Clinical trials: sponsored by Boston University
Obsessive-Compulsive Disorder
Pilot Trial of Cognitive and Behavioral Treatment of Compulsive Hoarding Compared to Wait List Control
This study developed and tested a specialized cognitive and behavioral treatment for the symptoms of hoarding disorder, including excessive acquiring, difficulty discarding items, and extensive clutter in the home.
- Trial name
- NCT00073346
- Testing
- Cognitive Behavioral Treatment
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- Boston University Charles River Campus
Chronic Pain, Alcohol Use, Unspecified
Internet-based Videoconferencing to Address Alcohol Use and Pain
This research seeks to develop a novel, integrated behavioral approach to reduce heavy drinking and chronic pain among patients in HIV-care delivered via internet-based videoconferencing.
- Trial name
- NCT03982433
- Testing
- Motivation and Cognitive Behavioral Management for Alcohol and Pain
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Boston University Charles River Campus
Transition-age Youth, Developmental Disabilities
Evaluation of Project TEAM (Teens Making Environmental and Activity Modifications)
The purpose of this study is to determine the extent to which Project TEAM (Teens making Environment and Activity Modifications) is an effective, socially valid, and feasible intervention that prepares youth with developmental…
- Conditions
- Transition-age Youth, Developmental Disabilities, Cerebral Palsy, Autism
- Trial name
- ProjectTEAM (NCT02714868)
- Testing
- Project TEAM, Matched Comparison
- Volunteers
- 82 people
- Sponsor
- Boston University Charles River Campus
Acne Vulgaris, Scar
Acne Scarring in Skin of Color: Laser vs Microneedling
Atrophic acne scars are a common and important sequelae of acne that affect up to 43-55% of patients with acne. Scarring impacts quality of life with reports of diminished self-esteem and frustration/sadness; additionally, some…
- Trial name
- NCT03395678
- Testing
- Microneedling, Fractional non-ablative 1,540nm laser
- Where
- United States
- Sponsor
- Boston University
Oral Surgery
Pilot Study: Effect of Dexamethasone vs Vicodin in Reducing Post-operative Pain
The main objective of the pilot study is to investigate the process that includes recruitment (to estimate the rate of enrollment), feasibility, protocol refinement, and willingness of the subject to be randomized.
- Trial name
- NCT04008043
- Testing
- Vicodin, Dexamethasone
- Where
- United States
- Sponsor
- Boston University
Postpartum Infection, Neonatal Infection
Intervention Zambia Rural L&D Infection Study
This is the intervention phase of a study to investigate the impact of low-cost bundled interventions on improving the infection control practices in the labor and delivery units in rural healthcare settings in Zambia.
- Trial name
- NCT03809741
- Testing
- Bundled L&D Infection Prevention Interventions
- Where
- 5 sites in Zambia
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Boston University
Heart Disease, Stroke
Using Virtual Counselors to Overcome Genetic Literacy Barriers
A Relational Agent (RA) "virtual counselor" (VICKY: VIrtual Counselor for Knowing Your Family History) has been developed to collect family health history information for common health conditions including heart disease, stroke…
- Conditions
- Heart Disease, Stroke, Diabetes, Cancer
- Trial name
- VICKY (NCT02344433)
- Testing
- VICKY, MFHP
- Volunteers
- 279 people, healthy volunteers welcome
- Sponsor
- Boston University
Tooth Extraction Status Nos, Post Operative Pain
A Mobile Application for Post-op Analgesic Consumption
Surgical extraction of third molars is one of the most common outpatient procedures performed by oral surgeons. The prescription of postoperative narcotic and NSAID analgesics is the standard of care practice to relieve symptoms…
- Conditions
- Tooth Extraction Status Nos, Post Operative Pain, Patient Satisfaction, Narcotic Use
- Trial name
- NCT03197311
- Testing
- Mobile app
- Where
- United States
- Sponsor
- Boston University
Depression, Major Depressive Disorder
The Treatment of Depression With Yoga and Walking
This randomized controlled trial is designed to test the Vagal-gamma amino-butyric acid (GABA) Hypothesis that one of the mechanisms by which yoga-based practices improve mood and decrease anxiety is by correcting an autonomic…
- Conditions
- Depression, Major Depressive Disorder, PTSD, Anxiety
- Trial name
- NCT02907476
- Testing
- Iyengar Yoga, Walking
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Boston University
Major Depressive Disorder
Efficacy of Adjunctive Exercise for the Behavioral Treatment of Major Depression
Major depressive disorder (MDD) is the leading cause of disability in the developed world and is associated with lost productivity, increased health care utilization, and mortality.
- Trial name
- NCT02176408
- Testing
- Behavioral Activation, Exercise Intervention, Stretching Intervention
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Boston University Charles River Campus
Anxiety, Traumatic Stress Disorders
Effectiveness of a Unified Transdiagnostic Treatment in Routine Care
The purpose of this study is to examine effectiveness and implementation for the Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders in trauma exposed veterans.
- Conditions
- Anxiety, Traumatic Stress Disorders, Depression
- Trial name
- NCT02944994
- Testing
- Unified protocol, Routine Care
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Boston University
HIV, Tuberculosis
Evaluation of South Africa's National Adherence Strategy
NOTE THAT THE STUDY IS LED BY SOUTH AFRICA NATIONAL DEPARTMENT OF HEALTH AND WORLD BANK WITH SUPPORT FROM BOSTON UNIVERSITY. The South Africa National Department of Health (NDOH) intends to launch its newly developed National…
- Conditions
- HIV, Tuberculosis, Diabetes, Hypertension
- Trial name
- ENHANCE (NCT02536768)
- Testing
- Minimum package of interventions to improve ART adherence
- Where
- South Africa
- Volunteers
- 8,020 people, healthy volunteers welcome
- Sponsor
- Boston University
Obesity, Bariatric Surgery Candidate
Reducing Fall Risks for Adults With Obesity
The objective of the clinical study was to examine if practice could improve walking patterns associated with fall risks before patients with obesity underwent weight loss surgery.
- Conditions
- Obesity, Bariatric Surgery Candidate, Gait, Unsteady
- Trial name
- ObesityFalls (NCT03558100)
- Testing
- Obstacle crossing intervention for adults with obesity
- Volunteers
- 100 people
- Sponsor
- Boston University Charles River Campus
Vitamin D Insufficiency
Gene Expression, Metabolomic, Microbiome, and Calcium Metabolism in Response to Varied Vitamin D Dosages
There continues to be debate as to how much vitamin D an adult requires to be vitamin D sufficient. A multitude of association studies have suggested that improving serum 25(OH)D >30 ng/mL may reduce risk of many chronic…
- Trial name
- NCT02856776
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Boston University
Eating Disorders
Effects of Cognitive and Emotional Functioning on Treatment Outcomes
The investigators are interested about the degree to which individuals can persist with individualized treatment goals when their cues (external such as food, or internal such as anxiety) are high for impulsive/maladaptive…
- Trial name
- CEO (NCT03050632)
- Testing
- N-back, White Bear Task
- Where
- United States
- Sponsor
- Boston University Charles River Campus
Cigarette Smoking
Cognitive and Emotional Skills to Aid Smoking Cessation
Cigarette smoking is a leading cause of morbidity and mortality in the United States. Among individuals who engage in smoking cessation treatment, attrition rates remain high.
- Trial name
- NCT03148652
- Testing
- Enhanced Intervention Condition
- Where
- United States
- Sponsor
- Boston University Charles River Campus
Substance Dependence
Stress, Distress Intolerance, and Drug Dependence
This study is designed to evaluate the relative efficacy of a novel treatment (CBT-IC) versus a standard individual drug-counseling treatment.
- Trial name
- NCT00430482
- Testing
- Cognitive Behavioral Therapy, Individual Counseling
- Where
- 2 sites in United States
- Volunteers
- 133 people
- Sponsor
- Boston University Charles River Campus
Lung Cancer, Shared Decision Making
Inpatient Smokers and LDCT Screening RCT
Current smokers who undergo annual low dose CT (LDCT) lung cancer screening and successfully quit smoking derive the greatest reduction in lung cancer mortality.
- Trial name
- NCT03276806
- Testing
- tobacco dependence/smoking cessation counseling, SDM, Decision Aid
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Boston University
Maternal Health
Impact Evaluation of Maternity Homes Access in Zambia
Objectives: The primary objective of this evaluation is to determine if well-constructed and well-resourced Maternity Waiting Homes are utilized by pregnant women living at distance from the health facility and are associated…
- Trial name
- MAHMAZ (NCT02620436)
- Testing
- Core Mother Shelter Model
- Where
- Zambia
- Volunteers
- 4,798 people
- Sponsor
- Boston University
Transthyretin Amyloidosis, Amyloidosis, Leptomeningeal, Transthyretin-Related
Short-term Effects of TOLCAPONE on Transthyretin Stability in Subjects With Leptomeningeal TTR Amyloidosis (ATTR)
The purpose of this study is to determine whether Tolcapone crosses from the blood stream into the fluid around the brain and stabilizes the protein that makes leptomeningeal amyloid.
- Trial name
- NCT03591757
- Testing
- Tolcapone
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Boston University