Clinical trials: sponsored by Aarhus University Hospital
Osteoporosis
Treatment With Zoledronic Acid Subsequent to Denosumab in Osteoporosis
Denosumab is an antibody against receptor-activator of nuclear factor kappa-B ligand that prevents recruitment and differentiation of mature osteoclasts.
- Trial name
- ZOLARMAB (NCT03087851)
- Testing
- Zoledronic Acid
- Where
- Denmark
- Volunteers
- 61 people
- Sponsor
- Aarhus University Hospital
Lung Cancer, ALK Gene Mutation
Monitoring Alectinib Treatment by Detection of ALK Translocations in Serial Blood Samples From Non-Small Cell Lung Cancer Patients
Circulating tumor DNA can be used to monitor the treatment effect and identify developing resistance mutations during ALK directed TKI treatment.
- Conditions
- Lung Cancer, ALK Gene Mutation, Resistance, Disease, Mutation
- Trial name
- MonAlec (NCT04708639)
- Testing
- Alectinib
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Aarhus University Hospital
Breast Cancer Female, Estrogen Receptor Positive Tumor
The MASTER Study (MAmmary Cancer STatin ER Positive Study)
Given the compelling evidence supporting a protective effect of statins on breast cancer recurrence, calls for prospective clinical trials have been expressed.
- Trial name
- NCT04601116
- Testing
- Atorvastatin 80 Mg Oral Tablet
- Where
- Denmark
- Volunteers
- 3,360 people
- Sponsor
- Aarhus University Hospital
Arthritis, Rheumatoid
Progression of Bone Erosions in Rheumatoid Arthritis Assessed by HR-pQCT and Conventional X-ray
Today, regular X-ray examination is not sufficiently sensitive for detecting progression of bone destruction in rheumatoid arthritis, but a new type of high-resolution CT scanner, the High-Resolution peripheral Quantitative…
- Trial name
- RACTX (NCT03429426)
- Where
- Denmark
- Volunteers
- 625 people
- Sponsor
- Aarhus University Hospital
Acute Lymphoblastic Leukemia
Hemostasis During Asparaginase Treatment in Acute Lymphoblastic Leukemia(ALL)
Asparaginase is an important drug in the treatment of childhood leukemia. One of the rare but severe side effects to the treatment is thrombosis in or outside the central nervous system.
- Trial name
- NCT01094392
- Where
- 4 sites in Denmark
- Volunteers
- 65 people
- Sponsor
- Aarhus University Hospital
Acute Kidney Injury, Hypoperfusion
The Predictive Performance of Renal Ultrasound on Changes in Renal Clearance
The study will examine the ability of renal ultrasound (Doppler and Contrast Enhanced Ultrasound (CEUS)) in distinguishing ICU patients who exhibit increases in glomerular filtration rate (GFR) in response to fluid loading, from…
- Conditions
- Acute Kidney Injury, Hypoperfusion, Fluid Overload
- Trial name
- NCT04198168
- Testing
- IV crystalloid fluid bolus
- Where
- Denmark
- Volunteers
- 2 people
- Sponsor
- Aarhus University Hospital
Rectal Neoplasms, Quality of Life
Surviving Rectal Cancer at the Cost of a Colostomy International Validation of the Colostomy Impact Score
The formation of a colostomy following surgery for rectal cancer changes body image, challenges patient practical skills and threatens quality of life.
- Conditions
- Rectal Neoplasms, Quality of Life, Colostomy Stoma
- Trial name
- NCT03516916
- Testing
- Questionnaires on HRQoL and sociodemography
- Where
- Denmark
- Volunteers
- 3,750 people
- Sponsor
- Aarhus University Hospital
Ammonia; Metabolic Disorder, Liver Failure, Chronic
Ammonia Metabolism Assessed by Ammonia Infusion
The present study will develop a method to assess ammonia metabolism by ammonia infusion and investigate ammonia production and clearance in healthy individuals and in patients with liver cirrhosis.
- Trial name
- NH4 inf (NCT04585672)
- Testing
- Ammonia infusion
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Atrial Flutter
A Randomized Trial of Contact Force in Atrial Flutter Ablation
A clinical randomized trial to evaluate if CF guided Radio Frequency Ablation (RFA) to a specific of LSI in atrial flutter i superior to standard RFA.
- Trial name
- CF-CTIA (NCT02917538)
- Testing
- RFA
- Where
- Denmark
- Volunteers
- 156 people
- Sponsor
- Aarhus University Hospital Skejby
Neurological Diseases or Conditions, Stroke, Acute
COVID-19 Prevalence and Cognitive Deficits in Neurological Patients
The purpose is to investigate the COVID-19 prevalence, associated morbidity and long-term cognitive deficits in consecutive patients presenting with acute neurological symptoms
- Conditions
- Neurological Diseases or Conditions, Stroke, Acute, Seizure Disorder
- Trial name
- Neuro-Covid (NCT04377425)
- Testing
- COVID-19 swap test PCR
- Where
- 4 sites in Denmark
- Sponsor
- Aarhus University Hospital
Contact Dermatitis, Sensitization Dermatitis
Prevention of Dermatitis in Epoxy Exposed Workers
The risk of sensitization and contact dermatitis among workers exposed to epoxy resin systems (ERS) is high despite extensive preventive efforts, probably because skin exposure is often left unrecognized.
- Trial name
- NCT03705182
- Testing
- Fluorescence visualization (feedback)
- Where
- Denmark
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Neoplasms, Geriatric Assessment
Oncogeriatric Intervention and Follow-up at Home
The study is a randomized study of patients living in four municipalities in Eastern Jutland. After geriatric assessment half of the patients will be offered a tailor-made intervention in their homes.
- Conditions
- Neoplasms, Geriatric Assessment, Lung Neoplasms, Colorectal Neoplasms
- Trial name
- NCT02837679
- Testing
- Geriatric Follow up
- Where
- Denmark
- Volunteers
- 350 people
- Sponsor
- Aarhus University Hospital
Neoplasms, Functional Magnetic Resonance Imaging
Quantitative MR Imaging in Locally Advanced Cervical Cancer
Hypoxic tumour cells within the primary tumour have shown prognostic importance for local and metastatic disease control in several cancer sites.
- Conditions
- Neoplasms, Functional Magnetic Resonance Imaging, Radiotherapy
- Trial name
- IQ-EMBRACE (NCT03210428)
- Where
- Denmark
- Volunteers
- 320 people
- Sponsor
- Aarhus University Hospital
Coronary Artery Disease in Transplanted Heart (Diagnosis), Platelet Dysfunction
Coronary Artery Disease After Heart Transplantation
This study evaluates coronary artery disease after heart transplantation and its relation to platelet function. Furthermore, we will evaluate extracorporeal photopheresis as treatment of coronary artery disease after heart…
- Trial name
- ECP (NCT03583229)
- Testing
- Aspirin 75mg, Extracorporeal photopheresis
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- Aarhus University Hospital
Acne Scars - Mixed Atrophic and Hypertrophic
Treatment of Acne Scars With Fractional CO2 Laser Versus Radio-frequency Microneedling
The study is a prospective, randomized, controlled, intra-person split-face trial with blinded evaluations. The objective is to compare efficacy and adverse effects of ablative fractional CO2 laser resurfacing versus…
- Trial name
- NCT04252352
- Testing
- Ablative fractional CO2 laser resurfacing/Radio-frequency microneedling
- Where
- Denmark
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Coronary Artery Disease
Diagnostic Accuracy of On-line Quantitative Flow Ratio (QFR). FAVOR II Europe-Japan
Quantitative Flow Ratio (QFR) is a novel method for evaluating the functional significance of coronary stenosis. QFR is assessed by calculation of the pressure in the vessel based on two angiographic projections.
- Trial name
- FAVOR II EJ (NCT02959814)
- Testing
- QFR (observational)
- Where
- 10 sites in Denmark, France and 5 more
- Volunteers
- 329 people
- Sponsor
- Aarhus University Hospital Skejby
Abdominal Donor-site
Reinforcement of the Abdominal Wall After Breast Reconstruction With the Pedicled TRAM-flap
The purpose of this study is to compare two methods for reinforcement of the abdominal donor-site after breast reconstruction with the pedicled TRAM-flap.
- Trial name
- NCT02076724
- Testing
- Biological mesh, Synthetic mesh
- Where
- Denmark
- Volunteers
- 29 people
- Sponsor
- Aarhus University Hospital
Breast Cancer, Breast Carcinoma in Situ
Immediate Breast Reconstruction With Acellular Dermal Matrix
The aim of this study is to contribute to the knowledge regarding immediate implant-based BR by investigating whether the one-stage technique with ADM is superior to the two-stage expander to implant technique.
- Conditions
- Breast Cancer, Breast Carcinoma in Situ, Mammaplasty, Acellular Dermis
- Trial name
- NCT04209010
- Testing
- one-stage technique
- Volunteers
- 44 people
- Sponsor
- Aarhus University Hospital
Glioblastoma
Enhancing Optune Therapy With Targeted Craniectomy
The present study proposes a new and potentially superior clinical approach to Optune™ therapy of selected glioblastoma patients.
- Trial name
- NCT02893137
- Testing
- Optune, Craniectomy
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Aarhus University Hospital
Lung Neoplasms
Blood Sample Monitoring of Patients With EGFR Mutated Lung Cancer
In non-small celled lung cancer (NSCLC) 10-15% of the patients harbor a mutation in the tumor's epidermal growth factor receptor (EGFR M+). This receptor is the target for treatment with erlotinib.
- Trial name
- NCT02284633
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- Aarhus University Hospital