Clinical trials: sponsored by Baylor Research Institute
Colorectal Cancer (CRC) Screening
Smartphone-enabled Hybrid Identification of Early CoLorectal Disease Using Blood-Based Cancer Testing Across TeXas
The goal of this prospective implementation study is to understand the impact of a blood-based screening test (BBST) for colorectal cancer (CRC) on patient acceptability of and adherence to CRC screening as well as the rate of…
- Trial name
- SHIELD-TX (NCT07398456)
- Testing
- Educational Information via Smartphone App
- Where
- United States
- Volunteers
- 5,500 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Triple Negative Breast Cancer
LY3023414 and Prexasertib in Metastatic Triple-negative Breast Cancer
This study evaluates efficacy of LY3023414 and prexasertib in patients with metastatic triple negative breast cancer.
- Trial name
- NCT04032080
- Testing
- Drug 1: LY3023414; Drug 2: Prexasertib
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Baylor Research Institute
Surgical Site Infection, Vaginal Cuff Cellulitis
Prevention of Vaginal Cuff Infection After Hysterectomy by Addition of Vaginal Clindamycin
This study seeks to determine ways to reduce the hospitals surgical site infection rate during hysterectomy operations.
- Conditions
- Surgical Site Infection, Vaginal Cuff Cellulitis, Bacterial Vaginosis
- Trial name
- NCT07888101
- Testing
- Clindamycin Vaginal Gel
- Where
- United States
- Volunteers
- 900 people
- Sponsor
- Baylor Research Institute
Stroke
Group Lifestyle Balance™ for Individuals With Stroke (GLB-CVA)
The purpose of this RCT is to examine the efficacy of the Group Lifestyle Balance (GLB) program adapted for people with stroke (CVA) on primary (weight) and secondary outcomes at 3, 6, 12 months from enrollment into the program.
- Trial name
- GLB-CVA (NCT03873467)
- Testing
- Group Lifestyle Balance, Usual Care
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Baylor Research Institute
Colon Cancer
COLON-MD: Colon Cancer Longitudinal Study
The goal of this proposal is to identify how the composition of the gut microbiome and diet interact to impact chemotherapy-induced diarrhea incidence and severity.
- Trial name
- COLON-MD (NCT04751448)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Baylor Research Institute
Traumatic Brain Injury
Group Lifestyle Balance™ for Individuals With Traumatic Brain Injury (GLB-TBI)
The purpose of this RCT is to examine the efficacy of a Group Lifestyle Balance™ (GLB) program adapted for people with traumatic brain injury (TBI) on primary (weight) and secondary outcomes at 3, 6, 12, and 18 months from…
- Trial name
- NCT03594734
- Testing
- Group Lifestyle Balance™, Attention Control Group
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Baylor Research Institute
Spinal Cord Injuries, PTSD
Brief Prolonged Exposure Therapy Versus Clinical Standard to Reduce Posttraumatic Stress Post Spinal Cord Injury
This study will examine the use brief prolonged exposure (Brief PE) therapy compared to standard clinical care to reduce posttraumatic distress among people who have had a spinal cord injury and are receiving rehabilitation in an…
- Conditions
- Spinal Cord Injuries, PTSD, Post-Traumatic Stress Disorder
- Trial name
- NCT05233111
- Testing
- Brief Prolonged Exposure Therapy, Treatment as Usual
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Baylor Research Institute
Chronic Disease, Quality of Life
Expanded Population Health Model Evaluation
This study will evaluate the impact of a comprehensive wellness and social determinants of health intervention on cardiovascular health in a community setting of the Bonton neighborhood.
- Trial name
- NCT06044831
- Testing
- Expanded Population Health Model
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Postoperative Pain
Enhanced Recovery After Surgery (ERAS) in Live Donor Kidney Transplant Recipients
The goal of this interventional study is to learn if an Enhanced Recovery After Surgery (ERAS) protocol works to reduce the need for narcotic pain medications in live donor kidney transplant recipients.
- Trial name
- NCT06997016
- Testing
- pre-operative carbohydrate drink, Acetaminophen, Gabapentin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Baylor Research Institute
Pancreatic Adenocarcinoma
Chemotherapy + Anakinra in Patients With Pancreatic Adenocarcinoma (PDAC)
Based on a central role of inflammation in pancreas cancer, the role of IL 1 in acute and chronic inflammation , the inhibitory effect of IL 1 alfa and beta by anakinra and preliminary experience with anakinra in combination with…
- Trial name
- NCT04926467
- Testing
- Anakinra
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Baylor Research Institute
Coronary Atherosclerosis Due to Calcified Coronary Lesion
ProActive Athlete Heart Program: Proposal for Cardiac Risk Screening in Former High-Intensity Athletes
AI-Guided Coronary CT Angiography Screening in Former High-Intensity Athletes
- Trial name
- NCT07460583
- Testing
- Coronary CTA
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Baylor Research Institute
Traumatic Injury, PTSD
Trauma BPE Prolonged Exposure Therapy for Injured Individuals Admitted to a Level I Trauma Center
The purpose of this research is to determine if a brief treatment method is effective for preventing posttraumatic stress disorder (PTSD) and a number of other concerns following injury.
- Conditions
- Traumatic Injury, PTSD, Posttraumatic Stress Disorder
- Trial name
- NCT06210711
- Testing
- Treatment as Usual, Brief Prolonged Exposure Therapy
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- Baylor Research Institute
Gastrointestinal Diseases
Foregut Leaks-Role of Microbiome
Aims 1. To understand the microbial composition involved with foregut leaks 2. To define the virulence changes in the microbiota following foregut leaks 3.
- Trial name
- NCT07424469
- Testing
- Biopsy and fluid samples
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Baylor Research Institute
Chronic Kidney Disease, Type 2 Diabetes
RAndomized EHR-based Prescribing to Improve Disease-modifying Therapies for Cardio-Kidney-Metabolic Care (RAPID-CKM)
The goal of this pragmatic randomized clinical trial is to determine whether an Epic-based clinician notification increases initiation of guideline-directed cardio-kidney-metabolic (CKM) therapies in adults with type 2 diabetes…
- Trial name
- NCT07605390
- Testing
- Epic-Based Clinician Notification, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 600 people
- Sponsor
- Baylor Research Institute
Chronic Kidney Disease, Type 2 Diabetes
Rapid and Simultaneous Initiation of Four Guideline-Directed CKD Therapies (RAPID-CKD)
The goal of this clinical trial is to learn if starting four kidney disease medicines quickly and together (a rapid treatment approach) is safe and works well in people with type 2 diabetes and chronic kidney disease.
- Trial name
- RAPID-CKD (NCT07547878)
- Testing
- Finerenone, Semaglutide, Lotensin
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Baylor Research Institute
Wound Edges
Intraoperative CO₂ (Carbon Dioxide)
To evaluate whether intraoperative fractionated CO₂ laser treatment of surgical wound edges improves postoperative scar appearance compared with untreated wound edges following Mohs micrographic surgery (MMS).
- Trial name
- NCT07592468
- Testing
- CO2 Fractionated Laser, Non CO2 Laser Treatment
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Baylor Research Institute
Spinal Cord Injuries
Dosing of Overground Robotic Gait Training With Functional Outcomes and Neuroplasticity After Spinal Cord Injury
The DOOR SCI project examines dosing effects of robotic gait training (RGT) and transcranial magnetic stimulation (TMS) initiated during inpatient rehabilitation and continued through early outpatient rehabilitation
- Trial name
- DOORSCI (NCT05218447)
- Testing
- Robotic Gait Training, Usual Care (UC) Gait Training
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Baylor Research Institute
Skin Substitutes, Secondary Intention Healing
Skin Subs vs Secondary Intention
The purpose of this study is to compare two ways of caring for wounds after Mohs micrographic surgery (MMS) for skin cancer using skin substitutes and secondary intention healing, to determine which option leads to better healing…
- Conditions
- Skin Substitutes, Secondary Intention Healing, Skin Cancer Healing
- Trial name
- NCT07587749
- Testing
- Skin Substitute, Secondary Intention Healing
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Baylor Research Institute
Metastatic Triple-Negative Breast Carcinoma, Breast Cancer
Neratinib in Combination With Ruxolitinib in Patients With mTNBC
The goal of this clinical trial is to assess the safety and efficacy of combined ruxolitinib and neratinib in patients with chemotherapy-pretreated metastatic triple negative breast cancer.
- Trial name
- NCT06008275
- Testing
- Neratinib Oral Tablet, Ruxolitinib Oral Tablet
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Baylor Research Institute
Stroke, Acute, Stroke
Efficacy of a Telehealth Delivered Group Lifestyle Balance for People Post Stroke (tGLB-CVA)
Investigators will conduct a randomized controlled trial (RCT) to assess intervention efficacy of telehealth delivery of the GLB-CVA (tGLB-CVA) compared to a 6-month wait-list control (WLC) in partnership with a diverse group of…
- Conditions
- Stroke, Acute, Stroke, Stroke, Cardiovascular, Stroke (CVA) or TIA
- Trial name
- tGLB-CVA (NCT06569121)
- Testing
- Group Lifestyle Balance for People Post Stroke (GLB-CVA)
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Baylor Research Institute