Clinical trials: sponsored by Aarhus University Hospital
Tracheostomy
Consequence of Open Versus Closed Tracheostomy Immediately After Decannulation
Tracheostomy is performed for prolonged mechanical ventilation. Ineffective bandaging following decannulation leaves the tracheostomy wound unsealed, reducing pulmonary function, coughing ability, and voice quality, ultimately…
- Trial name
- NCT06138093
- Testing
- Sealing device, No device
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Aarhus University Hospital
Melanoma, Cognitive Impairment
Cognitive Function in Melanoma Patients Treated With Adjuvant Immune Checkpoint Inhibitors
Immune checkpoint inhibitors (ICIs) are a group of novel immunotherapies that boost the body's own defense against the cancer by improving the immune system's ability to recognize and destroy cancer cells.
- Conditions
- Melanoma, Cognitive Impairment, Fatigue, Sleep
- Trial name
- NCT04565769
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Hepatitis B
Safety and Antiviral Activity of a Monoclonal Hepatitis B Antibody (The SAMBA Study)
Hepatitis B virus (HBV) remains a major global health problem with an estimated 257 million people living with the infection worldwide. Chronic HBV (CHB) is a major cause of liver cirrhosis and hepatocellular carcinoma.
- Trial name
- SAMBA (NCT06668727)
- Testing
- HepB mAb19
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Aarhus University Hospital
Acute Postoperative Pain, Chronic Post Operative Pain
Clinical Prediction of Post-surgical Pain
This study aims to externally validate two clinical prediction models for moderate-to-severe acute post-surgical pain and chronic post-surgical pain.
- Trial name
- NCT06661642
- Where
- 2 sites in Denmark
- Volunteers
- 748 people
- Sponsor
- Aarhus University Hospital
Heart Failure, Reduced Ejection Fraction
Does the Sequence of Heart Failure Medication Matter
This study will tests whether a strategy of upfront prescription of mineralocorticoid receptor antagonists (MRA) is different from usual care, where MRA are usually prescribes as the last drug of the four drug classes used in the…
- Trial name
- NCT06637618
- Testing
- up front use of mineralocorticoid receptor antagonist
- Volunteers
- 16,000 people
- Sponsor
- Aarhus University Hospital
Survival
Radical Surgery for Advanced Gastric- or GEJ-cancer With Oligometastatic Dissmination to the Liver
Offering treatment with potential to cure for participants with no such offer in today's standard treatment options, by offering metastatectomia and standard treatment with intention to cure i.e., neoadjuvant chemotherapy and…
- Trial name
- LEVECA (NCT06627634)
- Testing
- Metastatectomia and standard treatment for resectable disease.
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Aarhus University Hospital
Early Breast Cancer, Metabolic Health
Early Changes in Metabolic Health in Breast Cancer Patients Initiating Endocrine Therapy
This clinical trial aims to investigate early metabolic health changes in early breast cancer patients that initiate antihormone therapy.
- Conditions
- Early Breast Cancer, Metabolic Health, Estrogen Receptor Positive Breast Cancer
- Trial name
- EMETA (NCT06623903)
- Where
- Denmark
- Volunteers
- 112 people
- Sponsor
- Aarhus University Hospital
Dyspnea
Point-Of-Care Ultrasound-Driven vs Standard Diagnostic Pathway in Emergency Department Patients With Dyspnea
The POCUS PATHWAY-trial is a multi-center, randomized, investigator-initiated, open labelled, pragmatic, controlled trial of a point-of-care ultrasound-driven diagnostic pathway vs standard diagnostic pathway in dyspneic…
- Trial name
- POCUS PATHWAY (NCT05674916)
- Testing
- Point-of-care ultrasound-driven diagnostic pathway
- Where
- 9 sites in Denmark
- Volunteers
- 674 people
- Sponsor
- Aarhus University Hospital
Achilles Tendon Rupture, Achilles Tendon Injury
Outcome After Conservatively Treated Achilles Tendon Rupture
The main purpose of the study is to compare the patient-reported outcomes and adverse events of two different rehabilitation regimes for patients undergoing non-surgical treatment of Achilles Tendon Rupture.
- Trial name
- NCT05614908
- Testing
- 11 week restrictive regime, 8 week liberal regime
- Where
- Denmark
- Volunteers
- 220 people
- Sponsor
- Aarhus University Hospital
Turner Syndrome, Hypogonadism; Ovarian
Long Term Effects of Oral Versus Transdermal Estrogen Replacement Therapy in Turner Syndrome
This 14-month, phase IV, randomized controlled crossover trial aims to compare the effects of oral versus transdermal estrogen replacement therapy (ERT) in women with Turner syndrome (TS).
- Conditions
- Turner Syndrome, Hypogonadism; Ovarian, Hormone Replacement Therapy, Estrogen Replacement Therapy
- Trial name
- NCT06570460
- Testing
- 17-beta estradiol
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Turner Syndrome, Hypogonadism; Ovarian
Determining Dose Equivalence Between Oral and Transdermal Estrogen Treatment in Women With Turner Syndrome
This 5-week, phase IV randomized crossover trial aims to compare the effects of oral versus transdermal estrogen replacement therapy (ERT) in women with Turner syndrome (TS).
- Conditions
- Turner Syndrome, Hypogonadism; Ovarian, Hormone Replacement Therapy, Estrogen Replacement Therapy
- Trial name
- NCT06544473
- Testing
- 17-beta estradiol
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Aarhus University Hospital
Fear of Cancer Recurrence
CIFeR - A Clinician-led Intervention to Address Fear of Cancer Recurrence
The investigators will test a novel Clinician-led Intervention to address Fear of cancer Recurrence in cancer survivors (CIFeR), by 1) adapting the original Australian intervention manual to the Danish oncology context…
- Trial name
- NCT06554899
- Testing
- Clinician-led intervention to address fear of cancer recurrence (CIFeR)
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Aarhus University Hospital
Diabetes, Diabetes Mellitus
Discovering Early Biomarkers in Circulating Endothelial Cells for Diabetes Complications by Single Cell RNA Sequencing
The purpose of this study is to discover early biomarkers in circulating endothelial cells for diabetes complications, by investigating circulating endothelial cells in blood samples from patients with newly diagnosed…
- Conditions
- Diabetes, Diabetes Mellitus, Proliferative Diabetic Retinopathy, Diabetic Maculopathy
- Trial name
- CEC4DC (NCT05169502)
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Precursor Cell Lymphoblastic Leukemia-Lymphoma, Drug-Induced Diabetes Mellitus
Glucose Intolerance and Diabetes Related to Treatment With Steroids and PEG- Asparaginase in Children and Adolescents With ALL and Lymphoma
The overall survival of acute lymphoblastic leukemia (ALL) and lymphoma in children and adolescents is above 90%. The survival rate has increased significantly during the last decades as a consequence of more intensive…
- Conditions
- Precursor Cell Lymphoblastic Leukemia-Lymphoma, Drug-Induced Diabetes Mellitus, Impaired Glucose Tolerance, Lymphoma
- Trial name
- NCT05873322
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Aarhus University Hospital
Anal Cancer
NOAC9 - Circulating Tumor DNA Guided Follow-Up in Anal Cancer
This study investigates if circulating tumor DNA can improve the detection of early treatment failure or recurrence in localized squamous cell carcinoma of the anus (SCCA) after curative chemoradiotherapy thereby increasing the…
- Trial name
- NCT05572801
- Testing
- AMR B: HPV positive ctDNA guided imaging in follow-up
- Where
- 13 sites in Denmark, Finland and 2 more
- Volunteers
- 400 people
- Sponsor
- Aarhus University Hospital
Anal Cancer
PLAN-A Data- Bio- and Plan- Bank Collection for SCCA in Denmark
The study is a prospective registration of treatment related-, toxicity-, Quality of life- and outcome data from patients treated in Denmark with radiotherapy for squamous cell carcinoma of the anus (SCCA), as a cooperation…
- Trial name
- PLAN-A (NCT05570279)
- Where
- 3 sites in Denmark
- Volunteers
- 314 people
- Sponsor
- Aarhus University Hospital
Cancer of Gastrointestinal Tract
Rare Subtypes of Gastrointestinal Cancers
A single-arm prospective observational translational study of biomarkers in patients receiving targeted treatment for rare subtypes of cancer of the Gastrointestinal Tract.
- Trial name
- NCT04838327
- Where
- Denmark
- Volunteers
- 130 people
- Sponsor
- Aarhus University Hospital
Lung Cancer
Sleep and Immune Checkpoint Inhibitors
Sleep disturbances are prevalent in cancer patients and linked to levels of fatigue and depressive symptoms with a major impact on quality of life.
- Trial name
- NCT04070651
- Where
- Denmark
- Volunteers
- 49 people
- Sponsor
- Aarhus University Hospital
Rheumatoid Arthritis, Patient Involvement
E-learning in Patient Education to Patients With Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory disease that primarily causes pain, swelling and stiffness in the joints. The disease may reduce normal functioning and thereby quality of life.
- Conditions
- Rheumatoid Arthritis, Patient Involvement, Self Efficacy
- Trial name
- WEB-RA (NCT04669340)
- Testing
- E-learning patient education, Standard face-to-face patient education
- Where
- 5 sites in Denmark
- Volunteers
- 181 people
- Sponsor
- Aarhus University Hospital
Coronary Artery Disease
The Association Between Catheter-based Coronary Flow and Resistance and 15O-H2O Positron Emission Tomography Scan
Aims 1. To assess the correlation between absolute flow and resistance assessed by catheter-based thermodilution technique using CoroFlow®-system and myocardial blood flow (MBF) measured by positron emission tomography (PET) and…
- Trial name
- FLOW3 (NCT04973410)
- Testing
- Coronary Physiology, 15O-H2O-PET scan
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Aarhus University Hospital Skejby