Clinical trials: sponsored by Cedars-Sinai Medical Center
Pain, Anxiety
Active vs. Passive VR During Office-based ENT Procedures
The purpose of this research is to evaluate whether active virtual reality reduces pain and anxiety more effectively than passive virtual reality during office-based ENT procedures.
- Conditions
- Pain, Anxiety, Chronic Rhinosinusitis (CRS), Nasal Obstruction
- Trial name
- NCT07599826
- Testing
- Passive virtual reality headset or goggles, Active virtual reality headset or goggles
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Cedars-Sinai Medical Center
Bicuspid Aortic Valve Disease
TAVR vs SAVR in Severe Bicuspid Aortic Stenosis
The study is a multicenter, randomized superiority trial of standard of care therapies for severe aortic stenosis (AS) in patients with a bicuspid aortic valve (BAV).
- Trial name
- BELIEVERS (NCT07413965)
- Testing
- Transcatheter Aortic Valve Replacement, the open chest surgery to replace the aortic valve
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- Cedars-Sinai Medical Center
Anxiety, Pain
The Role of Virtual Reality During Regional Anesthesia
In this study, we will analyze the role of virtual reality in acute pain and anxiety management for regional anesthesia in pre-operative patients at Cedars-Sinai Medical Center.
- Trial name
- NCT04163809
- Testing
- Virtual Reality with Oculus Go headset
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Anxiety, Pancreatic Cancer
Feasibility Study of Oral Ketamine Versus Placebo for the Treatment of Anxiety in Patients With Pancreatic Cancer
This is a prospective, single center, double blind, randomized, crossover feasibility study of oral ketamine versus placebo for the treatment of anxiety in patients with pancreatic cancer currently receiving or within 12 weeks of…
- Trial name
- NCT05086250
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Cedars-Sinai Medical Center
Prostate Cancer
NLP-Based Feedback to Improve Risk Comms and Informed Shared Decision Making
In this pilot study, the investigators will show feasibility of the NLP-based feedback system in 20 consultations of men with newly diagnosed prostate cancer.
- Trial name
- NCT05923684
- Testing
- NLP-based Feedback
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Cedars-Sinai Medical Center
Fecal Incontinence
Functional Outcomes in Ulcerative Colitis Patients With Ileal Pouch Anal Anastomosis Treated With High Intensity Focused Electromagnetic Stimulation
The purpose of this research is to evaluate functional outcomes in patients with Ulcerative Colitis and IBDU who have received an ileal pouch anal anastomosis (IPAA), commonly referred to as a J pouch, after treatment with the…
- Trial name
- NCT07034443
- Testing
- High Intensity Focused Electromagnetic Stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
Atrial Fibrillation, Stroke
A Trial of Pharmacist Management of Oral Anticoagulation THerapy in the communitY for AF
This is a prospective, single-arm, feasibility pilot study of 20 participants (aged 60 years or older, with additional stroke risk factors and 'actionable' undertreated AF) recruited from a total of 4 retail and outpatient…
- Trial name
- APOTHECARYAF (NCT04907825)
- Testing
- Oral anticoagulant
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Breast Cancer
Safety and Efficacy of Omission of Sentinel Node Biopsy in Patients With Estrogen-Positive Breast Cancer Over Age 65
This study will examine the outcomes of lumpectomy, surgery to remove a tumor, without sentinel node biopsy (SNB) for women at least 65 years of age with clinically node-negative breast cancer.
- Trial name
- NCT02564848
- Testing
- Lumpectomy without sentinel node biopsy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Cedars-Sinai Medical Center
Colorectal Cancer Screening
Impact of Protect Your Colon™ on CRC Screening
The purpose of the research is to assess the impact of Protect Your Colon™, a colorectal cancer (CRC) screening decision aid, on patients' CRC screening behaviors.
- Trial name
- NCT05929820
- Testing
- Protect Your Colon™
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- Cedars-Sinai Medical Center
Recurrent Acute Pancreatitis, Chronic Pancreatitis
Simvastatin Treatment to Improve Patient-reported Outcomes in Patients With Chronic Pancreatitis
The purpose of this pilot study to examine the feasibility and acceptability of simvastatin in adults with Recurrent Acute Pancreatitis (RAP) and Chronic Pancreatitis (CP).
- Trial name
- SMV in CP (NCT05771675)
- Testing
- Simvastatin
- Where
- 5 sites in United States
- Volunteers
- 90 people
- Sponsor
- Cedars-Sinai Medical Center
HPV Positive Oropharyngeal Squamous Cell Carcinoma
Trial of De-Intensified Post-operative Chemoradiation Following Robotic Surgery for HPV-positive Oropharyngeal Cancer
This study will enroll patients with HPV-associated oropharyngeal cancer, undergoing resection of all gross visible disease at the primary site and in the lymph nodes.
- Trial name
- NCT04502407
- Testing
- Cisplatin-based Radiation Therapy, Cisplatin Chemotherapy
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Cedars-Sinai Medical Center
Chronic Pancreatitis
A PiLot ClinicaL TrIal of ParicAlcitol for ChroNiC PancrEatitis
The purpose of this pilot study to examine the feasibility and acceptability of paricalcitol in adults with Chronic Pancreatitis (CP).
- Trial name
- ALLIANCE (NCT05664880)
- Testing
- Paricalcitol
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Cedars-Sinai Medical Center
Glioblastoma Multiforme
A Phase 2 Study of the Ketogenic Diet vs Standard Anti-cancer Diet Guidance for Patients With Glioblastoma in Combination With Standard-of-care Treatment
This is a Phase 2, randomized two-armed, multi-site study of 170 patients with newly diagnosed glioblastoma multiforme. Patients will be randomized 1:1 to receive Keto Diet, or Standard Anti-Cancer Diet.
- Trial name
- NCT05708352
- Testing
- Keto Diet, Standard Anti-Cancer Diet
- Where
- 5 sites in United States
- Volunteers
- 170 people
- Sponsor
- Cedars-Sinai Medical Center
Chronic Pancreatitis, Recurrent Pancreatitis
VR Pilot for Pancreatitis
The purpose of the research is to test the feasibility and preliminary impact of a home-based, standardized, gut-directed, virtual reality cognitive behavioral therapy (VR CBT) on clinical and functional outcomes of patients with…
- Trial name
- NCT06362187
- Testing
- Gut Directed VR
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
TNBC, TNBC - Triple-Negative Breast Cancer
Phase II Trial of Ivonescimab in Combination With Carboplatin + Docetaxel in Patients With Early-Stage Triple Negative Breast Cancer
This is a single arm phase II trial combination of ivonescimab and carbo-docetaxel every 3 weeks for 6 cycles in patients with early-stage triple negative breast cancer.
- Conditions
- TNBC, TNBC - Triple-Negative Breast Cancer, Early Stage Triple-Negative Breast Carcinoma
- Trial name
- NCT07017673
- Testing
- Ivonescimab, Carboplatin, Docetaxel
- Where
- 4 sites in United States
- Volunteers
- 34 people
- Sponsor
- Cedars-Sinai Medical Center
Heart Failure, Chronic Kidney Disease
Staged Kidney Transplantation During Combined Heart/Kidney Transplantation
The primary purpose of this study is to evaluate the safety and efficacy of ex vivo machine perfusion with staged implantation of kidney allografts during combined heart/kidney transplantation.
- Conditions
- Heart Failure, Chronic Kidney Disease, End-stage Kidney Disease
- Trial name
- NCT06877169
- Testing
- Planned delayed implantation of kidney allograft with ex vivo machine perfusion kidney preservation.
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
Epilepsy Intractable
Neural Computations of Goal-directed Decision-making
The purpose of this research is to better understand how the human brain accomplishes the cognitive task of making goal-directed decisions.
- Trial name
- NCT06489561
- Testing
- Cedrus RB-844 response pad; Adtech Behnke-Fried micro-electrodes; Neurolynx electrophysiology system
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Cedars-Sinai Medical Center
Cardiac Amyloidosis
Artificial Intelligence Guided Echocardiographic Screening of Rare Diseases (EchoNet-Screening)
Despite rapidly advancing developments in targeted therapeutics and genetic sequencing, persistent limits in the accuracy and throughput of clinical phenotyping has led to a widening gap between the potential and the actual…
- Trial name
- NCT05139797
- Testing
- EchoNet-LVH screening for cardiac amyloidosis
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Cedars-Sinai Medical Center
Heart Failure
Safety and Efficacy Study of AI Wall Thickness Measurement (EchoNet-LVH-RCT)
To determine whether an integrated AI decision support can save time and improve accuracy of assessment of echocardiograms, the investigators are conducting a blinded, randomized controlled study of AI guided measurements of wall…
- Trial name
- NCT05791227
- Testing
- Sonographer Evaluation, AI Evaluation
- Where
- United States
- Volunteers
- 4,000 people
- Sponsor
- Cedars-Sinai Medical Center
Cardiac Amyloidosis
AI Echocardiographic Screening of Cardiac Amyloidosis
Recent advances in machine learning and image processing techniques have shown that machine learning models can identify features unrecognized by human experts and accurately assess common measurements made in clinical practice.
- Trial name
- NCT06664866
- Testing
- EchoNet-LVH Assessment
- Where
- 4 sites in United States
- Volunteers
- 500 people
- Sponsor
- Cedars-Sinai Medical Center