Clinical trials: sponsored by Baylor Research Institute
Pancreas Cancer
A Pilot, Prospective, Non-randomized Evaluation of the Safety of Anakinra Plus Standard Chemotherapy
The study's overall objectives are to evaluate the safety of anakinra in combination with standard chemotherapy regimens in patients with pancreatic ductal adenocarinoma, as well as to collect preliminary immune modulation and…
- Trial name
- NCT02021422
- Testing
- anakinra, Oxaliplatin, Irinotecan
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Baylor Research Institute
Emergency Department Overcrowding
ED Overcrowding Validation Study
The aim of this study is to externally validate a new emergency department overcrowding estimation tool (SONET) developed at John Peter Smith Health Network (JPS).
- Trial name
- EDOVS (NCT02754245)
- Volunteers
- 7,000 people
- Sponsor
- Baylor Research Institute
Concussion, Mild Traumatic Brain Injury
Implementation of an Evidence-Based Educational Resource for Children With Mild Traumatic Brain Injury
The goal of this prospective, observational study is to (1) collaborate with our stakeholders to identify essential mTBI-information from existing evidence-based materials to develop a Post-mTBI Educational Resource for children…
- Trial name
- POCKIT (NCT07414303)
- Testing
- Post-mTBI Educational Resource
- Where
- 3 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
PTSD, Alcohol Use Disorder
Peer Delivered, Emotion Regulation-Focused Mental Health Prevention Training for Fire Fighter Trainees
The goal of this clinical trial is to determine if a peer-delivered emotion regulation training (Brief-Unified Protocol) workshop is effective for preventing posttraumatic stress and other psychological health symptoms in…
- Conditions
- PTSD, Alcohol Use Disorder, Depression, Anxiety
- Trial name
- PEER UP (NCT06290778)
- Testing
- Brief Unified Protocol, Psychoeducation
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
End Stage Liver Disease
Quantitative Liver Function Tests Using Cholates
As the treatments for liver disease and the availability of liver transplantation have progressed, the number of patients with end stage liver disease continues to increase.
- Trial name
- NCT01907074
- Testing
- Cholates
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Baylor Research Institute
Benign Prostatic Hyperplasia, Urinary Tract Infections
Role of Prophylactic Postoperative Antibiotics in HoLEP
The purpose of this study is to investigate whether prescribing a 3-day course of antibiotics after Holmium laser enucleation of the prostate (HoLEP) reduces the risk of urinary tract infection.
- Trial name
- NCT05274672
- Testing
- Nitrofurantoin, Cephalexin, Sulfamethoxazole Trimethoprim Combination
- Where
- 2 sites in United States
- Sponsor
- Baylor Research Institute
Opioid Use
Laparoscopic Transversus Abdominis Plane (TAP) Block to Reduce Post-operative Opioids
This study evaluates laparoscopic-guided TAP block for reducing opioid use after minimally invasive foregut and bariatric surgeries, comparing Bupivacaine HCL with Exparel®.
- Trial name
- NCT04655339
- Testing
- Bilateral abdominal Lap-TAP
- Where
- United States
- Sponsor
- Baylor Research Institute
Alzheimer Disease
Early Onset Alzheimer's Disease Genomic Study
The purpose of this study is to collect samples from patients with Early-Onset Alzheimer's disease (AD) and their immediate family members for molecular analysis.
- Trial name
- TGen (NCT03645993)
- Testing
- Genetic Testing
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Baylor Research Institute
Breast Cancer, Breast Neoplasms
Tirzepatide Weight Loss for MRD+ Early Breast Cancer
This trial aims to asses if tirzepatide-induced weight loss will lead to metabolic and hormonal changes in hormone receptor-positive (HR+), human epidermal growth factor receptor-negative (HER2-), node-positive (N+) high risk…
- Conditions
- Breast Cancer, Breast Neoplasms, Breast Cancers
- Trial name
- TRIM-EBC (NCT06517212)
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Baylor Research Institute
Breast Cancer
Bortezomib Followed by Pembrolizumab and Cisplatin in metTNBC
The hypothesis of this pilot trial is that administration of bortezomib will inhibit NHEJ in metastatic TNBC leading at the time of disease progression to metastases that are HR-deficient and sensitive to pembrolizumab and…
- Trial name
- NCT04265872
- Testing
- Bortezomib; pembrolizumab and cisplatin injections--bortezomib followed by pembro/cis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Baylor Research Institute
Mobility Limitation
Group Lifestyle Balance Adapted for Individuals With Impaired Mobility (GLB-AIM)
This study tested the effectiveness of the Group Lifestyle Balance™ (GLB) program adapted specifically for people with impaired mobility using standard behavioral approaches for weight loss.
- Trial name
- GLB-AIM (NCT03307187)
- Testing
- GLB Adapted for Individuals with Impaired Mobility
- Volunteers
- 67 people
- Sponsor
- Baylor Research Institute
Diabetes, Hypertension
The Integrated Population (I-POP) Health Trial
The primary aim of this study is to determine whether community health worker (CHW) navigation improves outcomes of chronic disease and chronic disease risk factors in a low-income, primarily ethnic minority population when…
- Conditions
- Diabetes, Hypertension, Chronic Kidney Diseases, Obesity
- Trial name
- I-POP (NCT04761016)
- Testing
- Usual Care, I-POP + CHW navigation
- Where
- United States
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Mild to Moderate Dementia
Assessing Feasibility of Prolonged Repetitive Near Infrared Light Stimulation in Early to Mid-Stage Dementia
This study will gather data to see if infrared and near infrared light frequency can increase the activity of brain cells and provide support for the cell's ability to repair and protect themselves against further damage.
- Trial name
- NCT03750409
- Testing
- Helmet
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Baylor Research Institute
Return to Sport
Clinical Assessment of Sports Exertion
The Clinical Assessment for Sports Exertion (CASE) addresses the physical performance of athletes by quantifying physiological and symptomatic responses to dynamic exertion.
- Trial name
- CASE (NCT05013307)
- Testing
- CASE
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Cardiac Surgery, Surgery
Management of Antiplatelet Regimen During Surgical Procedures
There are key differences today in clinical practice regarding perioperative management of post-PCI patients on DAPT undergoing NCS.
- Conditions
- Cardiac Surgery, Surgery, Percutaneous Coronary Intervention, Surgery--Complications
- Trial name
- MARS (NCT03981835)
- Where
- 5 sites in United States
- Volunteers
- 147 people
- Sponsor
- Baylor Research Institute
Metastatic Colon Cancer
Curcumin in Combination With 5FU for Colon Cancer
The purpose of this study is to test the safety and find the response rate of combining the dietary supplement, curcumin, with the standard of care, FDA-approved chemotherapy drug 5-fluorouracil (5FU, Adracil) and see what…
- Trial name
- NCT02724202
- Testing
- Curcumin, 5-flurorouracil
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Baylor Research Institute
Cardioembolic Stroke, Atrial Fibrillation
Left Atrial Appendage Closure With SentreHeart Lariat® Device
The study cohort will consist of up to 50 patients who are candidates for Left Atrial Appendage (LAA) closure in whom oral anticoagulation is contraindicated.
- Trial name
- Lariat (NCT02681042)
- Testing
- Left atrial appendage closure, SentreHeart Lariat®
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Baylor Research Institute
Stroke
Early Robotic Gait Training After Stroke
The ERA Stroke project will compare the effects of robotic gait training (RGT) and usual care (UC) gait training in patients in the subacute phase of stroke recovery undergoing inpatient rehabilitation at the Baylor Scott \&…
- Trial name
- ERA Stroke (NCT06430632)
- Testing
- Robotic Gait Training, Usual Care Gait Training
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Baylor Research Institute
Peripheral Arterial Disease
Multi-Center Registry for Peripheral Arterial Disease Interventions and Outcomes
XLPAD is an observational study designed to evaluate the effectiveness and use of stent and non-stent based therapies among PAD patients.
- Trial name
- XLPAD (NCT01904851)
- Where
- 24 sites in United States
- Volunteers
- 14,000 people
- Sponsor
- Baylor Research Institute
Patients Post-cardiothoracic Surgery
Robotic Exoskeletons in Acute Care Therapy
The goal of this clinical trial is to establish the safety, feasibility, and preliminary findings of overground robotic exoskeleton early ambulation (ORE-EA) compared to usual care early ambulation (UC-EA) in the rehabilitation…
- Trial name
- REACT-CVTS (NCT07353892)
- Testing
- Overground robotic exoskeleton early ambulation (ORE-EA), Usual care early ambulation (UC-EA)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Baylor Research Institute