Clinical trials: sponsored by Anhui Medical University
Obsessive-Compulsive Disorder (OCD), Transcranial Magnetic Stimulation
Continuous Theta-Burst Stimulation for Obsessive-Compulsive Disorder: An Open-Label Study
This single-arm, open-label study evaluates short-term symptom improvement and tolerability of continuous theta-burst stimulation (cTBS), a non-invasive brain stimulation technique, in adults with obsessive-compulsive disorder…
- Conditions
- Obsessive-Compulsive Disorder (OCD), Transcranial Magnetic Stimulation, Electroencephalography
- Trial name
- NCT07896837
- Testing
- Continuous Theta-Burst Stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Anhui Medical University
Schizophrenia
Temporal Interference Stimulation (TI) for Schizophrenia (SCZ)
This study will evaluate whether temporal interference (TI) stimulation, added to usual clinical treatment, improves symptoms of schizophrenia and is safe and tolerable.
- Trial name
- TI-SCZ-Insular (NCT07887997)
- Testing
- Active transcranial temporal interference stimulation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Anhui Medical University
Cervical Cancer, Endometrial Cancer
PEG-rhG-CSF Primary Prophylaxis vs Therapeutic Short-Acting rhG-CSF for Neutropenia During Pelvic Chemoradiotherapy in Cervical or Endometrial Cancer
This single-center, prospective, randomized, open-label controlled study evaluates primary prophylaxis with pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) compared with a therapeutic short-acting…
- Trial name
- NCT07865650
- Testing
- Pegylated Recombinant Human Granulocyte Colony-Stimulating Factor (PEG-rhG-CSF), Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF)
- Where
- China
- Volunteers
- 90 people
- Sponsor
- The Second Hospital of Anhui Medical University
Transcranial Direct Current Stimulation, Functional Magnetic Resonance Imaging
High Definition Transcranial Direct Current Stimulation (HD-tDCS) for Early Alzheimer's Disease
This completed randomized trial evaluated the clinical and neural effects of high-definition transcranial direct current stimulation (HD-tDCS) combined with computerized cognitive training in patients with Alzheimer's disease.
- Conditions
- Transcranial Direct Current Stimulation, Functional Magnetic Resonance Imaging, Early Alzheimer's Disease
- Trial name
- HD-tDCS (NCT04599764)
- Testing
- HD-tDCS, computer-based cognitive training, Control cognitive training
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Anhui Medical University
Acute Ischemic Stroke
Intravenous Recombinant Human Prourokinase for Acute Medium Vessel Occlusion 4.5-24 Hours After Ischemic Stroke
The HOPE-MeVO study aims to evaluate the efficacy and safety of intravenous recombinant human prourokinase (rhPro-UK) in patients with acute ischemic stroke due to medium vessel occlusion presenting 4.5 to 24 hours after stroke…
- Trial name
- HOPE-MeVO (NCT07776873)
- Testing
- Recombinant Human Prourokinase for Injection (rhPro-UK), Standard medical treatment (SMT)
- Where
- China
- Volunteers
- 616 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Gastroesophageal Junction Adenocarcinoma
Sintilimab Combined With Chemoradiotherapy as Neoadjuvant Therapy for Locally Advanced Gastroesophageal Junction Cancer
This is a multicenter, prospective, single-arm, open-label exploratory clinical study evaluating sintilimab combined with neoadjuvant chemotherapy, concurrent chemoradiotherapy, and optional consolidation chemotherapy in patients…
- Trial name
- NCT07859410
- Testing
- Sintilimab, Capecitabine, Oxaliplatin
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Anhui Medical University
Weight Management, Health Outcomes
Weight Management and Health Outcomes in College Students
The goal of this study is to learn if a weight management program can improve the overall health of college students. The main questions it aims to answer are: Can a weight management program help college students improve their…
- Conditions
- Weight Management, Health Outcomes, Cardiometabolic Health
- Trial name
- NCT07837999
- Testing
- Weight Management
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Anhui Medical University
Transcranial Random Noise Stimulation (tRNS), Electroencephalography
Transcranial Random Noise (tRNS) for BPSD in Alzheimer's Disease: A Double-blind Randomized Controlled Trial
To investigate the treatment effect of Transcranial random noise (tRNS) on Alzheimer patients, and the underlying neural mechanism by EEG.
- Conditions
- Transcranial Random Noise Stimulation (tRNS), Electroencephalography, Alzheimer Disease, BPSD (Behavioral and Psychological Symptoms of Dementia)
- Trial name
- NCT07827196
- Testing
- High frequency transcranial random noise
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Anhui Medical University
Dynamic Balance, Postural Balance
The Effects of Brain Breaks on Dynamic Balance in University Students
The goal of this study is to learn if an online physical activity program called "Brain Breaks" can improve well-being among university students.
- Trial name
- NCT07546747
- Testing
- Brain Breaks Intervention
- Where
- China
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Anhui Medical University
Prostate Cancer Adenocarcinoma
Intratumoral Microbiota and Immune Microenvironment in Prostate Cancer
Prostate cancer is a common malignancy in men, with rising incidence worldwide. Current clinical risk assessment tools-including PSA, Gleason score/ISUP grade, pathological stage, margin status, perineural invasion, and…
- Trial name
- NCT07818421
- Testing
- Validate spatial localization of candidate microbial signals via 16S rRNA ISH, FISH, immunofluorescence, IHC, and spatial omics.
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Anhui Medical University
Prostate Cancer Adenocarcinoma
Spatial Multi-Omics of Perineural Invasion Microenvironment and Prognosis in Prostate Cancer
Prostate cancer is a common malignancy in men, with substantial prognostic heterogeneity that calls for improved risk stratification at the tissue microenvironment level.
- Trial name
- NCT07818395
- Testing
- Multi-omics profiling
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Anhui Medical University
Invasive Breast Cancer (Stage I-III)
Neoadjuvant Endocrine Therapy Combined With Chemotherapy in ER-positive, HER2-negative Stage I-III Breast Cancer
The goal of this investigator-initiated, open-label, phase II clinical trial is to evaluate the efficacy and safety of neoadjuvant chemotherapy combined with endocrine therapy in patients with hormone receptor-positive, human…
- Trial name
- NCT07801898
- Testing
- NaCET: For chemotherapy, the TEC or EC-T regimen is selected; for endocrine therapy, letrozole is administered; for premenopausal patients, an LHRH agonist-goserelin or leuprolide
- Where
- China
- Volunteers
- 36 people
- Sponsor
- The Second Hospital of Anhui Medical University
Medical Education, Endocrine System Diseases
Integrated PBL-CBL-CTTM Teaching to Enhance Clinical Self-Efficacy in Endocrine Critical Illness Among Internal Medicine Residents: An RCT
This randomized controlled trial evaluates whether an integrated online-offline multimodal teaching approach combining Problem-Based Learning (PBL), Case-Based Learning (CBL), and Case Three-Dimensional Teaching Method (CTTM)…
- Conditions
- Medical Education, Endocrine System Diseases, Critical Illness
- Trial name
- PBL-CBL-CTTM (NCT07801170)
- Testing
- Lecture-based learning (LBL), PBL plus LBL, Integrated PBL-CBL-CTTM
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Chaohu Hospital of Anhui Medical University
Metastatic Hormone-Sensitive Prostate Cancer
A Prospective Study Based on Spatial Multi-omics to Predict the Efficacy of ADT Combined With Second-generation Novel Hormonal Agents in Metastatic Hormone-sensitive Prostate Cancer.
This study plans to enroll patients with newly diagnosed metastatic hormone-sensitive prostate cancer (mHSPC) and conduct a prospective, single-center, observational study.
- Trial name
- NCT07795177
- Testing
- ADT plus abiraterone or other ARPIs（apalutamide, enzalutamide, rezvilutamide, darolutamide)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Anhui Medical University
Diabetic Foot Disease
Development and Pilot Application of a Solution-Focused Intervention for Social Isolation in Elderly Diabetic Foot Patients
The goal of this interventional study is to develop and preliminarily evaluate a solution-focused model-based intervention program for reducing social isolation in elderly patients with diabetic foot ulcers.
- Trial name
- NCT07787884
- Testing
- Intervention Group
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Anhui Medical University
Acute Ischemic Stroke
Real-World Evaluation of Recombinant Human Prourokinase for Acute Ischemic Stroke Within 4.5 Hours
Acute ischemic stroke is a major cause of disability and death. Intravenous thrombolytic therapy is an important treatment option when given within the appropriate time window.
- Trial name
- PRISM (NCT07787325)
- Testing
- Recombinant Human Prourokinase
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Type 2 Diabetes
Development and Pilot Implementation of a Shared Decision-Making Intervention for Type 2 Diabetes Using the Ottawa Framework
The goal of this clinical trial is to evaluate the effectiveness of a shared decision-making (SDM) intervention program based on the Ottawa Decision Support Framework in adult patients with type 2 diabetes (aged ≥18 years…
- Trial name
- NCT07785440
- Testing
- Intervention Group
- Volunteers
- 70 people
- Sponsor
- Anhui Medical University
Parkinson s Disease
The Efficacy and Safety of Temporal Interference Stimulation on Motor Symptoms of Parkinson's Disease
This study aimed to evaluate the clinical efficacy and safety of temporal interference stimulation (TIS) targeting different targets in patients with Parkinson's disease (PD), and to investigate the associated neurophysiological…
- Trial name
- NCT07572903
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 96 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Lung Cancer (NSCLC)
Construction and Empirical Study of Indirect Intervention Model for Protective Medical Lung Cancer Patients Based on Family System Theory
To clarify the irrational cognition of family caregivers of lung cancer patients at various perioperative stages under the background of protective medical treatment, construct an indirect intervention model for lung cancer…
- Trial name
- FST (NCT07749443)
- Testing
- Caregiver cognitive intervention based on printed handbook, Graded information disclosure strategies, Routine perioperative health education
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Anhui Medical University
Myopia, Randomized Controlled Trial (RCT)
The Rebound Effect on Repeated Low-Level Red Light Therapy for Myopia
Myopia is a global public health issue, projected to affect 49.8% of the world population by 2050, increasing risks of cataracts, glaucoma, macular degeneration, and retinal detachment.
- Trial name
- NCT07748546
- Testing
- Repeated low-level red light (RLRL) therapy
- Volunteers
- 159 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University