Clinical trials: sponsored by CHU de Reims
Suspicion of Tumor of the Small Intestine
EnteroCT With Enteroclysis Versus Enterography-MRI for the Diagnosis of Tumors of the Small Intestine: a Pilot Study
Early diagnosis of tumors of the small intestine is a challenge for clinicians and for radiologists. The detection of tumors of the small intestine is a field in which the video capsule endoscopy has the lowest performance.
- Trial name
- enteroMRI-TSI (NCT02872623)
- Testing
- Enterography-MRI without enteroclysis, enteroCT with enteroclysis
- Where
- France
- Volunteers
- 40 people
- Sponsor
- CHU de Reims
Bullous Pemphigoid
Interest of Dosage of Anti-PB230, Anti-PB180 and Cytokines for Monitoring of Patients Suffering From Bullous Pemphigoid
Bullous pemphigoid is the most common subepidermal autoimmune blistering disease of the skin in European countries, including France.
- Trial name
- Cyto-PB (NCT02883894)
- Testing
- Blood sample for dosages of cytokines (IL-17 and IL-23) and of the protease MMP-9
- Where
- France
- Volunteers
- 120 people
- Sponsor
- CHU de Reims
Melanoma
Clinical and Histological Features of Head and Neck Melanoma
The worldwide incidence of cutaneous melanoma has been increasing for the last 30 years in western populations. Among all melanomas, those located on the head and neck are more frequent than expected regarding the surface of this…
- Trial name
- head neck-mel (NCT02883933)
- Testing
- Data collection
- Where
- France
- Volunteers
- 1,548 people
- Sponsor
- CHU de Reims
Respiratory Symptoms
Work-related Respiratory Symptoms in Champagne Vineyard Workers
Work related asthma and rhinitis are frequent diseases with a significant morbidity and a social and economic impact. Farmers are highly exposed to various inhaled agents such as organic or inorganic dust, endotoxin…
- Trial name
- VIN-ALLERGO (NCT02883920)
- Testing
- Allergy and respiratory functional tests
- Where
- France
- Volunteers
- 307 people
- Sponsor
- CHU de Reims
Gastrointestinal Stromal Tumours
Sarcopenia in Patients With Gastrointestinal Stromal Tumours
The treatment of advanced gastrointestinal stromal tumours (GIST) has shifted since the arrival of targeted therapies. Imatinib is an active multikinase inhibitor that mainly targets C-kit tyrosine-kinase receptors and the…
- Trial name
- SARCO-GIST (NCT02877368)
- Testing
- Computed tomography
- Where
- France
- Volunteers
- 31 people
- Sponsor
- CHU de Reims
Solid Tumor
Interest of Routine Screening for Hepatitis B and C in Patients Receiving Chemotherapy for Solid Tumors
Immunosuppression induced by cancer treatment increases the risk of hepatitis B virus (HBV) and hepatitis C virus (HCV) reactivations. These viral reactivations may be asymptomatic but can cause fulminant hepatitis and death.
- Trial name
- HepScreen (NCT02877589)
- Testing
- hepatitis B virus (HBV) and hepatitis C virus (HCV) serologies and a screening questionnaire to detect risk factors of hepatitis B virus (HBV) and hepatitis C virus (HCV)
- Where
- France
- Volunteers
- 450 people
- Sponsor
- CHU de Reims
COPD
Regeneration of Bronchial Epithelium During Chronic Obstructive Pulmonary Disease
Airway epithelium integrity is essential to maintain its role of mechanical and functional barrier. Recurrent epithelial injuries require a complex mechanism of repair to restore its integrity.
- Trial name
- EPITHREGENCOPD (NCT02873988)
- Testing
- bronchial epithelial cell culture
- Where
- France
- Volunteers
- 25 people
- Sponsor
- CHU de Reims
Crohn's Disease
Comparison of Endoscopy and Diffusion-weighted Enterography-MRI for the Diagnosis of Crohn's Disease Recurrence Following Ileocolic Resection: a Pilot Study
Nearly three-quarters of patients with Crohn's disease have small bowel involvement and 80% of them will have complications that will require a surgical procedure, usually an ileocolonic resection with ileocolonic anastomosis.
- Trial name
- MRI-CROHN (NCT02867540)
- Testing
- MRI enterography
- Where
- France
- Volunteers
- 40 people
- Sponsor
- CHU de Reims
Enterobacteriaceae Infection
Qnr Genes in Enterobacteriaceae
Enterobacteriaceae are bacteria of the gastrointestinal tract which are also the most frequently involved in bacterial infections, especially urinary tract infections.
- Trial name
- NCT02834910
- Testing
- collection of bacterial sample
- Where
- France
- Volunteers
- 133 people
- Sponsor
- CHU de Reims
Frail Elderly People
Frail Elderly Subjects - Evaluation and Follow-Up
This was a prospective multicenter cohort study of elderly people admitted to medical wards via emergency departments. Subjects were followed up to 36 months.
- Trial name
- SAFES Cohort (NCT02834728)
- Testing
- telephone interview
- Where
- France
- Volunteers
- 1,306 people
- Sponsor
- CHU de Reims
Alcoholism
Cognitive Vulnerability Factors in Alcohol-dependence
The purpose of this study is to specify the cognitive and genetic pattern associated with alcohol dependence. Results will help identifying more precisely vulnerability factors associated with this disorder.
- Trial name
- CoVAD (NCT02842528)
- Testing
- Diagnostic Interview for Genetic Studies, Family Informant Schedule and Criteria, Temperament and Character Inventory
- Where
- France
- Volunteers
- 261 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Pneumonia
Lung Concentrations of Ceftazidime in Patients With Ventilator-associated Pneumonia
Ceftazidime is a beta-lactam compound that exerts a time-dependent bactericidal effect. Numerous arguments are in favor of continuous administration of ceftazidime, both for reasons of clinical efficacy and to preserve…
- Trial name
- CEFTALC (NCT02837835)
- Testing
- ceftazidime
- Where
- France
- Volunteers
- 34 people
- Sponsor
- CHU de Reims
Patients Ongoing Elective Abdominal Laparoscopy
Laparoscopic Surgery and Abdominal Compliance
The objective of the study is to describe factors influencing abdominal compliance during laparoscopic surgery, including neuromuscular blocking agents (NMBA).
- Trial name
- COELIOCUR (NCT02816567)
- Testing
- propofol, NMBA - cisatracurium, sufentanil
- Where
- France
- Volunteers
- 180 people
- Sponsor
- CHU de Reims
Henoch Schönlein Nephritis
Interest to Perform a Renal Biopsy Early in the Course of the Henoch-Schoenlein Nephritis
Henoch-Schönlein (HS) purpura is a common cause of renal glomerular injury in children. This condition is responsible for 10-15% of glomerulonephritis in children.
- Trial name
- NCT02811770
- Testing
- kidney biopsy
- Where
- France
- Volunteers
- 300 people
- Sponsor
- CHU de Reims
Bipolar Disorder, Schizophrenia
fMRI of Theory of Mind in Schizophrenia and Bipolar Disorder
Theory of mind (TOM), a main component of social cognition processes, refers to the capacity to infer one's own and other person's mental states.
- Trial name
- TOM-i (NCT02834182)
- Testing
- IRMf, Mini International Neuropsychiatric Interview, Positive And Negative Syndrom Scale
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Cancer of the Endometrium
Endometrial Cancer and Array CGH
Medical context: Several molecular studies showed chromosomal alterations in patients with endometrial cancer, with gains in 1q, 19p, 19q, 8q, 10q and 10p and loss of 4q, 16q and 18q.
- Trial name
- NCT02833896
- Testing
- surgery
- Where
- France
- Volunteers
- 95 people
- Sponsor
- CHU de Reims
Diabetic Foot - Telemedical Monitoring
The Role of Telemedical Monitoring in Diabetic Foot Ulcer Care
The role of telemedical monitoring in diabetic foot care is still uncertain. The aim is to compare telemedical + standard and standard alone outpatient monitoring in the care of patients with diabetic foot ulcers in a randomized…
- Trial name
- A15-06 (NCT02818322)
- Testing
- telemedical monitoring ( T), classic monitoring
- Where
- France
- Volunteers
- 150 people
- Sponsor
- CHU de Reims
Dental Disease
Effects of the Bone Tissue on the Haemostasis
The research for a haemostasis and for an effective osseous healing are a major stake in oral surgery. The use of glues of fibrin, amplifying the polymerization of the fibrin during the haemostasis is known to reduce the risk of…
- Trial name
- NCT02814799
- Testing
- bone removal
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Arthroscopic Rotator Cuff
Clinical Outcomes After Arthroscopic Tenotomy or Tenodesis of the Long Head of the Biceps
Degenerative changes of the long head of the biceps brachii (LHB) are frequent and often associated with cuff tendinopathy. The function of the LHB in the shoulder is still controversial and uncertain, whereas its function in the…
- Trial name
- NCT02811757
- Testing
- tenotomy, tenodesis
- Where
- France
- Volunteers
- 100 people
- Sponsor
- CHU de Reims
HPV Infection
Epidemiology of High-risk HPV Infection in Women Participating in a Pilot Screening Program for Cervical Cancer
Cervical cancer is due to a persistent infection with a group of viruses known as high-risk Human Papillomaviruses (hrHPV). Viral DNA can be easily detected in a cervical sample by a procedure called 'HPV testing', which can be…
- Trial name
- Epi-START (NCT02809352)
- Testing
- Human papillomavirus genotyping
- Where
- France
- Volunteers
- 348 people
- Sponsor
- CHU de Reims