Clinical trials: sponsored by Brown University
Tobacco Use Disorder, Schizophrenia
Nicotine and Sensorimotor Replacement for Smoking in Smokers With Schizophrenia
The objective of this study is to investigate the relative contributions of nicotine replacement and sensorimotor replacement (i.e., smoking denicotinized cigarettes) on abstinence-induced smoking urges, withdrawal-related…
- Trial name
- NCT01213524
- Testing
- sensorimotor replacement, 42 mg transdermal nicotine replacement, usual brand smoking
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Brown University
Alzheimer Disease, Dementia
Pragmatic Trial of Video Education in Nursing Homes
This is a pragmatic cluster-randomized control trial (RCT) of an Advance Care Planning (ACP) Video Program for nursing home (NH) patients ≥ 65 years old who are cared for in 360 NH facilities (intervention arm n=119; control arm…
- Conditions
- Alzheimer Disease, Dementia, Heart Failure, Pulmonary Disease, Chronic Obstructive
- Trial name
- PROVEN (NCT02612688)
- Testing
- ACP Video Program
- Where
- 2 sites in United States
- Volunteers
- 197,692 people
- Sponsor
- Brown University
Cannabis Abuse, Cannabis Dependence
Biobehavioral Effects of Topiramate on Cannabis-Related Outcomes in Adolescents
Cannabis use is a significant public health concern that disproportionately affect youth. Although promising psychosocial interventions are being developed, most youth do not benefit from these interventions alone.
- Trial name
- NCT01110434
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Brown University
Prehypertension, Hypertension
Mindfulness-Based Blood Pressure Reduction (MB-BP) Intervention Development - Stage 1 Single Arm Trial
Specific aims are: 1. To outline and evaluate key active elements of the Mindfulness-Based Blood Pressure Reduction (MB-BP) intervention.
- Trial name
- MB-BP (NCT02702258)
- Testing
- MB-BP
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Brown University
Hand or Wrist Surgery
Using Honest Placebos to Improve Pain Management in Hand Surgery Patients
America is in the midst of an opioid epidemic. One of the reasons opioid addiction and overdose deaths have recently increased is that doctors are frequently prescribing opioid medication as a treatment for pain.
- Trial name
- NCT03631251
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Brown University
HIV Infections
Project Minority AIDS Prevention: Reaching Black and Hispanic MSM About PrEP and TasP Using Social Media
This project has the potential to improve the implementation science of treatment as prevention and pre-exposure prophylaxis uptake as a public health strategy for reducing new HIV infections in the United States.
- Trial name
- MAP (NCT03404531)
- Testing
- Social Media Messages Intervention Group, Website Only Group
- Where
- United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Brown University
Diffuse Large B Cell Lymphoma
Early Systemic Central Nervous System Prophylaxis in Diffuse Large B-cell Lymphoma
Phase 2 single-institution trial of early systemic central nervous system prophylaxis in high-risk diffuse large B-cell lymphoma
- Trial name
- BrUOG-377 (NCT03719560)
- Testing
- Methotrexate, Cytarabine
- Where
- United States
- Sponsor
- Brown University
Metastatic Colorectal Cancer
Adjuvant Aflibercept for Metastatic Colorectal Cancer
The main purpose of this study is to evaluate if aflibercept can reduce the chance that metastatic (spread of) colorectal cancer can grow back after finishing standard treatment.
- Trial name
- C261 (NCT01669720)
- Testing
- Aflibercept
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Brown University
Metastatic Pancreatic Cancer
BrUOG 278: FOLFOX-A For Pancreatic Cancer A Brown University Oncology Research Group Study
The purpose of this study is to test the safety, activity and best doses of FOLFOX-A which consists of the standard chemotherapy drugs fluorouracil, leucovorin, oxaliplatin and abraxane.
- Trial name
- 278 (NCT01744353)
- Testing
- Dose level 1, Dose level 2/MTD, Dose level 3
- Where
- 3 sites in United States
- Volunteers
- 35 people
- Sponsor
- Brown University
Colorectal Cancer
First-Line FOLFOX-Bevacizumab for Advanced Colorectal Cancer With Wild-Type Ras
Bevacizumab given at 7.5mg/kg. IV over 10-90 minutes every 3 weeks until disease progression.Panitumumab given at 9mg/kg. IV over 30-90 minutes every 3 weeks until disease progression.Primary Objective: To determine the safety of…
- Trial name
- NCT01057017
- Testing
- intervention
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Brown University
Glioblastoma Multiforme
PPX and Concurrent Radiation for Newly Diagnosed Glioblastoma Without MGMT Methylation
To obtain preliminary data in a randomized phase II study whether PPX/RT improves progression-free survival as compared to temozolomide/RT for patients with GBM without MGMT methylation.
- Trial name
- NCT01402063
- Testing
- PPX (CT2103), Temozolomide
- Where
- 9 sites in United States
- Volunteers
- 63 people
- Sponsor
- Brown University
Liver Cancer
Lenalidomide for Advanced Hepatocellular Cancer:A Phase II Trial
This study will determine whether lenalidomide has activity in patients with advanced liver cancer that have had growth of their cancer after sorafenib.
- Trial name
- NCT00717756
- Testing
- lenalidomide
- Where
- 3 sites in United States
- Volunteers
- 41 people
- Sponsor
- Brown University
Esophageal Cancer, Gastric Cancer
Cetuximab, Paclitaxel, Carboplatin & Radiation for Esoph, Gastroesoph & Gastric Cancer
Cetuximab, Paclitaxel, Carboplatin and Radiation for Esophageal, Gastroesophageal Junction and Gastric Cancer
- Trial name
- NCT00439608
- Testing
- Cetuximab,Paclitaxel, Carboplatin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brown University
Metastatic Pancreatic Cancer
A Trial of GW572016, Gemcitabine and Oxaliplatin for Metastatic Pancreaticobiliary Cancer Schema
A Phase I Trial of GW572016, Gemcitabine and Oxaliplatin for Metastatic Pancreaticobiliary Cancer Schema
- Trial name
- BrUOG-PA205 (NCT00439179)
- Testing
- cohort 1, cohort 2, cohort 3
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Brown University
Anal Cancer
A Phase I/II Evaluation of ADXS11-001, Mitomycin, 5-fluorouracil (5-FU) and IMRT for Anal Cancer
The main purpose of this study is to study the safety and effectiveness of ADXS11-001 when combined with standard chemotherapy and radiation treatment for anal cancer.
- Trial name
- 276 (NCT01671488)
- Testing
- Treatment, 5FU, Mitomycin
- Where
- 3 sites in United States
- Volunteers
- 11 people
- Sponsor
- Brown University
Esophageal Cancer
Neoadjuvant Paclitaxel Poliglumex, Cisplatin and Radiation for Esophageal Cancer: A Phase II Trial (CTI#X64001)
Neoadjuvant Paclitaxel Poliglumex (PPX; CT-2103), Cisplatin and Radiation for Esophageal Cancer: A Phase II Trial. (CTI#X64001
- Trial name
- NCT00522795
- Testing
- PPX with cisplatin and radiation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brown University
Anxiety Disorders
Developing a Low-Intensity Primary Care Intervention for Anxiety Disorders (AIM-PC)
The purpose of the study is to develop a personalized, user-friendly computerized treatment for anxiety disorders linked to primary care.
- Trial name
- NCT02579915
- Testing
- FaceAnxiety, Symptom Tracking
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brown University
Suicide
Latino/a Adolescents With Suicidal Behavior
The study is about developing the best aftercare treatment possible for Latino/a adolescents who have been hospitalized in a psychiatric unit due to a suicidal crisis (suicidal thoughts or attempts).
- Trial name
- NCT02820636
- Testing
- S-CBT, Treatment as Usual
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Brown University
Stress Eating, Reward-based Eating
Bringing Awareness Into Eating
The purpose of this study is to test an app-based mindful eating intervention to decrease the reward value of unhealthy food.
- Conditions
- Stress Eating, Reward-based Eating, Craving-related Eating
- Trial name
- NCT04021745
- Testing
- App-based mindful eating
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Brown University
Smoking Cessation
Mechanisms of Mindfulness for Smoking Cessation
The purpose of this study is to understand brain mechanisms of app-based mindfulness training in smokers ages 21 to 65 years.
- Trial name
- NCT02943499
- Testing
- App/Training, Smartphone
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Brown University