Clinical trials: sponsored by Baylor Research Institute
Postpartum Hemorrhage
Does Cold Saline Used to Inflate a Balloon Tamponade Catheter More Significantly Reduce Blood Loss From Postpartum Hemorrhage Than Room Temperature Saline?
To determine if a balloon tamponade catheter filled with cold saline is more effective than a catheter filled with room temperature saline in controlling post partum hemorrhage.
- Trial name
- NCT02735733
- Testing
- Cold Bakri Balloon
- Volunteers
- healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Blood Loss, Dysfunctional Labor
Cooling the Uterus in C-section After Dysfunctional Labor
The objective of the study is to demonstrate whether cooling the uterine smooth muscle during cesarean section (following delivery of the fetus) will promote better uterine contraction and involution resulting in lower blood…
- Conditions
- Blood Loss, Dysfunctional Labor, Uterine Atony
- Trial name
- NCT02910115
- Testing
- Cold laparotomy sponges, Pitocin
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Intraoperative Pain
Management of Indwelling Labor Epidural Catheters for Cesarean Delivery
This is a prospective observational study that will survey patients who had an indwelling labor epidural catheter and subsequently underwent cesarean delivery.
- Trial name
- NCT07366307
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Epithelial Ovarian Cancer
Exploration of DNA Methylation as a Marker for Early Detection of High Grade Serous Epithelial Ovarian Cancer
The purpose of this study is to determine if there are markers in plasma that can be used to develop a diagnostic panel for early detection and diagnosis of high grade serous epithelial ovarian cancer.
- Trial name
- NCT03622385
- Testing
- DNA Methylation
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Posttraumatic Stress Disorder, Spinal Cord Injuries
Outcomes After Spinal Cord Injury (OASIS)
The study evaluates the effectiveness of Prolonged Exposure Therapy on a population of individuals with spinal cord injuries. Participants will be randomly assigned to either a treatment as usual or Prolonged Exposure therapy…
- Trial name
- NCT03624218
- Testing
- Prolonged Exposure Therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Baylor Research Institute
Heart Failure
Transplant of Redeemed Organs by Judicious Administration of New Direct-Acting Antivirals for Hepatitis-C Heart Recipients
This phase II, multi-center, open-label study will evaluate the safety and efficacy of utilizing HCV-positive donors for heart transplant in HCV-negative recipients treated with sofosbuvir 400 mg / velpatasvir 100 mg (Epclusa®).
- Trial name
- TROJAN-C (NCT03383419)
- Testing
- Epclusa
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- Baylor Research Institute
Transplant; Failure, Heart, Hepatitis C
The Hepatitis C Transplant Collaborative
In this study we seek to test the hypothesis that safety and clinical outcomes after cardiac transplantation utilizing HCV NAT+ donor organs as currently performed are acceptable.
- Trial name
- NCT04493385
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Heart Failure, Transplant; Failure, Heart
Cardiopulmonary Stress Testing (CPET) AlloSure Study
1. Cell-free DNA does not vary significantly as a function of the activity of immunologically quiescent cardiac transplant recipients, despite the metabolic demands of the transplanted organ.
- Trial name
- NCT04656080
- Testing
- CPET exercise testing
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Baylor Research Institute
Heart Transplant Failure and Rejection
Bioelectrical Impedance Spectroscopy in Heart Transplantation: Tracking Post-Transplant Changes in Body Composition and Correlation With Conventional Preoperative Risk Assessment Modalities
Patients with marginal physiologic reserve, severe frailty, and/or malnutrition may be regarded as unsuitable candidates for advanced cardiac replacement therapies.
- Trial name
- BIS (NCT03373279)
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Baylor Research Institute
Chronic Pancreatitis
Analysis of Graft Function Following Autologous Islet Transplantation
Analyze inflammatory markers and islet graft function through blood samples collected from subjects with chronic pancreatitis who undergo total pancreatectomy with auto islet transplantation.
- Trial name
- NCT03097185
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Baylor Research Institute
Copd
Outcomes of Once-Daily ICS/LABA/LAMA + PRN Respiratory Therapy Treatments in Hospitalized Patients With COPD Exacerbations
This is a single-center, prospective, open-label study evaluating outcomes of TRELEGY ELLIPTA (fluticasone furoate 100 mcg, umeclidinium 62.5 mcg, and vilanterol 25 mcg inhalation powder) on PRN nebulized short-acting beta…
- Trial name
- Sundial-COPD (NCT05292053)
- Testing
- TRELEGY ELLIPTA 100Mcg-62.5Mcg-25Mcg/Actuation Powder for Inhalation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Baylor Research Institute
High-grade Extra Pulmonary Neuroendocrine Cancer
TAS-102 in Extrapulmonary Neuroendocrine Carcinoma
The purpose of this study is to test the safety and efficacy of drug, TAS-102 (trifluridine/tipiracil), in patients with extrapulmonary (outside the lung) high-grade neuroendocrine cancer.
- Trial name
- TAS-102 NEC (NCT04042714)
- Testing
- All patients- TAS-102
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Baylor Research Institute
eHealth Literacy
eHealth Literacy Intervention for Spanish Speaking Older Adults in the US
The PI will assess the feasibility and acceptability of an eHealth literacy intervention with Spanish-preferred older adult Latinos.
- Trial name
- NCT07220395
- Testing
- eHiLLs
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Neonatal Hypoglycemia
The Feasibility of Cream for Treatment of Neonatal Hypoglycemia
Prolact CR (cream) is a fat supplement that is derived from pasteurized human donor milk. It has been utilized in babies who are born premature in the neonatal intensive care unit (NICU) setting to improve growth while avoiding…
- Trial name
- NCT07217483
- Testing
- Prolact CR for hypoglycemia
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Baylor Research Institute
Stroke
Cultural Modification of an Evidence Based Healthy Lifestyle Intervention for People Post Stroke Who Identify as Hispanic/Latino
The purpose of this trial is to examine weight loss for Hispanic/Latino people with stroke (CVA) who take part in a healthy lifestyle program that has been culturally modified for Hispanic/Latino people
- Trial name
- NCT06517459
- Testing
- Group Lifestyle Balance
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Baylor Research Institute
Spinal Cord Injuries, Obesity
Building an Evidence Base for Weight Loss Strategies Among Those With Chronic SCI-The GLB-SCI+
This study's overarching aim is to follow a systematic approach that incorporates community-based participatory research (CBPR) to develop a multi-component weight loss intervention that may yield significant effects for a…
- Conditions
- Spinal Cord Injuries, Obesity, Weight Loss, Diet Modification
- Trial name
- GLB-SCI+ (NCT03874988)
- Testing
- Portion-Controlled Meals, Enhanced Self-Monitoring, GLB-SCI
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Heart Transplant Rejection, Graft Failure
Phase II Study Evaluating the Efficacy of Tacrolimus Extended Release Tablets to Twice Daily Tacrolimus Dosing Regimen
This phase II, single-center, open-label study will evaluate the comparable efficacy of tacrolimus extended release tablets (Envarsus®) to the standard of care (SOC) twice daily tacrolimus (Prograf®) dosing regimen post-cardiac…
- Conditions
- Heart Transplant Rejection, Graft Failure, Compliance, Patient
- Trial name
- Veloxis (NCT03373227)
- Testing
- Envarsus
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Baylor Research Institute
Labor Pain
Analgesic Efficacy of a Multiport Versus Uniport Flexible Catheter for Labor Epidural Analgesia
The purpose of this study is to determine whether multiple ports improve the analgesic efficacy of flexible catheters used for the provision of epidural analgesia during the entire continuum of labor and delivery
- Trial name
- NCT01861821
- Testing
- Multiport flexible catheter, Uniport flexible catheter
- Where
- United States
- Volunteers
- 650 people
- Sponsor
- Baylor Research Institute
Liver Failure, Renal Failure
Assessment of Renal Function in Cirrhotic Patients
The purpose of this study is to help determine whether cystatin C is a more sensitive laboratory measurement for renal function in cirrhotic patients.
- Trial name
- NCT01895114
- Where
- United States
- Volunteers
- 213 people
- Sponsor
- Baylor Research Institute
Traumatic Brain Injury
Expanding Delivery of an Evidence-based Weight-loss Intervention to Enhance Access and Reach Underserved Groups After TBI
The goal of this clinical trial is to extend the accessibility of the Diabetes Prevention Program Group Lifestyle Balance (DPP-GLB) modified for people with TBI (GLB-TBI) to reduce health inequities and reach a broad and diverse…
- Trial name
- tGLB-TBI (NCT05699772)
- Testing
- Telehealth-delivered Group Lifestyle Balance for people with TBI (tGLB-TBI), Brain Health Group (BHG)
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Baylor Research Institute