Clinical trials: sponsored by Brown University
Adolescent Problem Behavior, Truancy; Unsocialized
Substance Use Interventions for Truant Adolescents
This study evaluates a brief motivation-building intervention for parents and teens to reduce truancy and substance use. It is hypothesized that the motivational intervention will result in better outcomes compared to an…
- Conditions
- Adolescent Problem Behavior, Truancy; Unsocialized, Marijuana Abuse, Truancy; Socialized
- Trial name
- GOALS (NCT03655574)
- Testing
- Motivational + Family Check-up (MET+FCU), Psychoeducation
- Where
- 2 sites in United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Brown University
Food Insecurity
Developing and Testing a Produce Prescription Implementation Blueprint to Improve Food Security in a Clinical Setting
The goal of this pilot feasibility implementation trial is to assess preliminary feasibility and acceptability of a set of produce prescription implementation strategies.
- Trial name
- NCT05941403
- Testing
- Enhanced Produce Prescription Implementation
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- Brown University
Alcohol Use Disorder, Smoking
Alcohol and Cigarette Craving During Oxytocin Treatment
This proposed research seeks to examine the behavioral and neural substrates of intranasal oxytocin compared to placebo on alcohol cue-induced alcohol and cigarette craving smokers with an alcohol use disorder (AUD).
- Trial name
- NCT04071119
- Testing
- Oxytocin nasal spray
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Brown University
Physical Inactivity
Pilot Testing an Innovative Physical Activity Intervention for Parents Attending Their Children's Sport Practices
The intervention aims to increase physical activity, an important health behavior, in a high-risk sample (i.e., Black and Hispanic/Latino mothers).
- Trial name
- NCT05461742
- Testing
- Physical activity intervention
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Brown University
Anxiety
Investigating How the Brain Processes Different Experiences
The goal of this clinical trial is to test the efficacy of an app-based program in reducing anxiety and exploring associated changes in brain activity.
- Trial name
- NCT06051084
- Testing
- App-Delivered Mindfulness Training (MT), App-Delivered Coloring
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Brown University
Anxiety, Stress
A Mindfulness Approach to UA for Afro-descendants
The goal of this clinical trial is to test an app-based mindfulness training program in an Afro-descendant population. The main question[s] it aims to answer are: What changes, if any, does the app need? Is it effective in…
- Trial name
- NCT05881681
- Testing
- App-Delivered Mindfulness Training (MT)
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Brown University
HIV, Pregnancy Related
Adherence to HIV Treatment Postpartum: The Implications of Transitions Among Women Living With HIV in South Africa
Despite high levels of adherence motivation during pregnancy, HIV treatment adherence and engagement in care is difficult for women in the postpartum period.
- Trial name
- NCT04846569
- Testing
- Transition Theory-based Intervention, Enhanced Standard of Care Control
- Where
- South Africa
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Brown University
Marijuana Smoking
Behavioral Economic Analysis of Demand for Marijuana
This laboratory study will employ a multi-session experimental design to examine the behavioral economic demand for marijuana, by studying effect of marijuana administration (High THC) on demand for marijuana, and marijuana…
- Trial name
- NCT03518567
- Testing
- Smoked marijuana cigarettes: High THC dose (6% THC)
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Brown University
Dementia
Home-delivered Meals for Persons With Dementia: Which Model Delays Nursing Home Placement?
This project is the pilot phase of a pragmatic randomized clinical trial comparing outcomes among older adults with Alzheimer's disease and related dementias (ADRD) receiving home-delivered meals.
- Trial name
- NCT04850781
- Testing
- Bi-weekly frozen meal home delivery, Daily home meal delivery
- Where
- 3 sites in United States
- Volunteers
- 243 people
- Sponsor
- Brown University
Nicotine Dependence, Cigarettes, Uncomplicated
Impact of Nicotine Reduction on Adolescent Cigarette Use, Alternative Tobacco Use, and Harm From Tobacco
Adolescents are an important vulnerable population to consider as the FDA moves toward a nicotine reduction policy. Such a policy, which would mandate a reduction of nicotine in all commercially available cigarettes, has the…
- Trial name
- SIREN (NCT03860077)
- Testing
- Very Low Nicotine Content Cigarettes, Normal Nicotine Content Cigarettes
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Brown University
Smoking, Cigarette, Electronic Cigarettes
Evaluating New Nicotine Standards for Cigarettes - Project 3
This study is designed to examine how the nicotine content of cigarettes and the nicotine concentration and flavors in e-liquids influence responses to and use of these products in adolescent smokers.
- Trial name
- CENIC2-P3 (NCT03194256)
- Testing
- Spectrum Research Cigarettes
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Brown University
BRCA1 Mutation, BRCA2 Mutation
BrUOG 390: Neoadjuvant Treatment With Talazoparib
Ovarian cancer is the most fatal gynecologic cancer; in the US alone an estimated 22,000 women will be diagnosed in 2019, with over 13,000 dying of the disease.
- Conditions
- BRCA1 Mutation, BRCA2 Mutation, Ovarian Cancer, Fallopian Tube Cancer
- Trial name
- NCT04598321
- Testing
- Talazoparib Oral Capsule
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Brown University
Healthy
Criticality, Working Memory, and Effort
The project examines electroencephalography, MRI, and behavioral measures indexing flexibility (critical state dynamics) in the brain when healthy young adults do demanding cognitive tasks, and in response to transcranial…
- Trial name
- NCT05797636
- Testing
- transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Brown University
Opioid-use Disorder, Medication Adherence
CoMBAT Opioid Use Disorder: A Combined Medication and Behavioral Activation Treatment for People Living With Opioid Use Disorder
This study seeks primarily to test, in a two-arm randomized controlled trial (RCT), the feasibility, acceptability, and preliminary efficacy of CoMBAT OUD, an intervention that integrates Behavioral Activation (BA) and substance…
- Conditions
- Opioid-use Disorder, Medication Adherence, Health Care Utilization
- Trial name
- CoMBAT_OUD (NCT04240093)
- Testing
- Behavioral Activation (BA) Therapy, Substance Abuse and Health Navigation Counseling, Medications for Opioid Use Disorder
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Brown University
Locally Advanced Pancreatic Cancer, Pancreatic Cancer
FOLFOX-A For Locally Advanced Pancreatic Cancer: A Phase II Brown University Oncology Research Group Trial
Preliminary data suggests that FOLFOX-A may have equal or superior activity as compared to FOLFIRINOX for patients with metastatic pancreatic cancer and appears to be better tolerated with the ability to administer at least 10…
- Trial name
- NCT02578732
- Testing
- FOLFOXA
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Brown University
Obesity, Physical Activity
Positive Psychology for Physical Activity Promotion
This study is for physically inactive adults. Participants will be enrolled in the Positive Psychology and Physical Activity intervention designed to help them overcome barriers to physical activity, based on the principals of…
- Trial name
- PPPA (NCT03826173)
- Testing
- PPPA, PA
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Brown University
Substance Abuse
Computer-Assisted Brief Intervention
Due to the "unmet needs" of substance abuse treatment among court involved but non-incarcerated (CINI) adolescents and their parents, reaching and engaging CINI adolescents in intervention programs addressing marijuana use is…
- Trial name
- JJMISCOPE (NCT03107117)
- Testing
- Computer Counseling, Standard Care
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Brown University
Smoking Cessation
Positive Psychotherapy for Smoking Cessation Enhanced With Text Messaging: A Randomized Controlled Trial
Positive Psychotherapy for Smoking Cessation (PPT-S) addresses an array of risk factors for poor smoking outcomes (low positive affect, depressive symptoms, and cynical cognitions), while also providing skills that may buffer…
- Trial name
- NCT02997657
- Testing
- Positive Psychotherapy, Standard smoking cessation counseling
- Where
- 2 sites in United States
- Volunteers
- 271 people, healthy volunteers welcome
- Sponsor
- Brown University
Acute Pain
Open Label Placebo to Reduce Prescription Opioid Use
The goal of the proposed study is to examine the efficacy of using an honest placebo to relieve pain for patients with an acute pain condition.
- Trial name
- NCT05014230
- Testing
- Opioid medication as part of standard care
- Where
- United States
- Volunteers
- 155 people
- Sponsor
- Brown University
Metastatic Colorectal Cancer
BrUOG 379 Phase Ib/II Trial ONC201 + Nivolumab in MSS mCRC
This is a single arm Phase Ib/II, open label, safety, pharmacokinetic, pharmacodynamics and efficacy study of ONC201 in combination with Opdivo (Nivolumab) in adult patients with metastatic colorectal cancer, for whom no standard…
- Trial name
- 379 (NCT03791398)
- Testing
- Dose level 1 ONC201 625mg, Dose level 2 ONC201 500mg, Dose level 3 ONC201 375mg
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Brown University