherlands are diagnosed with liver cancer. When liver cancer can no longer be treated with surgery or thermal ablation, cure is no longer possible.
- Trial name
- OvercomeHCC (NCT07895342)
- Testing
- External beam radiotherapy, transarterial radioembolization
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Radboud University Medical Center
Relapsed or Refractory Diffuse Large B Cell Lymphoma (DLBCL), Relapsed or Refractory Multiple Myeloma (MM)
Low-Dose TBI Plus CAR T-Cell Therapy for Relapsed/Refractory DLBCL and Multiple Myeloma
This is a clinical trial to evaluate the safety of combining CAR T-cell therapy with low-dose total body irradiation (LD-TBI) in patients with previously treated large B-cell lymphoma (LBCL) or multiple myeloma (MM).
- Trial name
- Prime REMIX (NCT07725406)
- Testing
- Lymphodepleting chemotherapy: Cyclophosphamide, Lymphodepleting chemotherapy: Bendamustine, Lymphodepleting chemotherapy: Fludarabine
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Weill Medical College of Cornell University
Chronic Thromboembolic Pulmonary Hypertension, CTEPH
TrEatment Approach in the Multimodal Era Registry
The goal of this observational patient registry is to learn how expert centers treat patients with chronic thromboembolic pulmonary hypertension (CTEPH).
- Trial name
- TEAM (NCT05629052)
- Testing
- Pulmonary endarterectomy, Balloon pulmonary angioplasty, Pulmonary hypertension (PH)-specific medication
- Where
- 25 sites in United States, Argentina and 18 more
- Volunteers
- 1,000 people
- Sponsor
- International CTEPH Association
Renal Pelvis and Ureter Urothelial Carcinoma
Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer
This phase II/III trial compares the effect of adding durvalumab to chemotherapy versus chemotherapy alone before surgery in treating patients with upper urinary tract cancer.
- Trial name
- NCT04628767
- Testing
- Biopsy Procedure, Biospecimen Collection, Cisplatin
- Where
- 258 sites in United States
- Volunteers
- 131 people
- Sponsor
- National Cancer Institute (NCI)
Spasmodic Dysphonia
EMG-Guided Versus Endoscopic-Catheter Botulinum Toxin Injection for Spasmodic Dysphonia
This randomized, controlled non-inferiority trial will compare two established botulinum toxin injection techniques for adductor spasmodic dysphonia: percutaneous electromyography-guided injection and transnasal endoscopic…
- Trial name
- NCT07894172
- Testing
- Intervention A - Electromyography (EMG)-Guided BTX Injection, Intervention B - Endoscopic Catheter BTX Injection
- Volunteers
- 17 people
- Sponsor
- Chinese University of Hong Kong