Clinical trials: sponsored by Brown University
Tobacco Dependence
Very Low Nicotine Cigarettes in Smokers With Schizophrenia
Smokers with serious mental illness including those with schizophrenia and bipolar disorder infrequently attempt and attain sustained smoking abstinence and have a 25-year shorter lifespan due to smoking-related illness.
- Trial name
- NCT02019459
- Testing
- Very low nicotine content cigarettes, standard nicotine content cigarettes
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Brown University
Accidental Overdose of Opiate
Rapid Self-Testing to Prevent Fentanyl Overdose Among Young People Who Use Drugs
The research team will enroll 100 young adults who use cocaine, heroin, inject drugs, or purchase prescription medications on the illicit market in a pilot study to be known as the Rhode Island Young Adult Prescription and…
- Trial name
- RAPiDS2 (NCT03373825)
- Testing
- Take home rapid drug test
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Brown University
Depression, Alcohol Use
Community-Based Integrated Treatment for Adolescents
This study will examine the effectiveness of an integrated treatment for adolescents who are depressed and use alcohol in an intensive outpatient setting in the community.
- Trial name
- NCT01667159
- Testing
- Integrated Cognitive Behavioral Therapy, Standard Care
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Brown University
Anxiety Disorders
Developing a Low-Intensity Primary Care Intervention for Anxiety Disorders
The purpose of the study is to develop a personalized, user-friendly computerized treatment for anxiety disorders linked to primary care.
- Trial name
- AIM-PC (NCT02266446)
- Testing
- Attention & Interpretation Modification
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Brown University
Depression, Suicide
Intensive Outpatient Services for Teens
This study will identify the effectiveness of an intensive treatment program for teens who are at high risk for harming themselves.
- Trial name
- INVEST (NCT01732601)
- Testing
- Intensive Outpatient CBT, Standard Care
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Brown University
Cigarette Smoking
Quit Smoking With Nicotine Patch and Exercise/Health Education (Females Only)
This research study is for FEMALE cigarette smokers who want to quit smoking. Participants will be provided with brief quit-smoking education at the beginning of the study and will receive the nicotine patch for 10 weeks, free of…
- Trial name
- QFH (NCT01522274)
- Testing
- Moderate intensity exercise, Health education
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Brown University
Binge Drinking, Unsafe Sex
Individual and Contextual Factors That Influence Sexual Decisions
For decades, men who have sex with men (MSM) have carried the heaviest burden associated with the HIV epidemic in the United States.
- Conditions
- Binge Drinking, Unsafe Sex, HIV/AIDS, Sexually Transmitted Diseases
- Trial name
- NCT03224416
- Testing
- Alcohol Administration, No Alcohol Administration
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Brown University
Family Child Care Homes
Improving Nutrition and Physical Activity Environments in Home-based Child Care
Drs. Patricia Risica (Brown University) and Kim Gans (University of Connecticut) are Dual Principal Investigators for this project.
- Trial name
- NCT02452645
- Testing
- Healthy Food and Physical Activity Environments, Comparison Group
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Brown University
Hazardous Drinking, Binge Drinking
A Stage 2 Cognitive-behavioral Trial: Reduce Alcohol First in Kenya Intervention
This study will determine whether a group cognitive-behavioral therapy intervention that demonstrates preliminary evidence of reducing alcohol use among HIV-infected outpatients in western Kenya is effective when compared against…
- Conditions
- Hazardous Drinking, Binge Drinking, HIV-infected
- Trial name
- RAFIKI (NCT01503255)
- Testing
- cognitive behavioral group therapy, health education group
- Where
- Kenya
- Volunteers
- 614 people
- Sponsor
- Brown University
Stress Disorders, Post-Traumatic, Depression
Prospective Evaluation of Family Care Rituals in the ICU
This study will evaluate whether or not engaging family members of patients admitted to the ICU in "Family Care Rituals" will reduce stress related symptoms of PTSD, depression and anxiety 90 days after patient death or discharge…
- Conditions
- Stress Disorders, Post-Traumatic, Depression, Anxiety
- Trial name
- FCR (NCT02875912)
- Testing
- Family Care Rituals
- Where
- 3 sites in United States, Italy
- Volunteers
- 452 people, healthy volunteers welcome
- Sponsor
- Brown University
Hazardous Drinking, Cigarette Smoking
Naltrexone for At-Risk and Problem Drinking in Smoking Cessation Treatment
To test whether naltrexone compared to placebo can reduce heavy drinking and improve smoking cessation outcomes in heavy drinkers seeking smoking cessation treatment.
- Trial name
- NCT00938886
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Brown University
Suicide
Coping Long Term With Attempted Suicide - Adolescents
This study is to develop an adjunctive intervention for acutely suicidal adolescents who have been admitted to a psychiatric inpatient unit.
- Trial name
- CLASP-A (NCT01748760)
- Testing
- CLASP-A intervention, Treatment as Usual
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Brown University
Tobacco Use Disorder
Improving Smoking Cessation Outcomes in Heavy Drinkers - 1
To test the effectiveness of an smoking cessation treatment for smokers who also drink alcohol heavily.
- Trial name
- NCT00107575
- Testing
- Standard treatment plus brief alcohol intervention, Standard treatment (ST)
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Brown University
Invasive Bladder Cancer, Bladder Cancer
Neoadjuvant Gemcitabine and Fractionated, Weekly Cisplatin For Muscle Invasive Bladder Cancer and Patients Not Candidates For High Dose Cisplatin
The standard treatment of muscle invasive bladder cancer is to administer chemotherapy for approximately 3 months then to have surgery to remove the bladder.
- Trial name
- NCT02030574
- Testing
- Gemcitabine and fractionated cisplatin (combination treatment)
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Brown University
Food Habits, Eating Behavior
Innovative Approaches to Increase F&V Intake Thru Worksites
The purpose of this project is to study the efficacy of a delivery system to offer fresh fruits and vegetables (F\&V) at discount prices for purchase at worksites in conjunction with educational interventions on increasing…
- Trial name
- Good to Go (NCT02729675)
- Testing
- Access Intervention, Enhanced Intervention, Comparison Behavioral Intervention
- Volunteers
- 1,804 people, healthy volunteers welcome
- Sponsor
- Brown University
Dietary Habits, Dietary Modification
Fresh to You: Multilevel Approaches in Low Income Housing to Increase F&V Intake
Live Well, Viva Bien (LWVB) is an NCI-funded, cluster randomized controlled trial (RCT) that was conducted in 15 subsidized housing complexes to evaluate the efficacy of a multicomponent intervention comprised of a year-round…
- Trial name
- LWVB (NCT02669472)
- Testing
- Environmental Intervention, Educational Intervention, Control
- Volunteers
- 1,598 people, healthy volunteers welcome
- Sponsor
- Brown University
Major Depressive Disorder, Miscarriage
Group Interpersonal Psychotherapy for Treatment of Major Depressive Disorder Following Perinatal Loss
The purpose of this study is to conduct a randomized pilot trial in a sample of 60 women who meet criteria for Major Depressive Disorder (MDD) 1-18 months after a perinatal loss to demonstrate the feasibility of the proposed…
- Conditions
- Major Depressive Disorder, Miscarriage, Stillbirth, Neonatal Death
- Trial name
- NCT01867749
- Testing
- Group Interpersonal Psychotherapy (IPT-G), Coping with Depression (CWD)
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Brown University
Major Depressive Disorder
Effectiveness of Interpersonal Psychotherapy (IPT) for Men and Women Prisoners With Major Depression
This study will examine the effects of a first-line treatment for major depressive disorder (MDD), interpersonal psychotherapy (IPT), among men and women prisoners.
- Trial name
- NCT01685294
- Testing
- Group IPT for Depression + TAU
- Where
- 5 sites in United States
- Volunteers
- 181 people
- Sponsor
- Brown University
Bipolar Disorder
Pilot Study of Adjunctive Yoga for Bipolar Depression
As a practice that incorporates elements of physical exercise, controlled breathing, and meditation, yoga is gaining increasing acceptance as an adjunctive intervention for many psychiatric disorders.
- Trial name
- NCT02402010
- Testing
- Adjunctive Yoga, Enhanced Treatment as Usual
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Brown University
Cardiovascular Diseases, Heart Diseases
Education and Counseling for Abstinence From Tobacco After Pregnancy
The purpose of this study is to develop and field test a maintenance of smoking abstinence program designed for a predominately low-income, high-risk population of women from a wide variety of ethnic and racial backgrounds who…
- Trial name
- NCT00139529
- Testing
- Motivational Interviewing Telephone Counseling, Educational Intervention
- Where
- United States
- Volunteers
- 757 people
- Sponsor
- Brown University