Clinical trials: sponsored by Aarhus University Hospital
Ischemic Heart Disease, Ischemic Coronary Artery Disease
Optical Coherence Tomography in Acute Vessel Evaluation
The purpose is to investigate if a strategy of routine OCT based diagnosis and guidance of PCI improves clinical outcomes compared with a standard strategy of guidance by angiography in patients presenting with ACS
- Conditions
- Ischemic Heart Disease, Ischemic Coronary Artery Disease, ACS (Acute Coronary Syndrome)
- Trial name
- OCTAVE (NCT07422688)
- Testing
- Angiographic Guided PCI, OCT Guided PCI
- Where
- 28 sites in Belgium, Denmark and 10 more
- Volunteers
- 3,000 people
- Sponsor
- Aarhus University Hospital Skejby
Lung Diseases
Investigating Novel Strategies in Pediatric Immune Responses and Microbiome Environment: Comprehensive Lung Disease Investigation in Children.
The INSPIRE CHILD-study is a clinical research project focused on understanding lung diseases in children. The study aims to explore how the presence of certain bacteria, immune responses, and inflammatory markers in the lungs…
- Trial name
- INSPIRE CHILD (NCT06746077)
- Testing
- No intervention
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Aarhus University Hospital
Pediatric Cancer, Cognitive Dysfunction
Engaging Parents in Neuropsychological Rehabilitation for Childhood Cancer Survivors: The ImPACT Program - A Pilot Study
The aim of the present pilot study is to evaluate the feasibility, acceptability, and preliminary efficacy of a novel, context-sensitive neuropsychological rehabilitation intervention for childhood cancer survivors and their…
- Trial name
- NCT05483166
- Testing
- ImPACT
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Aarhus University Hospital
Patellar Dislocation
Comparison of Two Graft Choices in Mediale Patellofemoral Ligament Reconstruction (MPFL)
The purpose of this study is to elucidate surgical techniques for reconstructing MPFL in the treatment of chronic patella instability.
- Trial name
- NCT05706363
- Testing
- Quadriceps graft
- Where
- Denmark
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Diabetes Mellitus, Type 1
INfluenza VaccInation To Mitigate typE 1 Diabetes
In a multicenter, prospective, randomized, controlled clinical trial to compare influenza vaccination and placebo in sustaining β cell function in early type 1 diabetes mellitus.
- Trial name
- INVITED (NCT05585983)
- Testing
- Vaxigrip Tetra Sanofi Pasteur Europe
- Where
- 10 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Aarhus University Hospital
Medial Patellofemoral Dislocation, Medial Patellofemoral Ligament Reconstruction
Medial Patellofemoral Ligament Reconstruction in Children - a 2-8 Years Follow-up Study
The purpose of this project is to investigate the treatment outcome after MPFL reconstruction in children as a treatment for chronic patellar instability, where the superficial part of the quadriceps tendon is fixed to the femur…
- Trial name
- MPFL (NCT06257836)
- Testing
- MPFL-reconstruction
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Keratitis
Evaluation of Next-Generation Sequencing-based Metabarcoding Versus Culturing for Microbiological Assessment in Infectious Keratitis
Infectious keratitis is a potential sight threatening condition. In conventional clinical practice culturing is performed in order to identify the causative microbial organism; however in recent years Next Generation Sequencing…
- Trial name
- NCT05183906
- Testing
- Next generation sequencing
- Where
- Denmark
- Volunteers
- 57 people
- Sponsor
- Aarhus University Hospital
Endothelial Dystrophy, Secondary Bullous Keratopathy
Topical Steroid Treatment After Posterior Lamellar Corneal Transplantation
After corneal transplantation, topical corticosteroids are used to reduce the risk of rejection. However, the optimal postoperative treatment regimen is unknown.
- Conditions
- Endothelial Dystrophy, Secondary Bullous Keratopathy, Posterior Lamellar Keratoplasty, Descemet's Stripping Endothelial Keratoplasty
- Trial name
- NCT01682421
- Testing
- Weak steroid (Flurolon, Allergan), Potent steroid (Maxidex, Alcon)
- Where
- Denmark
- Sponsor
- Aarhus University Hospital
Astigmatism
Surgical Correction of Astigmatism
Laser correction for myopia and astigmatism using an excimer laser has been performed with success for several years. During the last 2 years, a new method for correction of refractive errors has emerged.
- Trial name
- NCT01680354
- Testing
- ReLEx, LASIK
- Where
- Denmark
- Sponsor
- Aarhus University Hospital
Oncology, Infections
A Comparison of Static and Dynamic PET/CT (HYPOTHESIS Generation Study)
The general purpose of this initial study is to evaluate whether parametric PET/CT improves diagnosis and treatment monitoring in select diseases. The specific aim of the HYPOTHESIS GENERATION study is: 1.
- Conditions
- Oncology, Infections, Inflammation
- Trial name
- NCT05110443
- Testing
- D-WB PET/CT
- Where
- Denmark
- Volunteers
- 500 people
- Sponsor
- Aarhus University Hospital
Psoriasis Vulgaris, Psoriasis
Residual Disease MEMory in PSOriasis Skin During EnstiLAR® and Narrow-band Ultraviolet B Therapy: The MEMPSOLAR Study
Psoriasis is a non-communicable chronic immune-mediated disease. Psoriatic skin is characterized by excessive proliferation of skin cells and infiltration of immune cells. The cause of psoriasis is so far unknown.
- Conditions
- Psoriasis Vulgaris, Psoriasis, Skin Diseases, Skin Diseases, Papulosquamous
- Trial name
- MEMPSOLAR (NCT05185258)
- Testing
- Enstilar
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Aarhus University Hospital
Myopia
Wavefront-guided LASIK for Correction of Myopia
Laser in situ keratomileusis is a successful procedure for the treatment of low to moderate myopia. Advances over the last decade have allowed LASIK to also correct higher order wavefront aberrations.
- Trial name
- NCT01682434
- Testing
- Laser in situ keratomileusis (LASIK)
- Where
- Denmark
- Sponsor
- Aarhus University Hospital
Baker's Cyst
Focused Ultrasound of the Popliteal Fossa for Detection of Symptomatic Baker's Cysts in Patients With Suspected Deep Vein Thrombosis: A Pilot Diagnostic Accuracy Study
Quality improvement study with prospective observational design. The study explores the feasibility of testing diagnostic accuracy of an emergency department-performed focused ultrasound scan of the popliteal fossa in detecting…
- Trial name
- BAKER-DVT (NCT07791017)
- Testing
- Index Test (Focused Ultrasound of the Popliteal Fossa), Reference test (Routine DVT Diagnostic Pathway)
- Where
- Denmark
- Volunteers
- 94 people
- Sponsor
- Aarhus University Hospital
Lung Cancer (NSCLC)
Sublobar Wedge Resection or Stereotactic Radiotherapy Treatment of High-risk Patients With Early-stage Lung Cancer
In low-risk patients with stage I non-small cell lung cancer (NSCLC) surgical treatment with an anatomical resection is currently the standard of care.
- Trial name
- STRADOS (NCT07432802)
- Testing
- Stereotactic radiation therapy intervention, Surgical intervention
- Where
- 4 sites in Denmark
- Volunteers
- 182 people
- Sponsor
- Aarhus University Hospital
Chronic Obstructive Pulmonary Disease, Emphysema
The Lung Microbiome and Endobronchial Valve Treatment
Lung emphysema is an incurable disease and is often associated with chronic obstructive pulmonary disease (COPD). Dyspnea is the main, debilitating symptom and is relieved by inhaled bronchodilators and rehabilitation.
- Trial name
- NCT04932811
- Testing
- Endobronchial valve treatment
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Aarhus University Hospital
Thyroid Nodule (Diagnosis), Thyroid Cancer
Thyroid Nodule Gene Sequencing in a Danish Population
This pilot study aims at describing the prevalence and distribution of molecular alterations in thyroid nodules of benign and malignant origin at the level of DNA and RNA in a Danish population.
- Trial name
- NCT05377736
- Testing
- Molecular analyses
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Aarhus University Hospital
Obsessive Compulsive Behavior
Digital OC Training in Children and Adolescents
The project is an interventional trial that compares digital training programs with varying levels of therapeutic contact. All participating children and adolescents will receive a digital training program following a thorough…
- Trial name
- DOT-Y (NCT07864675)
- Testing
- Digital behavioral training
- Volunteers
- 20 people
- Sponsor
- Aarhus University Hospital
External Snapping Hip, Coxa Saltans External
Progressive Resistance Training for Adults With External Snapping Hip
External snapping hip is characterised by an audible and painful snap during hip movement among physical active people around 15-40 years old.
- Trial name
- Snappy Hip (NCT06924164)
- Testing
- Progressive resistance training, Waiting time, Self guided exercise
- Where
- 13 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Aarhus University Hospital
Oligometastatic Cancer
Clinical Utility of ctDNA in the Treatment of Oligometastatic Disease
This prospective observational study investigates the clinical utility of circulating tumor DNA (ctDNA) in patients with oligometastatic disease (OMD) undergoing definitive-intent local ablative treatment (LAT).
- Trial name
- NCT07426250
- Where
- Denmark
- Volunteers
- 500 people
- Sponsor
- Aarhus University Hospital
Ischemic Heart Disease, Coronary Artery Disease
Coronary Computed Tomography Angiography For Optimized Invasive Coronary examInation
Coronary computed tomography angiography (CCTA) is a non-invasive method for visualization of the coronary arteries. The anatomical information obtained by CCTA, however, is rarely integrated into a subsequent coronary…
- Trial name
- CT-FOCI (NCT05218694)
- Testing
- CCTA guided focused coronary angiography examination.
- Where
- Denmark
- Volunteers
- 122 people
- Sponsor
- Aarhus University Hospital Skejby