Clinical trials: sponsored by Brown University
Problematic Phone Use Behavior, Depression
The Mindful Smartphone Use Study
The goal of this clinical trial is to understand the feasibility and acceptability on a mindfulness-based intervention to address co-existing smartphone addiction and psychological distress among adolescents ages 13-19…
- Conditions
- Problematic Phone Use Behavior, Depression, Anxiety
- Trial name
- NCT07892807
- Testing
- Mindwire
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brown University
Alcohol Misuse
Using Virtual Reality to Augment Brief Interventions for Heavy Drinking Young Adults
The overarching goal of this research is to explore whether VR might be used to augment brief motivational interviewing (BMI) techniques among heavy drinking young adults (age 18-34) and to test the preliminary efficacy of the VR…
- Trial name
- VR for MI (NCT07902154)
- Testing
- Virtual Reality experience, Brief motivational intervention
- Volunteers
- 120 people
- Sponsor
- Brown University
Healthy
Deliver-EE: Evaluating Effects of Meal Delivery
This study will randomly assign 2,300 older adults on waiting lists at fourteen Meals on Wheels programs in Florida, Illinois, Maryland, Tennessee, Texas, North Carolina, South Carolina, and California into two groups who will…
- Trial name
- NCT05357261
- Testing
- Wellness Check and Socialization, Prepared Meals
- Where
- 14 sites in United States
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- Brown University
Opioid-use Disorder
Opioid Treatment and Peer Recovery Support
Determine whether a facilitated local change team intervention improves a probation organization's client-level medication for opioid use disorder (MOUD) outcomes and implementation outcomes relative to baseline across multiple…
- Trial name
- JCOIN (NCT04978168)
- Testing
- Core Intervention, Peer Support Specialists (PSS), Treatment as Usual (TAU)
- Where
- 3 sites in United States
- Volunteers
- 164 people
- Sponsor
- Brown University
Episodic Memory
The Dynamics of Representational Change Underlying Recall
The goal of this clinical trial is to examine how repeated memory retrieval changes visual representations in the brain in healthy adult participants.
- Trial name
- NCT07442266
- Testing
- Visual Memory Encoding and Retrieval Task During fMRI
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Brown University
HIV Prevention, HIV Infection Primary
Intervention to Enhance PrEP Persistence
The investigators will conduct a fully powered randomized controlled trial (RCT) to test the effect of a patient navigation intervention on PrEP initiation, adherence and retention in care.
- Trial name
- NCT06872307
- Testing
- RAMP-It-Up Initiation, Adherence, and Retention Intervention
- Where
- 3 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Brown University
Prevention
Optimizing PrEP Uptake and Adherence Among Male Sex Workers
"PrEPare for Work" is a randomized controlled trial (RCT) whose goal is to test the efficacy of a behavioral intervention (Short Title: PrEPare for Work) in improving PrEP uptake, adherence, and persistence among male sex workers…
- Trial name
- P4W (NCT05736614)
- Testing
- Stage 1 Strength Based Case Management (SBCM) Condition, Stage 2 PrEPare for Work Intervention Condition
- Where
- 5 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Brown University
Substance Dependence, HIV (Human Immunodeficiency Virus)
Pre-exposure Prophylaxis (PrEP) for Health
This randomized controlled trial will test the efficacy of "PrEP for Health," a behavioral intervention to improve the use of antiretroviral pre-exposure prophylaxis (PrEP) among at-risk people who inject drugs (PWID) in two…
- Trial name
- PrEP (NCT04430257)
- Testing
- HIV and PrEP education, Motivational interviewing, Problem-solving and planning
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Brown University
Anxiety, Depression
Improving Mental Health Among the LGBTQ+ Community
The overall aim of this program of research is to improve the mental health of people who identify as LGBTQ+ by increasing their social support through a brief intervention.
- Trial name
- NCT05540067
- Testing
- Acceptance-Based Behavior Therapy (ABBT), Treatment-as-Usual (TAU)
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Brown University
Suicide, Attempted
Skills to Enhance Positivity in Suicidal Youth
This is a Hybrid Type I Effectiveness-Implementation design. Specifically, this study proposes to test the effectiveness of STEP in reducing suicidal events and ideation in 216 adolescents, admitted to inpatient psychiatric care…
- Trial name
- STEP (NCT04994873)
- Testing
- STEP, Enhanced TAU
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Brown University
Phase I
Pilot Study on the Effects of Psilocybin on Belief Updating and Insight Formation
The primary aim of this phase I mechanistic pilot study is to evaluate the effects of psilocybin on aspects of cognition in healthy adult volunteers.
- Trial name
- NCT07818564
- Testing
- Psilocybin (Usona Institute)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Brown University
Alcohol Drinking, Cannabis Use
Cannabis' Impact on Alcohol Consumption
This study employs a repeated measures experimental design to examine the effect of THC-dominant dose of cannabis and CBD-dominant dose of cannabis, relative to placebo, on subsequent drinking in an alcohol choice task in which…
- Conditions
- Alcohol Drinking, Cannabis Use, Cannabis, Alcohol Use Disorder
- Trial name
- NCT05389930
- Testing
- THC-dominant cannabis, CBD-dominant cannabis, Alcohol
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Brown University
Unhealthy Alcohol Use
Supporting Health Through Alcohol Reduction and Relationship Enhancement Together
The aim of this project is to refine the couples-focused intervention with up to 24 adults with unhealthy alcohol use and their partners (N=12 couples) to obtain feedback on the intervention content and structure, as well as the…
- Trial name
- SHARE2Gether (NCT07854756)
- Testing
- SHARE2Gether
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Brown University
Music Therapy, Bereavement
Musical Playlist of the Grief Journey
The goal of this clinical trial is to learn about the effectiveness of a music-based intervention as a bereavement strategy for individuals who are a part of the Loss of Spouse/Life Partner Grief Support Group at HopeHealth, a…
- Trial name
- NCT06445010
- Testing
- Creating Musical Playlist
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Brown University
Malignant Ascites, Colorectal Adenocarcinoma
TLR9 Immunotherapy for Peritoneal Carcinomatosis
The goal of this clinical trial is to determine the safety and efficacy of of ACM-CpG for inoperable peritoneal metastases or malignant ascites.
- Conditions
- Malignant Ascites, Colorectal Adenocarcinoma, Peritoneal (Metastatic) Cancer, Appendiceal Adenocarcinoma
- Trial name
- TIPC (NCT07658196)
- Testing
- ACM-CpG
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Brown University
Alcohol Use Disorder
Intranasal Insulin for Treatment of Alcohol Use Disorder
This is a randomized controlled trial (RCT), within-subject, crossover, double-blind, placebo-controlled in non-treatment-seeking individuals with Alcohol Use Disorder (AUD) (N=40, 50% female) randomized to IN insulin or placebo.
- Trial name
- ITA (NCT05988632)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brown University
Health Behavior, Wellness, Psychological
Teen Health Choices & Wellness
The goal of this observational study is to learn more about changes in health, wellness, and substance-use behaviors as teenagers get older.
- Conditions
- Health Behavior, Wellness, Psychological, Substance Use
- Trial name
- THC&W (NCT06822569)
- Testing
- Cue reactivity paradigm
- Where
- United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Brown University
Alcohol Use Disorder (AUD)
Alpha-1 Blockade for Alcohol Use Disorder (AUD)
The goal of this research is to replicate findings previously conducted in a pilot trial and to understand, mechanistically, the role of stress in the development of AUD pharmacotherapies that target noradrenergic blockade.
- Trial name
- DOXY (NCT04135846)
- Testing
- Doxazosin
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- Brown University
Alcohol Drinking, HIV Viremia
Using Telehealth to Address Alcohol Misuse in HIV Care
This project will test the effects of a telehealth counseling program on reducing alcohol use and improving HIV viral control among people with HIV who drink heavily.
- Trial name
- ReACH3 (NCT04546971)
- Testing
- Brief Intervention, Telehealth Counseling, Text messaging
- Where
- United States
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- Brown University
Physical Inactivity
Comparing Self-paced Versus Moderate Intensity Physical Activity Recommendation for Midlife Adults
We will randomly assign (blocked on Gender (female, male, other), body mass index (BMI; overweight [25 < BMI < 30]) or obese (30 < BMI <40) and pain status (chronic pain vs not)) adults ages 50-64 into either; (a) self-selected…
- Trial name
- NCT05285748
- Testing
- Self-Paced Intensity Physical Activity, Prescribed Moderate Intensity Physical Activity
- Where
- United States
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- Brown University