Clinical trials: sponsored by Asan Medical Center
Leukemia
Nilotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
RATIONALE: Nilotinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or…
- Trial name
- NCT00844298
- Testing
- Nilotinib+mVPD
- Where
- 16 sites in South Korea
- Volunteers
- 91 people
- Sponsor
- Asan Medical Center
Depression
A Genotype Stratification Study for Pharmacokinetics and Pharmacodynamics of Amitriptyline in Healthy Male Subjects
A total of 24 healthy Korean male subjects will receive a single oral dose of amitriptyline, 25 mg. Subjects will be enrolled in this study based on their cytochrome P450 2D6 and cytochrome P450 2C19 genotypes, and serial blood…
- Trial name
- NCT02519400
- Testing
- Amitriptyline
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Cholestasis, Extrahepatic
EUS-guided Biliary Drainage Versus Percutanenous Transhepatic Biliary Darinage for Malignant Biliary Obstruction After Failed ERCP
Although ERCP is almost always successful in patients with malignant biliary obstruction, selective biliary cannulation fails in some cases and conventional ERCP may not be possible in patients with tumor invasion of the duodenum…
- Trial name
- NCT02103413
- Testing
- EUS-BD, PTBD
- Where
- 2 sites in South Korea
- Volunteers
- 66 people
- Sponsor
- Asan Medical Center
Gastrointestinal Stromal Tumors
Dovitinib in Combination With Imatinib in Patients With Gastrointestinal Stromal Tumors
The objective of this study is to determine the recommended dose of combination of dovitinib and imatinib in phase I study.
- Trial name
- NCT02268435
- Testing
- dovitinib plus imatinib
- Sponsor
- Asan Medical Center
Stage IV Gastric Cancer With Metastasis
Safety Study of Combined Systemic and Intraperitoneal Chemotherapy to Treat Stomach Cancer
A maximum of 8 cycles of chemotherapy will be administered. Depending on patients' tolerability, 8 cycles of chemotherapy will be given to the patients.
- Trial name
- XPID (NCT01525771)
- Testing
- Docetaxel
- Where
- South Korea
- Volunteers
- 37 people
- Sponsor
- Asan Medical Center
Central Serous Chorioretinopathy
Efficacy and Safety of Intravitreal Aflibercept Injection for Subacute Central Serous Chorioretinopathy
Central serous chorioretinopathy (CSC) is a self-limiting disease that usually associated with good visual prognosis. In some cases, however, CSC may persist and result in permanent retinal or retinal pigment epithelium (RPE)…
- Trial name
- NCT01971190
- Testing
- Intravitreal Aflibercept injection, Half-fluence photodynamic therapy
- Where
- 6 sites in South Korea
- Volunteers
- 43 people
- Sponsor
- Asan Medical Center
Metastatic Liver Cancer
Reproducibility and Repeatability of Multifunctional MRI Biomarkers of the Body
Advanced MRI (Magnetic Resonance Imaging) technique called DCE (Dynamic Contrast Enhanced) and DWI MRI can provide valuable information regarding tumor biology and response to treatment through various parameters.
- Trial name
- NCT02201797
- Testing
- DCE MRI
- Where
- South Korea
- Volunteers
- 13 people
- Sponsor
- Asan Medical Center
Colonic Polyp
Cold Snare Polypectomy Versus. Endoscopic Mucosal Resection
The investigators will investigate the efficacy of EMR compared to CSP in treatment of small colon polp (6~10mm). One aim of this study was to investigate the necessity of EMR on resection of small colon polyp.
- Trial name
- NCT02476747
- Testing
- EMR, CSP
- Where
- South Korea
- Volunteers
- 103 people
- Sponsor
- Asan Medical Center
Kidney Transplantation
The Usefulness of Tacrolimus Without Basiliximab in Well Matched Living Renal Transplantation in Korea
Basiliximab has been a routine induction therapeutic agent even for well-matched living kidney transplantation(KT) with tacrolimus-based immunosuppression in Korea.
- Trial name
- NCT02459977
- Testing
- Basiliximab, No basiliximab, Kidney transplantation
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Asan Medical Center
Kidney Failure
Thymoglobulin Induction Therapy in Kidney Transplantation (6mg/kg vs 4mg/kg)
This is a prospective randomized controlled study to evaluate feasibility and safety of early steroid withdrawal after 6mg/kg vs 4.5mg/kg Thymoglobulin induction therapy in kidney transplantation.
- Trial name
- NCT02447822
- Testing
- Thymoglobulin
- Volunteers
- 154 people
- Sponsor
- Asan Medical Center
Malignant Gastric Outlet Obstruction
The Usefulness of Self-expandable Metal Stents(SEMS) for Malignant Gastric Outlet Obstruction: a Prospective Study Using New Designed Stents
The purpose of this study is to evaluate usefulness of new designed winged stent(SEMS).
- Trial name
- SEMS (NCT02440724)
- Testing
- Winged stent (partially covered), Winged stent (uncovered)
- Where
- South Korea
- Volunteers
- 33 people
- Sponsor
- Asan Medical Center
Acromegaly
Hormonal Outcomes in Acromegalic Patients With Treated Surgery With or Without Long Acting Somatostatin Analogues
Long-term (up to 3 years) clinical and hormonal outcomes in acromegalic patients with treated surgery with or without long acting somatostatin analogues.
- Trial name
- acromegaly (NCT02427295)
- Testing
- Sandostatin (Octreotide Acetate)
- Where
- South Korea
- Volunteers
- 1 people
- Sponsor
- Asan Medical Center
Endocarditis
Early Surgery Versus Conventional Treatment in Infective Endocarditis
There have been no prospective clinical studies in infective endocarditis comparing early surgery with the conventional treatment strategy based on current guidelines.
- Trial name
- EASE (NCT00750373)
- Testing
- Valve surgery with removal of vegetations
- Where
- 2 sites in South Korea
- Volunteers
- 76 people
- Sponsor
- Asan Medical Center
Kidney Transplantation
Bortezomib With Steroid Pulse Therapy for Acute Cellular Rejection in Kidney Transplantation
The purpose of this study is to determine whether bortezomib is effective in the treatment of acute cellular rejection after kidney transplantation.
- Trial name
- NCT02351427
- Testing
- Bortezomib, Steroid
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Asan Medical Center
Healthy Volunteers
Clinical Trial for Evaluation of Ethnic Differences in Pharmacokinetics of Chloroquine, an Anti-malarial Drug
Chloroquine is an anti-malaria agent. This study is designed to evaluate inter-ethnic differences of therapeutic effect of chloroquine and search the cause of these ethnic differences.
- Trial name
- NCT01366235
- Testing
- chloroquine phosphate 1000 mg
- Where
- South Korea
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Renal Insufficiency, Kidney Diseases
Clinical Study to Investigate the Safety and Pharmacokinetics of SK3530 Tablet in Renal Impaired Male Patients
This study is designed to investigate the effect of renal impairment on the safety and pharmacokinetics of SK3530 in subjects with renal impairment compared to healthy subjects.
- Conditions
- Renal Insufficiency, Kidney Diseases, Urologic Diseases
- Trial name
- SK3530_RI_I (NCT01232010)
- Testing
- Mirodenafil
- Where
- South Korea
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Aortic Dissection, Aortic Aneurysm
Long-term Benefit of Aortic Stent-graft in Patients With Distal Aortic Dissection
Background: Aortic stent-graft is useful to occlude intimal tear and prevent further dilatation of the false lumen in patients with aortic dissection.
- Conditions
- Aortic Dissection, Aortic Aneurysm, Stent-graft
- Trial name
- NCT01354119
- Testing
- Aortic stent-graft
- Where
- South Korea
- Volunteers
- 7 people
- Sponsor
- Asan Medical Center
Cholestasis, Extrahepatic
Clinical Outcomes of EUS-guided Biliary Drainage Using Partially or Fully Covered Metallic Stents
Although endoscopic retrograde cholangiopancreatography (ERCP) is almost always successful in patients with malignant biliary obstruction, selective biliary cannulation fails in some cases and conventional ERCP may not be…
- Trial name
- NCT02114320
- Testing
- EUS-BD
- Where
- 2 sites in South Korea
- Volunteers
- 32 people
- Sponsor
- Asan Medical Center
Breast Cancer
Additional 4 Cycles of Cisplatin (CDDP4) in Patients With Triple Negative Breast Cancer for Neoadjuvant Chemotherapy
Achievement of pathologic complete response is important prognosticator to predict long term outcome in triple negative cancer. The efficacy of adding 4 cycles of cisplatin (CDDP4) is to be investigated whether addtional…
- Trial name
- PACER (NCT02001519)
- Testing
- AC4-CDDP4
- Where
- South Korea
- Volunteers
- 88 people
- Sponsor
- Asan Medical Center
Depression
The Preventive Effect of Escitalopram on Depression and Related Emotional Disorders in Acute Stroke Patients
Through this study, the investigators are to demonstrate the superiority of Escitalopram over placebo for the prevention of poststroke depression in patients with acute stroke The primary hypothesis of this study is; This study…
- Trial name
- EMOTION (NCT01278498)
- Testing
- Escitalopram, sugar pill
- Where
- 16 sites in South Korea
- Volunteers
- 444 people
- Sponsor
- Asan Medical Center