Clinical trials: sponsored by Capital Medical University
Cardiac Arrest, Brain Injuries
PET-CT to Assess Brain Damage in Cardiac Arrest Patients
This was a single-center, observational study. Patients with successful cardiopulmonary resuscitation (CPR) will be transferred to the emergency intensive care unit for further standardized management.
- Trial name
- NCT06660238
- Testing
- No interventions
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Capital Medical University
Acute Ischemic Stroke
Albumin for Patients With Acute Large Vessel Occlusive Stroke Undergoing Endovascular Reperfusion Therapy
The objective of this study is to evaluate the effectiveness and safety of endovascular therapy combined with 25% human albumin in the treatment of acute large vessel occlusive stroke.
- Trial name
- NCT06538844
- Testing
- Intravenous infusion of human albumin, Saline
- Where
- 8 sites in China
- Volunteers
- 134 people
- Sponsor
- Capital Medical University
Acute Ischemic Stroke, Reperfusion Injury
Ischemic Post-conditioning in Acute Ischemic Stroke Thrombectomy (PROTECT-1b)
Ischemic post-conditioning is a neuroprotective strategy attenuating reperfusion injury in animal stroke models. The investigators have conducted a 3 + 3 dose-escalation trial to demonstrate the safety and tolerability of…
- Trial name
- PROTECT (NCT05909982)
- Testing
- Mechanical thrombectomy combined with ischemic post-conditioning
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Capital Medical University
Retained Products of Conception
The Efficacy of Auto-cross Linked Hyaluronic Acid Gel in the Prevention of Adhesion Reformation After Hysteroscopic Resection of Retained Products of Conception
Retained product of conception (RPOC) is defined by abnormal trophoblastic persistence or retained placenta inside the uterus cavity after a pregnancy independently of the outcome. Untreated RPOC can compromise future fertility.
- Trial name
- NCT05085067
- Testing
- auto-crossed-linked hyaluronic acid gel
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Fu Xing Hospital, Capital Medical University
Intrauterine Adhesion, Asherman Syndrome
Platelet Rich Plasma in the Prevention of Adhesion Reformation
Asherman syndrome, which occurs after trauma to the basalis layer of the endometrium. It seems that the role of postoperative platelet rich plasma（PRP）therapy in the prevention of recurrence of IUA is still controversial.
- Trial name
- NCT06608407
- Testing
- PRP group
- Where
- 2 sites in China
- Volunteers
- 46 people
- Sponsor
- Fu Xing Hospital, Capital Medical University
Head and Neck Neoplasms, Quality of Life
Prospective, Observational, Real-world Oral Malignant Tumors Study
The aim of the study is to construct a register system of oral and maxillofacial malignant tumors based on a prospective, observational, real-world study in north Chinese population.
- Conditions
- Head and Neck Neoplasms, Quality of Life, Postoperative Complications
- Trial name
- POROMS (NCT02395367)
- Testing
- resection, adjuvant radiotherapy, neoadjuvant chemotherapy or adjuvant chemotherapy
- Where
- 7 sites in China
- Volunteers
- 30,000 people
- Sponsor
- Beijing Stomatological Hospital, Capital Medical University
Stroke
Blood Proteome Profiling Identifies Biomarkers in Ischemic Stroke
Endovascular thrombectomy and intravenous thrombolysis have become key therapeutic approaches for acute ischemic stroke. However, due to time window limitations, many patients are unable to receive reperfusion therapy, and the…
- Trial name
- NCT06729385
- Testing
- The blood Proteome Profiling
- Where
- 4 sites in China
- Volunteers
- 80 people
- Sponsor
- Capital Medical University
Stroke, Acute, Hypoxia-Ischemia, Brain
Normobaric Hyperoxia Combined With Endovascular Therapy in Patients With Stroke Within 6 Hours of Onset：Longterm Outcome
The overall incidence of good outcome for AIS following endovascular treatment is only proximately 50%. Whether NBO was safe and effective to improve acute ischemic stroke prognosis is still unclear.
- Conditions
- Stroke, Acute, Hypoxia-Ischemia, Brain, ENDOVASCULAR TREATMENT
- Trial name
- NBOL (NCT05039697)
- Testing
- oxygen
- Where
- China
- Volunteers
- 282 people
- Sponsor
- Capital Medical University
Critical Care, Acute Hypoxic Respiratory Failure
A Pilot Trial of Pressure Muscle Index-Targeted PSV Trial
Pressure support ventilation (PSV) is one of the most frequently used ventilator modes in the intensive care unit (ICU). The successful implementation of PSV depends on matching the patient's inspiratory effort with the…
- Conditions
- Critical Care, Acute Hypoxic Respiratory Failure, Ventilator Lung
- Trial name
- NCT06769360
- Testing
- PMI-targeted PSV setting, VT/RR-targeted PSV setting
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Capital Medical University
Stroke Acute
Adjuvant Cerebroprotection Using Normobaric Hyperoxia in Pre-hospital Patients with Suspected Stroke
The primary objective of this study is to determine the efficacy and safety of inhaled normobaric hyperoxia therapy (NBO) beginning in the pre-hospital setting in patients with suspected acute cerebral ischemia (ACI) due to large…
- Trial name
- AN-O2-EMS (NCT06801457)
- Testing
- NBO, Control
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Capital Medical University
Intracerebral Hemorrhage
Minimally Invasive Soft Channel Brain Haemorrhage Evacuation for Acute Basal Ganglia Haemorrhage--Small Hemorrhage Evacuation (MIRACLE-S)
The objective of this study is to determine whether minimally invasive soft channel brain hemorrhage evacuation (scMIS), compared to usual care, leads to superior functional recovery as measured by utility-weighted modified…
- Trial name
- MIRACLE-S (NCT06688162)
- Testing
- Usual Care, Minimally Invasive Soft Channel Brain Haemorrhage Evacuation (scMIS)
- Where
- China
- Volunteers
- 750 people
- Sponsor
- Capital Medical University
Hypersecretive Mechanically Ventilated Patients
Evaluating the Short-term Efficacy of Two Oscillation Techniques in Hypersecretive Mechanically Ventilated Patients
Although mechanical ventilation (MV) is life-saving, it is associated with several complications. The establishment of an artificial airway impairs the cough reflex and mucociliary function, leading to the accumulation of…
- Trial name
- NCT06675942
- Testing
- Oscillation and Lung Expansion, High-frequency chest wall oscillation
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Capital Medical University
Acute Exacerbation Chronic Obstructive Pulmonary Disease
MxA and CRP-Guided Use of Antimicrobial Agents for AECOPD
This randomized controlled trial will investigate the clinical impact of Myxovirus Resistance A (MxA) and C-Reactive Protein (CRP)-guided antimicrobial treatment compared to usual care in outpatients with acute exacerbations of…
- Trial name
- NCT06779344
- Testing
- MxA and CRP tests, MxA and CRP feedback, Follow up
- Where
- China
- Volunteers
- 458 people
- Sponsor
- Capital Medical University
Mechanical Ventilation
PMI Guide PS Setting in Pressure Support-ventilated Patients
Pressure support ventilation (PSV) is an assistant mechanical ventilation mode, that is widely implemented in mechanical ventilation treatment but there are no exact guidelines to guide PS setting.
- Trial name
- NCT05963737
- Testing
- PS setting strategy in pressure-support ventilated patients
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Capital Medical University
Acute Ischemic Stroke
Intra-arterial Hypothermic Magnesium Sulfate Infusion in Combination with Endovascular Thrombectomy in Acute Ischemic Stroke
The primary objective of this study is to estimate the safety of intra-arterial hypothermic magnesium sulfate infusion after endovascular thrombectomy in patients with acute ischemic stroke
- Trial name
- Hypo-Mag (NCT06760195)
- Testing
- Intra-arterial hypothermic magnesium sulfate infusion, Endovascular thrombectomy, Intravenous thrombolysis
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Capital Medical University
Influenza, Influenza Prophylaxis
Oseltamivir and Baloxavir Marboxil for Prophylaxis Against Influenza Under a Hospital-based Setting
This study aims to randomly assign close contacts of hospitalized influenza virus patients to receive baloxavir marboxil prophylaxis, oseltamivir prophylaxis or no antiviral prophylaxis and monitor the incidence of clinical…
- Conditions
- Influenza, Influenza Prophylaxis, Nosocomial Infection
- Trial name
- NCT06762587
- Testing
- Baloxavir Marboxil, Oseltamivir
- Where
- China
- Volunteers
- 372 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Intracerebral Hemorrhage
Minimally Invasive Soft Channel Brain Haemorrhage Evacuation for Acute Basal Ganglia Haemorrhage-- Large Hemorrhage Evacuation (MIRACLE-L)
To determine if minimally invasive soft channel brain hemorrhage evacuation (scMIS), compared with any other neurosurgical technique that includes open craniotomy, small skull window microsurgery , and endoscopic surgery, is at…
- Trial name
- MIRACLE-L (NCT06688201)
- Testing
- Other neurosurgical techniques, Minimally Invasive Soft Channel Brain Haemorrhage Evacuation
- Where
- China
- Volunteers
- 550 people
- Sponsor
- Capital Medical University
Stroke
Efficacy Study II on Remote Ischemic Conditioning for the Prevention of Stroke-Associated Pneumonia
Verifying whether remote ischemic adaptation can reduce the occurrence of stroke related pneumonia in acute stroke patients within 24 hours of onset
- Trial name
- RICA-2 (NCT05982015)
- Testing
- Remote ischemic conditioning
- Where
- China
- Volunteers
- 1,651 people
- Sponsor
- Capital Medical University
Acute Ischemic Stroke
Study on Hibernation-like Therapy Based on Mechanical Thrombectomy
The goal of this clinical trial is to learn whether chlorpromazine and promethazine（C+P）is safe in Acute Ischemic Stroke（AIS) patients and determine the maximum dosage.
- Trial name
- CHILL-1 (NCT06663631)
- Testing
- chlorpromazine and promethazine, endovascular thrombectomy, rt-PA
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Capital Medical University
Cerebral Venous Outflow Disorders
Intermittent Hypoxia-Hyperoxia Training in Cerebral Venous Outflow Disorders (IHHT-CVOD)
This study aims to investigate the safety and efficacy of intermittent hypoxia-hyperoxia treatment in patients with cerebral venous outflow disorders.
- Trial name
- IHHT-CVOD (NCT06738706)
- Testing
- intermittent hypoxia-hyperoxia treatment
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Capital Medical University