Clinical trials: sponsored by Aarhus University Hospital
Interstitial Lung Disease
Integration of Cryobiopsies for ILD Diagnoses- Experience Based on 250 Biopsy Procedures.
A retrospective study on safety and Diagnostic yield in using cryobiopsies as a Diagnostic tool in diagnosing patients under investigation for Interstitial lung diseases.
- Trial name
- NCT05311345
- Volunteers
- 250 people
- Sponsor
- Aarhus University Hospital
Malignant Melanoma
Co-stimulatory Markers and Vitamin D Status in Anti-PD1 Treated Melanoma Patients
An observational single center study designed to identify response-related biomarkers of anti-programmed death 1 (PD-1) therapy to advanced melanoma patients and to investigate if vitamin D levels are related to treatment…
- Trial name
- NCT03197636
- Testing
- Pembrolizumab
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Positron-Emission Tomography
Dynamic FDG PET/CT: Optimization and Validation of Data Acquisition
Quantification of the metabolic rate of glucose from Dynamic Whole-Body PET examinations requires measurements of the time course of the radioactivity concentrations in arterial blood by blood sampling, and in the tissue of…
- Trial name
- VALIDATE (NCT04660279)
- Testing
- Dynamic Whole-Body parametric PET/CT
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Invasive Breast Cancer, Mastectomy, Segmental
Digital Breast Tomosynthesis (DBT) to Improve Assessment of Resection Margins in Invasive Breast Cancer
The challenge of breast conserving surgery (BCS) is to obtain free resection margins, by removing the invasive tumor and the precursor cells: DCIS (Ductal Carcinoma in Situ).
- Conditions
- Invasive Breast Cancer, Mastectomy, Segmental, Margins of Excision
- Trial name
- DBT (NCT04478669)
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- Aarhus University Hospital
Anal Cancer, Locally Advanced Squamous Cell Carcinoma
Circulating Biomarkers in Patients With Anal Cancer Treated With Induction Chemotherapy
To investigate the prognostic and predictive value of plasma HPV (pHPV) prior, during and after induction chemotherapy (ICT) in locally advanced squamous cell carcinoma of the anus (SCCA) or synchronous metastatic SCCA patients…
- Conditions
- Anal Cancer, Locally Advanced Squamous Cell Carcinoma, Oligometastatic Disease, Circulating Tumor Cell
- Trial name
- NCT05233540
- Where
- 3 sites in Denmark
- Volunteers
- 60 people
- Sponsor
- Aarhus University Hospital
Testicular Neoplasm
Whole Body MRI With DWI for Monitoring Patients Treated for Testicular Cancer Stage II-III
Testicular cancer (TC) affects approx. 1% of Danish men and is the most common cancer in men aged 15-35 years. It is the most curable solid cancer type with a 5-year survival rate of 90-95%.
- Trial name
- TENY (NCT03436901)
- Testing
- MRI with DWI vs CT
- Where
- Denmark
- Volunteers
- 90 people
- Sponsor
- Aarhus University Hospital
Stem Cell Transplantation, Rehabilitation
Feasibility of a Rehabilitation Programme Targeted Patients Treated With Non-myeloablative Stem Cell Transplantation
Non-myeloablative allogeneic haematopoietic stem cell transplantation (NMA-HSCT) is associated with innumerable complications and side-effects and a high treatment-related mortality.
- Trial name
- HAPPY (NCT04798495)
- Testing
- Multimodal interdisciplinary rehabilitation programme (HAPPY)
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Aarhus University Hospital
Amyloidosis Cardiac, Carpal Tunnel Syndrome
Prevalence of Wild Type Transthyretin Cardiac Amyloidosis in Patients Operated for Idiopathic Carpal Tunnel Syndrome
Wild-type transthyretin cardiac amyloidosis is an underdiagnosed depository disease in which fibril monomers of misfolded amyloid protein accumulates in various tissues, including the heart, and cause tissue dysfunction.
- Trial name
- CACTuS (NCT03996382)
- Testing
- DPD Scintigraphy
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Aarhus University Hospital Skejby
Idiopathic Pulmonary Fibrosis
Health-related Quality of Life and Comorbidities in Danish Patients With Idiopathic Pulmonary Fibrosis - a Nationwide Follow-up
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with a high mortality. Health-related quality of life (HRQL) is impaired in patients with IPF.
- Trial name
- NCT02818712
- Where
- 3 sites in Denmark
- Volunteers
- 150 people
- Sponsor
- Aarhus University Hospital
Attention Deficit Disorder, Attention Deficit Hyperactivity Disorder
The Use of Lisdexamfetamine for Children Aged 7-13 With Attention Deficit Disorders
Aiming at improving clinical practice regarding the use of lisdexamfetamine for the treatment of ADHD in children, the investigators want to retrospectively map the clinical use of lisdexamfetamine at a specialised outpatient…
- Conditions
- Attention Deficit Disorder, Attention Deficit Hyperactivity Disorder, Hyperkinetic Disorder
- Trial name
- NCT04727476
- Testing
- Lisdexamfetamine
- Where
- Denmark
- Volunteers
- 413 people
- Sponsor
- Aarhus University Hospital
Bladder Cancer
EpiCheck and Short-term Intensive Chemoresection in NMIBC
The aim of this explorative study is to evaluate whether EpiCheck can be used as a predictor of tumour response to short-term, intensive chemoresection with Mitomycin.
- Trial name
- NCT04162704
- Testing
- EpiCheck
- Where
- Denmark
- Volunteers
- 22 people
- Sponsor
- Aarhus University Hospital
Ultrasonography, Renal, Cardiac Surgery
Evaluation of Patients After Cardiac Surgery: Novel Ultrasound Parameters for Quantification of Renal Perfusion & Analysis of Phenylephrines' Effect on Invasive Haemodynamics and Echocardiographic Measures
To investigate the influence of PEEP (Positive end-expiratory pressure), changes in preload (patient position) and changes in afterload (phenylephrine) on ultrasound measures of renal perfusion in patients after uncomplicated…
- Conditions
- Ultrasonography, Renal, Cardiac Surgery, Hemodynamics, Phenylephrine
- Trial name
- NCT04419662
- Testing
- Phenylephrine, Combination of PEEP and positioning
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Aarhus University Hospital
Prostate Cancer
Salvage HDR for Locally Recurrent Prostate Cancer
The study offers focal salvage brachytherapy for prostate cancer patients with a local recurrence after primary defintive radiotherapy
- Trial name
- PROSALBRA (NCT04231006)
- Testing
- High dose rate brachytherapy
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Aarhus University Hospital
Chronic Tic Disorder
Group Therapy Versus Individual Therapy for Tourette Syndrome and Chronic Tic Disorder
Chronic tic disorder (CTD) may have a huge impact on life quality. Habit Reversal Training (HRT) and Exposure Response Prevention (ERP) are effective therapeutic modalities.
- Trial name
- NCT04594044
- Testing
- tics training including habit reversal training and exposure response prevention
- Volunteers
- 59 people
- Sponsor
- Aarhus University Hospital
Neuropathic Pain
Cryoneurolysis for Cutaneous Neuropathic Pain
Feasibility study with 25 patients investigating the effect of cryoneurolysis on persistent cutaneous neuropathic pain after surgery and trauma. All patients receive active treatment (cryoneurolysis).
- Trial name
- NCT04911569
- Testing
- Cryoneurolysis
- Where
- Denmark
- Volunteers
- 25 people
- Sponsor
- Aarhus University Hospital
Prostate Cancer, Prostate Neoplasm
Early and Accurate Detection of Prostate Cancer in General Practice
Prostate cancer (PC) is the most common malignancy (4500 new cases/year) and the second leading cause of cancer-associated mortality (1200 deaths/year) among men in Denmark.
- Conditions
- Prostate Cancer, Prostate Neoplasm, Prostate Adenocarcinoma
- Trial name
- NCT03431753
- Testing
- PSA, STHLM3 and mpMRI for PC detection
- Where
- Denmark
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Cardiopulmonary Disease, Surgery
Focused Cardiac Ultrasound in Surgery
Mortality and morbidity remain high after non-cardiac surgery. Known risk factors include age, high ASA grade and emergency surgery.
- Conditions
- Cardiopulmonary Disease, Surgery, Morality, Complication
- Trial name
- PreOPFOCUS (NCT03501927)
- Testing
- FOCUS (focused cardiac ultrasound)
- Where
- Denmark
- Volunteers
- 337 people
- Sponsor
- Aarhus University Hospital
Acute Kidney Injury, Acute Renal Failure
Acute Kidney Injury After Cardiac Surgery: Novel Ultrasound Techniques for Prediction of Acute Kidney Injury
Acute Kidney Injury (AKI) is a frequent and important complication to cardiac surgery. This study will evaluate the diagnostic ability of ultrasonographic measures of blood flow in kidneys and liver in predicting AKI after…
- Conditions
- Acute Kidney Injury, Acute Renal Failure, Cardiac Surgery
- Trial name
- NCT03727204
- Testing
- On-pump cardiac surgery
- Where
- 2 sites in Denmark, South Africa
- Volunteers
- 150 people
- Sponsor
- Aarhus University Hospital
Cancer of Esophagus
Impact of Cancer Therapy on Myocardial Function in Patients With Esophagus Cancer
Introduction: Patients with cancer in esophagus and gastroesophageal junction (EGEJ) treated with chemoradiotherapy (chemoRT) have increased risk of cardiovascular disease.
- Trial name
- Heartcheck (NCT03619317)
- Where
- Denmark
- Volunteers
- 56 people
- Sponsor
- Aarhus University Hospital Skejby
Osteoporosis
Predictive Value of Bone Turnover Markers During Discontinuation With Alendronate
The study is a cohort study comprising 136 patients with osteoporosis stopping treatment with alendronate. The study will contribute with new knowledge about biochemical markers of bone turnover as predictors of bone loss after…
- Trial name
- PROSA (NCT03051620)
- Testing
- Discontinue alendronate
- Where
- Denmark
- Volunteers
- 142 people
- Sponsor
- Aarhus University Hospital