Clinical trials: sponsored by Anhui Medical University
Inflammation, Postoperative Delirium
Propofol and Dexmedetomidine on Inflammation
Dexmedetomidine, was reported to prevent postoperative delirium in elderly patients following its use in intensive care units. Possible mechanisms included improved quality of sleep and an inhibitory effect on inflammation.
- Conditions
- Inflammation, Postoperative Delirium, Anesthesia
- Trial name
- NCT03600727
- Testing
- Propofol, Dexmedetomidine
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Pathogenesis, Acute Kidney Injury
Perioperative Mechanism of Acute Kidney Injury in Cardiovascular Surgery
Continuous observation of acute renal injury after cardiac surgery, at the same time retention of blood samples, to test indicators，and to select the research route from the clinical actual test results .
- Conditions
- Pathogenesis, Acute Kidney Injury, Cardiac Surgery
- Trial name
- NCT03557047
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Postoperative Confusion, Delirium
Impact of Dexmedetomidine on the Post-Operative Cognition Dysfunction(POCD) in Geriatric Patients
Post-Operative Cognition Dysfunction (POCD) is a common complication after surgery, POCD can lead to a reduced ability and seriously affect the quality of life of patients, increase personal and social burden, POCD may also…
- Trial name
- NCT02275182
- Testing
- Dexmedetomidine, Saline
- Where
- 13 sites in China
- Volunteers
- 864 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Postoperative Nausea and Vomiting, Surgery
The Application of Transversus Abdominis Plane Block Plus Rectus Sheath Block in Clinical Anesthesia
Peritoneal dialysis (PD) catheter placement surgery for patients with end-stage renal disease (ESRD) can be performed under peripheral nerve block.
- Conditions
- Postoperative Nausea and Vomiting, Surgery, Anesthesia, Peritoneal Dialysis
- Trial name
- NCT02984865
- Testing
- Sulfentanyl, Nalbuphine, flubiprofen axetil
- Where
- China
- Volunteers
- 190 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Hepatobiliary Disease
Usefulness of BiClamp Forceps for Liver Resection: A Randomized Clinical Trial
The purpose of this study is to compare short-term and long-term efficacy of BiClamp forceps hepatectomy and clamp-crushing technique for parenchymal transection during elective hepatic resection.
- Trial name
- NCT02197481
- Testing
- Clamp-Crushing technique, BiClamp forceps
- Where
- China
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Anhui Medical University
Gastric Cancer
The Real World Study of Apatinib for Gastric Cancer Treatment in Anhui Province
The investigators conduct the real world study to explore the efficacy and safety of Apatinib in gastric cancer .
- Trial name
- NCT03333967
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Esophageal Squamous Cell Carcinoma
Apatinib Combined With Chemotherapy for Esophageal Squamous Cell Cancer After the Failure of Standard Treatment
We conduct the clinical trial to further explore the efficacy and safety of Apatinib combined with chemotherapy in treating recurrent or metastatic esophageal squamous cell carcinoma after the failure of conventional treatments.
- Trial name
- NCT03224221
- Testing
- Apatinib, fluorouracil and platinum
- Where
- China
- Volunteers
- 189 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Anesthesia, Local Anesthesia
Dexmedetomidine vs Propofol Sedation Reduces Postoperative Delirium in Patients Receiving Hip Arthroplasty.
With blocks of lumbar and lumbar plexus, we can reduce the intravenous anesthetics usage. To offer an satisfied surgery process for patients, a proper sedation is necessary.
- Trial name
- NCT02793986
- Testing
- propofol, dexmedetomidine
- Where
- China
- Volunteers
- 296 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Self Efficacy, Drug Toxicity
High-Dose,Pulsatile Erlotinib/Gefitinib for Advanced NSCLC Patients After Failure of Standard Dose EGFR-TKIs
the purpose of this study is to evaluate the efficacy and safety of high-dose，pulsatile Erlotinib/Gefitinib in advanced non small cell lung cancer (NSCLC) patients after failure of standard dose EGFR-TKIs（Epidermal Growth Factor…
- Trial name
- NCT01965275
- Testing
- Erlotinib or Gefitinib
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Anhui Medical University
NSCLC
Evaluation of the High Dose of Icotinib in Advanced Lung Cancer Patients After Failure of Target Therapy
The purpose of this study is to evaluate the efficacy and safety of dose escalation of Icotinib in advanced non small cell lung cancer (NSCLC) patients after the therapy of Icotinib, Iressa and Tarceva.
- Trial name
- NCT01963195
- Testing
- Icotinib
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Anhui Medical University
Surgery
Ultrasound-guided Thoracic Paravertebral Block Using Ropivacaine With/Without Dexamethasone in Elective Thoracotomy
The procedures of thoracotomy are among the most painful operations. In addition to post-thoracotomy pain, the outcomes of surgery are affected adversely by postoperative discomfort.
- Trial name
- NCT02871193
- Testing
- Ropivacaine, Dexamethasone, saline
- Where
- China
- Volunteers
- 68 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Intertrochanteric Femoral Fracture
Safety and Effectiveness of Proximal Femoral Nail Antirotation for the Treatment of Intertrochanteric Femoral Fracture
Minimally invasive PFNA fixation for the treatment of intertrochanteric femoral fracture will be used in 20 patients within 2 years to objectively validate the safety and effectiveness of PFNA in the treatment of fracture of long…
- Trial name
- NCT02880501
- Testing
- proximal femoral nail antirotation
- Volunteers
- 20 people
- Sponsor
- Chaohu Hospital of Anhui Medical University
Rectal Cancer
Trial to Evaluate Laparoscopy-assisted Nerve-preserved Total Mesorectal Excision (LNTME) Versus Open TME for Rectal Cancer
The purpose of this study is to determine: (1) whether laparoscopy-assisted nerve-preserved total mesorectal excision (LNTME) is as safe as open TME for rectal cancer, and (2) whether LNTME is more effective for protection of…
- Trial name
- NCT02830633
- Testing
- LNTME, OTME
- Volunteers
- 80 people
- Sponsor
- Anhui Medical University
Spinal Tuberculosis
Early Outcomes of Radical Debridement Versus no Debridement Under Different Surgical Procedures
Whether radical debridement is necessary for the treatment of thoracic and lumbar tuberculosis is still questionable. The objective of this prospective randomized study was to compare the outcomes of radical debridement versus no…
- Trial name
- NCT02638272
- Testing
- no debridement
- Volunteers
- 74 people
- Sponsor
- The Second Hospital of Anhui Medical University
Colorectal Cancer
Aspirin for Prevention of Postsurgical Recurrence and Metastasis in Asian Colorectal Cancer Patients: a Multi-center Randomized Trial
Background: Evidence of high quality has suggested that acetylsalicylic acid (ASA)/aspirin effectively reduces colorectal adenoma incidence and recurrence rate, and several randomized controlled trials (RCTs) strongly indicate…
- Trial name
- APREMEC (NCT02607072)
- Testing
- Acetylsalicylic acid (ASA)/aspirin 200 mg daily, Acetylsalicylic acid (ASA)/aspirin 100 mg daily
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- The Fourth Affiliated Hospital of Anhui Medical University
Secondary Hyperparathyroidism
Comparison of Total Parathyroidectomy With and Without Autotransplantation
The purpose of this study is to compare short-term and long-term efficacy of total parathyroidectomy with autotransplantation and total parathyroidectomy without autotransplantation for Secondary hyperparathyroidism.
- Trial name
- NCT02536287
- Testing
- total PTX without autotransplantation, total PTX with autotransplantation
- Where
- China
- Volunteers
- 96 people
- Sponsor
- The Second Hospital of Anhui Medical University
Pancreatic Fistula
One-layer Versus Two-layer Duct-to-mucosa Pancreaticojejunostomy After Pancreaticoduodenectomy
The aim of this study is to investigate a new pancreaticojejunal (PJ) anastomosis procedure named "One-layer duct-to-mucosa pancreaticojejunostomy" in pancreatoduodenectomy, which could provide a feasible option to pancreatic…
- Trial name
- NCT02511951
- Testing
- pancreaticojejunostomy
- Where
- China
- Volunteers
- 114 people
- Sponsor
- The Second Hospital of Anhui Medical University
Myopia
Effect of Increasing Time Spent Outdoors on Myopia Prevention in School-Aged Children in Northeast China
The purpose of this study is to develop a school-based intervention aimed at prevent the onset and development of myopia among school aged children by increasing time spent outdoors in northeast China.
- Trial name
- NCT02271373
- Testing
- increasing time spent outdoors
- Volunteers
- 3,521 people
- Sponsor
- Anhui Medical University
Stage IV Gastric Cancer With Metastasis
The Study of Irinotecan Plus Epirubicin as the Second-line Chemoregime for Advanced Gastric Cancer
This study is to determine the response rate and safety profile of irinotecan plus epirubicin as the second-line chemotherapy for advanced gastric cancer and fully evaluate the feasibility and effectiveness of the regime.
- Trial name
- SIEG (NCT01964027)
- Testing
- second line chemoregime for advanced gastric cancer
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Anhui Medical University
Gastrectomy
A Comparison of Dexmedetomidine and Epidural Anesthesia Under General Anesthesia in Patients Undergoing Gastrectomy
Clinically, combining epidural with general anaesthesia may confer many advantages to patients undergoing major thoracic, abdominal or orthopaedic surgery.
- Trial name
- NCT01657812
- Testing
- dexmedetomidine
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Anhui Medical University