Clinical trials: sponsored by Beijing Friendship Hospital
Mycoplasma Pneumoniae Pneumonia
Development and Validation of an Early Prediction Model for Severe Mycoplasma Pneumoniae Pneumonia in Children
Pneumonia is a major threat to the health of children. Mycoplasma pneumoniae infection is a core cause of pediatric pneumonia, and the incidence of severe mycoplasma pneumoniae pneumonia (SMPP) has increased in recent years.
- Trial name
- NCT07333833
- Testing
- medical history taking, blood test, pulmonary ultrasound
- Where
- China
- Volunteers
- 964 people
- Sponsor
- Beijing Friendship Hospital
Gastric Cancer (GC), Gastric Cancer (Diagnosis)
The Application of Extracellular Vesicle Detection in Gastric Juice Based on Metamaterial Sensing in the Diagnosis of Gastric Cancer and Related Diseases
After obtaining informed consent from the patients, all the medical history and treatment records of the patients who underwent gastroscopy since the onset of the disease, as well as gastric fluid samples, including laboratory…
- Trial name
- NCT07332104
- Testing
- In vitro surface plasmon resonance detection
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
Gastric Cancer (GC), Gastroesophageal Junction Cancer
Iparomlimab and Tuvonralimab (QL1706) Combined With Chemotherapy for Previously Untreated Advanced or Metastatic Gastric or Gastroesophageal Junction Cancer
The goal of this Phase II clinical trial is to evaluate the efficacy and safety of Iparomlimab and Tuvonralimab (QL1706) combined with SOX chemotherapy (S-1 plus Oxaliplatin) in patients with previously untreated advanced or…
- Conditions
- Gastric Cancer (GC), Gastroesophageal Junction Cancer, Advanced Gastric Cancer, Metastatic Gastric Cancer
- Trial name
- NCT07315854
- Testing
- Iparomlimab and Tuvonralimab (QL1706), SOX Chemotherapy
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Beijing Friendship Hospital
Hernia, Hiatal, GERD (Gastroesophageal Reflux Disease)
TLSA Versus TBSA Surgical Approach for Hiatal Hernia With Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD), characterized by pathological reflux of gastric contents, affects 10%-20% of the global population with Western predominance and escalating incidence over recent decades.
- Trial name
- NCT07252115
- Testing
- Laparoscopic total left-sided surgical approach, Laparoscopic traditional bilateral approach
- Where
- 2 sites in China
- Volunteers
- 143 people
- Sponsor
- Beijing Friendship Hospital
Obesity, Hypertension
Tongzhou Cohort Study
Long-term Impact of Overweight/Obesity and Hypertension on Cardiovascular Risk in Middle-aged and Elderly Adults
- Trial name
- NCT05156580
- Testing
- No intervention
- Where
- China
- Volunteers
- 31,080 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
Drug-induced Liver Injury
A Prognostic Model for Drug-induced Liver Injury in China
A prospective, multi-center, non-interventional cohort study is going to conduct to explore the clinical characteristics, culprit drug(s) or herb(s), outcomes and risk factors of Drug-induced liver injury (DILI) in China and…
- Trial name
- DILI-PM (NCT05060289)
- Where
- 13 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Beijing Friendship Hospital
Primary Biliary Cholangitis (PBC), Long-term Outcomes
PBC Long-term Outcomes Study
Primary biliary cholangitis (PBC) is an autoimmune liver disease predominantly affecting middle-aged women. While historically it was deemed rare, advancements in specific auto-antibody tests have led to increased recognition of…
- Conditions
- Primary Biliary Cholangitis (PBC), Long-term Outcomes, Prognosis, Multicenter Prospective Study
- Trial name
- NCT07149675
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Beijing Friendship Hospital
Severe Obesity
Mazdutide as Adjuvant Therapy Following Sleeve Gastrectomy in Severe Obesity
The SMART study is a 96-week, multicenter, randomized, double-blind, placebo-controlled superiority clinical trial. A total of 256 severe obesity patients are randomized 1:1 to either receive the bariatric surgery plus GCG/GLP-1…
- Trial name
- SMART (NCT07135141)
- Testing
- Sleeve gastrectomy plus early mazdutide initiation
- Where
- 14 sites in China
- Volunteers
- 256 people
- Sponsor
- Beijing Friendship Hospital
Decompensated Cirrhosis, Hepatitis B Virus (HBV) Infection
A Study to Predict Recompensation in Patients With Decompensated Cirrhosis Using Spleen Stiffness and Simple Blood Tests
The goal of this observational study is to learn if spleen stiffness and other non-invasive markers can help predict recompensation in people with decompensated cirrhosis who are receiving effective treatment for the cause of…
- Conditions
- Decompensated Cirrhosis, Hepatitis B Virus (HBV) Infection, Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), Alcohol-Related Liver Disease
- Trial name
- LEAD-2 (NCT07087041)
- Where
- 28 sites in China
- Volunteers
- 735 people
- Sponsor
- Beijing Friendship Hospital
Flurbiprofen Axetil, Preemptive Analgesia
Effect of Preemptive Analgesia With Flurbiprofen Axetil on Perioperative Sleep Quality and Postoperative Pain in Patients Undergoing Laparoscopic Gynecological Surgery.
In humans and animals, circadian rhythm sleep cycle is an important function to maintain and regulate basic physiological homeostasis, such as cognitive function, glucose metabolism, memory consolidation, immune function and…
- Conditions
- Flurbiprofen Axetil, Preemptive Analgesia, Postoperative Pain, Perioperative Sleep Quality
- Trial name
- NCT04611763
- Testing
- Flurbiprofen axetil preoperatively, Flurbiprofen axetil postoperatively
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Beijing Friendship Hospital
Metabolic Dysfunction Associated Steatotic Liver Disease, Compensated Cirrhosis
Prognostic Model for MASLD Related Cirrhosis
This study enrolled 228 patients with MASLD-related cirrhosis confirmed by histopathology or clinical diagnosis. Follow-up was conducted every 3-6 months.
- Trial name
- NCT07082751
- Testing
- Lifestyle Guidance
- Where
- 9 sites in China
- Volunteers
- 228 people
- Sponsor
- Beijing Friendship Hospital
Lumbar Spinal Stenosis
Percutaneous Unilateral Biportal Endoscopy Versus Uniportal Endoscopy for Lumbar Spinal Stenosis: Study Protocol
A prospective study aimed to compare the efficacy and safety of Unilateral biportal endoscopic (UBE) technique and uniportal endoscopic (UE) technique for treating patients with lumbar spinal stenosis (LSS).
- Trial name
- NCT06365229
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Beijing Friendship Hospital
Choledocholithiasis With Acute Cholangitis
Effectiveness and Safety of Single-session Endoscopic Stone Extraction
This is a prospective study, including approximately 64 patients with acute cholangitis accompanied with choledocholithiasis at Beijing Friendship Hospital.
- Trial name
- NCT06349954
- Testing
- single-session ERCP, two-session ERCP
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Beijing Friendship Hospital
Degenerative Spondylolisthesis, Lumbar Spinal Stenosis
Effect of Degenerative Spondylolisthesis on the Clinical Outcome of Unilateral Biportal Endoscopy for Lumbar Spinal Stenosis: Study Protocol
A single-center, prospective cohort trial aims to provide stronger evidence regarding the impact of degenerative spondylolisthesis on the clinical outcome of unilateral biportal endoscopy for lumbar spinal stenosis
- Trial name
- NCT06394089
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Beijing Friendship Hospital
Lung Cancer, Sarcoidosis
Comparison of Three Different Puncture Techniques in EBUS-TBNA
The purpose of this study was to compare the accuracy and sensitivity of slow-pull capillary technique, traditional suction aspiration and non negative pressure puncture in the diagnosis of mediastinal and/or hilar lymph node…
- Conditions
- Lung Cancer, Sarcoidosis, Tuberculosis
- Trial name
- NCT05628454
- Testing
- Endobronchial ultrasound-guided transbronchial needle Slow-pull capillary sampling, Endobronchial ultrasound-guided transbronchial needle aspiration, Endobronchial ultrasound-guided transbronchial needle capillary sampling
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Beijing Friendship Hospital
Locally Advanced Rectal Cancer
Neoadjuvant Chemoradiotherapy Combined With PD-1 Inhibitor and Thymalfasin for pMMR/MSS Locally Advanced Mid-low Rectal Cancer
This is an open, prospective, multi-center, single-arm phase II clinical study assessing the efficacy and safety of neoadjuvant chemoradiotherapy combined with PD-1 inhibitor and thymalfasin in patients with pMMR/MSS locally…
- Trial name
- NCT06056804
- Testing
- capecitabine, tislelizumab, thymalfasin
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- Beijing Friendship Hospital
Chronic Hepatitis B Virus (HBV) Infection, Liver Fibrosis
Non-Invasive Model for Fibrosis Regression in HBV Patients
A total of 1000 chronic hepatitis B (CHB) patients with liver biopsy performed at least 1 year after antiviral therapy are retrospectively enrolled. All the patients received NAs treatment.
- Trial name
- NCT06874127
- Testing
- Nucleos(t)ide Analogs (NA)
- Where
- China
- Volunteers
- 1,100 people
- Sponsor
- Beijing Friendship Hospital
Gastric Cancer Stage
Expanded Indications of Endoscopic Submucosal Dissection for Early Gastric Cancer in China
Background: The main treatment methods for early gastric cancer (EGC) include endoscopic submucosal dissection (ESD) and radical gastrectomy.
- Trial name
- NCT06869356
- Testing
- D2 gastrectomy
- Where
- China
- Volunteers
- 1,291 people
- Sponsor
- Beijing Friendship Hospital
Gastric Cancer
Plasma Metabolic Biomarkers for Gastric Cancer Diagnosis
The aim of this observational study is to comprehensively analyze the metabolites in plasma samples from gastric cancer patients using advanced mass spectrometry detection technology, in conjunction with both broad-spectrum and…
- Trial name
- NCT06109805
- Testing
- Gastric cancer
- Where
- 4 sites in China
- Volunteers
- 1,706 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
MCRC
"Thymalfasin Immunotherapy Study with Triple Regimen in Advanced MSS/pMMR Colorectal Cancer"
This is a multicenter, open-label, prospective, randomized controlled Phase II clinical study. All eligible subjects will be randomly assigned in a 1:1 ratio to either the triple therapy group or the double therapy group.
- Trial name
- THYMI (NCT06829355)
- Testing
- Thymalfasin (Thymosin alpha 1, Ta1), Regorafenib (BAY 73-4506), Tislelizumab (BGB-A317)
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Beijing Friendship Hospital