Clinical trials: sponsored by Canadian Cancer Trials Group
Vulvar Squamous Cell Carcinoma
STRatIfication of Vulvar SCC by HPV and p53 Status to Guide Excision
This study is being done to answer the following question: Are there types of early-stage vulvar cancer that require either less or more treatment than the usual approach?
- Trial name
- STRIVE (NCT06358469)
- Testing
- Surgery, Active Surveillance
- Where
- 12 sites in Canada, New Zealand
- Volunteers
- 249 people
- Sponsor
- Canadian Cancer Trials Group
Hepatocellular Carcinoma
STRIDE (Durvalumab + Tremelimumab) With Lenvatinib vs STRIDE Alone in Unresectable Hepatocellular Carcinoma
The purpose of this study is to compare the effects on participants' and liver cancer by adding a drug that is used on its own to treat this disease to a combination of two other drugs which is also used to treat liver cancer…
- Trial name
- SLIDE-HCC (NCT06880523)
- Testing
- STRIDE (durvalumab + tremelimumab), Durvalumab, Lenvatinib
- Where
- 13 sites in Canada
- Volunteers
- 140 people
- Sponsor
- Canadian Cancer Trials Group
Advanced Rare Tumours
A Phase II Study of Sunitinib or Temsirolimus in Patients With Advanced Rare Tumours
This research is being done because there is no treatment that will cure this type of cancer. Although some types of chemotherapy can cause this cancer to shrink for a time, better options are needed.
- Trial name
- NCT01396408
- Testing
- Sunitinib, Temsirolimus
- Where
- 17 sites in Canada
- Volunteers
- 137 people
- Sponsor
- Canadian Cancer Trials Group
Gastroesophageal Adenocarcinoma
Paclitaxel and Ramucirumab +/- Zanidatamab in HER2 Postive Advanced Gastroesophageal Adenocarcinoma
This study is being done to answer the following question: Can the chance of gastroesophageal cancer growing or spreading be lowered by adding a drug called zanidatamab to the usual combination of drugs? We are doing this study…
- Trial name
- NCT06043427
- Testing
- Paclitaxel, Ramucirumab, Zanidatamab
- Where
- 18 sites in Canada
- Volunteers
- 168 people
- Sponsor
- Canadian Cancer Trials Group
Lung Cancer
Study of CTDNA Response Adaptive Immuno-Chemotherapy in Lung Cancer
The standard or usual treatment for this disease is pembrolizumab given by needle into the veins (IV). Some cancers shed DNA (circulating tumour DNA or ctDNA) or genes (biomarkers) into the blood, and levels of these biomarkers…
- Trial name
- NCT04093167
- Testing
- Pembrolizumab
- Where
- 11 sites in United States, Canada
- Volunteers
- 53 people
- Sponsor
- Canadian Cancer Trials Group
Ovarian Cancer
Immunotherapy Platform Study in Platinum Resistant High Grade Serous Ovarian Cancer
This study is being done to answer the following question: What are the effects of a new drug or drugs on ovarian cancer? The pre-study screening may be done to test a sample of tissue for biomarkers to determine participation in…
- Trial name
- IPROC (NCT04918186)
- Testing
- Durvalumab, BA3011, BA3021
- Where
- 6 sites in United States, Canada
- Volunteers
- 60 people
- Sponsor
- Canadian Cancer Trials Group
Cancer, Psychological
Smartphone App-Based Mindfulness Intervention for French and English Speaker Cancer Survivors
There is a need to develop, evaluate, and disseminate self-directed, easily accessible, safe, affordable, and effective psychosocial interventions to people living with cancer (PLWC) post-treatment.
- Trial name
- SEAMLESS (NCT05470010)
- Testing
- Mindfulness
- Where
- 7 sites in Canada
- Volunteers
- 300 people
- Sponsor
- Canadian Cancer Trials Group
Colorectal Cancer
Botensilimab + Balstilimab vs Best Supportive Care as Therapy in Chemo-refractory, Unresectable, Colorectal Adenocarcinoma
This study is being done to answer the main question of: Do patients with colorectal cancer that cannot be removed by surgery, that is treated with two new immunotherapy drugs, botensilimab and balstilimab, live longer? Other…
- Trial name
- BATTMAN (NCT07152821)
- Testing
- Best Supportive Care, Balstilimab, Botensilimab
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Canadian Cancer Trials Group
Rectal Cancer
Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer
This study is being done to answer the following questions: Is the chance of rectal cancer responding the same if chemotherapy alone is given before limited surgery compared to chemotherapy and radiation therapy given together…
- Trial name
- NEO-RT (NCT06205485)
- Testing
- Leucovorin, Oxaliplatin, Fluoruracil
- Where
- 113 sites in United States, Canada
- Volunteers
- 250 people
- Sponsor
- Canadian Cancer Trials Group
Prostate Cancer (Adenocarcinoma)
Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response
This study is being done to answer the following question: can the chance of prostate cancer growing or spreading be lowered by adding a drug to the usual combination of drugs? This study would like to find out if this approach…
- Trial name
- TRIPLE-SWITCH (NCT06592924)
- Testing
- Abiraterone, Enzalutamide, Apalutamide
- Where
- 395 sites in United States, Canada and 2 more
- Volunteers
- 830 people
- Sponsor
- Canadian Cancer Trials Group
Oropharyngeal Cancer
SPECT-CT Guided ELEctive Contralateral Neck Treatment for Patients With Lateralized Oropharyngeal Cancer
This study is being done to answer the following question: Is the chance of cancer spreading or returning the same if radiotherapy to the neck is guided, by using a special imaging study called lymph node mapping (lymphatic…
- Trial name
- SELECT (NCT05451004)
- Testing
- Lymphatic Mapping with SPECT-CT, Ipsilateral and Contralateral Neck
- Where
- 38 sites in United States, Canada
- Volunteers
- 510 people
- Sponsor
- Canadian Cancer Trials Group
Non-small Cell Lung Cancer
Radiotherapy to Block Oligoprogression In Metastatic Non-Small-Cell Lung Cancer
This study is being done to answer the following question: Can the chance of lung cancer growing or spreading be lowered by adding targeted radiotherapy to the usual combination of drugs? This study is being done to find out if…
- Trial name
- CURB2 (NCT06686771)
- Testing
- SBRT, First or second-line standard of care therapy
- Where
- 75 sites in United States, Canada
- Volunteers
- 320 people
- Sponsor
- Canadian Cancer Trials Group
Breast Cancer
Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer
The purpose of this study is to compare the effects on low risk breast cancer receiving usual care that includes regional radiation therapy, with receiving no regional radiation therapy.
- Trial name
- TAILOR RT (NCT03488693)
- Testing
- Radiation, No Radiation
- Where
- 485 sites in United States, Canada
- Volunteers
- 2,138 people
- Sponsor
- Canadian Cancer Trials Group
Chronic Lymphocytic Leukemia
Economic Analysis of Alliance A041202 CLL Study
The prospective cost-effectiveness (cost-utility) analysis from the perspective of the Canadian public healthcare system was completed in 2021.
- Trial name
- NCT02414022
- Where
- 15 sites in Canada
- Volunteers
- 55 people
- Sponsor
- Canadian Cancer Trials Group
Lymphoma, B-Cell
Phase I Master Protocol of Novel Combination Therapy for Patients With Relapsed or Refractory Aggressive B-Cell Lymphoma
The purpose of this study is to find the highest dose of a new drug, in combination with standard drugs, which can be tolerated without causing very severe side effects.
- Trial name
- NCT04161248
- Testing
- Venetoclax, Rituximab Injection, Rituximab SC
- Where
- 4 sites in Canada
- Volunteers
- 40 people
- Sponsor
- Canadian Cancer Trials Group
Bladder Cancer
Trimodality Therapy With/Out Durvalumab to Treat Patients With Muscle-Invasive Bladder Cancer
The purpose of this study is to find out what effects durvalumab has on bladder cancer, combined with treatment after completion of surgery, chemotherapy and radiotherapy.
- Trial name
- NCT03768570
- Testing
- Durvalumab
- Where
- 31 sites in Canada, Spain and 1 more
- Volunteers
- 82 people
- Sponsor
- Canadian Cancer Trials Group
Brain Metastases
Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases
Stereotactic radiosurgery (SRS) is a commonly used treatment for brain tumors. It is a one-day (or in some cases two day), out-patient procedure during which a high dose of radiation is delivered to small spots in the brain while…
- Trial name
- NCT03550391
- Testing
- Memantine, Hippocampal-avoidant (HA-WBRT) Radiotherapy, Stereotactic Radiosurgery (SRS)
- Where
- 86 sites in United States, Canada
- Volunteers
- 206 people
- Sponsor
- Canadian Cancer Trials Group
Unresectable/Metastatic Melanoma
Duration of Anti-PD-1 Therapy in Metastatic Melanoma
The purpose of this study is to compare the effects on patients with metastatic melanoma of taking a government approved and paid-for PD-1 inhibitor intermittently, with taking the same type of agent continuously.
- Trial name
- STOP-GAP (NCT02821013)
- Testing
- Intermittent PD-1 inhibitor therapy, Continuous PD-1 inhibitor therapy
- Where
- 30 sites in Australia, Canada
- Volunteers
- 614 people
- Sponsor
- Canadian Cancer Trials Group
Breast Cancer
Liquid-biopsy Informed Platform Trial to Evaluate CDK4/6-inhibitor Resistant ER+/HER2- Metastatic Breast Cancer
This study is being done to answer the following question: Can testing breast cancer for DNA abnormalities or "biomarkers" help predict which patients are most likely to be helped by certain treatments? The pre-study screening is…
- Trial name
- NCT05601440
- Testing
- RP-6306, Gemcitabine, Observation
- Where
- 10 sites in Canada
- Volunteers
- 484 people
- Sponsor
- Canadian Cancer Trials Group
Anxiety Disorder, Cognitive/Functional Effects
Health Education Materials With/Out a Physical Activity Program for Patients Who Have Undergone Treatment for High-Risk Stage II or Stage III Colon Cancer
RATIONALE: Participating in a physical activity program designed to increase free time physical activity and receiving written health education materials may influence the chance of cancer recurring as well as impact on physical…
- Conditions
- Anxiety Disorder, Cognitive/Functional Effects, Colorectal Cancer, Depression
- Trial name
- CHALLENGE (NCT00819208)
- Testing
- exercise intervention, counseling intervention, educational intervention
- Where
- 47 sites in United States, Australia and 4 more
- Volunteers
- 889 people
- Sponsor
- Canadian Cancer Trials Group