Clinical trials: sponsored by Cedars-Sinai Medical Center
Obesity
Benefits of Endoscopic Bariatric Procedures
This 12-months long pilot study will include patients undergoing an endoscopic procedure (endoscopic sleeve gastroplasty [ESG] or transoral outlet reduction [TORe]) as clinically indicated, and subsequent follow up clinic visits…
- Trial name
- NCT05514288
- Testing
- Endobariatric procedure
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Social Isolation, Fall
The Impact of Community Exercise on Social Connectedness and Falls in Older Adults: Leveraging Exercise to Age in Place
The goal of this study is to reduce risk of falls and social isolation in older adults age 50+ through participation in community based health and exercise programs.
- Trial name
- LEAP (NCT03624049)
- Testing
- Exercise, Health Class
- Where
- 9 sites in United States
- Volunteers
- 671 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Cancer, Coronary Artery Disease
Calibration of MR and PET-MR Imaging Protocols at RIC
This is a protocol to facilitate on-site calibration of the technical aspects of the Siemens Biograph mMR (molecular MR) Positron Emission Tomography-Magnetic Resonance (PET-MR) scanner and the 3T Siemens Vida MR scanner at the…
- Trial name
- NCT02249520
- Testing
- PET-MR imaging on Biograph mMR scanner, MR-only imaging on Biograph mMR scanner, MR imaging on the Siemens Vida 3T MR scanner
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Burnout, Professional
Integrative Self-care Approaches for HCP Wellbeing
The purpose of this pilot study is to assess the impact of a hospital-based integrative self-care program (e.g., a. Reiki and b.
- Trial name
- NCT05387746
- Testing
- Caring Science, Mindful Practice and Reiki Training
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Hip Injuries, Hip Dislocation
Does Limb Pre-Conditioning Reduce Pain After Hip Arthroscopy
The purpose of this study is to determine if the utilization of Ischemic Pre-Conditioning 24-hours prior to hip arthroscopy decreases patient's post-operative pain and opioid consumption.
- Conditions
- Hip Injuries, Hip Dislocation, Hip Fractures
- Trial name
- NCT04925791
- Testing
- standardized pre-conditioning treatment, Partial occlusion
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Congestive Heart Failure, Heart Failure, Diastolic
Regression of Fibrosis & Reversal of Diastolic Dysfunction in HFpEF Patients Treated With Allogeneic CDCs
Perform a randomized, double blind, placebo-controlled Phase 2a feasibility study to determine whether treatment of HFpEF patients with intracoronary allogeneic CDCs affects clinical functional status (QOL scores), exercise…
- Trial name
- RegressHFpEF (NCT02941705)
- Testing
- Allogeneic Derived Cells
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Cedars-Sinai Medical Center
Cardiovascular Disease, Hyperlipidemia
Effect of Evolocumab on Coronary Atherosclerosis
This study will quantify changes in coronary plaque volumes and plaque composition in patients treated with evolocumab. Previous intravascular ultrasound studies have shown that treatment with a lipid-lowering PCSK9 enzyme…
- Trial name
- NCT03689946
- Testing
- Evolocumab, 18F-NaF PET, CCTA
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Cedars-Sinai Medical Center
Kidney Transplant Rejection
Comparison of Tacrolimus Extended-Release (Envarsus XR) to Tacrolimus Immediate-Release in Human Leukocyte Antigen (HLA) Sensitized Kidney Transplant Recipients
This is a randomized, open-label, controlled clinical trial designed to compare clinical outcomes after kidney transplantation using extended-release tacrolimus (Envarsus XR) versus immediate tacrolimus among highly-sensitized…
- Trial name
- NCT04225988
- Testing
- Extended-release tacrolimus, Immediate-release tacrolimus
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
Anesthesia, Deep Sedation
Comparison of Two Electroencephalograms (EEG) Monitors in Patients Undergoing General Anesthesia
Hypothesis: There is a statistically measurable correlation between qNOX and rough clinical signs of insufficient anti-nociception such as movements during Laryngeal Mask Airway (LMA) insertion, skin Incision, LMA removal.
- Trial name
- NCT02928172
- Testing
- qCON-qNOX, BIS
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Cedars-Sinai Medical Center
Laparoscopic Surgery
Short Title: Standard vs. Lower Pressure Pneumoperitoneum
This study aims to investigate the effect of varying insufflation pressures on post-operative pain and adequacy of surgical field visualization among patients undergoing laparoscopic surgery with a minimally invasive gynecologic…
- Trial name
- NCT06338865
- Testing
- Carbon dioxide, Bupivacaine, Oxycodone
- Where
- United States
- Volunteers
- 294 people
- Sponsor
- Cedars-Sinai Medical Center
Laparoscopic Surgery
Blunt Fascial vs. Veress Needle Peritoneal Entry in Laparoscopic Gynecologic Surgery
This study aims to investigate the effect of two peritoneal entry techniques on intraoperative and post-operative outcomes among patients undergoing laparoscopic surgery with a minimally invasive gynecologic surgeon.
- Trial name
- BluntFascial (NCT06305975)
- Testing
- Blunt fascial abdominal entry, Veress needle abdominal entry
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Acromegaly
Diet in the Management of Acromegaly
Impact of low carbohydrate and low gluten diet on acromegaly progression, symptoms, complications, and treatment outcomes.
- Trial name
- NCT05401084
- Testing
- Diet
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Cedars-Sinai Medical Center
Bladder Cancer Stage II
Radiogenomics of Muscle Invasive Bladder Cancer
Patients with suspected bladder tumor will undergo novel 4D MRI imaging along with single cell RNA sequencing in hopes of identifying a radiogenomic signature that can improve our staging of patients with muscle invasive bladder…
- Trial name
- NCT04806334
- Testing
- MRI imaging of the pelvis/bladder, genomic analysis of tumor
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Cedars-Sinai Medical Center
Pouchitis, Ileal Pouchitis
Tofacitinib For Treatment Of Chronic Pouchitis
A phase 2 pilot study to evaluate the effectiveness of tofacitinib in subjects with chronic pouchitis
- Conditions
- Pouchitis, Ileal Pouchitis, Ileal Pouch
- Trial name
- NCT04580277
- Testing
- Tofacitinib 10 mg
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Cedars-Sinai Medical Center
Prostate Cancer
High Resolution MRI Study for Prostate Cancer
This high resolution MRI (hrMRI), along with stand MRI (sMRI) will be obtained at baseline and again in approximately 1 year in patients on prostate cancer active surveillance.
- Trial name
- NCT03292874
- Testing
- high resolution MRI (hrMRI)
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Cedars-Sinai Medical Center
Depression, Heart Failure
Personalized Treatments for Depressive Symptoms in Patients With Advanced Heart Failure
We are doing this study to help patients, caregivers, and providers make decisions about how best to manage depressive symptoms in advanced heart failure.
- Trial name
- NCT03688100
- Testing
- Behavioral Activation Therapy, Medication Management
- Where
- United States
- Volunteers
- 494 people
- Sponsor
- Cedars-Sinai Medical Center
Parkinson Disease
Safety and Efficacy of Liraglutide in Parkinson's Disease
The purpose of this study is to test the efficacy and safety of liraglutide in the treatment of patients with idiopathic Parkinson's disease (PD).
- Trial name
- NCT02953665
- Testing
- Liraglutide
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Cedars-Sinai Medical Center
Cancer
Personalized Cancer Care at Cedars-Sinai Medical Center Samuel Oschin Comprehensive Cancer Institute
The purpose of this study is to examine the usefulness of matching patients to targeted therapy by analyzing a tumor sample taken at diagnosis and testing it against 50 cancer-associated genes.
- Trial name
- NCT03098576
- Testing
- Matched targeted drug treatment, Unmatched standard of care
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Cedars-Sinai Medical Center
Laminectomy
The Effects of Ketamine and Methadone on Postoperative Pain for Laminectomy
The purpose of this research is to determine the pain-reducing effects of ketamine (Ketalar, an FDA-approved drug for anesthesia) and methadone (Dolophine, a long-acting narcotic) after lumbar laminectomy.
- Trial name
- NCT02252432
- Testing
- Ketamine, Methadone, Ketamine + methadone
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Cedars-Sinai Medical Center
Carotid Artery Disease
3D Multi-Contrast Atherosclerosis Characterization of the Carotid Artery
This is a technical development study with the goal to develop 3D techniques for atherosclerosis plaque characterization. We hypothesize that 3D MRI is superior to 2D MRI in characterizing major plaque constituents that…
- Trial name
- NCT02163408
- Testing
- MRI with/without contrast
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center