Clinical trials: sponsored by Asan Medical Center
Hand-foot Syndrome
Study of Pyridoxine for Hand-Foot Syndrome
Although pyridoxine has been used empirically for the prevention of capecitabine associated hand-foot syndrome (HFS), its efficacy needs to be demonstrated in prospective controlled trials.
- Trial name
- NCT00446147
- Testing
- Pyridoxine
- Volunteers
- 389 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Chronic Periodontitis
Diagnosis of Periodontal Disease Using Genetic Marker in Saliva
The purpose of the present study is to identify the novel periodontal disease biomarkers using differentially expressed microRNA in the saliva.
- Trial name
- NCT02069574
- Testing
- non-surgical periodontal therapy
- Where
- South Korea
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Hepatitis B, Chronic
Entecavir Plus Adefovir in Lamivudine-Resistant Chronic Hepatitis B Patients Who Fail Lamivudine Plus Adefovir
The presence of persistent inadequate or suboptimal virologic response is a strong risk factor for viral resistance and breakthrough and also for disease progression of chronic hepatitis B, and thus, a change in therapy is…
- Trial name
- CAESAR (NCT01023217)
- Testing
- Adefovir, Entecavir, Lamivudine
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Asan Medical Center
Cholangiocarcinoma
S-1 and Photodynamic Therapy in Cholangiocarcinoma
In patients with unresectable perihilar cholangiocarcinoma, photodynamic therapy with biliary stent has been known for palliation of jaundice and improving survival.
- Trial name
- NCT00869635
- Testing
- S-1 Chemotherapy, Photodynamic therapy, Systemic chemotherapy except S-1
- Where
- South Korea
- Volunteers
- 43 people
- Sponsor
- Asan Medical Center
Benign Paroxysmal Positional Vertigo
The Treatment of Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo
The purpose of this study was to compare the treatment effectiveness of three different methods for posterior semicircular canal benign paroxysmal positional vertigo.
- Trial name
- BPPV (NCT02029508)
- Testing
- Modified Epley maneuver, Semont maneuver, Reverse Epley maneuver
- Where
- South Korea
- Volunteers
- 99 people
- Sponsor
- Asan Medical Center
Chronic Obstructive Pulmonary Disease
Strategy to Improve Adherence of Roflumilast
Main adverse events of Roflumilast are weight loss, loss of appetite, insomnia, headache, diarrhea, vomiting, and nausea. Although the majority of these adverse reactions were mild or moderate.
- Trial name
- NCT02018432
- Testing
- Roflumilast escalation dosage, Roflumilast conventional dosage
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Asan Medical Center
Kidney Transplant Recipient
Isoniazid (INH) Treatment Based on ELISPOT Assay
It has been recommended that all transplant recipients undergo a tuberculin skin test (TST) before transplantation. However, the ability of TST to diagnose latent tuberculosis infection (LTBI) in transplant candidates has been…
- Trial name
- NCT01087190
- Testing
- Isoniazid treatment
- Where
- South Korea
- Volunteers
- 831 people
- Sponsor
- Asan Medical Center
Tuberculosis, Latent Tuberculosis
The Epidemiology of TST Change in Korea
TST will be analyzed in young general population in Korea. Young adults undertake TST as CDC recommendation. Participants with chest radiograph showing active TB lesion are excluded from this study.
- Trial name
- NCT01850043
- Where
- South Korea
- Volunteers
- 5,552 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Prostate Cancer
GEMOX in Docetaxel-Refractory Castration-Resistant Prostate Cancer
Prostate cancer is one of the most common malignancies affecting men all over the World. Metastatic prostate cancer responds to androgen deprivation for a variable period (20-25 months).
- Trial name
- NCT01487720
- Testing
- GEMOX
- Where
- South Korea
- Volunteers
- 33 people
- Sponsor
- Asan Medical Center
Thyroid Nodule
RFA (Radiofrequency Ablation) Versus EA (Ethanol Ablation) for Predominantly Cystic Thyroid Nodules
Ultrasound-guided ethanol ablation is an effective treatment modality for patients with cystic thyroid nodules (cystic portion > 90%); however it is less effective in predominantly cystic thyroid nodules (90% > cystic portions >…
- Trial name
- NCT01778400
- Testing
- radiofrequency ablation, Ethanol ablation
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Asan Medical Center
Liver Transplant Recipient
Micafungin Versus Fluconazole for Prevention of Invasive Fungal Disease in Living Donor Liver Transplant Recipients
The purpose of this study is to demonstrate non-inferiority of micafungin at a dose of 100 mg/day versus fluconzeole for the prevention of Invasive Fungal Disease, defined according to the revised EORTC/MSG criteria, undergoing…
- Trial name
- KOPIN (NCT01974375)
- Testing
- micafungin, Fluconazole
- Where
- South Korea
- Volunteers
- 172 people
- Sponsor
- Asan Medical Center
Invasive Fungal Infection
Voriconazole Plasma Level in Intensive Care Unit (ICU) Patients
Voriconazole, a newer triazole-derivative, has become the drug of choice for many invasive fungal infections, including invasive Aspergillosis.
- Trial name
- NCT01185405
- Testing
- Use of different strategy for voriconazole dosage adjustment
- Where
- South Korea
- Sponsor
- Asan Medical Center
Neurosurgery
Characterization and Differential Diagnosis of Postneurosurgical Meningitis
Meningitis is a rare complication following neurosurgical procedures and is associated with high morbidity and mortality. The aim of this study is to describe the clinical characteristics and microbiological characteristics in…
- Trial name
- NCT01122537
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Asan Medical Center
Breast Cancer
Premenopausal Patient With Hormone Responsive, HER2 Negative, Lymph Node Positive Breast Cancer
The purpose of this study is to compare neo-adjuvant therapy of cytotoxic chemotherapy versus GnRHa with tamoxifen , of response rate(RR) in patients of hormone responsive and HER2 negative, lymph node positive, primary breast…
- Trial name
- NEST (NCT01622361)
- Testing
- Adriamycin+Cyclophosphamide>Docetaxel, GnRHa with Tamoxifen
- Where
- South Korea
- Volunteers
- 290 people
- Sponsor
- Asan Medical Center
Colorectal Neoplasms
Brief Title : Optimized Endoscopic Submucosal Dissection With Snaring for Colorectal Neoplasm
This study is aimed to analyze the outcomes after conventional endoscopic submucosal dissection (ESD) and optimized ESD with snaring (oESD-S) for colorectal neoplasm that is more than 20 mm in diameter of laterllay spreading…
- Trial name
- NCT01944540
- Testing
- Optimized ESD with snaring, Conventional ESD
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Asan Medical Center
EUS-FNA, Cytodiagnosis
Comparison of EUS-Guided Fine Needle Aspiration Technique
EUS-guided fine needle aspiration (EUS-FNA) is a safe and effective method for diagnosing pancreatic and peripancreatic solid masses.
- Trial name
- NCT01923883
- Testing
- EUS-FNA, Echoendoscope Olympus GF-UCT240
- Where
- South Korea
- Volunteers
- 51 people
- Sponsor
- Asan Medical Center
Ovarian Cancer
Paclitaxel-Loaded Polymeric Micelle and Carboplatin as First-Line Therapy in Treating Patients With Advanced Ovarian Cancer
RATIONALE: Drugs used in chemotherapy, such as paclitaxel-loaded polymeric micelle and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00886717
- Testing
- carboplatin, paclitaxel-loaded polymeric micelle
- Where
- 4 sites in South Korea
- Volunteers
- 74 people
- Sponsor
- Asan Medical Center
Schizophrenia, Social Cognition
Social Dysfunction and Brain Dysfunction in Patients With Schizophrenia
There were a few studies about the relationship of structural or functional abnormalities of brain and social cognitive dysfunctions in patients with schizophrenia.
- Trial name
- NCT01903915
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Tuberculosis
Latent Tuberculosis Infection in Bone Marrow Transplant Recipients
The aim of this study is to estimate the usefulness of a T cell-based assay (i.e. Quantiferon-Gold In-Tube assay) for diagnosis of latent tuberculosis infection (LTBI) in bone marrow transplant recipients.
- Trial name
- NCT01021124
- Where
- South Korea
- Volunteers
- 409 people
- Sponsor
- Asan Medical Center
Healthy
Early Clinical Evaluation of the Pharmacokinetics and Mechanism Based Pharmacodynamics of Haloperidol Using Positron Emission Tomography in Healthy Volunteers
In the present study, the investigators will establish the clinical trial technology for early evaluation of drug characteristics in terms of pharmacokinetics and pharmacodynamics for haloperidol as a model drug, using positron…
- Trial name
- NCT01193621
- Testing
- haloperidol, PET
- Where
- South Korea
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center