Clinical trials: sponsored by Beijing Tiantan Hospital
Cerebral Small Vessel Diseases, Hereditary
Hereditary Cerebral Small Vessel Diseases Registry-Trial Ready Cohort
We took hereditary cerebral small vessel disease (hCSVD) patients as our main subjects, aiming to establish a platform for a comprehensive evaluation and long-term follow-up.
- Trial name
- HCSVD-TRC (NCT06512376)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Beijing Tiantan Hospital
Carotid Stenosis, Cognitive Impairment
Cognitive Improvement After Carotid Stenting in Hyperbaric Oxygen Therapy Trial
The purpose of CARE-HBOT study is to evaluate whether patients with symptomatic severe carotid artery stenosis with cognitive impairment who underwent hyperbaric oxygen therapy plus standard medical treatment after stent…
- Conditions
- Carotid Stenosis, Cognitive Impairment, Hyperbaric Oxygen Therapy, Stent Implantation
- Trial name
- NCT05980195
- Testing
- Hyperbaric oxygen therapy, Standard medical treatment, Risk factor management
- Volunteers
- 90 people
- Sponsor
- Beijing Tiantan Hospital
Ischemic Stroke, Acute, TIA
Tirofiban for Patients With intraCranial Artery Stenosis and High-risk Acute Non-disabling Cerebrovascular Events(CHANCE-4）
This is a multicenter, double-blind, double-dummy, randomized clinical trial comparing the efficacy and safety of tirofiban versus placebo in preventing recurrence of stroke for patients with intracranial artery stenosis and…
- Conditions
- Ischemic Stroke, Acute, TIA, Symptomatic Intracranial Artery Stenosis
- Trial name
- NCT06319846
- Testing
- Tirofiban
- Where
- 5 sites in China
- Volunteers
- 4,674 people
- Sponsor
- Beijing Tiantan Hospital
Vagus Nerve Stimulation
Transauricular Vagal Nerve Stimulation Improves Postoperative Delirium in Elderly Patients
To investigate the efficacy and safety of perioperative Transauricular vagal nerve stimulation in improving Postoperative Delirium in elderly patients undergoing elective surgery Lay the groundwork for a Phase III study.
- Trial name
- Vnstar-IIa (NCT06421090)
- Testing
- Transauricular Vagal Nerve Stimulation
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Beijing Tiantan Hospital
Ischemic Stroke, TIA
Colchicine in High-risk Patients With Acute Minor-to-moderate Ischemic Stroke or Transient Ischemic Attack (CHANCE-3)
This study is a multicentre, randomized, double-blind, placebo-controlled, investigator-sponsored study that aims to investigate the efficacy of colchicine in preventing recurrent stroke in the patients with acute…
- Trial name
- NCT05439356
- Testing
- Colchicine
- Where
- 244 sites in China
- Volunteers
- 8,343 people
- Sponsor
- Beijing Tiantan Hospital
Prolonged Disorders of Consciousness
Effects of Esketamine on Consciousness-related Brain Network Characteristics in Patients With Prolonged Disorders of Consciousness
Prolonged disorders of consciousness (pDoC) are pathologies in which there is a loss of consciousness for more than 28 days. The number of patients with pDoC is increasing as the level of critical care treatment and monitoring…
- Trial name
- NCT06473285
- Testing
- Drug: Esketamine (Continuous infusion)
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Beijing Tiantan Hospital
Carotid Stenosis
Risk Prediction Model for Cerebrovascular Events in Carotid Artery Stenosis
Atherosclerotic carotid artery stenosis is a major cause of stroke, and early identification of high-risk patients combined with surgical intervention can significantly reduce stroke risk.
- Trial name
- NCT06452173
- Testing
- Plasma, carotid high-resolution magnetic resonance imaging
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Beijing Tiantan Hospital
Glioma
Study on Radiogenomics Features Associated With Radiochemotherapy Sensitivity in Gliomas
The MRI data were collected from patients with gliomas before surgery, 2 weeks before initiating radiochemotherapy, 1 month after completing the radiotherapy (for lower-grade gliomas, LGG), or 4 and 10 months after completing the…
- Trial name
- NCT06454097
- Testing
- Assess the response glioma to radiochemotherapy using radiogenomics-based AI model
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Tiantan Hospital
Cerebrovascular Disease
Improvement of Medical Quality and Outcomes Through Intelligent Management and Decision System of Cerebrovascular Diseases Based on Hospital Information System
This study applied a cerebrovascular disease organizational management and decision system based on hospital information system, aiming to verify the effect of intervention and management after stroke on improving the functional…
- Trial name
- NCT06452888
- Testing
- Clinical decision support system., no intervention
- Volunteers
- 3,540 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke
Y-3 Injection in the Treatment of Acute Ischemic Stroke Phase II Clinical Trial
The objective of this clinical trial was to explore the efficacy and safety of Y-3 injection at different doses in patients with acute ischemic stroke within 48 hours of onset.
- Trial name
- NCT06429384
- Testing
- Y-3 Injection/Y-3 blank injection
- Where
- 30 sites in China
- Volunteers
- 240 people
- Sponsor
- Beijing Tiantan Hospital
GBM, DIPG Brain Tumor
Clinical Study of Allogeneic Vγ9Vδ2 T Cells in the Treatment of Brain Malignant Glioma
Primary brain malignant tumor has become the first lethal tumor in children and young adults, and the treatment is limited, and the prognosis of patients is poor.
- Conditions
- GBM, DIPG Brain Tumor, Medulloblastoma
- Trial name
- CSAγδTBMG (NCT06396481)
- Testing
- Vγ9Vδ2 T cell
- Where
- China
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Advanced Parkinson's Disease, Refractory Epilepsy
An Automated Navigation System for Deep Brain Electrode Implantation
1. Analysis of the correlation between imaging and electrophysiological signals. 2. Real time analysis method for optimal implantation position. 3. Simultaneous Imaging and electrophysiology navigation. 4.
- Conditions
- Advanced Parkinson's Disease, Refractory Epilepsy, Obsessive-compulsive Disorder
- Trial name
- NCT06396494
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Tiantan Hospital
Amyotrophic Lateral Sclerosis
Nerve Growth Factor Encapsulated With 2-methacryloyloxyethyl Phosphorylcholine Nanocapsules in the Treatment of Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is one of the most lethal neurodegenerative diseases, with most patients dying from respiratory failure 3-5 years after the onset.
- Trial name
- NATURAL (NCT06391645)
- Testing
- Nerve Growth Factor
- Volunteers
- 60 people
- Sponsor
- Beijing Tiantan Hospital
Ischemic Stroke, Acute
Teneteplase Reperfusion Therapy in Acute Ischemic Cerebrovascular Events-III
The trial is a phase 3, multicenter, prospective, randomized, open-label, blinded-endpoint (PROBE) controlled design. Patients with acute ischemic stroke due to anterior circulation large vessel occlusion within 4.5-24 hours from…
- Trial name
- TRACE III (NCT05141305)
- Testing
- tenecteplase (0.25 mg/kg, Max 25 mg), standard medical treatment
- Where
- China
- Volunteers
- 516 people
- Sponsor
- Beijing Tiantan Hospital
Stroke, Acute Ischemic
Y-3 Injection Through Skull Bone Marrow in the Treatment of Acute Malignant Middle Cerebral Artery Infarction (SOLUTION)
The mortality of malignant middle cerebral artery infarction (mMCAI) is up to 80%, while current available treatment is limited.
- Trial name
- NCT05849805
- Testing
- Intracalvaria bone marrow injection, Conventional treatment
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Tiantan Hospital
Chronic Subdural Hematoma
Association Between Dietary Factors and Chronic Subdural Hematoma (DISH)
A prospective, multicenter, case control trial is designed to compare difference in dietary and nutritional factors in patients with and without chronic subdural hematoma.
- Trial name
- DISH (NCT05599217)
- Testing
- Dietary and nutritional questionnaire, Neurological function, cognitive function, and life quality assessment, Peripheral blood test
- Where
- 4 sites in China
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Chronic Subdural Hematoma, Anesthesia
Nerve Block Anesthesia Combined With Sedative Anesthesia Versus General Anesthesia in Surgery for CSDH
A prospective, multicenter, randomized controlled trial is designed to evaluate the safety of nerve block anesthesia combined with sedative anesthesia versus general anesthesia during burr hole craniostomy with drainage for…
- Trial name
- NCT05888389
- Testing
- Cranial Nerve Block Anesthesia Combined With Sedative Anesthesia, General Anesthesia
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Beijing Tiantan Hospital
Pain, Postoperative
Preemptive Co-infiltration of Dexamethasone Palmitate With Ropivacaine for Postoperative Pain in Major Spinal Surgery
Patients undergoing major spinal surgery usually experience moderate-to-severe postoperative pain. Inadequate pain control may lead to severe complications.
- Trial name
- NCT05693467
- Testing
- Dexamethasone palmitate emulsion(DXP) plus ropivacaine, Ropivacaine alone
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Beijing Tiantan Hospital
Intracranial Aneurysm
An Early Warning Model of Unfavorable Outcomes Following Endovascular Interventional Treatment of Intracranial Aneurysm
Endovascular treatment has become one of the primary treatment methods for intracranial aneurysms. The unfavorable outcomes during follow-up included aneurysm recurrence and long-term incomplete-occlusion, which would bring a…
- Trial name
- NCT06364293
- Testing
- Observational design does not include interventional behavior.
- Where
- China
- Volunteers
- 750 people
- Sponsor
- Beijing Tiantan Hospital
Recurrent Glioblastoma
Tris-CAR-T Cell Therapy for Recurrent Glioblastoma
This is a Phase 1 study of recurrent glioblastoma locoregional adoptive therapy with autologous peripheral blood T cells lentivirally transduced to express a dual-target, truncated IL7Ra modified chimeric antigen receptor (CAR)…
- Trial name
- NCT05577091
- Testing
- Inverse correlated dual-target, truncated IL7Ra modified CAR -expressing autologous T-lymphocytes.
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Beijing Tiantan Hospital