Clinical trials: sponsored by Beijing Anzhen Hospital
AF - Atrial Fibrillation, Intracranial Hemorrhage, Spontaneous
SAfety and eFfectiveness of cathetER Ablation for Atrial Fibrillation With Intracranial Hemorrhage (SAFER-AF)
SAFER-AF is an investigator-initiated, multicenter, open-label, parallel-group trial comparing catheter ablation versus usual care in patients with atrial fibrillation and intracranial hemorrhage.
- Trial name
- NCT07316270
- Testing
- Catheter Ablation, Usual Care
- Where
- 7 sites in China
- Volunteers
- 646 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Artery Disease (CAD)
Study on Risk Factors and Prognostic Value of Non-target Lesion Progression in Patients With Coronary Artery Disease
The goal of this observational study is to explore the risk factors and prognostic value of non-target coronary lesion progression in patients aged 18-80 years with established coronary artery disease who are scheduled for repeat…
- Trial name
- NCT07748754
- Testing
- Progression of non-target vessels
- Where
- China
- Volunteers
- 1,400 people
- Sponsor
- Beijing Anzhen Hospital
Ventricular Tachycardia (VT), Structural Heart Disease
Ventricular Tachycardia：A Registry Study
Structural heart disease-related ventricular tachycardia (SHD-VT) is associated with substantial morbidity and mortality. Although catheter ablation, ICD therapy, antiarrhythmic drugs, and other treatment strategies are widely…
- Trial name
- NCT07149701
- Testing
- Standard Clinical Care
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Beijing Anzhen Hospital
Hip Fracture, MACE
AI-Based Risk Factor Analysis and Prediction Model of MACE in Elderly Hip Fracture Patients Postoperatively
This is a multicenter ambispective observational cohort study led by Beijing Anzhen Hospital, Capital Medical University, with China-Japan Friendship Hospital serving as the external validation center.
- Conditions
- Hip Fracture, MACE, Elderly, Perioperative Complications
- Trial name
- NCT07709377
- Where
- 2 sites in China
- Volunteers
- 600 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Heart Disease, Cognitive Impairment, Mild
Modifiable Risk Factors for Cognitive Dysfunction in Patients With Coronary Heart Disease
This prospective observational study aims to investigate the association between risk factors and cognitive function in patients with coronary heart disease (CHD), and to explore the underlying mechanisms involving metabolic…
- Trial name
- NCT07657624
- Where
- China
- Volunteers
- 2,352 people
- Sponsor
- Beijing Anzhen Hospital
Atrial Fibrillation (AF), Heart Failure and Reduced Ejection Fraction
Wearable Device-Assisted Remote Management to Improve Prognosis in Patients With Acute Heart Failure Complicated by Atrial Fibrillation: WARM-HF Trial (Stage 2)
With the advancement of wearable technology, continuous non-invasive monitoring of vital signs, arrhythmia burden, and physical status has become increasingly feasible.
- Trial name
- NCT07687862
- Testing
- wearable device based remote management (GDMT titration for HF, rhythm control and anticoagulation management for AF)
- Volunteers
- 818 people
- Sponsor
- Beijing Anzhen Hospital
Atrial Fibrillation (AF)
Wellbeing and Survival Improvement With Event Reduction by Ablation for Atrial Fibrillation in the Very Elderly
The WISER-AF trial is a multicenter, double-blind, sham-controlled, randomized controlled trial. It aims to evaluate the efficacy and safety of catheter ablation compared to a sham procedure in improving the quality of life…
- Trial name
- WISER-AF (NCT07403760)
- Testing
- Catheter Ablation
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Beijing Anzhen Hospital
Thoracoabdominal Aortic Aneurysm, Cardiopulmonary Bypass
CompaRison of FEmorofemoral Bypass and Left-Heart ByPass Techniques in Open Thoracoabdominal AortIc Aneurysm Repair
The study is a multicenter, two-arm, open-label, randomized, parallel-controlled trial, which plans to enroll 236 participants diagnosed with TAAA from 4 hospitals in China.
- Conditions
- Thoracoabdominal Aortic Aneurysm, Cardiopulmonary Bypass, Open Repair
- Trial name
- REPAIR (NCT07518251)
- Testing
- Thoracoabdominal aortic aneurysm repair under fCPB, Thoracoabdominal aortic aneurysm repair under LHB
- Where
- China
- Volunteers
- 236 people
- Sponsor
- Beijing Anzhen Hospital
HFrEF - Heart Failure With Reduced Ejection Fraction, AF - Atrial Fibrillation
Wearable Device-Assisted Remote Management in Atrial Fibrillation Complicated by Heart Failure: WARM-HF Trial
Patients with acute decompensated heart failure (HF) have a significantly high risk of death and HF re-hospitalization during the vulnerable phase post discharge.
- Trial name
- WARM-HF (NCT07411170)
- Testing
- Wearable Device-Assisted Intervention
- Volunteers
- 400 people
- Sponsor
- Beijing Anzhen Hospital
Postoperative Cognitive Dysfunction (POCD)
Cohort Study of Postoperative Cognitive Dysfunction After Off-Pump Coronary Artery Bypass Grafting
This prospective cohort study aims to investigate postoperative cognitive dysfunction in patients undergoing off-pump coronary artery bypass grafting. Eligible patients will be enrolled before surgery and followed after surgery.
- Trial name
- OPCAB-POCD (NCT07643194)
- Testing
- Off-Pump Coronary Artery Bypass Grafting
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Beijing Anzhen Hospital
Hemophagocytic Lymphohistiocytosis (HLH)
All-Trans Retinoic Acid for the Treatment of Hemophagocytic Lymphohistiocytosis
This study is designed to evaluate the safety and preliminary efficacy of all-trans retinoic acid (ATRA) as an initial treatment for patients with active hemophagocytic lymphohistiocytosis (HLH).
- Trial name
- NCT07626398
- Testing
- ATRA
- Volunteers
- 30 people
- Sponsor
- Beijing Anzhen Hospital
Atrial Fibrillation
Prospective Study on the Effectiveness and Safety of Bi-polar Pulse-field Tip-catheter Ablation for Atrial Fibrillation in China（POTENTIAL-AF）
POTENTIAL-AF is a prospective, multicentre, observational registry study evaluating the real-world effectiveness and safety of bi-polar pulse-field tip-catheter ablation (PFA) for atrial fibrillation (AF) in China.
- Trial name
- POTENTIAL-AF (NCT07627685)
- Testing
- Bi-polar Pulse-field Ablation (PFA) - LEAD-PFA System with PulsedFA catheter
- Where
- China
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
Atrial Fibrillation
Effectiveness of Patch-Electrocardiogram Recorders in Screening for Atrial Fibrillation in Elderly People in the Chinese Community
This prospective, multicenter, single-arm study evaluates the effectiveness of a single-lead patch electrocardiogram (ECG) recorder in screening for atrial fibrillation (AF) among community-dwelling elderly individuals aged ≥60…
- Trial name
- NCT07627672
- Testing
- Single-lead patch ECG recorder
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
Atrial Fibrillation (AF), Ventricular Tachycardia (VT)
Complex Arrhythmia Registry
This is a prospective, non-randomized, multicenter observational registry study designed to systematically evaluate the long-term efficacy and safety of catheter ablation for treating atrial fibrillation (AF) and ventricular…
- Trial name
- CAR (NCT07024927)
- Testing
- AF ablation, VT ablation
- Where
- 2 sites in China
- Volunteers
- 4,000 people
- Sponsor
- Beijing Anzhen Hospital
Heart Failure
Correlation and Prognostic Value of Body Composition, Cardiac Structure and Function in Patients With Different Heart Failure Subtypes
Heart failure (HF) refers to impaired cardiac function caused by various heart diseases. Patients commonly present with dyspnea, fatigue, edema and other symptoms, ranking among the leading causes of death from cardiovascular…
- Trial name
- NCT07619222
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
STEMI (ST Elevation MI), STEMI - ST Elevation Myocardial Infarction
Effect of Guanxinning Tablet on Coronary Microcirculation After Primary Percutaneous Coronary Intervention in Patients With Acute Myocardial Infarction
①Research objective: In a small sample population, through the pre - experimental method, explore and evaluate the effect of Guanxinning tablets on the coronary microcirculation after primary percutaneous coronary intervention…
- Conditions
- STEMI (ST Elevation MI), STEMI - ST Elevation Myocardial Infarction, STEMI, CMD
- Trial name
- NCT07621107
- Testing
- Guanxinning Tablet(GXNT)
- Volunteers
- 70 people
- Sponsor
- Beijing Anzhen Hospital
Atherosclerotic Cardiovascular Disease (ASCVD)
Target-Oriented Strategy of Ultra-Low LDL-C (<1.0 vs. 1.0-1.39 mmol/L) in Extreme-High-Risk ASCVD Patients: Clinical Benefit, Safety and Cost-Effectiveness Assessment
The goal of this clinical trial is to learn whether an ultra-low LDL-C target (<1.0 mmol/L) can improve clinical outcomes compared with a moderately low LDL-C target (1.0-1.39 mmol/L) in Chinese patients with extreme-high-risk…
- Trial name
- TARGET-EXTREME (NCT07615296)
- Testing
- Lipid-lowering therapy targeting LDL-C <1.0 mmol/L, Lipid-lowering therapy targeting LDL-C 1.0-1.39 mmol/L
- Where
- China
- Volunteers
- 6,000 people
- Sponsor
- Beijing Anzhen Hospital
Aortic Stenosis, Aortic Regurgitation
Active Post-Market Surveillance of Innovative Devices for Valvular Heart Disease
This prospective, multicenter, observational cohort study aims to establish a post-market registry framework to evaluate the real-world clinical applicability, long-term safety, and effectiveness of innovative heart valve devices…
- Conditions
- Aortic Stenosis, Aortic Regurgitation, Mitral Regurgitation, Tricuspid Regurgitation
- Trial name
- NCT07605624
- Testing
- Transcatheter Aortic Valve Replacement, Transcatheter Edge-to-Edge Repair, Transcatheter Tricuspid Valve Annuloplasty
- Where
- China
- Volunteers
- 5,500 people
- Sponsor
- Beijing Anzhen Hospital
ECMO, High-risk PCI
Standby Cannulated ECMO for High-Risk Percutaneous Coronary Intervention
The goal of this multicenter, randomized trial is to compare standby cannulated ECMO versus prophylactic ECMO in patients undergoing high-risk percutaneous coronary intervention (PCI).
- Trial name
- ECMO-READY (NCT06274411)
- Testing
- Standby cannulated ECMO, Prophylactic ECMO
- Where
- China
- Volunteers
- 176 people
- Sponsor
- Beijing Anzhen Hospital
Cardiac Surgical Procedures, Cardiopulmonary Bypass
Artificial Intelligence for Ulinastatin Responder Outcome & Risk Assessment in CPB
This is a multicenter, retrospective, real-world observational study aimed at developing and validating an artificial intelligence-based tool for identifying ulinastatin treatment responders and risk stratification in cardiac…
- Conditions
- Cardiac Surgical Procedures, Cardiopulmonary Bypass, Systemic Inflammatory Response Syndrome, Multiple Organ Dysfunction Syndrome
- Trial name
- AURORA (NCT07583290)
- Testing
- ulinastatin
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Beijing Anzhen Hospital