Clinical trials: sponsored by CHU de Reims
Fluid Responsiveness in Early Post-kidney Transplantation Period
Collapsibility Index of the Inferior Vena Cava and Kidney Transplantation
Delayed graft function following renal transplantation is common occurrence and is associated with an increased risk of acute rejection and chronic allograft nephropathy.
- Trial name
- CIVC-KT (NCT06799299)
- Testing
- No Intervention
- Where
- France
- Volunteers
- 150 people
- Sponsor
- CHU de Reims
Intermittent Claudication
Home-based Exercice Therapy for Patients With Intermittent Claudication Using a New Smartphone Application
The main characteristic of PAD is to limit physical activity by the appearance of claudication of the lower limbs which limits the walking distance, or the maximum distance traveled by the patient before the pain forces to stop.
- Trial name
- APAISE (NCT05457738)
- Testing
- E-REVA® app, No E-REVA® app
- Where
- France
- Volunteers
- 52 people
- Sponsor
- CHU de Reims
Respiratory Insufficiency
Pathophysiology of Gas Exchange and Time Course Changes in Spontaneously Breathing Patients With Acute Respiratory Failure Due to COVID-19. A Multicenter Prospective Study.
The pathophysiology of SARS-COV-2 related respiratory disease is still poorly understood, especially in its most severe form called acute respiratory distress syndrome (ARDS).
- Trial name
- COVAQ (NCT05392062)
- Testing
- Pathophysiology of gas exchange
- Where
- France
- Volunteers
- 59 people
- Sponsor
- CHU de Reims
Spinal Muscular Atrophy
Study of the Functional Effects of Nusinersen in 5q-spinal Muscular Amyotrophy Adults (SMA Type 2 or 3 Forms)
Spinal Muscular Atrophy (SMA) is an autosomal recessive disease caused by a mutation of exon 7, in 95% of cases, encoding the gene for the motor neuron survival protein called SMN1 (Survival Motor Neuron) located on chromosome…
- Trial name
- NUSI-AD-5qSM (NCT04576494)
- Testing
- Monthly assessments of functional motor abilities by a trained therapist, Nusinersen
- Where
- France
- Volunteers
- 4 people
- Sponsor
- CHU de Reims
Chronic Kidney Diseases
New Approach of Loco Regional Analgesia in Kidney Transplant
Kidney transplant is considered as a moderate painful surgery. Unfortunately, patients with chronic kidney disease are not able to degrade opioid drugs and are therefore most likely to be subjected to the secondary effects of…
- Trial name
- CARRENAL (NCT05391451)
- Testing
- efficacy of quadratus lumborum block in post-operative analgesia in kidney transplant surgery, general anesthesia
- Where
- France
- Volunteers
- 48 people
- Sponsor
- CHU de Reims
Sarcopenia, Hepatocellular Carcinoma
Comparison of Serum Myokine Dosages and Imaging Methods in the Evaluation of Sarcopenia in Patients With Hepatocellular Carcinoma
It is known that some substances present in the blood, called 'myokines,' influence muscle loss. Some may accelerate this loss, while others may prevent it. Inflammatory substances in the blood can also contribute to muscle loss.
- Trial name
- Myomachia (NCT06475118)
- Testing
- Dynamometry measurement, myokine dosing, sarcopenia calculation
- Where
- France
- Volunteers
- 139 people
- Sponsor
- CHU de Reims
Duration of Hospitalization in Intensive Care Unit
Evaluation of the Effectiveness of the Administration of Local Anesthetics Via Two Catheters Placed During Surgery, and Study of the Benefits on Respiratory Function and Therefore on Recovery Time
Currently intravenous analgesics are used for postoperative analgesia. But the analgesia of these products is tempered by their adverse effects (sedation, confusion, nausea or vomiting, delayed transit, urinary retention and…
- Trial name
- PARALSTER (NCT06463899)
- Testing
- multi-perforated catheter, Classic procedure
- Where
- France
- Volunteers
- 114 people
- Sponsor
- CHU de Reims
Aortic Stenosis
Cardiac Amyloidosis Prevalence and Outcome in Aortic Stenosis Patients Undergoing Transcatheter Aortic Valve Implantation
Aortic stenosis (AS) is the most frequent valvulopathy in the general population in France and more generally in developed countries, due to populations aging.
- Trial name
- CAMPOS-TAVI (NCT05384418)
- Testing
- HDP-Tc99m bone scintigraphy
- Where
- France
- Volunteers
- 103 people
- Sponsor
- CHU de Reims
Infectious Keratitis, Microbial Keratitis
Use of a New Method for the Microbiological Diagnosis of Severe Corneal Infection
Microbial keratitis is a severe and often blindness-inducing pathology which represents today the first reason for long-term hospitalization (more than 5 days) in ophthalmology.
- Conditions
- Infectious Keratitis, Microbial Keratitis, Corneal Infection
- Trial name
- ABCORFILM (NCT05888987)
- Testing
- PCR multiplex by FilmArray
- Where
- France
- Volunteers
- 46 people
- Sponsor
- CHU de Reims
Pancreas
Is There a Pancreatic Segmentation Based on the Pancreatic Duct Branching?
Limited pancreatic resections are increasingly performed, but the rate of postoperative fistula is higher than after classical resections.
- Trial name
- NCT03348319
- Testing
- radiation
- Volunteers
- healthy volunteers welcome
- Sponsor
- CHU de Reims
Mucosal Melanoma
Molecular Characterization of Primary Mucosal Melanoma
Primary mucosal melanomas (MPM) are rarer than cutaneous melanomas, but also more severe. They are usually refractory to conventional approaches, regularly excluded from major therapeutic programs and not sensitive to new…
- Trial name
- MELMUQ (NCT03319693)
- Testing
- Somatic Genetic
- Where
- France
- Volunteers
- 65 people
- Sponsor
- CHU de Reims
Cataract Surgery
Evaluation of a Protocol of Pupil Dilation Before Laser-assisted Cataract Surgery
Laser-assisted cataract surgery is an innovative and growing procedure to improve the safety and results of modern cataract surgery.
- Trial name
- MYFLACS (NCT03375996)
- Testing
- cyclopentolate 0.5% eye drops
- Where
- France
- Volunteers
- 60 people
- Sponsor
- CHU de Reims
Septic Shock
Cardiovascular Effects of Norepinephrine
Previous studies of our team reported the improvement of myocardial contractility both on hemodynamic parameters (by transpulmonary thermodilution) and morphological (by transthoracic echocardiography: TTE), during the early…
- Trial name
- NCT05761522
- Testing
- transthoracic echocardiography
- Where
- France
- Volunteers
- 49 people
- Sponsor
- CHU de Reims
Multidrug Resistance
Are the Patients Having Pets at Greater Risk of Carrying Multidrug Resistance Bacteriae?
Introduction : The multidrug resistance (MDR) Bacteriae are growing and are a public health problem. The known risk factors to be expanding of MDR Bacteriae are: taken antibiotics, hospitalization, journey in a country at risk.
- Trial name
- BRANITRANS (NCT03352804)
- Testing
- Screening of MDR Bacteriae
- Where
- France
- Volunteers
- 900 people
- Sponsor
- CHU de Reims
Reduction in DMFT Index and Plaque Index in Patients at the Treatment Completion, an Average of 4 Years, DMFT Index, ICDAS Score, Dental Plaque Index, Communication, Prevention, Dentist, Orthodontist
A New Digital Communication Tool Between Dentist and Orthodontist to Improve Dental Prevention
Dentists and orthodontists of the oral medicine department of Reims University Hospital noted that many children presented white spots around orthodontic brackets, or decays at the end of their multi-brackets orthodontic…
- Trial name
- ComDentODFPrev (NCT06517238)
- Testing
- There is no intervention
- Where
- France
- Volunteers
- 30 people
- Sponsor
- CHU de Reims
Structure Cochlea, Temporal Envelope Cochlea
Study of the Fine Structure and Temporal Envelope of the Human Cochlea in Response to Human Vocalizations
In humans, surface electrophysiological recordings of the cochlear nerve in response to a sound stimulus provide information about the cochlear's ability to encode sound.
- Trial name
- CosySpeech (NCT06499584)
- Testing
- near field recording of human auditory nerve activity during retro sigmoid approach with contact electrode
- Where
- France
- Volunteers
- 20 people
- Sponsor
- CHU de Reims
Low Back Pain, Osteoarthritis
Platelet-rich Plasma Infiltration Versus Corticosteroid Infiltration (Prednisolone) in Treatment of Lumbar Facet Joint Syndrome
The prevalence of low back pain is estimated at 90% . Recent studies have shown that 15% to 52% of back pain is attributable to facet joint syndrome .
- Trial name
- IAPRP (NCT05105256)
- Testing
- Prednisolone, Platelet-rich plasma
- Where
- France
- Volunteers
- 76 people
- Sponsor
- CHU de Reims
Hearing Loss
Coding of Speech Signals in the Human Auditory Nerve
The fine evaluation of the function of auditory neurons in silence and in noise in humans is difficult, if not impossible, to date with the conventional methods available.
- Trial name
- NeuroSpeech (NCT06490237)
- Testing
- near field recording of human auditory nerve activity during retro sigmoid approach with contact electrode
- Where
- France
- Volunteers
- 60 people
- Sponsor
- CHU de Reims
Bullous Pemphigoid
Deciphering IL-17-dependant Inflammatory Response in Bullous Pemphigoid
Bullous pemphigoid (BP) is the most frequent autoimmune skin disease and mainly affects elderly individuals. BP classically manifests with tense blisters over urticarial plaques on the trunk and extremities accompanied by intense…
- Trial name
- BP-IL17RB (NCT06479018)
- Testing
- Blood sampling, Liquid bubble sampling, Cutaneous biopsy
- Where
- France
- Volunteers
- 140 people
- Sponsor
- CHU de Reims
Chronic Lymphocytic Leukemia
Description of the Immune Deficiency in Patients With Untreated Chronic Lymphocytic Leukemia and Search for Predictive Factors of Infectious Risk
Chronic Lymphocytic Leukemia (CLL) is the most common adult leukemia in western countries. CLL is most often discovered incidentally when a blood test carried out for another reason highlights an increase of subpopulation of…
- Trial name
- NCT06475469
- Testing
- Blood sampling & Chest CT without injection
- Where
- France
- Volunteers
- 75 people
- Sponsor
- CHU de Reims