Clinical trials: sponsored by Aarhus University Hospital
Osteoporosis
The Effect of Denosumab on Muscle and Strength and Insulin Sensitivity
Randomized, placebo controlled prospective trial evaluating the effect of denosumab on insulin sensitivity and muscle strength.
- Trial name
- DENMUSIN (NCT07271771)
- Testing
- Denosumab, Saline (0.9% NaCl)
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Aarhus University Hospital
Covert Brain Infarction
A EUROpean Randomized Study on Blood-thinners and Cholesterol-lowering Treatments to Prevent Future Vascular Events in People With Covert Brain Infarcts (CBI)
Magnetic resonance imaging (MRI) is commonly used in healthcare, and sometimes it shows small areas of brain damage called Covert Brain Infarcts (CBIs).
- Trial name
- EURO-CBI (NCT07012629)
- Testing
- acetylsalicyclic acid (ASA), Clopidogrel, Rosuvastatin
- Where
- 14 sites in Denmark, Germany and 3 more
- Volunteers
- 1,652 people
- Sponsor
- Aarhus University Hospital
Migraine
Cabergoline for Episodic Migraine
The goal of this randomized, placebo-controlled, double-blind clinical trial is to evaluate the efficacy, safety, and tolerability of cabergoline for the prevention of episodic migraine in adults with 4-14 monthly migraine days…
- Trial name
- PROTECT (NCT07072910)
- Testing
- Cabergoline 0.5 MG, Cabergoline 1 MG
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Aarhus University Hospital
Thyroid Cancer
Surgery for Thyroid Cancer With or Without Autofluorescence to Prevent Hypoparathyroidism
The study aims to test if use of autofluorescence imaging (AF) reduces the risk of developing hypoparathyroidism (hypoPT) following surgery for thyroid cancer, either total thyroidectomy (TT) or completion hemithyroidectomy (cHT).
- Trial name
- NCT06222606
- Testing
- Surgery with autofluorescence
- Where
- Denmark
- Volunteers
- 160 people
- Sponsor
- Aarhus University Hospital
Tuberculosis
Increased Tuberculosis Case Detection - DiOpTB
As estimated by the WHO 10.6 million new Tuberculosis (TB) cases were identified in 2022- while more than three million went undetected and untreated.
- Trial name
- DiOpTB (NCT06437184)
- Testing
- ODP
- Where
- 2 sites in Ethiopia, Guinea-Bissau
- Volunteers
- 1,584 people
- Sponsor
- Aarhus University Hospital
Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia
Remote Ischemic Conditioning in Aneurysmal SAH
The goal of this clinical trial is to examine the effect of limb occlusion therapy (remote ischemic conditioning, RIC) in subjects with aneurysmal subarachnoid hemorrhage.
- Trial name
- RESCUE-SAH (NCT06032533)
- Testing
- Remote Ischemic Conditioning with Automatic Tourniquet Device
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Aarhus University Hospital
Brain Cancer, Cognitive Impairment
Contextualized Neuropsychological Rehabilitation for CNS Cancer Survivors: The ImPACT Program
The aim of the present randomized-controlled study is to evaluate the feasibility, acceptability, and preliminary efficacy of a novel, context-sensitive neuropsychological rehabilitation intervention for brain cancer survivors.
- Trial name
- ImPACT (NCT05858359)
- Testing
- ImPACT program
- Where
- Denmark
- Volunteers
- 27 people
- Sponsor
- Aarhus University Hospital
Rupture of Anterior Cruciate Ligament, Anterolateral Ligament Reconstruction
Reconstruction of the Anterolateral Ligament (ALL) With Revision Anterior Cruciate Ligament (ACL) Surgery
Patients with combined Anterolateral ligament (ALL) reconstruction- Anterior cruciate ligament (ACL) revision will have a better rotational knee stability and therefore better patient reported outcome measure (PROM) scores…
- Trial name
- NCT02680821
- Testing
- ALL reconstruction (Anterolateral ligament), ACL revision (Anterior cruciate ligament )
- Where
- Denmark
- Volunteers
- 102 people
- Sponsor
- Aarhus University Hospital
Osteoporosis, Postmenopausal
Treatment With Zoledronate Subsequent to Denosumab in Osteoporosis 2 (ZOLARMAB2)
The aims of ZOLARMAB2 are fourfold. First, the investigators want to investigate if multiple infusions of zoledronate can prevent the rebound activation of bone turnover and the subsequent bone loss in patients previously treated…
- Trial name
- NCT05655013
- Testing
- Zoledronate
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Aarhus University Hospital
Patella Subluxation, Patellofemoral Pain Syndrome
Translation, Cross-cultural Validity and Reliability of a Danish Version of the Anterior Knee Pain Scale
The Anterior Knee Pain Scale (Kujala) is a questionnaire designed to assess adults with patellofemoral disorders and is widely used in both anterior knee pain and patellar dislocation patients.The questionnaire is a…
- Trial name
- Kujala-DK (NCT06257862)
- Where
- Denmark
- Volunteers
- 130 people
- Sponsor
- Aarhus University Hospital
Patella Dysplasia
Validity and Reliability of a Danish Version of the Banff Patella Instability Instrument (BPII 2.0-DK)
The Banff Patella Instability Instrument (BPII 2.0) is a disease-specific quality of life questionnaire designed to assess adults with patellar dislocations.
- Trial name
- NCT06257849
- Testing
- BPII 2.0
- Where
- 2 sites in Denmark
- Volunteers
- 65 people
- Sponsor
- Aarhus University Hospital
Anterior Cruciate Ligament Rupture
Comparison of Different Anterior Cruciate Ligament Surgery Techniques in Skeletally Immature Patients.
This cohort study compares to groups of patients with reconstruction of anterior cruciate ligament (ACL). Patients in group 1 had ACL-reconstruction in the years 2001-2010 with a transphyseal drilling technique.
- Trial name
- NCT04644497
- Testing
- ACL-reconstruction
- Where
- Denmark
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
ACL Injury
Rehabilitation Treatment of Anterior Cruciate Ligament Rupture
The purpose with this present study is to investigate the effect og a non-surgical regime in patients with an Anterior Cruciate ligament injury.
- Trial name
- NCT04408885
- Testing
- Rehabilitation
- Where
- Denmark
- Volunteers
- 400 people
- Sponsor
- Aarhus University Hospital
Hip Injuries
Capsula Closure vs. Non-Capsula Closure: Hip Arthroscopy in Danish Patients With Femoroacetabular Impingement (FAI)
The purpose of this study is to investigate whether patients undergoing surgical treatment (hip arthroscopy) of FAI syndrome will positively benefit from capsular closure, in terms of higher scores in validated patient reported…
- Trial name
- NCT03158454
- Testing
- Capsula Closure, Non-Capsula Closure
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Aarhus University Hospital
Heart Failure With Reduced Ejection Fraction
Effects of 2-week Ketosis on the Heart's Ketone Body Consumption, Utilization, and Energetic Efficiency in Patients With Chronic Heart Failure
Heart Failure (HF) is a significant health concern, affecting around 1-2% of people in Western countries. The risk of developing HF during a lifetime is about 20%.
- Trial name
- KETO-CHF PET (NCT06398964)
- Testing
- 3-hydroxybutyrat
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Aarhus University Hospital
Musculoskeletal Disorders, Emergency Care
Effect and Cost of a Physiotherapy-led Care Model in Emergency Departments for Patients With Minor Musculoskeletal Injuries
Both in Denmark and internationally, emergency departments have been overwhelmed for several years by a growing number of patients, combined with a shortage of doctors and nurses.
- Conditions
- Musculoskeletal Disorders, Emergency Care, Physiotherapy
- Trial name
- NCT07137754
- Testing
- Advanced practice physiotherapy, Usual Care
- Where
- Denmark
- Volunteers
- 800 people
- Sponsor
- Aarhus University Hospital
Diabetes Mellitus, Type 2, Insulin Resistance
Bone Properties Following Exercise Induced Changes in Insulin Sensitivity in People With Type 2 Diabetes
Diabetes mellitus type 2 is associated with low bone turnover and increased risk of bone fractures. Bone mineral density, however, is increased and cannot explain the increased fracture risk per se.
- Conditions
- Diabetes Mellitus, Type 2, Insulin Resistance, Bone Diseases, Metabolic, Osteoporosis, Osteopenia
- Trial name
- NCT06668090
- Testing
- Moderate intensity bike exercise
- Where
- Denmark
- Volunteers
- 42 people
- Sponsor
- Aarhus University Hospital
Allergic Rhinitis Due to Grass Pollen, Allergic Conjunctivitis of Both Eyes
Documentation of Efficacy of Intralymphatic Allergen Immunotherapy
Investigation of the clinical efficacy of 3 intralymphatic injections with grass pollen extract into inguinal lymph nodes on combined symptom-medication scores during grass pollen season in grass pollen allergic patients compared…
- Conditions
- Allergic Rhinitis Due to Grass Pollen, Allergic Conjunctivitis of Both Eyes, Allergic Asthma
- Trial name
- ILITNU (NCT05191186)
- Testing
- Grass pollen extract - Alutard Phleum pratense, ALK
- Where
- 2 sites in Denmark, Sweden
- Volunteers
- 450 people
- Sponsor
- Aarhus University Hospital
Acute Heart Failure (AHF)
Exogenous KETOne Supplements in Patients Hospitalized for Acute Heart Failure
This is a multicenter, randomized, double-blind, placebo-controlled trial to investigate the clinical efficacy of treatment with exogenous dietary ketone supplement containing 1,3-butanediol in patients hospitalized with acute…
- Trial name
- KETO-AHF (NCT06653725)
- Testing
- 1,3-butanediol
- Where
- 8 sites in Denmark
- Volunteers
- 250 people
- Sponsor
- Aarhus University Hospital
Gambling Disorder
Internet-based Versus Synchronous Cognitive Behavioural Therapy for Patients With Gambling Disorder
The aim of this two-armed, randomized controlled trial is to determine if internet-based cognitive behavioural therapy (CBT) is as effective as synchronous CBT (sCBT) for treating Gambling Disorder (GD) in adults.
- Trial name
- NCT06989125
- Testing
- Internet-based cognitive behavioral therapy, Synchronous cognitive behavioral therapy
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Aarhus University Hospital