Clinical trials: sponsored by Capital Medical University
Advanced Cancer, Metastatic Cancer
Personalized Vaccine Generated by Autologous Dendritic Cells Pulsed With Autologous Whole Tumor Cell Lysate Treat Advanced Solid Tumor Patients With High Tumor Mutation Burden
The study is to investigate the safety and efficacy of dendritic cells vaccines pulsed with autologous whole tumor cell lysate for treating advanced solid tumor patients with high tumor mutation burden.
- Trial name
- NCT03671720
- Testing
- personalized DC vaccine
- Where
- China
- Sponsor
- Capital Medical University
Cancer, Abdominal Cancer
Hyperthermia Combined With Immunotherapy in the Treatment of Abdominal and Pelvic Malignancies or Metastases
It is a non-randomized pilot study.The allocation will be determined by patients or their immediate family members who were cooperative with physician's interpretations on the disease progression and updated information of…
- Conditions
- Cancer, Abdominal Cancer, Pelvic Cancer, Metastatic Cancer
- Trial name
- NCT03757858
- Testing
- Thermotron RF-8, Adoptive cellular Immunotherapy, Anti-PD-1 antibody
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Capital Medical University
Brain Tumor, Pediatric
Immunomodulation Analysis of Radiation Therapy in Pediatric Malignant Brain Tumors
To investigate the effect of radiotherapy on peripheral blood immune cell composition and function in pediatric malignant brain tumor patients.
- Trial name
- NCT04019470
- Where
- China
- Sponsor
- Capital Medical University
Intracerebral Hemorrhage, Statins
Statin for Neuroprotection in Spontaneous Intracerebral Hemorrhage
Brain injury after spontaneous intracerebral hemorrhage results from pathophysiologic responses in the brain parenchyma due to hematoma formation, release of clot components, and surrounding edema.
- Trial name
- STATIC (NCT04857632)
- Testing
- Statin
- Where
- 3 sites in China
- Volunteers
- 98 people
- Sponsor
- Capital Medical University
Influenza A
A Prospective, Multicenter, Randomized Controlled Clinical Study on the Efficacy and Safety of Xuanfei Baidu Granule in the Treatment of Influenza A
This study is a prospective, multicenter, randomized controlled trial and aims to evaluate efficacy and safety of Xuanfei Baidu Granule in the treatment of influenza A. This study plans to enroll 584 subjects.
- Trial name
- NCT06205641
- Testing
- Xuanfei Baidu Granule, Baloxavir Marboxil Tablet
- Where
- China
- Volunteers
- 584 people
- Sponsor
- Capital Medical University
Stroke, Acute, Neuroprotection
Treatment Duration on Normobaric Hyperoxia in Acute Ischemic Stroke
Normoxia Hyperoxia (NBO) is a neuroprotective approach that can be implemented early. NBO is simple and non-invasive and can be used at home or in an ambulance to ensure the shortest possible time after cerebral ischemia occurs.
- Conditions
- Stroke, Acute, Neuroprotection, Endovascular Treatment
- Trial name
- NCT05404373
- Testing
- Normobaric Hyperoxia (NBO), Low flow oxygen
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Capital Medical University
High Altitude Polycythemia
The Efficacy of Combination of Traditional Tibetan and Remote Ischemic Conditioning on High Altitude Polycythemia
A multicenter, randomized controlled trial was designed to evaluate the effectiveness and safety of the comprehensive traditional Tibetan medicine program combined with remote ischemic conditioning on high altitude polycythemia.
- Trial name
- NCT06082583
- Testing
- Remote Ischemic Conditioning, Tibetan Medicine (Shiliu Jianwei Powder, Ershiwuwei Yuganzi Pills, Qiwei Tiexue Pill)
- Volunteers
- 300 people
- Sponsor
- Capital Medical University
Aneurysmal Subarachnoid Hemorrhage, Hyperchloremia
Impact of Multiple Electrolytes Injection Ⅱ and Saline on Hyperchloremia in Patients With Aneurysmal Subarachnoid Hemorrhage:a Pilot Study
The goal of this pilot randomized trial is to compare the effect of Multiple Electrolytes Injection Ⅱand saline on the occurrence of hyperchloremia within 72h of randomization in patients with aneurysmal subarachnoid…
- Trial name
- NCT06076590
- Testing
- maintenance fluid
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Capital Medical University
Ventilator-induced Lung Injury
Intraoperative Lung-Protective Ventilation in Neurosurgery
The purpose of this study is to explore the effectiveness of lung-protective ventilation during general anesthesia for neurosurgical procedures on postoperative pulmonary outcome, compared with traditional ventilation.
- Trial name
- NCT02386683
- Testing
- lung-protective ventilation
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Capital Medical University
Stroke, Acute
Normobaric Hyperoxia Combined With Reperfusion for Acute Ischemic Stroke
NBO is a nonpharmacological measure of neuroprotection. The purpose of our study is to evaluate the safety and efficiency of NBO（Normobaric hyperoxia) in the acute ischemic stroke patients who received endovascular treatment.
- Trial name
- NCT03620370
- Testing
- Normobaric oxygen therapy
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Capital Medical University
Stroke, Acute, Neuroprotection
Normobaric Hyperoxia Combined With Endovascular Treatment in Acute Ischemic Stroke (OPENS-2)
The current endovascular treatment has increased the recanalization rate to more than 90%. Even so, the prognosis rate of stroke is still less than 50%.
- Trial name
- NCT04681651
- Testing
- Normobaric Hyperoxia, Endovascular Thrombectomy
- Where
- China
- Volunteers
- 282 people
- Sponsor
- Capital Medical University
Had a Computed Tomography Scan of the Chest Within 24 Hours After Stroke Onset
Pulmonary Infection After Ischemic Stroke
To assess the frequency of signs of pulmonary infection on a chest CT and development of clinical diagnose of poststroke pneumonia，and its effect on functional outcome in patients with acute ischemic stroke.
- Trial name
- PICAS (NCT05923034)
- Where
- 6 sites in China
- Volunteers
- 500 people
- Sponsor
- Capital Medical University
Venous Thromboembolism, Neurosurgery
Prospective Validation of Clinical Prediction Model for Venous Thromboembolism Following Neurosurgery
Validation of Clinical Prediction Model for Venous Thromboembolism Following Neurosurgery: A Multicenter, Prospective, and Cohort Study
- Conditions
- Venous Thromboembolism, Neurosurgery, Risk Assessment
- Trial name
- NCT05860790
- Testing
- Clinical Prediction Model for Venous Thromboembolism Following Neurosurgery
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Capital Medical University
Chronic Cerebral Hypoperfusion
Exploratory Study of Intermittent Hypoxia Treatment in Chronic Cerebral Hypoperfusion
This study aims to investigate the safety and efficacy of intermittent hypoxia treatment in patients with chronic cerebral hypoperfusion.
- Trial name
- NCT05824104
- Testing
- Intermittent Hypoxia
- Volunteers
- 20 people
- Sponsor
- Capital Medical University
Abnormal Cerebral Venous Sinus Morphology, Internal Jugular Vein Stenosis
Brain Imaging in Cerebral Venous Outflow Disturbance
Cerebral venous outflow disturbance can lead to cerebral hemodynamic disturbances, altered cerebrospinal fluid dynamics, cerebral venous blood stasis, increased cerebral venous pressure and decreased cerebral perfusion, cerebral…
- Conditions
- Abnormal Cerebral Venous Sinus Morphology, Internal Jugular Vein Stenosis, Image
- Trial name
- NCT05820165
- Testing
- high-resolution 3D-T1, diffusion tensor imaging (DTI), resting-state functional magnetic resonance imaging (rs-fMRI)
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Venous Sinus Thrombosis, Cranial
Anatomical Variation of Cerebral Venous Sinus in Healthy Individuals
The anatomical characteristics of veins and venous sinus result in great differences between cerebral venous system diseases and cerebral artery diseases in etiology, pathophysiology and clinical features.Therefore, understanding…
- Trial name
- NCT05413837
- Testing
- anotomy and variation of venous sinus, the level of biomarker in bood
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Acute Mountain Sickness
The Effects of Intermittent Hypoxia on Acute Hypoxic Injury
This study intends to further reveal the effectiveness of intermittent hypoxia in preventing acute hypoxic injury.
- Trial name
- NCT05733338
- Testing
- Intermittent Hypoxia
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Intracerebral Hemorrhage
A Cohort Study of Patients With Intracranial Hemorrhage
As one of the most serious forms of acute stroke, the early mortality rate of intracerebral hemorrhage(ICH) can be as high as 30-40%. The incidence of intracerebral hemorrhage increases with the increase of age.
- Trial name
- NCT05760950
- Testing
- Routine clinical treatment
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Capital Medical University
Chronic Kidney Diseases, Fracture
Denosumab Treatment in CKD Patients at High Risk of Fracture
Objective: To verify the efficacy and safety of denosumab in the prevention and treatment of CKD-MBD in CKD patients with high risk of fracture.
- Conditions
- Chronic Kidney Diseases, Fracture, Bone Density, Low, End Stage Renal Disease
- Trial name
- NCT05692297
- Testing
- Denosumab, Non-denosumab
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Capital Medical University
Acute Ischemic Stroke
Ischemic Post-conditioning in Acute Ischemic Stroke Thrombectomy
Ischemic post-conditioning is a neuroprotective strategy that has been proven to attenuate reperfusion injury in animal models of stroke.
- Trial name
- PROTECT (NCT05153655)
- Testing
- Local ischemic post-conditioning
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Capital Medical University