Clinical trials: sponsored by Baylor Research Institute
Pancreas Cancer, Localized Pancreas Cancer
Neoadjuvant FOLFIRINOX Regimen in Patients With Non-metastatic Pancrease Cancer
A prospective evaluation of neoadjuvant FOLFIRINOX regimen in patients with non-metastatic pancreas cancer (Baylor University Medical Center and Texas Oncology Experience)
- Conditions
- Pancreas Cancer, Localized Pancreas Cancer, Non-metastatic Pancreas Cancer
- Trial name
- NCT01771146
- Testing
- FOLFIRINOX Regimen
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Baylor Research Institute
End Stage Liver Disease, Hepatitis C
Study of Liver Transplant For End-Stage Liver Disease Caused By Chronic Hepatitis C Infection
The purpose of this study is to compare three treatment regimens in patients who have received a liver transplant for end-stage liver disease caused by Chronic Hepatitis C infection.
- Trial name
- NCT00163657
- Testing
- Daclizumub, Tacrolimus, Cyclosporine
- Where
- United States
- Volunteers
- 312 people
- Sponsor
- Baylor Research Institute
Malignant Melanoma Stage III, Malignant Melanoma Stage IV
IL15 Dendritic Cell Vaccine for Patients With Resected Stage III (A, B or C) or Stage IV Melanoma
The purpose of the study is to gather data on feasibility as well as immune and clinical efficacy of of a dendritic cell vaccine using IL15 in patients with resected stage III or stage IV melanoma
- Trial name
- NCT01189383
- Testing
- IL15-DC Vaccine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Baylor Research Institute
Post-operative Pain, Respiratory Depression
Dexmedetomidine for the Control of Post-Operative Pain in Thoracotomy Patients
The purpose of this study is to evaluate the safety, efficacy, hemodynamic and respiratory stability of a low-dose of dexmedetomidine infusion in post-operative surgical in-patients undergoing thoracic surgery after discharge…
- Trial name
- NCT00345384
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Baylor Research Institute
Liver Transplantation
Evaluation of Liver Disease With Elastography Measurements in Patients Undergoing Liver Transplant Surgery
The purpose of the study is to compare ultrasound measurements of the liver obtained prior to surgery on the skin to measurements obtained during surgery directly on the diseased liver.
- Trial name
- SupersonicOR (NCT01890460)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Baylor Research Institute
Chronic Graft-versus-host Disease
Bortezomib for the Treatment of Refractory Chronic Graft-vs-Host Disease(cGVHD)
The purpose of this study is to see if bortezomib (Velcade) is effective in the treatment of refractory cGVHD.
- Trial name
- NCT01158105
- Testing
- Bortezomib
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Baylor Research Institute
Menorrhagia
Evaluation of the Endometrial Cavity After Endometrial Ablation
The purpose of this study is to evaluate the shape, size and appearance of the inside of the uterus six months following an endometrial ablation procedure.
- Trial name
- Postablation (NCT02087228)
- Testing
- Genesys HydroTherm Ablator, radiofrequency energy ablation device
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Baylor Research Institute
Cardiac Transplant Failure
BIIR Gene to Manage Heart Allograft Patients
This is a single center observational study. Duration of the study is 1 year. Participants will be followed in 2 groups. Group 1 will include all patients who have undergone a heart transplant, through the first year post…
- Trial name
- NCT01929785
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Baylor Research Institute
Fabry Disease
Androgenetic Alopecia in Fabry Disease
The purpose of this study is to assess whether patients with the classic form of Fabry disease have significantly less androgenic alopecia (male pattern baldness).
- Trial name
- NCT01295008
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Respiratory Insufficiency
Transcutaneous Carbon Dioxide Monitoring Post Cardiac Surgery: Incidence and Severity Resp Insufficiency
The purpose for the investigators study is to investigate the severity and incidence of respiratory insufficiency using transcutaneous carbon dioxide (TcPCO2) monitoring as an adjunct to the current standard of care for early…
- Trial name
- NCT01188590
- Testing
- TOSCA 500 monitor
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Baylor Research Institute
Fabry Disease
Dosing Study of Replagal in Patients With Fabry Disease
This study will determine the safety and effectiveness of increasing Replagal infusions in certain patients with Fabry disease. Replagal is a genetically engineered form of Alpha-galactosidase A, an enzyme that normally breaks…
- Trial name
- NCT00068107
- Testing
- Replagal
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Baylor Research Institute
Coronary Artery Disease
Study to Improve Long Term Vein Graft Patency After Coronary Bypass Surgery by Using a Novel Endoscopic Harvesting Technique
The purpose of this study is to demonstrate improved vein graft patency rates at 12 months for endoscopically harvested saphenous vein grafts.
- Trial name
- NCT01540422
- Where
- 2 sites in United States
- Volunteers
- 93 people
- Sponsor
- Baylor Research Institute
Deglutition Disorders
Comparing FEES to VFSS in Diagnosing Laryngeal Penetration and Aspiration in Infants in the NICU
The main purpose of the study is to determine whether the Fiberoptic Endoscopic Evaluation of Swallowing (FEES) is effective in detecting laryngeal penetration and tracheal aspiration when compared with the Videofluoroscopic…
- Trial name
- NCT02003287
- Testing
- VFSS, FEES
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Baylor Research Institute
Rheumatoid Arthritis
The Controlled Trial of Apremilast for Rheumatoid Arthritis Treatment (CARAT)
The purpose of this study is to compare the effects of apremilast with a placebo (an inactive substance that looks like apremilast) on you and other people with rheumatoid arthritis.
- Trial name
- NCT01250548
- Testing
- apremilast
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Baylor Research Institute
Palmoplantar Pustulosis
Immune Signature of Palmoplantar Pustulosis
This study is being done to learn more about a less common "type" of psoriasis, called palmoplantar pustulosis (PPP). The majority of the current treatments used for this type of psoriasis have only a moderate effect on PPP.
- Trial name
- PPP (NCT01780857)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Congestive Heart Failure
Effect of Posture on Left Ventricular (LV) Transvenous Lead Capture Thresholds (EXPECT)
The purpose of this study is to determine whether changes in a patient's position affect LV capture thresholds in a clinically significant way.
- Trial name
- EXPECT (NCT01520714)
- Testing
- Medtronic 4195 active fixation LV lead and Medtronic passive fixation LV lead
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Baylor Research Institute
Cardiovascular Diseases, Heart Diseases
Impact of Medical and Surgical Therapy on Functional Mitral Regurgitation
The Transesophageal Echocardiography (TEE) Surgical Treatment of Ischemic Heart Failure (STICH) ancillary study will define the mechanism(s) of functional mitral regurgitation (MR) by TEE in patients with ischemic cardiomyopathy…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease
- Trial name
- NCT00224809
- Testing
- Angiotensin-Converting Enzyme Inhibitors, Coronary Artery Bypass Graft, Angiotensin Receptor Blockers
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Baylor Research Institute
Dysfunction of Vestibular System, Nausea Persistent
Vestibular Dysfunction as a Cause of Chronic Nausea & Vomiting: A Follow up Survey
The purpose of this study is to characterize the accompanying symptoms, evaluation and management of patients with chronic vestibular dysfunction presenting with nausea and vomiting.
- Conditions
- Dysfunction of Vestibular System, Nausea Persistent, Vomiting
- Trial name
- NCT01378351
- Testing
- Questionnaire survey
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Baylor Research Institute
Coronary Artery Disease
Comparing Blood Loss, RBC Transfusions and Inflammatory Marker Changes Among Methods of CPB
The purpose of this study is to compare blood loss and the number of transfusions received by each patient having coronary bypass surgery.
- Trial name
- NCT01083914
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Baylor Research Institute
Acute Myelogenous Leukemia, Myelodysplastic Syndromes
Clofarabine and Ara-C for the Treatment of Relapsed AML and Untreated MDS
The purpose of this trial is to to determine the safety and effectiveness of therapeutic combination - Clofarabine and Cytarabine for the treatment of AML and MDS.
- Conditions
- Acute Myelogenous Leukemia, Myelodysplastic Syndromes, Chronic Myelogenous Leukemia
- Trial name
- NCT00334074
- Testing
- Clofarabine and Cytarabine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Baylor Research Institute