Clinical trials: sponsored by Capital Medical University
Mild Cognitive Impairment(MCI), Alzheimer Disease, Late Onset
China Cognition and Aging Study
The aim of this study is to establish and perfect the China Cognition and Aging Study (China COAST) cohort, to clarify the epidemiology, influencing factors, genetic characteristics, pathogenesis, disease characteristics and…
- Conditions
- Mild Cognitive Impairment(MCI), Alzheimer Disease, Late Onset, Familial Alzheimer Disease (FAD), Vascular Dementia (VaD)
- Trial name
- COAST (NCT03653156)
- Where
- 65 sites in China
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Vascular Dementia
Efficacy and Safety of Butylphthalide Soft Capsule for the Treatment of Vascular Dementia
Butylphthalide soft capsule has been confirmed to have beneficial effects for patients with vascular dementia (VaD) in clinical trial of phase II study.
- Trial name
- NCT03804229
- Testing
- Butylphthalide soft capsule
- Where
- China
- Volunteers
- 707 people
- Sponsor
- Capital Medical University
Alzheimer Disease
Study on Biomarkers for Early Diagnosis of Alzheimer's Disease
The project of Bio-AD is a population- based cohort study among the elderly in China. The project includes not only Alzheimer's disease (AD including familial AD and sporadic AD), but also other clinical stage of AD, as well as…
- Trial name
- NCT04575337
- Where
- China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Alzheimer's Disease
The Diagnostic Cut-off Value of Core Biomarkers of Alzheimer's Disease
The participant in this study includes Alzheimer's disease (AD including familial AD and sporadic AD) patients, amnestic mild cognitive impairment (aMCI) patients, non-AD dementia patients and cognitively normal control.
- Trial name
- NCT05020106
- Where
- China
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Influenza
Suraxavir Marboxil And Oseltamivir for Influenza Prophylaxis Under a Hospital-based Setting
This study aims to evaluate the efficacy of antiviral prophylaxis in preventing in-hospital influenza transmission. We will enroll hospitalized patients with confirmed influenza (index cases) and their uninfected roommates (room…
- Trial name
- NCT07236814
- Testing
- Suraxavir marboxil, Oseltamivir
- Where
- 2 sites in China
- Volunteers
- 384 people
- Sponsor
- Capital Medical University
Type 2 Diabetes Mellitus
Feasibility and Preliminary Efficacy of a Theory-driven BALANCE Dietary Program Among Patients With Type 2 Diabetes
This study explores the effect of an individualized dietary intervention program based on COM-B theory on improving health outcomes in patients with T2DM, improvement in metabolic health indicators and an increased diabetes…
- Trial name
- BALANCE (NCT07472855)
- Testing
- Psychological capability education, Physical capability education, motivation management
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Capital Medical University
Community Acquired Pneumonia (CAP)
Effect of tNGS on CAP Patients With Initial Treatment Failure
This is a multicenter, randomized controlled trial designed to evaluate the impact of tNGS in patients with community-acquired pneumonia who experience initial treatment failure.
- Trial name
- NCT07472114
- Testing
- Targeted next-generation sequencing, Conventional microbiological testing, Follow-up at Day 30
- Where
- China
- Volunteers
- 524 people
- Sponsor
- Capital Medical University
Tracheostomy Decannulation
Effects of Tracheostomy Decannulation on Respiratory Function
This single-center prospective study enrolls adult patients with long-term tracheostomy who are ready for tube removal (decannulation).
- Trial name
- NCT07191509
- Testing
- Speaking Valve ，Tracheostomy Tube Occlusion ，Tracheostomy Tube Ventilation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Capital Medical University
Acute Ischaemic Stroke, Stroke-associated Pneumonia
Ultra-early Chest CT for SAP Prediction
Stroke-associated pneumonia (SAP) is a common and serious complication after acute ischaemic stroke (AIS). Existing scores rely mainly on clinical variables, and the added prognostic value of inflammatory markers and early chest…
- Trial name
- SENTRY (NCT07321275)
- Where
- 8 sites in China
- Volunteers
- 1,499 people
- Sponsor
- Capital Medical University
Atelectasis
The Effect of Oscillation and Lung Expansion (OLE) Therapy in Prolonged Mechanical Ventilated Patients With Atelectasis Evaluated in Multiple Methods
High frequency chest wall oscillation (HFCWO) is currently one of the most common and widespread mechanical airway clearance techniques (ACTs) in clinical practice in China.
- Trial name
- NCT07451405
- Testing
- High frequency chest wall oscillation or other airway clearance therapy, Oscillation and lung expansion
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Capital Medical University
Respiratory Viral Infections, Influenza
MxA-Guided Antiviral Treatment in Respiratory Viral Infections
This pilot randomized controlled trial (RCT) will investigate the clinical impact of Myxovirus Resistance Protein A (MxA)-guided antiviral treatment versus standard treatment in patients with respiratory viral infections.
- Conditions
- Respiratory Viral Infections, Influenza, SARS CoV-2
- Trial name
- NCT06668025
- Testing
- MxA tests, MxA feedback, Follow-up at Day 30
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Capital Medical University
Insomnia, Primary
Efficiency of Intermittent Hypoxia Intervention in Primary Insomnia
The purpose of this study was to understand the effectiveness of intermittent hypoxia in the treatment of primary insomnia.
- Trial name
- NCT07394699
- Testing
- Intermittent Hypoxia
- Volunteers
- 30 people
- Sponsor
- Capital Medical University
Acute Ischemic Stroke
Telemedicine-supported Management for Acute Ischemic Stroke
Telemedicine-supported stroke care can provide standardized guidance to hospitals and regions with limited medical resources, thereby improving treatment outcomes for stroke patients in these areas.
- Trial name
- TOGETHER (NCT07302971)
- Testing
- Telemedicine-Supported Management
- Where
- China
- Volunteers
- 2,400 people
- Sponsor
- Capital Medical University
Brain Aging
Haematococcus Pluvialis Astaxanthin for Brain Aging
We recruit community-dwelling older adults aged 50 and above for a 6-month intervention. Participants are divided into three groups: Placebo Group, Low-Dose Group ( 6 mg/d Haematococcus pluvialis Astaxanthin), High-Dose Group (12…
- Trial name
- NCT07379437
- Testing
- Low-Dose AST, High-Dose AST
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Neurology
Physician Diagnosis of Neurologic Cases With Large Language Models
This study is a prospective randomized controlled trial that aims to evaluate whether large language model (LLM) assistance improves physicians' diagnostic performance compared with conventional assistance.
- Trial name
- NCT07344792
- Testing
- LLM assistance
- Where
- 3 sites in China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Ischemic Stroke, Transient Ischemic Attack
Follow-up Extension Study of Regular Physical Exercise in Patients With Symptomatic Intracranial Arterial Stenosis
This study will include the subjects with symptomatic intracranial arterial stenosis (ICAS) who have participated in and completed the 1-year follow-up of RESIST trial (NCT06615726).
- Trial name
- RESIST-FE (NCT07242768)
- Testing
- Non-Interventional Study
- Where
- China
- Volunteers
- 1,300 people
- Sponsor
- Capital Medical University
Breast Cancer, Surgery
Hypofractionation With Simultaneous Integrated Boost for Early Breast Cancer
Simultaneous integrated boost radiotherapy has been investigated in some malignant tumors and appears to be safe and feasible. However, Hypofractionation with simultaneous integrated boost has been investigating in breast cancer.
- Conditions
- Breast Cancer, Surgery, Adjuvant Radiotherapy
- Trial name
- NCT04913532
- Testing
- Hypofractionation with simultaneous integrated boost
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Capital Medical University
Critical Care, Acute Hypoxic Respiratory Failure
Inspiratory Effort-Targeted Pressure Support Ventilation (IT-PSV) Trial
The Inspiratory effort-Targeted Pressure Support Ventilation (IT-PSV) is a cluster randomized controlled trial. Its main aim is to determine whether an inspiratory effort-targeted pressure support setting strategy, compared to…
- Conditions
- Critical Care, Acute Hypoxic Respiratory Failure, Ventilator-Induced Lung Injury
- Trial name
- IT-PSV (NCT06526598)
- Testing
- PMI-targeted pressure support setting and adjustment, VT/RR-targeted pressure support setting and adjustment
- Where
- China
- Volunteers
- 619 people
- Sponsor
- Capital Medical University
Tracheostomy
SV With TTPEE Measurement Predicts Upper Airway Patency in Prolonged Tracheostomy Patients
The aim of this study is to evaluate the feasibility of predicting upper airway patency in patients with prolonged tracheostomy using a non-invasive method combining speaking valve (SV) and transtracheal end-expiratory pressure…
- Trial name
- NCT07107243
- Testing
- Speaking valve combined with airway pressure, Bronchoscopy
- Where
- 5 sites in China
- Volunteers
- 300 people
- Sponsor
- Capital Medical University
Diabetes
Raman Spectroscopy-Based Non-Invasive Blood Glucose Detection
Diabetes is a chronic metabolic disease that is widely prevalent globally, with its incidence rate continuously increasing, posing significant challenges to patient health and public health systems.
- Trial name
- Raman Glucose (NCT07311421)
- Testing
- Raman spectroscopy for blood glucose measurement
- Where
- 2 sites in China
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Beijing Shijitan Hospital, Capital Medical University