Clinical trials: open to volunteers, sponsored by Asan Medical Center
STOMACH NEOPLASM, Gastric Cancer
Lenvatinib in Combination With Nivolumab Plus Chemotherapy in Metastatic Gastric Cancer Patients With Malignant Ascites
To investigate efficacy and safety of lenvatinib in combination with nivolumab plus chemotherapy in gastric cancer patients with peritoneal metastasis and grade ≥ 2 ascites.
- Conditions
- STOMACH NEOPLASM, Gastric Cancer, Gastric Cancer Adenocarcinoma Metastatic
- Trial name
- NCT07149090
- Testing
- Lenvatinib
- Where
- South Korea
- Volunteers
- 61 people
- Sponsor
- Asan Medical Center
Mitral Valve Insufficiency
Clinical Outcomes of Edwards Lifesciences MITRIS RESLILA Mitral Valve in the Asian Population
The purpose of this study is to evaluate the early and mid-term safety and performance of the MITRIS RESILIA mitral valve in Asian patients in a real-world setting
- Trial name
- KOREA MITRIS (NCT06757049)
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Asan Medical Center
Esophageal Cancer
Circulating Tumor DNA MRD-Guided Adjuvant Therapy for Curatively Resected Locally Advanced Esophageal Squamous Cell Carcinoma
This study was a multicenter, randomized, phase 3 trial to determine whether adjuvant chemotherapy including tisleliizumab improves recurrence-free survival compared to follow-up alone without chemotherapy in patients with…
- Trial name
- MRD2START (NCT06914011)
- Testing
- Tislelizumab
- Volunteers
- 172 people
- Sponsor
- Asan Medical Center
Severe Pneumonia
Detection and Characterization of Lower Respiratory Infections in Critically Ill Patients
This study is a prospective observation study for lower respiratory tract infections in medical intensive care unit. Microbiologic and clinical characteristics and outcomes of patients with severe pneumonia in medical intensive…
- Trial name
- NCT01068990
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Asan Medical Center
ICU-acquired Weakness
Evidence-based, Customized, Motion-recognition Rehabilitation System Development for Bed-ridden Patients - Validation of Effectiveness: Rehabit: Swim
This pilot study aims to evaluate the efficacy, safety, feasibility, and user satisfaction of "Rehabit: swim," a customized, evidence-based, motion-recognition-based rehabilitation exergame designed for hospitalized patients with…
- Trial name
- NCT07896057
- Testing
- Rehabilitation
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Asan Medical Center
Ischemic Stroke, Transient Ischemic Attack
Zastaprazan for the prEvention of Upper GI Bleeding in Ischemic Stroke
The goal of this clinical trial is to learn if zastaprazan can help prevent upper gastrointestinal bleeding in adults who have recently had a transient ischemic attack (TIA) or ischemic stroke and are taking antiplatelet or…
- Trial name
- NCT07730840
- Testing
- Zastaprazan
- Where
- 15 sites in South Korea
- Volunteers
- 984 people
- Sponsor
- Asan Medical Center
Metastatic Breast Cancer (HR+/ HER2-)
Predicting Endocrine Resistance Using Molecular Imaging and Liquid Biopsy in Metastatic Breast Cancer
This prospective observational study aims to evaluate the prognostic value of molecular imaging biomarkers derived from baseline [18F]FES and [18F]FDG PET/CT for progression-free survival in patients with estrogen receptor…
- Trial name
- NCT07867925
- Testing
- [18F] FES
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Asan Medical Center
Coronary Artery Disease
OPTIMIZE-APT: Tailored Versus Conventional Antiplatelet Therapy After Intravascular Imaging-guided Drug-eluting Stent Implantation
Objectives: To assess the safety of tailored antiplatelet therapy (short DAPT followed by P2Y12 inhibitor alone strategy) in patients who received optimized DES implantation guided by intravascular imaging (IVUS or OCT)…
- Trial name
- OPTIMIZE-APT (NCT05418556)
- Testing
- aspirin
- Where
- 33 sites in South Korea
- Volunteers
- 3,944 people
- Sponsor
- Asan Medical Center
Postoperative Complications, Intracranial Surgery
Blood Viscosity and Outcomes After Elective Craniotomy
This prospective observational study aims to evaluate the association between intraoperative blood viscosity and postoperative clinical outcomes in adult patients undergoing elective intracranial craniotomy.
- Trial name
- NCT07530393
- Testing
- Observational Assessment of Blood Viscosity
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Asan Medical Center
Hematologic Neoplasms, Influenza
Influenza Vaccination Strategy for Patients With Hematologic Malignancy
This randomized controlled trial evaluates and compares the immunogenicity of three different influenza vaccine formulations: high-dose trivalent (HD-IIV3), MF59-adjuvanted quadrivalent (aIIV4), and standard-dose trivalent…
- Conditions
- Hematologic Neoplasms, Influenza, Immunogenicity
- Trial name
- (HEM-FLU) (NCT07485855)
- Testing
- High-dose trivalent inactivated influenza vaccine (HD-IIV3), MF59-adjuvanted quadrivalent inactivated influenza vaccine (aIIV4), Standard-dose trivalent inactivated influenza vaccine (SD-IIV3)
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Asan Medical Center
Septic Shock
Albumin and Crystalloid Administration in Septic Shock
The current guideline emphasizes fluid resuscitation as the mainstay of initial management for septic shock. Albumin has the oncotic activity to maintain intravascular volumes with additional beneficial properties in sepsis.
- Trial name
- ALCAMIST (NCT05148286)
- Testing
- Treatment
- Where
- South Korea
- Volunteers
- 2,426 people
- Sponsor
- Asan Medical Center
Carcinoma, Hepatocellular
A Prospective Study to Evaluate the Safety and Efficacy of the Combination Therapy of Irpagratinib, Atezolizumab, and Bevacizumab in Patients With Hepatocellular Carcinoma
This is a phase 2, open-label study to evaluate the safety, tolerability and efficacy of Irpagratinib in combination with Atezolizumab and Bevacizumab in patients with advanced or unresectable HCC harboring FGF19 overexpression.
- Trial name
- IAPETUS (NCT07010497)
- Testing
- irpagratinib
- Where
- 3 sites in South Korea
- Volunteers
- 33 people
- Sponsor
- Asan Medical Center
Valve Replacement Surgery
Comparison of Anti-Thrombotic Treatments Between Aspirin and Warfarin During Initial Six Months After Bioprosthetic Heart Valve Replacement
This trial is a multinational, multicenter, randomized, open-label, active-controlled clinical trial comparing the safety of aspirin versus vitamin K antagonists (warfarin) as oral antithrombotic therapy during the initial 6…
- Trial name
- CONCLAVE (NCT07431762)
- Testing
- Aspirin, Vitamin K antagonist(warfarin)
- Where
- 3 sites in Japan, South Korea
- Volunteers
- 1,058 people
- Sponsor
- Asan Medical Center
Ovarian Neoplasms, Carcinoma, Ovarian Epithelial
Blood-Based Minimal Residual Disease in Advanced Epithelial Ovarian Cancer After 1st Line Therapy
The purpose of this observational study is to learn if a specialized blood test can help predict whether advanced ovarian cancer will return after a patient's initial treatments are finished.
- Conditions
- Ovarian Neoplasms, Carcinoma, Ovarian Epithelial, Ovarian Cancer
- Trial name
- NCT07670962
- Testing
- Blood-based ctDNA minimal residual disease (MRD) test
- Volunteers
- 300 people
- Sponsor
- Asan Medical Center
Coronary Artery Disease
Clinical Impact of Intravascular Ultrasound-Based Artificial Intelligence Technologies (INNOVATE-PCI)
This study is a prospective, multicenter study in the real practice to validate the diagnostic performances and clinical impact of coronary angiography \& intravascular ultrasound (IVUS)-based models developed by machine learning…
- Trial name
- NCT05807841
- Testing
- percutaneous coronary intervention
- Where
- 16 sites in South Korea
- Volunteers
- 3,000 people
- Sponsor
- Asan Medical Center
Pancreatoduodenectomy, PPPD
Duration of Perioperative Antibiotics in Pancreatoduodenectomy
The goal of this clinical trial is to compare two perioperative antibiotic prophylaxis regimens in adult patients undergoing pancreatoduodenectomy (PD) or pylorus-preserving pancreatoduodenectomy (PPPD).
- Conditions
- Pancreatoduodenectomy, PPPD, Infectious Complications
- Trial name
- NCT07043855
- Testing
- single dose preoperative antibiotic, Prolonged perioperative antibiotics
- Where
- South Korea
- Volunteers
- 558 people
- Sponsor
- Asan Medical Center
Hepatocellular Carcinoma (HCC)
Lenvatinib or Regorafenib for Advanced Hepatocellular Carcinoma After Immunotherapy (REVIVE)
The goal of this clinical trial is to learn if lenvatinib or regorafenib can help treat people with advanced liver cancer (hepatocellular carcinoma, HCC) that cannot be removed with surgery after first treatment with…
- Trial name
- REVIVE (NCT07495579)
- Testing
- Lenvatinib, regorafenib
- Where
- South Korea
- Volunteers
- 146 people
- Sponsor
- Asan Medical Center
Solid Carcinoma
Utilization of Microbiome as Biomarkers and Therapeutics in Immuno-Oncology
This is an open label, single-center, non-randomized clinical trial on utilization of microbiome as biomarkers and therapeutics in immuno-oncology.
- Trial name
- NCT04264975
- Testing
- fecal microbiota transplantation
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Asan Medical Center
Gastrointestinal Stromal Tumors
The Efficacy and Safety of Temozolomide in SDH-deficient GIST
The goal of this clinical trial is to investigate the efficacy and safety of temozolomide in SDH deficiency GIST patients.
- Trial name
- GIST (NCT05661643)
- Testing
- Temozolomide capsule
- Where
- South Korea
- Volunteers
- 29 people
- Sponsor
- Asan Medical Center
Gastrointestinal Stromal Tumors
GIST Oral Paclitaxel(Liporaxel)
The purpose of this study is to evaluate safety and efficacy of Liporaxel for patients with GIST who failed on prior standard treatments, including imatinib, sunitinib, and regorafenib, and with low P-glycoprotein expression.
- Trial name
- NCT06326346
- Testing
- Liporaxel
- Where
- South Korea
- Volunteers
- 28 people
- Sponsor
- Asan Medical Center