Clinical trials: sponsored by Baylor Research Institute
Metastatic Esophageal Adenocarcinoma, Metastatic Gastroesophageal Junction Adenocarcinoma
Abemaciclib Plus Ramucirumab for Esophageal/Gastroesophageal Junction Ca
CDK4/6 and Cyclin D1 are significantly expressed in approximately 80% of esophageal and gastroesophageal junction tumors suggesting that CDK4/6 inhibition may be a successful strategy in these chemotherapy and immunotherapy…
- Trial name
- NCT04921904
- Testing
- Abemaciclib, Ramucirumab
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Baylor Research Institute
Left Atrial Appendage Closure
Intracardiac Versus Transesophageal Echocardiographic Guidance for Left Atrial Appendage Occlusion
This single-center, prospective, randomized study will evaluate the safety and feasibility of Intracardiac echocardiography (ICE)-guided Left atrial appendage closure (LAAC) when compared to the traditional Transesophageal…
- Trial name
- ICETEE (NCT06348394)
- Testing
- Intracardiac Echocardiography, Traditional transesophageal echocardiography
- Where
- United States
- Volunteers
- 444 people
- Sponsor
- Baylor Research Institute
Post-operative Pain
A Trial Assessing The Association Between Type Of Local Anesthesia Treatment And Postoperative Pain In Patients In Having Undergone Arrhythmia Surgery
The goal of the proposed study is to investigate the relationship between two standard treatments, lidocaine or a mixture of lidocaine and bupivacaine, and 1) postoperative pain, and; 2) narcotic use following pacemaker or…
- Trial name
- NCT01300377
- Testing
- Bupivacaine / Lidocaine, Lidocaine
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Baylor Research Institute
Iliac Disease, Aortic Valve Stenosis
Intravascular Lithotripsy in High Risk Calcified Iliac Anatomy for Transfemoral TAVR
To assess the efficacy and safety of Intravascular Lithotripsy (IVL) in subjects undergoing transfemoral TAVR in patients with severe iliac disease, prohibitive for transfemoral TAVR in patients with severe symptomatic aortic…
- Trial name
- ILIT (NCT05862558)
- Testing
- Shockwave Balloon
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Baylor Research Institute
Radiation Protection
Study to Evaluate the Clinical Utility of Radiation Exposure Reduction: Multi-site Rampart Guardian Peripheral Trial
Study to Evaluate the Clinical Utility of Radiation Exposure Reduction (SECURE): Multi-site Rampart Guardian Peripheral Trial
- Trial name
- SECURE (NCT07467720)
- Testing
- Rampart IC System
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Baylor Research Institute
Respiratory Failure, Interstitial Lung Disease
Bio-Banking of Specimens for Advanced Lung Disease and Lung Transplant Research
A major goal of this protocol is to support biomarker studies in advanced lung diseases, lung transplantation care, and to improve our understanding of the effects of viral and other infectious exposures to outcomes in our lung…
- Conditions
- Respiratory Failure, Interstitial Lung Disease, Lung Diseases
- Trial name
- ALD Biobank (NCT04664192)
- Testing
- Patient Biospecimen Registry (observational and blood sampling)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Baylor Research Institute
CHW Certification
Train and EMPOWER A Community Health Workforce
The investigators propose a multi-step approach to improve access to mental health care. The plan focuses on three goals: increasing diversity in the mental health workforce, bringing more expertise into the community, and…
- Trial name
- TEACH (NCT06868498)
- Testing
- A semester-long course for training of students as CHWs with additional EMPOWER training for delivering a brief trans-diagnostic psychosocial intervention.
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- Baylor Research Institute
Peripheral Arterial Disease, Lower Extremity Arterial Disease
Intravascular Ultrasound Imaging Guidance for Optimal Revascularization of Limb Arteries
This study will test whether using ultrasound imaging within blood vessels during minimally invasive treatment of leg arteries in patients with peripheral artery disease leads to better clinical outcomes.
- Trial name
- INVIGOR (NCT07353905)
- Testing
- Intravascular Ultrasound (IVUS), Angiographic-guided Intervention
- Where
- 6 sites in United States
- Volunteers
- 350 people
- Sponsor
- Baylor Research Institute
Abandoned Endocardial Leads, Broken Endocardial Leads
Diagnostic Utility of Cardiac MRI
This is a prospective cohort study looking to systematically evaluate the safety of conducting cardiac Magnetic Resonance Imaging (MRI) in this high-risk patient group with abandoned, fractured endocardial leads or surgically…
- Conditions
- Abandoned Endocardial Leads, Broken Endocardial Leads, Permanent Epicardial Leads
- Trial name
- NCT07679009
- Testing
- Cardiac MRI (CMR)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Baylor Research Institute
Transcatheter Aortic Valve Replacement, Closure Technique
This Study Will Evaluate the Safety and Potential Complications of Dual ProGlide vs Single ProGlide and Angioseal for Common Femoral Arteriotomy Closure Following Transcatheter Aortic Valve Replacement
This prospective, randomized, parallel, single-center, open-label, non-inferiority study will evaluate the safety and potential complications of dual ProGlide vs single ProGlide and Angioseal for common femoral arteriotomy…
- Trial name
- TAVI-CLOSE (NCT06983938)
- Testing
- Double Perclose Proglide, Single Perclose Proglide plus Angioseal
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Baylor Research Institute
Traumatic Brain Injury, Brain Injuries, Traumatic
Scale-Up Evaluation Trial of the Diabetes Prevention Program to Improve Obesity and Cardiometabolic Health After Traumatic Brain Injury
The Investigators have proposed targeted efforts to address the feasibility, effectiveness, fidelity, and evaluation of the GLB-TBI Evidence Based Intervention (EBI) in a real world setting at a CDC-recognized site
- Conditions
- Traumatic Brain Injury, Brain Injuries, Traumatic, Brain Injury, Chronic
- Trial name
- GLB Scale-Up (NCT07648901)
- Testing
- Group Lifestyle Balance for People with TBI (GLB-TBI)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Baylor Research Institute
Stroke, Chronic Stroke
Wireless Nerve Stimulation Device To Enhance Recovery After Stroke
Texas Biomedical Device Center (TxBDC) has developed an innovative strategy to enhance recovery of motor and sensory function after neurological injury termed targeted plasticity therapy (TPT).
- Conditions
- Stroke, Chronic Stroke, Upper Extremity Paresis, Ischemic Stroke
- Trial name
- NCT04534556
- Testing
- Active Vagus Nerve Stimulation
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Baylor Research Institute
Heart Failure
CALM Study: Cardiomems Assisted Lvad Management
This prospective, open label, randomized, single-center pilot clinical trial will determine if the rate of heart failure related (HFR) hospitalizations is less in LVAD patients whose PAP is monitored with the CardioMEMS device vs…
- Trial name
- CALM (NCT07096544)
- Testing
- CardioMEMS Device
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Baylor Research Institute
Common Femoral Artery Stenosis, Calcification; Heart
Shockwave™ vs Surgical Endarterectomy for Calcified Severe Common Femoral Artery Stenosis: Comparison of Efficacy, Safety and Long-Term Outcomes
The investigators hypothesize that Shockwave with DCB is non-inferior to surgical endarterectomy for common femoral artery (CFA) stenosis with regard to primary efficacy and safety endpoints.
- Trial name
- Shockify (NCT06829914)
- Testing
- Shockwave Catheter, CFA Endarterectomy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Baylor Research Institute
Mohs Micrographic Surgery, Anesthesia, Local
Local Anesthetic Clinical Trial
To compare several local anesthetics when used during dermatological surgery.
- Trial name
- NCT07601750
- Testing
- Lidocaine, Bupivacaine Hydrochloride, Mepivacaine Hydrochloride
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Baylor Research Institute
Cutaneous Tumors, Mohs Micrographic Surgery
Suzetrigine vs Norco-postoperative Mohs Pain
To compare suzetrigine versus hydrocodone/acetaminophen for postoperative pain control following dermatologic surgery.
- Trial name
- NCT07575230
- Testing
- Norco 5Mg-325Mg Tablet, Suzetrigine
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Baylor Research Institute
ANOCA - Angina With Non-obstructive Coronary Arteries, INOCA (Ischemia With Non Obstructive Coronary Artery Disease)
Analysis of Coronary Reactivity Testing With and Without Intracoronary Nitrate Testing
This single-arm, multi-center, prospective study will assess the coronary flow reserve (CFR), index of microcirculatory resistance (IMR), and determinants thereof (transit time, Pa, Pd) in patients before and after intracoronary…
- Trial name
- CRT-NITRO (NCT06896903)
- Testing
- Coronary reactivity testing with and without nitrates
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Baylor Research Institute
Spinal Cord Injuries
Foundational Ingredients of Robotic Gait Training for People With Spinal Cord Injury During Inpatient Therapy
The FIRST project compares the dose of robotic gait training (RGT) with usual care gait training for patients with spinal cord injury (SCI) undergoing rehabilitation at Baylor Scott \& White Institute for Rehabilitation (BSWIR).
- Trial name
- FIRST (NCT04781621)
- Testing
- Robotic Gait Training, Usual Care Gait Training
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- Baylor Research Institute
Gastroparesis
Combined Role of Gastric Peroral Endoscopic Myotomy and Gastric Electrical Stimulator
This study is looking at how safe and effective G-POEM, GES and a combination of both are for people with severe stomach problems (gastroparesis) that haven't gotten better with medicine.
- Trial name
- NCT07526935
- Testing
- GES + Upper endoscopy, GES on + Upper endscopy, GES off + G-POEM
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Baylor Research Institute
Head and Neck Cancer
Optimal Tube Feeding Method in Head and Neck Cancer Patients
The purpose of this study is to assess the optimal tube feeding method (bolus, gravity or pump) by analyzing percent weight loss, tolerance of enteral feeds, and percent of estimated calorie and protein needs in 60 patients with…
- Trial name
- NCT01536782
- Testing
- Bolus, Gravity, Pump
- Where
- United States
- Sponsor
- Baylor Research Institute