Clinical trials: sponsored by Beijing Tiantan Hospital
Basilar Artery Occlusion, Endovascular Treatment
A Comparison of Contact Aspiration Versus Stent Retriever for Acute Basilar Artery Occlusion
Compare the effectiveness and safety of contact aspiration (CA) and stent retriever (SR) in acute ischemic stroke patients with basilar artery occlusion.
- Trial name
- ANGEL-COAST (NCT05615038)
- Testing
- Contact aspiration Thrombectomy, Stent retriever thrombectomy
- Where
- 6 sites in China
- Volunteers
- 338 people
- Sponsor
- Beijing Tiantan Hospital
Zoster; Herpes, Trigeminal Neuralgia (Etiology)
Esketamine Combined Pulsed Radiofrequency for Acute/Subacute Zoster-associated Trigeminal Neuralgia
To assess the 1-month effects and safety of esketamine combined PRF and standardized treatment to relieve pain in patients with acute/subacute zoster-related trigeminal neuralgia(ZRTN).
- Trial name
- NCT06890897
- Testing
- Esketamine group, PRF group
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Beijing Tiantan Hospital
Postherpetic Neuralgia
Esketamine Combined Pregabalin and Duloxetine for Postherpetic Neuralgia
To assess the 1-week effects and safety of esketamine in combination with pregabalin and duloxetine to relieve pain in patients with postherpetic Neuralgia(PHN).
- Trial name
- NCT06896994
- Testing
- esketamine group, control group
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Beijing Tiantan Hospital
Vagus Nerve Stimulation
Transcutaneous Auricular Vagus Nerve Stimulation Prevents Postoperative Delirium in Elderly Patients
According to the 3D-CAM scale, evaluate the incidence of Postoperative Delirium within 5 days after surgery in elderly patients receiving taVNS.The results are expected to provide evidence of the safety and efficacy of…
- Trial name
- Vnstar (NCT06421077)
- Testing
- transauricular auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 1,776 people
- Sponsor
- Beijing Tiantan Hospital
Visual Evoked Potentials
Effects of Desflurane-propofol Balanced Anesthesia on Visual Evoked Potentials Monitoring
Intraoperative flash visual evoked potentials (FVEPs) can be used to monitor the integrity of the visual pathway in real-time during surgeries, and is to prevent the damage and deterioration of visual function caused by visual…
- Trial name
- NCT05465330
- Testing
- Desflurane, Desflurane, Propofol
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Beijing Tiantan Hospital
Gene Mutation
Safety and Tolerance of RAG-17 in Amyotrophic Lateral Sclerosis Patients With SOD1 Gene Mutation
The goal of this clinical trial is to evaluate the safety, tolerability and pharmacokinetics of RAG-17 in adult amyotrophic lateral sclerosis (ALS) patients with SOD1 mutation.
- Trial name
- CREATION (NCT05903690)
- Testing
- RAG-17
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Beijing Tiantan Hospital
Deep Intracerebral Hemorrhage (ICH)
Neuronavigation-assisted Stereotactic Puncture With Tenecteplase for Acute Intracerebral Hemorrhage
Background Minimally invasive puncture surgery followed by thrombolysis has been proven to be an effective approach for managing hypertensive intracerebral hemorrhage.
- Trial name
- NAS-TNK (NCT06868511)
- Testing
- Neuronavigation-assisted Stereotactic Minimally Invasive Puncture Combined with Tenecteplase, Standard medical treatment
- Where
- China
- Volunteers
- 732 people
- Sponsor
- Beijing Tiantan Hospital
Craniofacial Dystonia, Deep Brain Stimulation
Deep Brain Stimulation for Idiopathic Craniofacial Dystonia: GPi or STN
MEIGES is a prospective, multicenter, randomized controlled clinical trial with the primary hypothesis that, STN-DBS is non-inferior to GPi-DBS for motor symptoms improvements at 365 days postoperatively in patients with…
- Trial name
- MEIGES (NCT05416905)
- Testing
- STN-DBS, GPi-DBS
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Beijing Tiantan Hospital
Healthy Adult Male and Female Volunteers
Safety and Pharmacokinetics of Y-4 Tablets in Healthy Subjects
Y-4 is a new fixed-dose combination drug product containing two active ingredients of pregabalin and riluzole. The primary objective is to evaluate the safety and tolerability of Y-4 tablets in Chinese healthy adult subjects…
- Trial name
- NCT06935682
- Testing
- Y-4 tables
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Healthy Male and Female Subjects
Pharmacokinetics of Y-4 Tablets With Pregabalin Capsules and Riluzole Tablets in Chinese Healthy Subject
Y-4 is a new fixed-dose combination drug product containing two active ingredients of pregabalin and riluzole. The objective of the trial is to compare pharmacokinetic characteristics of Y-4 tablets with pregabalin capsules…
- Trial name
- NCT06935721
- Testing
- Y-4 tablet, Pregabalin capsule, Riluzole tablet
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Cerebrovascular Disease
Multi-Modality Imaging Standard Cohort Of Cerebrovascular Disease
The aim of this study is to establish a multi-center and multi-modality imaging standard cohort of cerebrovascular disease, analyze the potential mechanisms affecting the prognosis of cerebrovascular disease based on a variety of…
- Trial name
- NCT06925178
- Where
- China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Postherpetic; Neuralgia, Trigeminal (Etiology)
Esketamine Combined With PRF for Trigeminal Postherpetic Neuralgia
This trial's primary objective is to compare the analgesic efficacy of esketamine in combination with pulsed radiofrequency (PRF) against that of PRF monotherapy in patients with trigeminal postherpetic neuralgia (TPHN).
- Trial name
- NCT06914180
- Testing
- esketamine group, control group
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Beijing Tiantan Hospital
Postherpetic Neuralgia
Esketamine Combined With PRF of DRG for Postherpetic Neuralgia
This trial's primary objective is to compare the analgesic efficacy of esketamine in combination with pulsed radiofrequency (PRF) of dorsal root ganglion(DRG) against that of PRF monotherapy in patients with postherpetic…
- Trial name
- NCT06914193
- Testing
- esketamine+PRF treatment group, PRF treatment group
- Where
- China
- Volunteers
- 186 people
- Sponsor
- Beijing Tiantan Hospital
Herpes Zoster
Esketamine Combined With PRF of DRG for Acute/Subacute Zoster-associated Pain
To assess the 1-month effects and safety of esketamine - PRF -standardized drug treatment against PRF -standardized drug treatment acute/subacute zoster-associated pain (ZAP) patients.
- Trial name
- NCT06914206
- Testing
- esketamine group, PRF group
- Where
- China
- Volunteers
- 184 people
- Sponsor
- Beijing Tiantan Hospital
Spontaneous Intracerebral Hemorrhage
Early-Start Antiplatelet Treatment After Neurosurgery in Patients With Spontaneous Intracerebral Hemorrhage
This study is a multicenter, prospective, open-label, endpoint-blind, randomized controlled study.Patients receiving surgical treatment for SICH were divided into groups using the random machine method.
- Trial name
- NCT04820972
- Testing
- Antiplatelet Agents
- Where
- China
- Volunteers
- 269 people
- Sponsor
- Beijing Tiantan Hospital
Intracranial Aneurysm
Establishment of Online Registration Platform for Unruptured Intracranial Aneurysms Based on Regional Medical Centers in China and Population Follow-up Study (Phase Ⅱ)
Intracranial aneurysm is the main cause of subarachnoid hemorrhage, and the incidence of subarachnoid hemorrhage in Chinese population is about 5%.
- Trial name
- NCT05608122
- Testing
- Obervation
- Where
- China
- Volunteers
- 3,740 people
- Sponsor
- Beijing Tiantan Hospital
Subarachnoid Hemorrhage, Aneurysmal, Cerebrocardiac Syndrome
Mechanisms of Brain-Heart Injury of Post-Intracranial Hemorrhage
Intracranial hemorrhage is a condition characterized by high mortality rates and suboptimal functional outcomes. It precipitates both direct brain injury and subsequent secondary injuries, including delayed cerebral ischemia…
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Cerebrocardiac Syndrome, Mass Spectrometry, Heart Failure
- Trial name
- NCT06906432
- Testing
- Multi-disciplinary assessment
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Trigeminal Neuralgia, Idiopathic, PRP
The Efficacy and Safety of Pulsed Radiofrequency Combined With Platelet-rich Plasma for the Trigeminal Neuralgia
Trigeminal neuralgia (TN), characterized by brief, recurrent paroxysms of lancinating pain in the distribution of 1 or more branches of the trigeminal nerve (fifth cranial nerve [CNV]), is one of the most common, severe forms of…
- Trial name
- NCT06472323
- Testing
- PRF+PRP, PRF
- Where
- China
- Volunteers
- 270 people
- Sponsor
- Beijing Tiantan Hospital
Cerebrovascular Disease
Application of QDSA Platform in Cerebrovascular Diseases
Cerebrovascular diseases pose a major global public health challenge, characterized by exceptionally high mortality and disability rates, with their pathogenesis closely linked to hemodynamic abnormalities.
- Trial name
- RADAR (NCT06902415)
- Testing
- QDSA (Quantitative Digital Subtraction Angiography)
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Beijing Tiantan Hospital
Asymptomatic Carotid Artery Stenosis
Efficacy and Safety Study of Endovascular Treatment of Asymptomatic Carotid Artery Stenosis
This study is a multicenter, prospective, open-label, endpoint-blinded, randomized controlled trial designed to evaluate the safety and efficacy of endovascular stenting combined with optimal medical therapy versus optimal…
- Trial name
- NCT06899399
- Testing
- Endovascular treatment, Best medical treatment
- Where
- China
- Volunteers
- 982 people
- Sponsor
- Beijing Tiantan Hospital