Clinical trials: sponsored by CHU de Reims
Preload Responsiveness, Fluid Responsiveness
Study of End Tidal Carbon Dioxide (EtCO2) Variation After an End- Expiratory Occlusion Test as a Predictive Criteria of Fluid Responsiveness in Mechanically Ventilated Patients
Hypovolemia is one of major factor of haemodynamic instability. Fluid administration is not totally riskless. Indeed, it can create or inflate pulmonary oedema, alter gaz exchanges and increase post operative respiratory…
- Trial name
- CapnoPause (NCT04889807)
- Testing
- measure of EtCO2 variation
- Where
- France
- Volunteers
- 41 people
- Sponsor
- CHU de Reims
Preterm Delivery
Factors Associated With Post-Traumatic Stress Disorder in Patients With After Preterm Delivery
Each year in France, between 50,000 and 60,000 children are born prematurely (< 37 weeks of amenorrhea). Literature has shown that preterm deliveries can be associated with the development of PTSD (Post-Traumatic Stress Disorder)…
- Trial name
- PTSD-preterm (NCT03344471)
- Testing
- Passation of questionnaires
- Where
- France
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Patients With Non-small Cell Lung Cancer (NSCLC) and Pleural Mesothelioma and Treated With a Pemetrexed-based Chemotherapy
Association Between Proton Pump Inhibitors and Hematologic Toxicity of Pemetrexed
Pemetrexed is a multi-folate inhibitor approved in the treatment of non-small cell lung cancer (NSCLC) and pleural mesothelioma.
- Trial name
- IPPEM (NCT03537833)
- Testing
- pemetrexed-related hematological toxicity
- Where
- France
- Volunteers
- 172 people
- Sponsor
- CHU de Reims
Intracranial Aneurysm
Prevalence and Factors Associated With the Occurrence of Depression Six Months After an Endovascular Treatment of Intracranial Aneurysm
During the last decade, the embolization has become the treatment of choice for ruptured intracranial aneurysms, to improve the neurological outcome of patients.
- Trial name
- DEP-AIC (NCT02866812)
- Testing
- questionnaires assessing the state of fatigue, depression and anxiety
- Where
- France
- Volunteers
- 133 people
- Sponsor
- CHU de Reims
Lumbar Disk Herniation
Effectiveness of Lumbar Traction in Lumbar Disk Herniation
The purpose of this study is to compare the clinical outcome of medical treatment associated with lumbar traction and medical treatment alone in the treatment of lumbar disk herniation.
- Trial name
- NCT02793440
- Testing
- cortivazol treatment, lumbar traction
- Where
- France
- Volunteers
- 412 people
- Sponsor
- CHU de Reims
Polycystic Ovary Syndrome, Exposure to Endocrine Disruptors
History of Exposure to Endocrine Disruptors in Women With Polycystic Ovary Syndrome
Polycystic ovary syndrome is a common endocrine disorder that affects between 7% and 14% of women of childbearing age, leading to impaired fertility, clinical and biological hyperandrogenism.
- Trial name
- NCT04998448
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Upper Limb Spasticity
Randomised, Evaluation-blinded, Crossover, Controlled Study Assessing Dynamic Hand Splinting in Adults With Post-stroke Hemiplegia (Orthox)
Upper limb spasticity is currently mainly managed with local toxin treatments. Recent studies suggested combining botulinum toxin injections with splinting to optimise rehabilitation in spastic patients.
- Trial name
- ORTHOX (NCT02888548)
- Testing
- botulinum toxins (Dysport°) alone, orthosis (Saebo Strech°) + botulinum toxins (Dysport°) combined
- Where
- France
- Volunteers
- 1 people
- Sponsor
- CHU de Reims
Unruptured Intracranial Aneurysms
Analysis of Thrombo-embolic Complications After Endovascular Treatment of Unruptured Intracranial Aneurysms
Endovascular treatment of ruptured and unruptured intracranial aneurysms presents complications, mainly the thrombo-embolic complication.
- Trial name
- ACET (NCT02862756)
- Testing
- diffusion-weighted MRI and clinical examination
- Where
- France
- Volunteers
- 250 people
- Sponsor
- CHU de Reims
Subacromial Impingement of the Shoulder
Glenohumeral Re-centering During Closed Kinetic Chain for Shoulder Physiotherapy. A Prospective and Randomized Study.
The rotator cuff tendinopathy is very common and associated with degenerative or traumatic changes of the rotator cuff and/or the sub-acromial bursa or the long head of the biceps.
- Trial name
- SCAPULEO (NCT02874105)
- Testing
- Group C: physiotherapy protocol with Conventional physiotherapy., Group S: physiotherapy protocol with Dynamic Humeral Centering.
- Where
- France
- Volunteers
- 24 people
- Sponsor
- CHU de Reims
Chronic Obstructive Bronchopneumopathy, Infectious Pneumonia
Study of Collagen IV and XIX in Bronchoalveolar Lavage, Pulmonary Aspiration and Bronchial Biopsies
Collagens are proteins present in all tissues. Besides their structural role, recent data showed that they were able to regulate many cellular functions.
- Conditions
- Chronic Obstructive Bronchopneumopathy, Infectious Pneumonia, Pneumonitis, Lung Cancer
- Trial name
- BRONCOLL (NCT02788643)
- Testing
- biological fluids (serum, bronchoalveolar lavage and pulmonary aspiration) and bronchial biopsies collection
- Where
- France
- Volunteers
- 51 people
- Sponsor
- CHU de Reims
CORONAVIRUS INFECTIONS
sFlt1: a Biomarker of Organ Dysfunction in Critically-ill Patients With COVID-19?
Short description of the protocol intended for the lay public. Include a brief statement of the study hypothesis (Limit : 5000 characters) The management of critically-ill patients with organ failure due to COVID-19 represents a…
- Trial name
- COVIDsFlt1 (NCT04394195)
- Testing
- measurement of circulating sFlt1 concentration
- Where
- France
- Volunteers
- 72 people
- Sponsor
- CHU de Reims
Premature Newborns
Dosage of Serum Tryptase Levels in a Population of Premature Newborns to Evaluate Mast Cell Activity
Compare serum tryptase levels of premature babies (<37 weeks of amenorrhea) to children born at full term. Study the evolution of serum tryptase levels in premature babies(<37 weeks of amenorrhea).
- Trial name
- NCT02787980
- Testing
- Additional taking blood
- Where
- France
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Bariatric Surgery Candidate
Contraception and Bariatric Surgery: Evaluation of Contraception and Contraceptive Knowledge of Women Undergoing Bariatric Surgery at the University Hospital of Reims
Obesity is a public health phenomenon affecting more than 17% of women in France, and more than 20% of men and women in Champagne-Ardenne.
- Trial name
- NCT04219852
- Testing
- data collection
- Where
- France
- Volunteers
- 100 people
- Sponsor
- CHU de Reims
Patient Coming to the Emergency Department for Any Reason
the Observance of Emergency Exit Treatments During the Stay of Care at the Exit of Reims Emergencies
The investigators would like to include patients consulting in a Accident and Emergency Department (AED) during the permanence of care the week of March 11 to 17, 2018.
- Trial name
- NCT03836534
- Testing
- adherence to treatment of patients coming out of emergencies
- Where
- France
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Emergency Caesarean
Bicarbonate Epidural Injection in Emergency Caesarian
During labor, pain is systematic. In France, epidural analgesia is the gold standard to fight pain. Sometimes, emergency situations involve the maternal or fetal prognosis and require an emergency fetal extraction by caesarean.
- Trial name
- BiEpIC (NCT04255121)
- Testing
- 2% adrenaline lidocaine associated with 4.2% sodium bicarbonate, 2% adrenaline lidocaine
- Where
- France
- Volunteers
- 400 people
- Sponsor
- CHU de Reims
Intimate Protections
Women and Women's Hygienic Protection: Evaluation of Women's Practices, Knowledge and Expectations for Intimate Protection.
Intimate protections are designed to absorb menstrual flow during menstruation. A woman will use an average of 6,000 intimate protections during her lifetime.
- Trial name
- R-PO19076 (NCT04580719)
- Where
- France
- Volunteers
- 1,153 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Acute Low Back Pain
Clinical Pathways and Patients' Attitudes in Acute Low Back Pain
In France the prevalence of low back pain is 70 to 80 %. It's the leading cause of health expenditure in Europe and costs 900 million euros per year to health insurance in France.
- Trial name
- AcuteLBP (NCT04575714)
- Testing
- Data record
- Where
- France
- Volunteers
- 250 people
- Sponsor
- CHU de Reims
Haemophilia A and B
TFPI Levels in Haemophilia A and B Patients
The goal of this study is to measure the TFPI plasma level, a molecule involved in the regulation of the coagulation system, in haemophilia patients.
- Trial name
- NCT04570696
- Testing
- NON INTERVENTIONAL
- Where
- France
- Volunteers
- 100 people
- Sponsor
- CHU de Reims
Intensivist, Resident
Physical Activity of Staff on Medical Duty in a Department of Anesthesia and Critical Care During Guards
On-call work is an integral part of senior and junior patricians in a critical care department. Several studies have examined the effect of sleep deprivation on physicians on call and the impact of sleep deprivation on the…
- Conditions
- Intensivist, Resident, Night Work
- Trial name
- AMAC (NCT04567017)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Chronic Hemolysis, VKA
Possibility to Stop Perdialytic Heparin Therapy in Hemodialysed Patients With HeprAN ™ Membrane and Treated by Long-term Anticoagulation With VKA
Use HeprAN ™ membrane (coated with heparin) should be allow the success of dialysis sessions, with adequate dialysis parameters, in patients treated by long-term anticoagulation with VKA, without addition of heparin perdialytic.
- Conditions
- Chronic Hemolysis, VKA, Anticoagulants / Administration & Dosage, Coated Materials
- Trial name
- REMARK (NCT04462614)
- Testing
- Decrease per-dialytic heparin therapy
- Where
- France
- Volunteers
- 49 people
- Sponsor
- CHU de Reims