Clinical trials: sponsored by Cedars-Sinai Medical Center
Coronary Artery Disease
Women's IschemiA TRial to Reduce Events In Non-ObstRuctive CAD
The Ischemia-IMT (Ischemia-Intensive Medical Treatment Reduces Events in Women with Non-Obstructive CAD), subtitle: Women's Ischemia Trial to Reduce Events in Non-Obstructive CAD (WARRIOR) trial is a multicenter, prospective…
- Trial name
- WARRIOR (NCT03417388)
- Testing
- High dose potent statin, ACE-I (lisinopril) or ARB (losartan), Aspirin 81 enteric coated tablet daily
- Where
- 81 sites in United States, Puerto Rico
- Volunteers
- 2,476 people
- Sponsor
- Cedars-Sinai Medical Center
Colorectal Cancer, Breast Cancer
Time-Restricted Eating and Cancer: Clinical Outcomes, Mechanisms, and Moderators
The purpose of this study is to test whether the timing of meals can improve treatment adverse events, influence tumor biology and alter a person's mood and behaviors.
- Trial name
- NCT04722341
- Testing
- Time-Restricted Eating (TRE), Control
- Where
- 2 sites in United States
- Volunteers
- 98 people
- Sponsor
- Cedars-Sinai Medical Center
Post Operative Swelling
Geko™ Device in Prevention of Pain and Swelling Following Knee Arthroscopy
report on post-operative effectiveness of the Geko™ device in prevention of pain and swelling after arthroscopic anterior cruciate ligament reconstruction and repairs
- Trial name
- NCT07896499
- Testing
- Geko, control
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Ostomy - Ileostomy or Colostomy
Ostomy Readmission Reduction Program
The purpose of this study is to reduce complications like peristomal skin issues, stoma-related problems, dehydration, and other preventable factors that can lead to re-hospitalization within the first 30 days after surgery.
- Trial name
- NCT06956274
- Testing
- Preoperative Telehealth, Measure Ostomy Output
- Where
- United States
- Sponsor
- Cedars-Sinai Medical Center
Melanoma
Community Based Strategies for Early Detection of Melanoma
The purpose of this study is to pilot the use of community education and digital dermatology to increase the early detection of curable melanomas.
- Trial name
- NCT04799106
- Testing
- Community Based Strategies for Early Detection of Melanoma
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Crohn's Disease, Ulcerative Colitis (UC)
Online Pain Education for Crohn's Disease and Ulcerative Colitis
Through a pilot randomized controlled trial (RCT), we aim to test the feasibility and preliminary impact of two online pain educations programs among adult patients with inflammatory bowel disease (IBD) who experience chronic…
- Conditions
- Crohn's Disease, Ulcerative Colitis (UC), Inflammatory Bowel Disease (Crohn's Disease; Ulcerative Colitis)
- Trial name
- NCT07671313
- Testing
- Empowered Relief, Living Better with Chronic Pain
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Cedars-Sinai Medical Center
Social Isolation, Loneliness
LEAPTogether: An Intergenerational Intervention to Address Loneliness and Social Isolation
Older adult participants will engage in exercise videos twice a week for 8 weeks either while paired with a peer (same age group) or paired with a younger adult with the ability to simultaneously video chat while exercising.
- Conditions
- Social Isolation, Loneliness, Intergenerational Relations
- Trial name
- LEAPTogether (NCT05831475)
- Testing
- Intergenerational Virtual Paired Exercise, Peer Virtual Paired Exercise
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Clinical Decision Support
Artificial Intelligence (AI)-Initiated Clinical Decision Support in Hospitalist Practice
This study will evaluate the feasibility of using artificial intelligence (AI)-generated clinical decision support during routine inpatient hospital medicine care.
- Trial name
- NCT07889063
- Testing
- AI Clinical Decision Support: Automated EHR Data Retrieval, AI Clinical Decision Support: Admission H&P Note
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Intracranial Atherosclerosis, Intracranial Arterial Stenosis
EDAS Revascularization for Symptomatic Intracranial Atherosclerotic Steno-occlusive Disease
ERSIAS IIb is a multicenter randomized controlled trial, with a Phase IIb design, to find out whether encephaloduroarteriosynangiosis (EDAS), a type of indirect surgical revascularization of the brain, added to intensive medical…
- Conditions
- Intracranial Atherosclerosis, Intracranial Arterial Stenosis, Ischemic Stroke
- Trial name
- ERSIAS IIb (NCT07864649)
- Testing
- Encephaloduroarteriosynangiosis (EDAS), Intensive medical management
- Volunteers
- 170 people
- Sponsor
- Cedars-Sinai Medical Center
Rejection Chronic Renal, Kidney Transplant Rejection
Longitudinal Changes in Donor-Derived Cell-Free DNA With Tocilizumab Treatment for Chronic Antibody-Mediated Rejection
Our group recently reported that tocilizumab, a humanized monoclonal antibody against the IL-6 receptor, may be effective when administered monthly to patients with chronic antibody-mediated rejection (ABMR).
- Trial name
- NCT03859388
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Cedars-Sinai Medical Center
Pregnancy Related, Pregnancy Complications
Resources, Inspiration, Support and Empowerment (RISE) for Black Pregnant Women
Perinatal Mood and Anxiety Disorders (PMADs) encompass a range of mental health disorders that occur during pregnancy and up to one year postpartum. Approximately 13% of women experience PMADs.
- Conditions
- Pregnancy Related, Pregnancy Complications, Pregnancy, High Risk, Depression
- Trial name
- RISE (NCT05552053)
- Testing
- MWSH plus Candlelit Care, MWSH
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Pre-Eclampsia, Depression
Preeclampsia Research on Vitamin D, Inflammation, & Depression
This study is designed to comprehensively investigate the anti-inflammatory role of vitamin D in reproductive aged women, and its association with preeclampsia and depression.
- Conditions
- Pre-Eclampsia, Depression, Inflammation, Vitamin D Deficiency
- Trial name
- PROVIDE (NCT03018132)
- Testing
- mental health screening, education and referral program
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Obesity, Overweight
Avoid and Resist Strategies for Weight Management
The proposed randomized controlled trial tests two self-regulatory approaches to improve intentional weight loss and diet quality in individuals with overweight or obesity: (1) an environmental control strategy (AVOID) and (2) an…
- Trial name
- NCT05143931
- Testing
- Home food environment and grocery delivery (AVOID), Inhibitory control training (RESIST), WW
- Where
- United States
- Volunteers
- 503 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Pancreatic Adenocarcinoma, Weight Loss
Small Intestinal Bacterial Overgrowth (SIBO) in Pancreatic Adenocarcinoma (PDAC)
The purpose of this study is to prospectively analyze the prevalence of SIBO in patients with Pancreatic adenocarcinoma (PDAC) and understand its association with weight loss and pancreatic resection status.
- Trial name
- SIBO in PDAC (NCT06988150)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Cedars-Sinai Medical Center
Bladder Cancer
A Novel Multiplex ELISA Assay for Evaluating Patients With Gross Hematuria for Bladder Cancer
To improve upon the non-invasive detection of BCa by further validating a multiplex ELISA assay directed at a BCa-associated diagnostic signature in voided urine samples of patients with gross hematuria.
- Trial name
- NCT03193528
- Where
- 6 sites in United States, Japan
- Volunteers
- 450 people
- Sponsor
- Cedars-Sinai Medical Center
Kyphosis
Managing Kyphosis With Exercise
The primary objective of this study is to determine if stretching exercises as a conservative treatment option will correct kyphosis in postural and Scheuermann's kyphosis.
- Trial name
- NCT06082739
- Testing
- Exercises
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Cedars-Sinai Medical Center
Cushing Disease
Multicenter Study of Seliciclib (R-roscovitine) for Cushing Disease
This phase 2 multicenter, open-label clinical trial will evaluate safety and efficacy of 4 weeks of oral seliciclib in patients with newly diagnosed, persistent, or recurrent Cushing disease.
- Trial name
- NCT03774446
- Testing
- Seliciclib
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Cedars-Sinai Medical Center
Age-Related Lung Function Decline
Ongoing Lung Decline With Age Intensified Response
This Phase II, randomized, double-blind, placebo-controlled pilot study will evaluate the effects of fisetin, a senolytic flavonoid compound, on lung function and biomarkers of cellular senescence in older adults aged 60 years…
- Trial name
- OLD AIR (NCT07676435)
- Testing
- Fisetin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Alzheimer's Disease
Transcranial Photobiomodulation (tPBM) in Alzheimer's Disease Study
The purpose of this study is to see if a special light treatment, called photobiomodulation, can help people with memory problems such as Mild Cognitive Impairment or Mild Dementia due to Alzheimer's disease.
- Trial name
- NCT07224607
- Testing
- Photobiomodulation
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Cedars-Sinai Medical Center
Prostate Cancer (Diagnosis), Prostate Cancer Stage IV
High Cardiovascular Risk Intervention With Cardio-Oncology Consultation for Prostate Cancer Following Androgen Receptor Pathway Inhibitor (ARPI) Therapy (Heart-Safe)
In patients with prostate cancer (PC), cardiovascular disease (CVD) causes significant morbidity and is the second leading cause of death.
- Conditions
- Prostate Cancer (Diagnosis), Prostate Cancer Stage IV, CV Risk
- Trial name
- NCT07223385
- Testing
- Cardio-Oncology Referral, Notification to PCP/General Cardiologist
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Cedars-Sinai Medical Center