Clinical trials: sponsored by Beijing Tiantan Hospital
Pain, Postoperative
Effect of the Peri-incisional Multimodal Cocktail Infiltration on Postcraniotomy Headache
Postcraniotomy headache (PCH) has been underestimated for the past decades. However, current treatments for PCH are either considered insufficient or accompanied by severe side-effects.
- Trial name
- NCT03915639
- Testing
- Peri-incisional injection
- Volunteers
- 100 people
- Sponsor
- Beijing Tiantan Hospital
Vagus Nerve Stimulation
Multi-device Testing for Autonomic Nervous System Stimulation
The Vagus nerve (VN) serve as an "unconscious inner brain" that integrates messages from the body and provides metabolic homeostatic regulation to various organs.In this study the investigators want to compare different ways to…
- Trial name
- NCT04341649
- Testing
- Manual Head Massage, BREO Helmet Massager, Low Laser Therapy (LLT)
- Where
- China
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Healthy Subjects
PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events
The objective of this study is to characterize the prevalence of clinical or subclinical polyvascular lesions and 4-year progression rate of plaque in intracranial and carotidal arteries in a Chinese community population using…
- Trial name
- PRECISE (NCT03178448)
- Where
- 2 sites in China
- Volunteers
- 3,067 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
AVM - Cerebral Arteriovenous Malformation, Language
Mechanism of Aphasia and Recovery of Language After the Injury of Geschwind's Territory: a Study Based on the Brain Network Analysis
At present, functional imaging studies have suggested that the Geschwind's territory (the inferior parietal lobe) is an important language area. It is the hub for semantics and phonetic language processing.
- Trial name
- NCT04295980
- Testing
- Surgical removal of the BAVMs
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Cerebral Arteriovenous Malformation
Lovastatin for Treatment of Brain Arteriovenous Malformations
The purpose of this pilot study is to evaluate the disease-modifying efficacy of lovastatin in patients with brain arteriovenous malformation.
- Trial name
- NCT04297033
- Testing
- Lovastatin
- Where
- China
- Volunteers
- 1,244 people
- Sponsor
- Beijing Tiantan Hospital
Pain, Postoperative, Post-Craniotomy Headache
Pre-emptive Scalp Infiltration With Dexamethasone Plus Ropivacaine for Postoperative Pain After Craniotomy
A majority of patients would suffer from moderate-to-severe postoperative pain after undergoing craniotomy. As a result, adequate pain control is essential for patients' prognosis and their postoperative life quality.
- Trial name
- NCT03618264
- Testing
- Miscible liquid of dexamethasone and ropivacaine, Ropivacaine
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Beijing Tiantan Hospital
Pain, Supratentorial Brain Tumor
Effects of Pre-emptive Scalp Infiltration With Ketorolac and Ropivacaine for Post-craniotomy Pain
The PAINLESS study is a single-center, prospective, randomized, open-label, blinded-endpoint (PROBE) controlled clinical study to compare the efficacy and safety of pre-emptive scalp infiltration with ropivacaine plus ketorolac…
- Trial name
- NCT04141319
- Testing
- Ketorolac, Ropivacaine, Epinephrine
- Volunteers
- 100 people
- Sponsor
- Beijing Tiantan Hospital
Intracranial Artery Occlusion With Infarction (Disorder)
Endovascular Treatment Key Technique and Emergency Work Flow Improvement of Acute Ischemic Stroke (ANGEL-ACT): Phase Two
The study is the second phase of Endovascular Treatment Key Technique and Emergency Work Flow Improvement of Acute Ischemic Stroke (ANGEL-ACT).
- Trial name
- ANGEL-ACT II (NCT04151589)
- Testing
- ANGEL Intervention Package and Toolbox
- Where
- China
- Volunteers
- 664 people
- Sponsor
- Beijing Tiantan Hospital
Moyamoya Disease, Remote Ischemic Preconditioning
Effects of Remote Ischemic Pre-Conditioning in Moyamoya Disease Patients
In the present study, investigators evaluated whether RIPC reduce the major neurological complications in adult moyamoya disease patients undergoing encephaloduroarteriosynangiosis (EDAS).
- Trial name
- RIME (NCT04064658)
- Testing
- Remote ischemic preconditioning, Encephaloduroarteriosynangiosis
- Where
- 2 sites in China
- Volunteers
- 328 people
- Sponsor
- Beijing Tiantan Hospital
High Grade Glioma, Glioblastoma
Combination of Immunization and Radiotherapy for Malignant Gliomas (InSituVac1)
The study will investigate combined radiotherapy and immunotherapy on malignant gliomas. Immune adjuvants will be injected intratumorally and systemically to induce antitumor-specific immunity after radiation induced…
- Conditions
- High Grade Glioma, Glioblastoma, Glioma of Brainstem, Glioma, Malignant
- Trial name
- InSituVac1 (NCT03392545)
- Testing
- Combined immune adjuvants and radiation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Tiantan Hospital
Glioblastoma
Supra-early Post-Surgery Chemotherapy in the Treatment on GBM Patients
The primary purpose of the study is to evaluate the efficacy and safety of supra-early post-surgery chemotherapy versus standard TEMODAL® regimen in treatment of patients with newly diagnosed glioblastoma multiforme.
- Trial name
- NCT02520635
- Testing
- supra-early TEMODAL® chemotherapy, standard TEMODAL® chemotherapy, Radiotherapy 60Gy
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Beijing Tiantan Hospital
Trigeminal Neuralgia, Secondary
3D-CT-guided Percutaneous Radiofrequency Thermocoagulation for Tumor-related Trigeminal Neuralgia
This study is designed to investigate the effectiveness and safety of 3D-CT-guided percutaneous radiofrequency thermocoagulation for the treatment of tumor-related trigeminal neuralgia.
- Trial name
- NCT03549013
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Beijing Tiantan Hospital
Dystonia
Clinical Trial of STN-DBS for Primary Cranial-Cervical Dystonia
Primary cranial-cervical dystonia is managed mainly by repeated botulinum toxin injections.This study is to establish whether subthalamic nucleus neurostimulation could improve symptoms in patients not adequately responding to…
- Trial name
- STN-CCD (NCT02583074)
- Testing
- Stimulation
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- Beijing Tiantan Hospital
Glioblastoma
IRDye800CW-BBN PET-NIRF Imaging Guiding Surgery in Patients With Glioblastoma
This is an open-label positron emission tomography/near infrared (PET/NIRF) study to investigate the imaging navigation performance and evaluation efficacy of dual modality imaging probe 68Ga-BBN-IRDye800CW in glioblastoma (GBM)…
- Trial name
- NCT02910804
- Testing
- 68Ga-BBN-IRDye800CW, PET/NIRF, PET/NIR fluorescent imaging-guided surgery
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Cerebral Aneurysm, Arteriovenous Malformations
Exploration of Anticoagulation Program in Cerebral Aneurysm and Arteriovenous Malformations With Hybrid Operation 1
In the stage of registration study, our purpose is to find out the safety range of activated coagulation time level in cerebral aneurysm and arteriovenous malformations with hybrid operation.
- Trial name
- EAPCAAMHO1 (NCT03306823)
- Where
- China
- Volunteers
- 556 people
- Sponsor
- Beijing Tiantan Hospital
Cerebral Aneurysm, Arteriovenous Malformations
Exploration of Anticoagulation Program in Cerebral Aneurysm and Arteriovenous Malformations With Hybrid Operation 2
In the stage of randomized controlled study, our purpose is to obtain the Intraoperative anticoagulation program supported by evidence-based medicine.
- Trial name
- EAPCAAMHO2 (NCT03306836)
- Testing
- Heparin Sodium
- Where
- China
- Volunteers
- 408 people
- Sponsor
- Beijing Tiantan Hospital
Intracerebral Hemorrhage
Deproteinised Calf Blood Serum Injection for the Treatment of Acute Intracerebral Hemorrhage
The purpose of this study is to investigate the efficacy and safety of Deproteinised Calf Blood Serum Injection in alleviating perihematomal edema (PHE) and secondary brain injury, as well as neurologic deficits in patients with…
- Trial name
- NCT03260153
- Testing
- Deproteinised Calf Blood Serum Injection
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Tiantan Hospital
Glioma
Sedatives' Effects on Neurological Function in Patients With Eloquent Area Glioma
Sedation in the operating room, the Post Anesthesia Care Unit and the Intensive Care Unit is common and often necessary for patients with intracranial brain tumor.
- Trial name
- NCT02439164
- Testing
- Midazolam
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Vestibular Schwannoma, Neurofibromatosis Type 2
Endostatin Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors
1)Preliminarily evaluate the treatment effect of continuous vein injection of recombinant human endostatin on NF2; 2)Preliminarily evaluate the safety and the patient's tolerance of the treatment of endostatin; 3)Provide an…
- Trial name
- Endostatin (NCT02104323)
- Testing
- Endostatin
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Tiantan Hospital
Grade II/III Glioma
CCRT With Temozolomide Versus RT Alone in Patients With IDH Wild-type/TERT Promoter Mutation Grade II/III Gliomas
The management of lower-grade gliomas (Diffuse low-grade and intermediate-grade gliomas, WHO II and III) is largely based on surgery followed by radiotherapy.
- Trial name
- NCT02766270
- Testing
- Temozolomide, Radiotherapy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Tiantan Hospital