Clinical trials: sponsored by Brown University
Schizophrenia and Disorders With Psychotic Features, Tobacco Use Disorder
Contingent Incentives Plus Bupropion for Smoking in People With Schizophrenia
There is a high prevalence of smoking among people with schizophrenia, and there are few smoking treatment programs for these smokers.
- Trial name
- NCT00136760
- Testing
- Bupropion, non-contingent reinforcement plus bupropion
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Brown University
Tobacco Dependence, Cigarette Craving
Acute Effects of Exercise in Smokers With Schizophrenia
People with schizophrenia have two- to three-times the mortality risk of the general population. This is primarily due to their unusually high rates of cigarette smoking, as well as other cardiovascular risk factors such as…
- Conditions
- Tobacco Dependence, Cigarette Craving, Smoking Behavior
- Trial name
- NCT01635075
- Testing
- Exercise, passive control
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Brown University
Depression, Suicide
Concurrent Treatment for Depressed Parents and DepressedAdolescents
This study will develop an integrated treatment for adolescents who are depressed and suicidal and their parents who are depressed and have a history of suicidality.
- Trial name
- NCT00951821
- Testing
- Concurrent treatment, Adolescent treatment only
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Brown University
Lymphoma, Non-Hodgkins
Ofatumumab and Bortezomib for Patients With Low-grade B-cell Non-hodgkin Lymphoma That Relapse After Rituximab
The purpose of this study is to: Investigate the Overall Response Rate (ORR) of the combination of ofatumumab and bortezomib in patients with low-grade B-cell non-Hodgkin lymphoma (LG-NHL) that relapse beyond 6 months of a…
- Trial name
- NCT01119794
- Testing
- Ofatumumab and Bortezomib
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- Brown University
Alcoholism,, Alcoholic Liver Disease
A Novel Pharmacotherapy for Alcoholism and Alcohol Liver Disease
It is proposed to test metadoxine (MTDX) that it is hypothesized to be significantly beneficial for the treatment of alcoholism and ALD.
- Trial name
- NCT01504295
- Testing
- Metadoxine
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Brown University
Smoking
Development of Positive Psychotherapy for Smoking Cessation
The primary objective of this study is to test a manualized adaptation of positive psychotherapy (PPT) for smoking cessation (PPT-S).
- Trial name
- NCT01451814
- Testing
- Positive Psychotherapy for smoking cessation, Nicotine polacrilex, Relaxation training
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Brown University
Parkinson's Disease
The Effect of Rasagiline on Cognition in Parkinson's Disease
While Parkinson's disease has historically been defined in terms of its motor symptomatology, studies have shown that non-motor deficits form an important part of the syndrome.
- Trial name
- NCT01382342
- Testing
- Rasagiline
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Brown University
Alcoholic Intoxication, Marijuana Abuse
Motivational Interviews for Incarcerated Teens - 1
The purpose of this study is to test the efficacy of an individual motivational interview for reducing alcohol and marijuana-related harm as well as alcohol and marijuana use in incarcerated teens.
- Trial name
- NCT00227916
- Testing
- Behavior Therapy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Brown University
Non-Small Cell Lung Cancer
A Study of Dasatinib With Concurrent Chemoradiation for Stage III Non-Small Cell Lung Cancer (NSCLC)
The purpose of this study is to evaluate if a maximum dose of 100 mg of dasatinib with concurrent chemoradiation can be tolerated in patients with chemotherapy naive stage III NSCLC in separate cohorts of locally advanced and…
- Trial name
- NCT00787852
- Testing
- Group 1: Radiation, Paclitaxel,Carbo, Dasatinib days 1-47, Group 2: Radiation, Paclitaxel, Carbo, Dasatinib days 1-38
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Brown University
Alcohol Abuse
Family Check-Up for Adolescents and Siblings
A two group randomized design will be used to test the primary hypothesis that the experimental intervention will reduce alcohol consumption and alcohol-related negative consequences significantly more than a comparison…
- Trial name
- NCT00925340
- Testing
- Family Check Up, Psychoeducation
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Brown University
Depression, Overweight
Integrated Treatment for Comorbid Depression and Obesity in Adolescents
Lifetime prevalence of major depression is estimated at 28% by age 18 (Lewinsohn et al., 1999), with higher cumulative rates in females (35%) than males (19%).
- Trial name
- NCT01128764
- Testing
- CBT for depression and healthy lifestyle plus exercise, CBT for depression
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Brown University
Alcoholism
Effects of Ghrelin on Alcohol Cue Reactivity and Craving
Only a few medications are approved for the treatment of alcohol dependence and there exists a substantial need for discovering ways to provide more effective treatments.
- Trial name
- NCT01190085
- Testing
- Ghrelin, Saline solution
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Brown University
Rectal Cancer
Rectal Cancer Consortium
The purpose of this study is to study which genes are abnormal in rectal cancer and see if this predicts how well chemotherapy and radiation will reduce the size of cancer and whether cancer recurs after surgery.
- Trial name
- NCT01835925
- Testing
- Tissue specimen
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Brown University
Pancreatic Cancer
Gemcitabine and Monoclonal Antibody Therapy in Treating Patients With Metastatic Cancer of the Pancreas
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Monoclonal antibodies such as trastuzumab can locate tumor cells and either kill them or deliver…
- Trial name
- NCT00003797
- Testing
- trastuzumab, gemcitabine hydrochloride
- Where
- 12 sites in United States
- Volunteers
- 41 people
- Sponsor
- Brown University
Extrahepatic Bile Duct Cancer, Gallbladder Cancer
Liposomal Doxorubicin in Treating Patients With Liver or Bile Duct Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of liposomal doxorubicin in treating patients with liver…
- Conditions
- Extrahepatic Bile Duct Cancer, Gallbladder Cancer, Liver Cancer
- Trial name
- NCT00003296
- Testing
- filgrastim, pegylated liposomal doxorubicin hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Brown University
Alcoholism
A Study on the Biobehavioral Mechanisms of Baclofen and Alcohol Drinking
This pilot trial has the goal to demonstrate the feasibility of a study to test the effects of baclofen in a laboratory experiment using cue-reactivity and alcohol-self administration paradigms in non-treatment seeking…
- Trial name
- NCT01076283
- Testing
- Baclofen, Cyproheptadine
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Brown University
Unspecified Adult Solid Tumor, Protocol Specific
Personalized Nutrition Education in Improving Eating Habits of Healthy Participants Who Eat an Unhealthy Diet
RATIONALE: Decreasing the amount of fat in the diet and increasing fruit, vegetable, and fiber intake may help prevent some types of cancer.
- Trial name
- NCT00301678
- Testing
- behavioral dietary intervention, educational intervention, preventative dietary intervention
- Where
- United States
- Volunteers
- 2,520 people, healthy volunteers welcome
- Sponsor
- Brown University
Unspecified Adult Solid Tumor, Protocol Specific
Nutrition Education for Low-Income Healthy Participants Who Eat an Unhealthy Diet
RATIONALE: Decreasing the amount of fat in the diet and increasing fruit and vegetable intake may help prevent some types of cancer.
- Trial name
- NCT00301691
- Testing
- behavioral dietary intervention, educational intervention, preventative dietary intervention
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Brown University
Emotional Distress, Behavior Problems
Teens Coping With Parental Military Deployment
The total number of military personnel is over 3.5 million and approximately 43% have children. The deployment cycle can be associated with depression, anxiety, and behavior problems in children as well as psychological distress…
- Trial name
- Helping Hand (NCT01128777)
- Testing
- Cognitive Behavioral Group Therapy, Nondirective supportive group therapy
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Brown University
Adolescent Substance Use
Substance Use Prevention in Teen Psychiatric Patients
The earlier a child initiates alcohol and other drug (AOD) use, the greater the risk of long-range problems. This association persists despite changes in national substance use rates over time, indicating its stability and…
- Trial name
- tCheckup (NCT01170013)
- Testing
- Family Check-up, Parent psychoeducation
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Brown University