Clinical trials: sponsored by Case Comprehensive Cancer Center
Breast Cancer
Paclitaxel Plus Radiation Therapy in Treating Women With Stage II or Stage III Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00006256
- Testing
- paclitaxel, adjuvant therapy, radiation therapy
- Where
- 9 sites in United States
- Volunteers
- 44 people
- Sponsor
- Case Comprehensive Cancer Center
Metastatic Pancreatic Adenocarcinoma
Regorafenib Plus Gemcitabine in Metastatic Pancreatic Cancer
This phase II trial studies how well regorafenib and gemcitabine hydrochloride work as second-line therapy (treatment given when initial treatment doesn't work) in treating patients with pancreatic cancer that has spread to other…
- Trial name
- NCT02383433
- Testing
- Regorafenib, Gemcitabine Hydrochloride
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Case Comprehensive Cancer Center
Bone Marrow Fibrosis, Myeloproliferative Neoplasm
Captopril Use on the Degree of Marrow Fibrosis in Bone Marrow Fibrosis/Myeloproliferative Neoplasms
The purpose of this study is to evaluate the safety and tolerability of captopril and evaluate the effectiveness captopril as measured by changes in the grade of bone marrow scar tissue.
- Trial name
- NCT04629651
- Testing
- Captopril
- Where
- United States
- Sponsor
- Case Comprehensive Cancer Center
Metastatic Triple Negative Breast Cancer
Carboplatin, Nab-Paclitaxel and Pembrolizumab for Metastatic Triple-Negative Breast Cancer
The purpose of this study is to see how effective the combination of the two chemotherapy drugs (carboplatin and nab-paclitaxel) are when added to a third drug, pembrolizumab.
- Trial name
- NCT03121352
- Testing
- Carboplatin, Nab-paclitaxel, Pembrolizumab
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Case Comprehensive Cancer Center
Chronic Myelogenous Leukemia, Acute Lymphoblastic Leukemia
Tac, Mini-MTX, MMF Versus Tac, MTX for GVHD Prevention
This randomized clinical trial studies standard GVHD prophylaxis with tacrolimus and methotrexate compared to tacrolimus, mycophenolate mofetil and a reduced-dose methotrexate in patients with hematologic malignancies undergoing…
- Conditions
- Chronic Myelogenous Leukemia, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Acute Biphenotypic Leukemia
- Trial name
- NCT01951885
- Testing
- tacrolimus, methotrexate, Mycophenolate mofetil
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Case Comprehensive Cancer Center
Monoclonal Gammopathy, Smoldering Myeloma
Dendritic Cell DKK1 Vaccine for Monoclonal Gammopathy and Stable or Smoldering Myeloma
The purpose of this study is to study the safety and preliminary efficacy of a dendritic cell DKK1 vaccine against myeloma. Dendritic cells are immune cells that are collected from the blood of the patient at Case Western Reserve…
- Conditions
- Monoclonal Gammopathy, Smoldering Myeloma, Myeloma
- Trial name
- NCT03591614
- Testing
- DKK1
- Where
- 2 sites in United States
- Sponsor
- Case Comprehensive Cancer Center
Metastatic Renal Cell Cancer
Axitinib Given on an Individualized Schedule for Metastatic Renal Cell Cancer
Axitinib is a drug which is approved by the FDA for patients with advanced kidney cancer who have already received some treatment. It works by reducing blood flow to a tumor.
- Trial name
- NCT02579811
- Testing
- Axitinib
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Case Comprehensive Cancer Center
Breast Reconstruction Following Mastectomy
Prepectoral vs Partial Subpectoral Two-Stage Implant-Based Breast Reconstruction
The purpose of this study is to investigate the to analyze the patient satisfaction and complication rates under controlled conditions of the increasingly popular prepectoral technique for implant-based breast reconstruction.
- Trial name
- NCT04874402
- Testing
- Prepectoral approach, Partial Subpectoral approach
- Where
- United States
- Sponsor
- Case Comprehensive Cancer Center
Prostate Cancer
Correlation of Imaging Findings With Clinical Findings and Patient Outcomes in Prostate Cancer
MRI is being increasingly relied upon for detection, staging and management of prostate cancer. In this study patients with risk of prostate cancer will be recommended to have a pelvic MRI prior to the standard biopsy of the…
- Trial name
- NCT03122470
- Testing
- MRI guided biopsy, TRUS biopsy
- Sponsor
- Case Comprehensive Cancer Center
Pancreatic Resection, Preoperative Frailty
Prehabilitation in Pancreatic Surgery
The purpose of this study is to use functional studies to study the effectiveness of prehabilitation prior to surgery. The investigators know that stronger patients have better outcomes after surgery compared to weaker patients.
- Trial name
- NCT03688867
- Testing
- Prehabilitation regimen
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Case Comprehensive Cancer Center
Malignant Small Bowel Obstruction, Malignant Gastric Outlet Obstruction
AspireAssist for Palliative Venting Gastrostomy in Malignant Bowel Obstruction Patients
Individuals with cancer causing an intestinal or stomach obstruction often require gastric drainage to prevent symptoms of nausea, vomiting, and to prevent aspiration.
- Trial name
- NCT04375462
- Testing
- AspireAssist device, Standard decompressive PEG tube, gastric outlet obstruction scoring system (GOOSS) questionnaire
- Where
- United States
- Sponsor
- Case Comprehensive Cancer Center
Breast Cancer
Assessment of Candidate Protein Expression in Breast Cancer Specimens
RATIONALE: Studying the genes expressed in samples of tumor tissue from patients with cancer may help doctors identify biomarkers related to cancer.
- Trial name
- NCT00918892
- Testing
- gene expression analysis, immunohistochemistry staining method, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 460 people
- Sponsor
- Case Comprehensive Cancer Center
Prostate Carcinoma
Informed Decision Making Intervention in Screening for Prostate Cancer of Predominantly African American Participants in a Community Outreach Program
This clinical trial studies an informed decision making intervention of screening for prostate cancer in predominantly African American participants.
- Trial name
- NCT02419846
- Testing
- Educational Intervention, digital rectal examination, Pre-test administration
- Where
- United States
- Volunteers
- 319 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Gynecologic Malignancies
Weight-based Dosing for Dense Weekly Paclitaxel and Carboplatin in Overweight Patients w/ Body Surface Area (BSA) > 2.0
The purpose of this study is to evaluate the side effects and effectiveness of giving standard paclitaxel chemotherapy in doses based on actual body surface area in combination with standard dosed carboplatin chemotherapy for…
- Trial name
- NCT02756013
- Testing
- Paclitaxel, Carboplatin
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Case Comprehensive Cancer Center
Stage I Breast Cancer, Stage II Breast Cancer
Comparison of Use of Indocyanine Green and 99mTc-labeled Radiotracer for Axillary Lymphatic Mapping in Patients With Breast Cancer
This clinical trial will enroll up to 130 adult women with a confirmed diagnosis of clinical stage 1 or 2 breast cancer who are undergoing breast cancer surgery with lumpectomy or mastectomy and planned axillary sentinel node…
- Trial name
- NCT02419807
- Testing
- Indocyanine Green Solution, Technetium Tc-99m Sulfur Colloid, Lymphoscintigraphy
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Case Comprehensive Cancer Center
Squamous Cell Carcinoma of the Head and Neck
The Addition of Pembrolizumab to Postoperative Radiotherapy in Cutaneous Squamous Cell Cancer of the Head and Neck
A small group of skin cancers of the head and neck, called resected cutaneous squamous carcinomas, are more aggressive than most cancers of this type, even after being treated with standard therapy.
- Trial name
- NCT03057613
- Testing
- Pembrolizumab, IMRT 60-66Gy
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Case Comprehensive Cancer Center
Hepatocellular Carcinoma
Assessment of Novel MRI Quantification Free Breathing Technique in Evaluation of Liver Lesions
The primary objective of this study is to develop and validate simultaneous free-breathing 4D fat and water quantification and quantitative dynamic contrast enhanced perfusion in the liver.
- Trial name
- NCT02095678
- Testing
- liver biopsy, free-breathing MRI
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Case Comprehensive Cancer Center
Prostate Cancer
Pilot Study Evaluating the Role of Histopathology Correlation in Treatment Planning
This clinical research study tests the Uronav system. Patients with prostate cancer will be asked to take part in this study. Uronav system is an investigational device that is used on this study to help place markers in the…
- Trial name
- NCT02681614
- Testing
- Uronav guided biopsy, Magnetic resonance imaging
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Case Comprehensive Cancer Center
Adolescent and Young Adult Cancer
Adolescent and Young Adult Survivor Transition
The purpose of this study is to help adolescents and young adult cancer survivors address their psycho-social needs during the transitional period.
- Trial name
- AYAST (NCT02948712)
- Testing
- Distress Screening Thermometer, NCCN Guidelines: Distress management
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Case Comprehensive Cancer Center
Gynecologic Cancer
Improving Sexual Health in Gynecologic Cancer Patients
This study seeks to find out if an early intervention of providing directed sexual health education and treatment for gynecologic cancer patients will improve patient outcomes as compared to routine clinic visits.
- Trial name
- NCT03827993
- Testing
- dedicated sexual health clinic appointment
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Case Comprehensive Cancer Center