Clinical trials: sponsored by CHU de Reims
Ankylosing Spondylarthritis
Ankylosing Spondylitis and Antiphospholipid Antibodies
The main objective is to evaluate the prevalence of anti-phospholipid antibodies (APLA) in patients with ankylosing spondylitis (AS).
- Trial name
- ASAA (NCT02809300)
- Testing
- blood collection
- Where
- France
- Volunteers
- 80 people
- Sponsor
- CHU de Reims
Sarcopenia, Malnutrition
Impact of Preoperative Sarcopenia on Morbidity and Mortality in Patients Operated on From Digestive Cancers
Sarcopenia (loss of muscle mass and function) can be observed at any age and results of multiple factors (age, activity, inflammatory factors, nutritional status...).
- Conditions
- Sarcopenia, Malnutrition, Pancreatic Cancer, Liver Cancer
- Trial name
- A15-10 (NCT02811666)
- Testing
- Assessment of sarcopenia by CT-Scan, hand gauge
- Where
- France
- Volunteers
- 200 people
- Sponsor
- CHU de Reims
Lumbar Disk Surgery
Ambulatory Lumbar Disk Surgery
Primary Goal: To compare the clinical outcomes of spinal anesthesia and general anesthesia in surgery for lumbar disc herniation.
- Trial name
- NCT02807194
- Testing
- spinal anesthesia, general anesthesia, lumbar disc herniation
- Where
- France
- Volunteers
- 51 people
- Sponsor
- CHU de Reims
Bipolar Disorder, Schizophrenia
Emotions in Schizophrenia and Bipolar Disorders: a Common Vulnerability?
The initial aim of the project was to gain an understanding of the comprehension of "language-oriented" emotions among schizophrenic and bipolar patients.
- Trial name
- ELISE (NCT02805088)
- Testing
- Electroencephalographic recordings, neuropsychological evaluation, clinical evaluation of symptoms
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Infection With Beta-lactam Resistance in Enterobacteriaceae
Prevalence of Enterobacteria With Decreased Susceptibility to Carbapenems in Eastern Inter- Region
Upon penicillins' introduction, inactivation of beta- lactam antibiotics by enzymes produced by bacteria was demonstrated. Until recently, carbapenems were a relatively spared subclass by these enzymes which makes the molecules…
- Trial name
- CARBAFREST (NCT02803710)
- Testing
- Microbiological study
- Where
- France
- Volunteers
- 315 people
- Sponsor
- CHU de Reims
Renal Transplantation
Contribution of Diffusion MRI in Renal Graft Transplantation
While renal graft outcomes were really improved for the last decade, long time outcomes remains stable. Indeed, at 10 years after transplantation, the renal graft survival rate reaches 50%.
- Trial name
- NCT02803684
- Testing
- MRI examination with tensor diffusion protocol acquisition. No injection needed.
- Where
- France
- Volunteers
- 50 people
- Sponsor
- CHU de Reims
Multiple Sclerosis
Fingolimod Real World Experience: the French Grand-Est Cohort
Objectives: This study describes efficacy and safety of Fingolimod in patients treated for at least 6 months in the east of France from January 2011 to December 2014.
- Trial name
- Gilenya (NCT02799199)
- Volunteers
- 1,014 people
- Sponsor
- CHU de Reims
Alzheimer Disease
Determinants of Quality of Life Related to Health in Alzheimer Disease
Study the factors that explain Health-Related Quality of Life (HRQL) in patients with Alzheimer disease including: The influence of the environment (physical and human) on Health-Related Quality of Life (HRQL), The influence of…
- Trial name
- NCT01570322
- Where
- France
- Volunteers
- 400 people
- Sponsor
- CHU de Reims
Type 1 Diabetes in Children
Patient With Any Pathology (According to the Appreciation of the Investigator) Which Could Disturb the Participation in the Study
The objective of the study is to quantify the products of non-enzymatic glycation of proteins (called AGEs for advanced glycation end-products) in serum of type 1 diabetic patients without clinical complications in order to…
- Trial name
- AGEDIA (NCT02793427)
- Testing
- blood sample collection
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Bipolar Disorder
Mental Time Travel and Identity in Bipolar Disorder Patients
Self-defining memories (SDMs) are memories that are still important today to understand who the investigators are and participate to the maintain of personal identity.
- Trial name
- NCT02793518
- Testing
- psychological tests
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Colon Cancer, Adenocarcinoma
LRP1 and Colon Cancer
Colorectal cancer (CRC) is a major public health problem in France and worldwide. CRC is the third most common cancer in incidence and mortality in France.
- Trial name
- NCT02788669
- Where
- France
- Volunteers
- 100 people
- Sponsor
- CHU de Reims
Neuroendocrine Tumors With Metastasis
Interest of Whole-body MRI Correlated to Spreading Sequences for Staging Neuroendocrine Tumors
The diagnosis and the follow-up of neuroendocrine tumors can be difficult to assess, especially in the detection of metastasis as they can grow in different organs such as liver, lungs, bones or lymph nodes.
- Trial name
- LAB-2013-01 (NCT02786303)
- Testing
- Whole-body diffusion- weighted MRI
- Volunteers
- 100 people
- Sponsor
- CHU de Reims
Peripheral Vascular Diseases
Bone Marrow Autograft in Limb Ischemia
BALI (Bone marrow Autograft in Limb Ischemia) is a randomized double-blind trial comparing implantation of bone marrow - mononuclear cells versus placebo in patients presenting with critical leg ischemia and no surgical option.
- Trial name
- BALI (NCT00904501)
- Testing
- Bone marrow harvest
- Where
- 15 sites in France
- Volunteers
- 40 people
- Sponsor
- CHU de Reims
Emphysema
Lung Volume Reduction Coil Treatment in Emphysema.
BACKGROUND: Medical therapeutic options for the treatment of emphysema remain limited. Lung volume reduction surgery is infrequently used because of its high morbi-mortality.
- Trial name
- STICREVOLENS (NCT01822795)
- Testing
- Lung volume reduction coïl treatment, Regular medical treatment
- Where
- 9 sites in France
- Volunteers
- 100 people
- Sponsor
- CHU de Reims
Chronic Kidney Insufficiency, Kidney Transplantation
EPLErenone in CsA-Treated Recipients (EpleCsAT): Safety
Kidney transplant recipients usually lose their graft by rejection or by immunosuppressive drugs toxicity. In kidney transplantation, calcineurin-inhibitors (including cyclosporine A) are widely used.
- Trial name
- EpleCsAT (NCT01834768)
- Testing
- Eplerenone
- Where
- France
- Volunteers
- 31 people
- Sponsor
- CHU de Reims
Peripheral Vascular Diseases
Cell Therapy in Chronic Limb Ischemia
The primary focus of the trial is safety and efficacy of the intra-muscular implantation of either bone-marrow, or peripheral blood mononuclear cells, in critical limb ischemia, as judged by the proportion of patients which are…
- Trial name
- NCT00533104
- Testing
- BM-MNC preparation, PB-MNC preparation
- Where
- France
- Volunteers
- 40 people
- Sponsor
- CHU de Reims