Clinical trials: sponsored by CHU de Reims
Head and Neck Squamous Cell Carcinoma
Predictive Value of Diffusion-weighted MRI Performed in Early Post-treatment in the Occurrence of Tumor Recurrence or Progression in Head and Neck Squamous Cell Carcinoma Treated With Chemoradiotherapy: a Pilot Study
Head and neck squamous cell carcinoma are frequent. The chemoradiotherapy protocols are part of the reference treatment of locally advanced stage tumors.
- Trial name
- ORODIFF (NCT02862678)
- Testing
- diffusion-weighted MRI
- Where
- France
- Volunteers
- 59 people
- Sponsor
- CHU de Reims
Metastatic Melanoma
Molecular Characterization of Advanced Stage Melanoma by Blood Sampling
Analysis of somatic mutations in tumors is currently indicated for daily practice in all metastatic melanoma. Actually, this research is limited to the mutation of three biomarkers validated by the l'Institut National du CAncer…
- Trial name
- MELCIRC (NCT02862743)
- Testing
- patients with metastatic melanoma
- Where
- France
- Volunteers
- 50 people
- Sponsor
- CHU de Reims
Pregnancy
Pregnancy Denial and Attachment
Described in the 1970's, pregnancy denial occurs as the un-consciousness of being pregnant for several months or throughout the entire period. Body transformations are most of the time not clearly noticeable.
- Trial name
- Denial-attach (NCT02867579)
- Testing
- evaluation of the child quality attachment ("Strange situation")
- Where
- France
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Proliferative Diabetic Retinopathy
Genetic Markers and Proliferative Diabetic Retinopathy
Type 2 Diabetes (TD2) is the leading cause of new cases of preventable blindness in these countries (and the gold-standard treatment, laser photocoagulation has proven to be effective in preventing vision loss at the end stage of…
- Trial name
- REDIAGEN (NCT02879422)
- Testing
- genetic analysis
- Where
- France
- Volunteers
- 302 people
- Sponsor
- CHU de Reims
Preterm Children
Preterm Birth and Social Cognition
The study aims at investigating social cognition outcomes of children born prematurely. Social cognition can be briefly defined as a process which underlines people's social and emotional behaviors.
- Trial name
- TERM-COG (NCT03007095)
- Testing
- Evaluation of the children's social cognitive development
- Where
- France
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Parkinson's Disease
Attributional Style and Parkinson's Disease
Parkinson's disease (PD) is a common neurodegenerative disorder affecting 1-2% of the population over 65 years-old. In addition to the motor impairment characterized by resting tremor, bradykinesia, rigidity and postural…
- Trial name
- ParkAIHQ (NCT03371277)
- Testing
- Medical visit for specific questionnaires
- Where
- France
- Volunteers
- 32 people
- Sponsor
- CHU de Reims
Lupus Nephritis
Detection of Anti-glomerular Basement Membrane Antibodies (Anti-GBM): a Promising Biomarker for Lupus Nephritis (LN)?
Introduction and background : Glomerulonephritis and auto-immune diseases are often associated. Lupus nephritis (LN) is one of the major clinical manifestations of systemic lupus erythematosus (SLE) which have a severe impact on…
- Trial name
- GOODLUPUS (NCT03664908)
- Testing
- Detection of circulating anti-GBM antibodies (using chemiluminescence method and indirect immunofluorescence (IIF) method).
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Rheumatoid Arthritis
Kinetics of Elimination of Methotrexate and Its Major Metabolite 7-OH-methotrexate for Observant Patients
Methotrexate is a key treatment for inflammatory rheumatism. Therapeutic compliance with methotrexate is difficult to measure because of a lack of objective testing; however, therapeutic compliance is essential for the proper…
- Trial name
- MetU (NCT03852888)
- Testing
- Urine samples taken to measure methotrexate and its major metabolite 7-OH-methotrexate level
- Where
- France
- Volunteers
- 62 people
- Sponsor
- CHU de Reims
Obesity
Smallest Significant Value in Osteodensitomery in an Obese Population
The aim of this study is to determined the smallest significant value in osteodensitometry in obese population. The study population will be divided in 3 groups according to their BMI.
- Trial name
- PPVS-ob (NCT04301427)
- Testing
- Bone mineral density
- Where
- France
- Volunteers
- 120 people
- Sponsor
- CHU de Reims
Severe SARS-CoV2 Pneumonia
Prevalence of Long-term Respiratory Complications of Severe SARS-CoV-2 Pneumonia - COVID-19
Studies performed after coronavirus epidemics (severe acute respiratory syndrome coronavirus, SARS-CoV and Middle East respiratory syndrome coronavirus, MERS-CoV) have shown a long-term impact on respiratory morbidity…
- Trial name
- NCT04376840
- Testing
- Blood sample and data record
- Where
- France
- Volunteers
- 150 people
- Sponsor
- CHU de Reims
Carcinoma, Pancreatic Ductal
Organochlorine Concentration in Adipose Tissue and Pancreatic Adenocarcinoma
Pancreatic adenocarcinoma represents more than 90% of pancreatic neoplasms. Around 14000 new cases of pancreatic adenocarcinoma are being diagnosed each year in France and about 8.6% in Grand Est region.
- Trial name
- PESTIPAC (NCT04429490)
- Testing
- Adipose tissue sampling during surgery and urine sampling
- Where
- France
- Volunteers
- 56 people
- Sponsor
- CHU de Reims
Alcohol Use Disorder
Social Cognition and Executive Functions in Alcohol Use Disorders - Transverse Study
Over the past few years, researchers and clinicians have stressed the major role of executive and social cognition impairments in the development and the maintenance of Alcohol Use Disorders (AUD).
- Trial name
- COSEFEX-T (NCT04647422)
- Testing
- Analysis of executive functioning and of social cognition processes
- Where
- France
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Weaning From Mechanical Ventilation
Nurses-driven, Capnography-guided Protocol Weaning From the Mechanical Ventilation at Bedside: A Feasibility Study
Background: Prolonged mechanical ventilation (MV) exposes patients to increased risk of infection and mortality. A weaning protocol (WP) reduces the duration of MV.
- Trial name
- NURSES-WEAN (NCT05000034)
- Testing
- Weaning protocol
- Where
- France
- Volunteers
- 50 people
- Sponsor
- CHU de Reims
Lumbar Radicular Pain
Interest of Virtual Reality Headset During Injection in Patients With Back Pain and Sciatica
For a few years, publications have been published concerning the use of virtual reality headsets in the field of medicine and particularly in various specialities.
- Trial name
- Epi-RéV (NCT05505968)
- Testing
- Virtual Reality Headset
- Where
- France
- Volunteers
- 116 people
- Sponsor
- CHU de Reims
Intensive Care, Pupil Assessment
Pupillometry Use & Professional's Inspection : Leveling Subjectivity
This prospective, non interventionneal, mono-centric study aims to evaluate the accuracy and quality of pupil assessment among three different groups: senior physicians, anesthesiology residents, and nurses.
- Conditions
- Intensive Care, Pupil Assessment, Pupillometry, Neurological Examination
- Trial name
- PUPILS (NCT06733207)
- Testing
- Pupil examination
- Where
- France
- Volunteers
- 30 people
- Sponsor
- CHU de Reims
Urinary Retention
Evaluation of the Efficacy of the Addition of Magnesium Sulfate to Morphine on the Occurrence of Acute Urinary Retention Following Epidural Anesthesia for Cesarean Section.
Peri-medullary anesthesia is the preferred anesthetic technique for Caesarean surgery. Compared with general anesthesia, it reduces maternal and fetal morbidity and mortality, as well as postoperative pain.
- Trial name
- EPIMAG (NCT06442995)
- Testing
- Injection of 500 mg magnesium sulfate + 2 mg morphine into the epidural space, Injection of Isotonic saline + 2 mg morphine into the epidural space
- Where
- France
- Volunteers
- 290 people
- Sponsor
- CHU de Reims
Validation of Raman Spectroscopy Usefulness in Systemic Sclerosis
Skin Fibrosis Analysis by Raman Spectroscopy in Systemic Sclerosis
Systemic sclerosis (SSc) is a rare connective tissue disease characterized by a high clinical heterogeneity with unpredictable evolution that could engage functional and life-threatening prognosis.
- Trial name
- RAMSES (NCT04996082)
- Where
- France
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Primary Immunodeficiency, Common Variable Immunodeficiency
Bronchiectasis Prevalence in Patients With Primary Humoral Immunodefiency in Champagne-Ardenne Region, France
Primary humoral immunodeficiency (PHID), such as common variable immunodefiency, are the most common symptomatic primary immunodeficiency in adults, in France.
- Conditions
- Primary Immunodeficiency, Common Variable Immunodeficiency, Igg Subclass Deficiency, Selective IgM Deficiency
- Trial name
- PREDDICHA (NCT06355323)
- Testing
- Blood test, chest CT scan
- Where
- France
- Volunteers
- 46 people
- Sponsor
- CHU de Reims
Hearing Loss
Fundamental and Clinical Study of Cochlear Synaptopathy
In humans, surface electrophysiological recording of the cochlear nerve in response to a sound stimulus provides information about the integrity and function of synapses (synaptic transmission) and nerve fibre function.
- Trial name
- FunCoSy (NCT06556160)
- Testing
- near field recording of human auditory nerve activity during retro sigmoid approach with contact electrode
- Where
- France
- Volunteers
- 19 people
- Sponsor
- CHU de Reims
Sickle Cells Patients
Study of Vitamin B12 Metabolism in Children With Sickle Cell Disease Exposed to MEOPA
Short description of the protocol intended for the lay public. Include a brief statement of the study hypothesis (Limit : 5000 characters) The sickle cells anemia is a monogenic disease linked to the presence of Hemoglobin S due…
- Trial name
- DREPAM (NCT06581900)
- Testing
- Vitamin B12
- Where
- France
- Volunteers
- 29 people
- Sponsor
- CHU de Reims